GO:0043410

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Name positive regulation of MAPK cascade
Categary Process
Go Slim No
Go Link GO:0043410
Unique Molecular Interactions 3383
Total Molecular Interactions 5011
Total Single Events 42807
Pain Genes Associated 139

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
2 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25
3 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
4 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
5 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
6 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
7 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
8 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
9 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
10 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
11 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
12 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
13 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
14 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
15 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
16 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
17 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
18 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
19 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
20 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
21 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
22 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
23 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
24 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
25 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
26 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
27 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
28 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59
29 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
30 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
31 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
32 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
33 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
34 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
35 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
36 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
37 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
38 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
39 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
40 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
41 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
42 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
43 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
44 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
45 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
46 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
47 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
48 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
49 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
50 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
51 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
52 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
53 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
54 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
55 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
56 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
57 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
58 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
59 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
60 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
61 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
62 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
63 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
64 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
65 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59
66 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
67 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
68 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
69 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
70 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
71 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
72 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
73 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
74 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
75 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
76 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
77 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
78 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
79 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
80 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
81 INT202912 Uchl1 Positive_regulation of Gene_expression of Ntrk2 1 0.08 1.64 1.42
82 INT225019 PDGFB Positive_regulation of Gene_expression of Cxcl1 1 0.27 0.54 1.4
83 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
84 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
85 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
86 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
87 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
88 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
89 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
90 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
91 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
92 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
93 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
94 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
95 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
96 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
97 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
98 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
99 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
100 INT271602 Binding of Pdgfa and Pdgfrl 1 0.02 0.86 1.25
101 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
102 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
103 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
104 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
105 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
106 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
107 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
108 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
109 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
110 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
111 INT287749 Dmbx1 Positive_regulation of Gene_expression of Lpar1 1 0.41 0.82 1.16
112 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
113 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
114 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
115 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
116 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
117 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
118 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
119 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
120 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
121 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
122 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
123 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
124 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
125 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
126 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
127 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
128 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
129 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
130 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
131 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
132 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
133 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
134 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
135 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
136 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
137 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
138 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
139 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
140 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
141 INT8416 LIF Regulation of TAC1 1 0.13 0.36 1.04
142 INT8415 LIF Regulation of VIP 1 0.13 0.36 1.04
143 INT181434 Binding of Ccr2 and Ccl2 1 0.27 6.06 1.04
144 INT231391 Binding of Lpar1 and Rbm39 1 0.00 1.04 1.04
145 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
146 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
147 INT122429 Prkci Regulation of Gene_expression of Ighm 1 0.00 0 1.02
148 INT122431 Prkci Negative_regulation of Negative_regulation of Ighm 1 0.00 0 1.02
149 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
150 INT56743 LIF Positive_regulation of Cck 1 0.08 0.18 1.02
151 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
152 INT122433 Prkci Negative_regulation of Ighm 1 0.00 0 1.02
153 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
154 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
155 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
156 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
157 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
158 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
159 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
160 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
161 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
162 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
163 INT167173 Binding of Ccl2 and Ccr2 2 0.30 1.15 0.98
164 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
165 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
166 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
167 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98
168 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
169 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
170 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
171 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
172 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
173 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
174 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
175 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
176 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
177 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
178 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
179 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
180 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
181 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
182 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
183 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93
184 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
185 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
186 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
187 INT196591 Binding of Lpar1 and Pax3 1 0.05 1.1 0.92
188 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
189 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
190 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 0.13 1.31 0.91
191 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
192 INT271601 Pdgfa Positive_regulation of Pdgfrl 1 0.03 0.83 0.91
193 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
194 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
195 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
196 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
197 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
198 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
199 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
200 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of MAPK cascade. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of MAPK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
3 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
4 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
5 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
6 INT812 Localization of INS 1026 0.81 515.6 145.31
7 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
8 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
9 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
10 INT12082 Localization of IL6 365 0.81 241.78 105.78
11 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
12 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
13 INT19511 Localization of Il6 212 0.81 118.17 67.67
14 INT11937 Localization of Il6 228 0.81 139.83 64.39
15 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
16 INT10706 Regulation of Il6 150 0.62 93.23 62.34
17 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
18 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
19 INT251 Regulation of INS 398 0.62 232.47 55.04
20 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
21 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
22 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
23 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
24 INT9210 Regulation of IL6 166 0.62 125.61 49.95
25 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
26 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
27 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
28 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68
29 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
30 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
31 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
32 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
33 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
34 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
35 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
36 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
37 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
38 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
39 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
40 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23
41 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
42 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
43 INT9655 Regulation of Il6 98 0.62 70.92 31.95
44 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
45 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
46 INT8691 Localization of Insr 85 0.80 9.27 30.32
47 INT1158 Regulation of Agt 106 0.61 29.4 30.29
48 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
49 INT86437 Binding of IL6 154 0.48 121.22 29.3
50 INT5300 Regulation of Insr 54 0.60 11.33 29.26
51 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
52 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
53 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
54 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
55 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
56 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
57 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
58 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
59 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
60 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
61 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
62 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
63 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71
64 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
65 INT51474 Binding of Il6 55 0.48 44.99 20.52
66 INT49985 Transcription of Il6 62 0.72 40.13 20.29
67 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
68 INT102545 Gene_expression of Ccr2 42 0.78 61.43 19.81
69 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
70 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59
71 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
72 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
73 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
74 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
75 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
76 INT61626 Transcription of IL6 73 0.72 42.04 17.86
77 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
78 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
79 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
80 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
81 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
82 INT151434 Positive_regulation of Ccr2 26 0.68 18.34 16.34
83 INT2066 Localization of Agt 56 0.80 9.95 16.25
84 INT153913 Positive_regulation of Lpar1 31 0.70 33.5 16.14
85 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
86 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
87 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46
88 INT75908 Regulation of LEP 77 0.60 60.16 15.19
89 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
90 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
91 INT663 Negative_regulation of Adrb3 55 0.59 15.95 14.68
92 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
93 INT110 Regulation of Adrb3 33 0.60 8.09 13.84
94 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78
95 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
96 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
97 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
98 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
99 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4
100 INT14572 Binding of INS 205 0.48 175.43 13.38
101 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
102 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08
103 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
104 INT3962 Regulation of AGT 50 0.62 20.96 13.01
105 INT54763 Binding of Il6 82 0.48 63.27 12.89
106 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
107 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
108 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
109 INT4199 Binding of Agt 76 0.48 21.06 12.66
110 INT73641 Regulation of Lep 45 0.62 26.2 12.59
111 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
112 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
113 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
114 INT53866 Gene_expression of Sstr4 17 0.77 6.67 11.83
115 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
116 INT50933 Transcription of Il6 38 0.72 24.31 11.58
117 INT398 Localization of AGT 45 0.78 16.97 11.54
118 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
119 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
120 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
121 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
122 INT8065 Binding of AGT 54 0.48 20.54 10.85
123 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
124 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
125 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
126 INT8188 Positive_regulation of Adrb3 27 0.68 7.32 10.44
127 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
128 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
129 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
130 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
131 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
132 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
133 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
134 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
135 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
136 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
137 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
138 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
139 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
140 INT35366 Binding of AR 87 0.47 30.52 8.9
141 INT161222 Positive_regulation of Ccr2 13 0.55 13.77 8.89
142 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
143 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77
144 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75
145 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
146 INT166119 Negative_regulation of Gene_expression of Lpar1 17 0.51 13.86 8.7
147 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
148 INT88047 Positive_regulation of Gene_expression of Ccr2 15 0.60 10.5 8.63
149 INT34777 Localization of IGF1 82 0.80 42.68 8.62
150 INT47682 Transcription of Ntrk2 19 0.69 6.32 8.6
151 INT82082 Localization of Lep 63 0.81 26.41 8.56
152 INT75907 Binding of LEP 53 0.46 46.65 8.44
153 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42
154 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
155 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
156 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39
157 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
158 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
159 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
160 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
161 INT205203 Gene_expression of Lpar1 6 0.39 11.83 8.08
162 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
163 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
164 INT48314 Gene_expression of NTRK2 17 0.75 7.84 7.83
165 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
166 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56
167 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
168 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
169 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41
170 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
171 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
172 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
173 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
174 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
175 INT102548 Negative_regulation of Ccr2 14 0.59 19.84 7.22
176 INT121752 Gene_expression of IL11 54 0.62 18.05 7.16
177 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
178 INT47691 Positive_regulation of Gene_expression of Ntrk2 17 0.62 13.64 6.96
179 INT110104 Localization of Prkce 17 0.79 3.75 6.92
180 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9
181 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
182 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
183 INT2111 Gene_expression of LIF 34 0.77 16.82 6.76
184 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
185 INT50387 Negative_regulation of AR 67 0.45 26.31 6.61
186 INT3795 Positive_regulation of Ighm 46 0.68 22.43 6.47
187 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
188 INT205198 Positive_regulation of Lpar1 2 0.35 7.35 6.37
189 INT64052 Positive_regulation of FGFR1 26 0.52 28.47 6.36
190 INT47681 Regulation of Ntrk2 17 0.62 3.61 6.31
191 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
192 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
193 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
194 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
195 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
196 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
197 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
198 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
199 INT335 Binding of Adra1a 16 0.36 6.16 6
200 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
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