GO:0043422

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Name protein kinase B binding
Categary Function
Go Slim No
Go Link GO:0043422
Unique Molecular Interactions 94
Total Molecular Interactions 120
Total Single Events 656
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein kinase B binding. They are ordered first by their pain relevance and then by number of times they were reported for protein kinase B binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
2 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
3 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
4 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
5 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
6 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
7 INT146097 Positive_regulation of Binding of Rgs9 and Arrb2 1 0.28 0 1.04
8 INT146098 Binding of Rgs9 and Arrb2 1 0.19 0 1.03
9 INT143916 Arrb2 Regulation of Rbm39 1 0.04 0.18 1
10 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
11 INT111632 Arrb2 Negative_regulation of Regulation of Rbm39 1 0.03 0 0.96
12 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
13 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
14 INT5856 Bad Positive_regulation of Gene_expression of Penk 1 0.02 0.37 0.5
15 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
16 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
17 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
18 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
19 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
20 INT143914 Binding of Rbm39 and Arrb2 1 0.03 0.07 0.37
21 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
22 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
23 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
24 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
25 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
26 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
27 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
28 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
29 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
30 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
31 INT29984 Bad Positive_regulation of Localization of Prl 1 0.15 0 0.3
32 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
33 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
34 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
35 INT172901 Binding of Bad and Bcl2l1 3 0.13 6.51 0.27
36 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
37 INT120376 Bad Positive_regulation of Gene_expression of Oxtr 1 0.08 0 0.22
38 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
39 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
40 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
41 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
42 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
43 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
44 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
45 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
46 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
47 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
48 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
49 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
50 INT275184 Bad Positive_regulation of Positive_regulation of Bcl2l1 1 0.12 0.62 0.09
51 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
52 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
53 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
54 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
55 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
56 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
57 INT331153 Akt1 Positive_regulation of Bad 1 0.03 0.92 0.04
58 INT331155 Akt1 Positive_regulation of Binding of Bad 1 0.04 0.93 0.04
59 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
60 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
61 INT331156 Akt1 Positive_regulation of Phosphorylation of Bad 1 0.02 0.91 0.04
62 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
63 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
64 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
65 INT303056 Rorb Regulation of Bad 1 0.00 0.52 0.03
66 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
67 INT182918 Binding of DR1 and RARA 2 0.08 0 0
68 INT229815 Fos Regulation of Bad 1 0.09 0.31 0
69 INT182949 Binding of RARA and VDR 1 0.20 0 0
70 INT285909 AKT1 Regulation of Phosphorylation of Bad 1 0.01 0.4 0
71 INT335953 Binding of BCL2 and Bad 1 0.14 0.37 0
72 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
73 INT295048 Bad Regulation of RYBP 1 0.00 1.64 0
74 INT348020 Binding of Traf6 and Irak2 1 0.13 0.05 0
75 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
76 INT182961 Binding of RARA and KCNIP3 1 0.21 0.76 0
77 INT172908 Binding of Bad and Bax 1 0.01 1.34 0
78 INT348037 Irak2 Positive_regulation of Binding of Traf6 1 0.18 0.05 0
79 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0
80 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0
81 INT201760 Binding of BCL2L1 and Positive_regulation of Bad 1 0.01 0.3 0
82 INT234440 Binding of PROC and RARA 1 0.00 0.73 0
83 INT335951 Binding of Bad and Tgif2lx1 1 0.00 0.37 0
84 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
85 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
86 INT242612 Bcl10 Positive_regulation of Skull19 1 0.01 1.2 0
87 INT225504 Binding of gr and Rara 1 0.02 0 0
88 INT201743 Bad Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
89 INT182948 KCNIP3 Regulation of Transcription of RARA 1 0.23 0.55 0
90 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0
91 INT317311 Binding of Cdc37 and Pink1 1 0.13 0.56 0
92 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein kinase B binding. They are ordered first by their pain relevance and then by number of times they were reported in protein kinase B binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
2 INT94981 Gene_expression of Arrb2 12 0.70 2.11 11.75
3 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
4 INT100079 Positive_regulation of Gene_expression of Arrb2 7 0.63 2.26 6.77
5 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52
6 INT94979 Regulation of Arrb2 6 0.54 0.51 6.45
7 INT94986 Positive_regulation of Arrb2 5 0.61 1.3 6.24
8 INT85685 Gene_expression of Arrb2 5 0.74 0.66 5.13
9 INT85681 Negative_regulation of Arrb2 5 0.47 0.79 4.71
10 INT108935 Transcription of Arrb2 5 0.59 0.5 4.38
11 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
12 INT92797 Regulation of Arrb2 4 0.44 0.81 4.28
13 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
14 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2
15 INT33229 Gene_expression of Bad 9 0.70 6.95 4.15
16 INT51654 Regulation of Bad 21 0.40 12.18 4.06
17 INT85679 Binding of Arrb2 4 0.39 0.79 3.82
18 INT94983 Negative_regulation of Arrb2 2 0.52 0.26 3.47
19 INT85682 Positive_regulation of Arrb2 4 0.46 0.22 3.05
20 INT3437 Negative_regulation of Bad 5 0.48 1.66 2.99
21 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
22 INT29983 Localization of Bad 5 0.28 4.44 2.52
23 INT108937 Negative_regulation of Transcription of Arrb2 1 0.38 0.31 2.31
24 INT108939 Regulation of Transcription of Arrb2 1 0.24 0.19 2.1
25 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07
26 INT43143 Binding of Bad 8 0.21 5.12 1.81
27 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
28 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
29 INT125844 Positive_regulation of Gene_expression of Arrb2 2 0.48 0.45 1.66
30 INT93427 Negative_regulation of Bad 4 0.02 2.5 1.63
31 INT5855 Positive_regulation of Bad 12 0.61 12.26 1.56
32 INT67457 Binding of Rara 12 0.24 8.28 1.45
33 INT18495 Regulation of Bad 6 0.19 4.79 1.45
34 INT108936 Positive_regulation of Positive_regulation of Arrb2 1 0.41 0.25 1.4
35 INT154081 Negative_regulation of Localization of Bad 2 0.16 2.06 1.31
36 INT81400 Binding of RARA 25 0.36 12.93 1.27
37 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
38 INT302068 Phosphorylation of Arrb2 1 0.01 0.27 1.19
39 INT182985 Transcription of RARA 9 0.60 3.52 1.12
40 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
41 INT108943 Positive_regulation of Negative_regulation of Arrb2 1 0.61 0.06 0.97
42 INT159668 Positive_regulation of Bad 8 0.45 6.32 0.89
43 INT192090 Localization of Rara 6 0.46 4.15 0.89
44 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
45 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
46 INT133767 Transcription of Bad 2 0.57 1.72 0.84
47 INT48250 Regulation of Rara 3 0.29 2.47 0.83
48 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
49 INT212109 Localization of RARA 5 0.65 3.17 0.79
50 INT275180 Positive_regulation of Phosphorylation of Bad 4 0.40 3.79 0.77
51 INT201628 Positive_regulation of Gene_expression of Bad 12 0.68 13.86 0.72
52 INT91398 Regulation of RARA 7 0.59 5.84 0.67
53 INT331152 Positive_regulation of Localization of Bad 1 0.19 1.35 0.64
54 INT331150 Negative_regulation of Gene_expression of Bad 1 0.10 1.33 0.63
55 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
56 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
57 INT147679 Binding of Arrb2 1 0.24 0.22 0.58
58 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
59 INT142871 Negative_regulation of Gene_expression of Bad 7 0.51 6.52 0.49
60 INT159667 Negative_regulation of Positive_regulation of Bad 4 0.20 3.13 0.48
61 INT105886 Phosphorylation of Bad 3 0.23 2.15 0.47
62 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
63 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
64 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
65 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
66 INT168112 Phosphorylation of Arrb2 1 0.00 0 0.41
67 INT94933 Positive_regulation of Gene_expression of Bcl10 1 0.01 1.74 0.38
68 INT150812 Regulation of Regulation of Arrb2 1 0.26 0 0.38
69 INT217464 Binding of Traf6 5 0.29 1.28 0.35
70 INT30049 Gene_expression of Bcl10 4 0.51 2.36 0.35
71 INT192983 Regulation of Regulation of Bad 1 0.01 0.3 0.33
72 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
73 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
74 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
75 INT135807 Positive_regulation of Negative_regulation of Bad 1 0.35 0.24 0.27
76 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
77 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
78 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
79 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
80 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
81 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
82 INT201637 Regulation of Gene_expression of Bad 4 0.23 2.99 0.17
83 INT273054 Positive_regulation of Binding of Bad 2 0.14 2.66 0.16
84 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
85 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
86 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
87 INT153486 Positive_regulation of Gene_expression of Bad 1 0.62 0.74 0.13
88 INT172857 Binding of Bad 2 0.36 2.86 0.12
89 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
90 INT162014 Protein_catabolism of Bad 1 0.76 0.29 0.1
91 INT275179 Localization of Bad 2 0.69 0.66 0.09
92 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
93 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
94 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
95 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
96 INT190021 Negative_regulation of Gene_expression of Bcl10 1 0.32 0.77 0
97 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
98 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
99 INT242531 Negative_regulation of Bcl10 1 0.02 1.09 0
100 INT161736 Negative_regulation of Gene_expression of Arrb2 1 0.50 0 0
101 INT298986 Positive_regulation of Gene_expression of Traf6 1 0.23 0.4 0
102 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
103 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
104 INT175515 Regulation of Phosphorylation of Bad 1 0.08 1.69 0
105 INT298982 Positive_regulation of Positive_regulation of Traf6 1 0.23 0.4 0
106 INT330030 Positive_regulation of Regulation of Bad 1 0.21 0.71 0
107 INT190024 Regulation of Bcl10 1 0.20 0.77 0
108 INT335937 Negative_regulation of Phosphorylation of Bad 1 0.15 0.41 0
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