GO:0043423

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Name 3-phosphoinositide-dependent protein kinase binding
Categary Function
Go Slim No
Go Link GO:0043423
Unique Molecular Interactions 67
Total Molecular Interactions 91
Total Single Events 1120
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 3-phosphoinositide-dependent protein kinase binding. They are ordered first by their pain relevance and then by number of times they were reported for 3-phosphoinositide-dependent protein kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
8 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
9 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
10 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
11 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
12 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
13 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
14 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
15 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
16 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
17 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
18 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
19 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
20 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
21 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
22 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
23 INT191686 Igh-Dex Positive_regulation of Sgk1 1 0.04 1.79 0.46
24 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
25 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
26 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
27 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
28 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
29 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
30 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
31 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
32 INT319311 Binding of Glud1 and Ptk2b 1 0.36 0 0.19
33 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18
34 INT319314 Binding of Ptk2b and Rbm39 1 0.01 0.08 0.14
35 INT319316 Binding of GRIN1 and Ptk2b 1 0.52 0.08 0.14
36 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1
37 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
38 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
39 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
40 INT355604 VEGFA Regulation of Positive_regulation of Ptk2b 1 0.22 1.47 0.08
41 INT319309 Egr2 Regulation of Ptk2b 1 0.29 0.37 0.07
42 INT333256 Gene_expression of Cxcl12 Negative_regulation of Ptk2b 1 0.10 0.99 0.07
43 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
44 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
45 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
46 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
47 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
48 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
49 INT89385 INS Positive_regulation of Phosphorylation of PTK2B 1 0.15 0.59 0.04
50 INT144761 Binding of INSR and Insr 1 0.05 0 0
51 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
52 INT235623 Binding of INS and INSR 1 0.14 0.47 0
53 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
54 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
55 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
56 INT180672 Sgk1 Regulation of Ecm1 1 0.03 0 0
57 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
58 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
59 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
60 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
61 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
62 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
63 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
64 INT144762 Negative_regulation of Binding of INSR and Insr 1 0.06 0 0
65 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 3-phosphoinositide-dependent protein kinase binding. They are ordered first by their pain relevance and then by number of times they were reported in 3-phosphoinositide-dependent protein kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
7 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
8 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
9 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
10 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
11 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
12 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
13 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
14 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
15 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
16 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
17 INT168151 Gene_expression of Sgk1 10 0.76 5.58 4.35
18 INT51084 Binding of Insr 13 0.30 4.25 4.23
19 INT83035 Binding of INSR 16 0.47 9.29 4.11
20 INT10116 Localization of INSR 11 0.57 5.43 3.48
21 INT191667 Positive_regulation of Sgk1 6 0.68 4.59 3.45
22 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
23 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
24 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
25 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
26 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
27 INT233660 Transcription of Sgk1 3 0.70 0.51 2.03
28 INT114059 Localization of Insr 10 0.46 3.49 1.87
29 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
30 INT232645 Transcription of INSR 2 0.09 1.19 1.71
31 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
32 INT19342 Regulation of Insr 12 0.24 6.11 1.54
33 INT180712 Gene_expression of Sgk1 2 0.47 1.52 1.41
34 INT233665 Positive_regulation of Transcription of Sgk1 2 0.49 0.3 1.29
35 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
36 INT319293 Phosphorylation of Ptk2b 9 0.80 3.14 1.24
37 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
38 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
39 INT139236 Regulation of Sgk1 2 0.37 0.84 1.14
40 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
41 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
42 INT233633 Negative_regulation of Positive_regulation of Sgk1 1 0.37 0.11 1.08
43 INT233644 Negative_regulation of Sgk1 1 0.38 0.11 1.02
44 INT290411 Gene_expression of Ptk2b 10 0.65 3.72 1.01
45 INT236927 Positive_regulation of Ptk2b 9 0.67 3.41 0.94
46 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
47 INT144543 Localization of Sgk1 1 0.71 0.96 0.91
48 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
49 INT117444 Regulation of Sgk1 4 0.60 1.35 0.87
50 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
51 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
52 INT233632 Regulation of Transcription of Sgk1 1 0.39 0.22 0.78
53 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
54 INT247255 Positive_regulation of Gene_expression of Sgk1 1 0.30 0.84 0.72
55 INT117392 Binding of Insr 8 0.23 4.88 0.68
56 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
57 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
58 INT18446 Transcription of Insr 2 0.18 0.84 0.62
59 INT144545 Positive_regulation of Sgk1 1 0.44 0.62 0.59
60 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
61 INT191670 Positive_regulation of Gene_expression of Sgk1 1 0.33 2.42 0.46
62 INT319254 Localization of Ptk2b 1 0.78 0.26 0.46
63 INT319284 Binding of Ptk2b 1 0.36 0.9 0.45
64 INT319552 Regulation of Gene_expression of Sgk1 1 0.60 0 0.44
65 INT109920 Positive_regulation of PTK2B 5 0.43 2.21 0.43
66 INT319286 Transcription of Ptk2b 1 0.52 1.17 0.4
67 INT109922 Negative_regulation of PTK2B 3 0.26 1.63 0.39
68 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
69 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
70 INT109919 Positive_regulation of Positive_regulation of PTK2B 1 0.31 0.09 0.35
71 INT319276 Positive_regulation of Phosphorylation of Ptk2b 1 0.49 0.62 0.32
72 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
73 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
74 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
75 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
76 INT89400 Phosphorylation of PTK2B 4 0.38 1.16 0.19
77 INT319247 Regulation of Ptk2b 1 0.60 0 0.18
78 INT319544 Localization of Sgk1 1 0.73 0.34 0.16
79 INT89409 Negative_regulation of Phosphorylation of PTK2B 2 0.13 0.89 0.12
80 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
81 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
82 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
83 INT135555 Localization of PTK2B 1 0.57 0.32 0.1
84 INT117441 Negative_regulation of Regulation of Sgk1 1 0.43 0.19 0.09
85 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
86 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
87 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
88 INT200683 Gene_expression of PTK2B 2 0.67 1.02 0
89 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
90 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
91 INT243389 Transcription of PTK2B 1 0.64 0.52 0
92 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
93 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
94 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
95 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
96 INT200665 Negative_regulation of Gene_expression of PTK2B 1 0.04 0.69 0
97 INT156922 Positive_regulation of Phosphorylation of PTK2B 1 0.23 0 0
98 INT290418 Regulation of Gene_expression of Ptk2b 1 0.17 0.1 0
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