GO:0043425

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Name bHLH transcription factor binding
Categary Function
Go Slim No
Go Link GO:0043425
Unique Molecular Interactions 452
Total Molecular Interactions 562
Total Single Events 3492
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bHLH transcription factor binding. They are ordered first by their pain relevance and then by number of times they were reported for bHLH transcription factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT335405 Binding of Arntl and Npas2 1 0.28 1.82 1.61
2 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
3 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
4 INT148778 Binding of Usf1 and Rtn1 1 0.40 0.85 1.3
5 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
6 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
7 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 0.15 1.14 1.27
8 INT281373 Tcf21 Regulation of Fig4 1 0.03 0.67 1.2
9 INT281379 Tcf21 Regulation of FSCN1 1 0.01 0.66 1.19
10 INT119887 Binding of Atf4 and Usf1 1 0.21 0.15 1.05
11 INT119888 Binding of Creb1 and Usf1 1 0.18 0.15 1.05
12 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
13 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
14 INT316128 TCF21 Negative_regulation of Gene_expression of HLA-DRA 1 0.07 0.13 0.99
15 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99
16 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
17 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98
18 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
19 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
20 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
21 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
22 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
23 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
24 INT335404 Binding of Arntl and Hspg2 1 0.06 0.93 0.82
25 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
26 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
27 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
28 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
29 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
30 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
31 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
32 INT148773 Binding of Calca and Usf2 1 0.46 0.42 0.64
33 INT148776 Binding of Usf2 and Rtn1 1 0.38 0.42 0.64
34 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
35 INT148780 Binding of Usf2 and Usf1 1 0.40 0.41 0.62
36 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
37 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
38 INT148779 Usf1 Negative_regulation of Calca 1 0.44 0.4 0.59
39 INT148771 Usf2 Negative_regulation of Calca 1 0.42 0.4 0.59
40 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
41 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55
42 INT249001 Gabrg1 Positive_regulation of Arntl 1 0.29 0 0.55
43 INT249006 Gabrg1 Positive_regulation of Transcription of Arntl 1 0.31 0 0.55
44 INT222246 Binding of Ccr2 and Tcf21 1 0.29 0.67 0.55
45 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
46 INT222249 Positive_regulation of Binding of Ccr2 and Tcf21 1 0.39 0.67 0.55
47 INT281124 Tcf21 Positive_regulation of Binding of Ddc 1 0.04 1.21 0.54
48 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54
49 INT281129 Tcf21 Positive_regulation of Binding of Cd4 1 0.04 1.21 0.54
50 INT281152 Tcf21 Positive_regulation of Binding of ITIH4 1 0.03 1.21 0.54
51 INT281131 Tcf21 Positive_regulation of Rent1 1 0.00 1.19 0.53
52 INT281374 Tcf21 Positive_regulation of Gene_expression of Sds 1 0.03 0 0.51
53 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
54 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
55 INT304576 Binding of Arntl and Clock 6 0.37 0.43 0.5
56 INT135755 Pomc Positive_regulation of Positive_regulation of Id3 1 0.17 0 0.5
57 INT135752 Pomc Positive_regulation of Id3 1 0.16 0 0.5
58 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
59 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48
60 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
61 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
62 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
63 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
64 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
65 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
66 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
67 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
68 INT335850 Snrpc Negative_regulation of Gene_expression of Isl1 1 0.00 1.51 0.45
69 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
70 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
71 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
72 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.03 0.07 0.36
73 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
74 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
75 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
76 INT112024 Binding of Hand1 and Ighg1 2 0.30 0.84 0.33
77 INT209312 Trpc5 Positive_regulation of Gene_expression of Scx 1 0.15 0.05 0.33
78 INT112018 Binding of Hand1 and IgG2a 2 0.22 0.84 0.32
79 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
80 INT112022 Binding of Hand1 and Ifng 1 0.09 0.3 0.32
81 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32
82 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
83 INT222251 Negative_regulation of Binding of Cxcl10 and Tcf21 1 0.23 0.34 0.32
84 INT188707 Binding of IFNA1 and Hand1 1 0.01 0.56 0.32
85 INT222247 Binding of Cxcl10 and Tcf21 1 0.20 0.34 0.32
86 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
87 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
88 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
89 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
90 INT243631 Binding of Hand1 and Nfatc1 1 0.04 0.76 0.3
91 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
92 INT281127 Tcf21 Positive_regulation of Gene_expression of Cxcr4 1 0.08 0.42 0.3
93 INT252604 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Hand1 1 0.24 0.5 0.29
94 INT148774 Usf2 Regulation of Calca 1 0.11 0.24 0.27
95 INT246439 Hand1 Positive_regulation of Gene_expression of Cd79a 1 0.04 0.78 0.27
96 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
97 INT96787 SP1 Positive_regulation of GDF15 1 0.08 0.27 0.27
98 INT125515 SP1 Regulation of GDF15 1 0.14 0.47 0.26
99 INT169837 Sp1 Positive_regulation of Gene_expression of Kcnq3 1 0.04 0.08 0.26
100 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
101 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
102 INT169836 Sp1 Positive_regulation of Gene_expression of Kcnq2 1 0.05 0.08 0.26
103 INT294514 Safb Positive_regulation of Localization of Hand1 1 0.08 0.38 0.25
104 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
105 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
106 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
107 INT213813 Binding of Tcf4 and Tfeb 1 0.14 0.81 0.24
108 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
109 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
110 INT213805 Binding of Tcf12 and Tcf4 1 0.00 0.79 0.23
111 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22
112 INT333758 Hand1 Positive_regulation of Eae1 1 0.05 1.6 0.22
113 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22
114 INT302822 Tnfsf10 Positive_regulation of Protein_catabolism of Psmd9 1 0.03 0.78 0.21
115 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
116 INT311987 Binding of Cd40 and Negative_regulation of Regulation of Hand1 1 0.28 0.27 0.21
117 INT276241 Slc11a1 Positive_regulation of Gene_expression of Hand1 1 0.02 1.24 0.21
118 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2
119 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
120 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
121 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
122 INT238010 Binding of Cxcr3 and Hand1 1 0.12 1.55 0.19
123 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
124 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
125 INT284889 Gene_expression of Hand1 Positive_regulation of Gene_expression of Il4 1 0.21 0.4 0.18
126 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18
127 INT252600 Ppig Regulation of Hand1 1 0.06 0.43 0.17
128 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
129 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
130 INT252598 Ppig Regulation of Gene_expression of Hand1 1 0.06 0.43 0.17
131 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
132 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
133 INT190635 Binding of Lmo2 and Nr1h2 1 0.09 0.59 0.16
134 INT190629 Binding of Lmo2 and Usf1 1 0.11 0.6 0.16
135 INT277990 Binding of Cd3e and Hand1 1 0.01 0.5 0.16
136 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
137 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
138 INT190634 Binding of Lmo2 and Maz 1 0.14 0.59 0.16
139 INT190633 Binding of Lmo2 and Deaf1 1 0.18 0.59 0.16
140 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
141 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
142 INT279102 Renbp Regulation of Hand1 1 0.02 0.27 0.14
143 INT223538 Binding of HAND1 and Tcf3 1 0.39 1.13 0.14
144 INT294761 Binding of Hand1 and Cerk 1 0.23 0.36 0.14
145 INT253564 Binding of Lpl and Sp1 1 0.13 0.9 0.14
146 INT225989 Il10 Negative_regulation of Gene_expression of Hand1 1 0.11 0.68 0.13
147 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
148 INT347019 Cd80 Regulation of Hand1 1 0.01 0.05 0.13
149 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
150 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
151 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
152 INT347014 Cd86 Regulation of Hand1 1 0.02 0.05 0.13
153 INT223539 Binding of HAND1 and Szf1 1 0.33 0.92 0.13
154 INT223530 Binding of Tcf3 and Szf1 1 0.33 0.92 0.13
155 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
156 INT200315 Binding of Sp1 and Sp3 1 0.29 0 0.12
157 INT68802 Sp1 Regulation of Gene_expression of Pebp1 1 0.24 0 0.12
158 INT325057 Binding of Hand1 and Ang 1 0.01 1.29 0.12
159 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
160 INT318993 Hand1 Positive_regulation of Gene_expression of Fas 1 0.03 0.76 0.12
161 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
162 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
163 INT253572 Binding of Csnk2a2 and Sp1 1 0.17 0 0.11
164 INT332893 Ppara Regulation of Gene_expression of Arntl 1 0.43 0 0.11
165 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
166 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
167 INT298267 Tcf3 Positive_regulation of Gene_expression of Runx1 1 0.21 0.6 0.1
168 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
169 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
170 INT171163 Creb1 Regulation of Sp1 1 0.03 0.62 0.1
171 INT194822 Negative_regulation of MAPK1 Negative_regulation of Binding of Sp1 1 0.04 0.05 0.1
172 INT231134 Itbq1 Regulation of HAND1 1 0.00 0.18 0.1
173 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
174 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
175 INT253571 Positive_regulation of Binding of Lpl and Sp1 1 0.17 0.42 0.09
176 INT253579 Negative_regulation of Binding of Lpl and Sp1 1 0.15 0.42 0.09
177 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
178 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
179 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
180 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
181 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
182 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08
183 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
184 INT278218 Hand1 Negative_regulation of Gene_expression of Il4 1 0.20 0.37 0.08
185 INT350721 Binding of Hand1 and TBX21 1 0.13 0.22 0.08
186 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08
187 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
188 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08
189 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
190 INT343792 Binding of TCF21 and CORO7 1 0.01 0.51 0.07
191 INT223536 Binding of HAND1 and Hmga1 1 0.26 0.57 0.07
192 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
193 INT271493 Ctbs Negative_regulation of Hand1 1 0.04 0.63 0.07
194 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
195 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
196 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
197 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
198 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
199 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
200 INT223531 Binding of Hmga1 and Tcf3 1 0.26 0.57 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for bHLH transcription factor binding. They are ordered first by their pain relevance and then by number of times they were reported in bHLH transcription factor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
2 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
3 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
4 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
5 INT41558 Localization of Sp1 9 0.48 0.56 14.9
6 INT20378 Localization of Hand1 53 0.71 41.96 13.31
7 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
8 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
9 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
10 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
11 INT215353 Gene_expression of Tcf21 16 0.59 9.71 9.49
12 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
13 INT48555 Binding of SP1 30 0.46 11.38 6.53
14 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
15 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
16 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
17 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
18 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05
19 INT72834 Negative_regulation of Tcf21 10 0.58 5.8 4.84
20 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
21 INT203443 Gene_expression of Isl1 27 0.67 11.12 4.65
22 INT151736 Binding of Hand1 15 0.26 9.77 4.04
23 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
24 INT22566 Positive_regulation of Tcf21 8 0.65 3.06 3.75
25 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
26 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
27 INT72618 Regulation of Tcf3 5 0.44 1.48 3.16
28 INT123409 Binding of Sp1 20 0.39 3.18 3.15
29 INT103607 Binding of Sp1 7 0.42 1.26 2.92
30 INT281367 Regulation of Gene_expression of Tcf21 1 0.09 1.39 2.89
31 INT116540 Binding of Twist1 35 0.48 16.32 2.85
32 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
33 INT94463 Regulation of Gene_expression of Hand1 10 0.36 5.17 2.72
34 INT128328 Gene_expression of Arntl 44 0.74 3.77 2.63
35 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
36 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
37 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
38 INT281369 Negative_regulation of Gene_expression of Tcf21 1 0.08 1.4 2.44
39 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
40 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
41 INT103608 Negative_regulation of Binding of Sp1 4 0.35 0.69 2.1
42 INT228061 Positive_regulation of Localization of Hand1 8 0.26 6.39 2.06
43 INT41495 Regulation of Sp1 7 0.42 2.96 2.05
44 INT112015 Negative_regulation of Regulation of Hand1 5 0.33 3.48 2.05
45 INT41557 Gene_expression of Sp1 5 0.68 1.17 2.04
46 INT72616 Negative_regulation of Tcf3 2 0.41 0.97 2.04
47 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
48 INT90004 Gene_expression of TCF21 4 0.65 2.48 2.02
49 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
50 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
51 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
52 INT24906 Negative_regulation of SP1 8 0.40 4.48 1.77
53 INT316162 Localization of TCF21 1 0.18 0.28 1.71
54 INT285510 Regulation of Localization of Hand1 6 0.14 6.13 1.61
55 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
56 INT41605 Positive_regulation of Localization of Sp1 1 0.05 0 1.58
57 INT244735 Gene_expression of Ascl1 12 0.58 2.48 1.54
58 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
59 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
60 INT248979 Transcription of Arntl 15 0.69 3.47 1.43
61 INT128316 Regulation of Gene_expression of Arntl 6 0.43 0.68 1.43
62 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
63 INT222228 Positive_regulation of Gene_expression of Tcf21 4 0.38 0.84 1.39
64 INT123414 Transcription of Sp1 5 0.48 2.2 1.38
65 INT10873 Localization of Twist1 21 0.74 10.43 1.37
66 INT110485 Binding of Tcf21 2 0.36 0.76 1.37
67 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
68 INT290803 Binding of Arntl 10 0.37 1.82 1.34
69 INT119880 Binding of Usf1 5 0.20 2.55 1.28
70 INT94692 Positive_regulation of Gene_expression of Sp1 3 0.17 0.39 1.28
71 INT24000 Regulation of Sp1 2 0.22 1.25 1.27
72 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
73 INT316154 Positive_regulation of TCF21 4 0.17 1.22 1.23
74 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2
75 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
76 INT72614 Negative_regulation of Regulation of Tcf3 1 0.41 0.17 1.2
77 INT200838 Positive_regulation of Isl1 6 0.60 0.73 1.19
78 INT93216 Negative_regulation of Phosphorylation of Sp1 2 0.14 0.4 1.13
79 INT172809 Gene_expression of ISL1 33 0.40 21.63 1.12
80 INT148765 Gene_expression of Usf1 1 0.77 0.72 1.12
81 INT237904 Negative_regulation of Localization of Hand1 5 0.24 3.52 1.09
82 INT332771 Phosphorylation of Tcf21 1 0.09 0.21 1.07
83 INT332772 Positive_regulation of Phosphorylation of Tcf21 1 0.06 0.21 1.07
84 INT325047 Gene_expression of Hand1 1 0.07 6.42 1.06
85 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
86 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
87 INT167650 Binding of Ep300 1 0.09 0.14 1
88 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
89 INT123408 Positive_regulation of Gene_expression of Sp1 2 0.62 0.9 0.96
90 INT43484 Binding of Runx2 7 0.37 3.22 0.95
91 INT123407 Negative_regulation of Binding of Sp1 6 0.47 0.72 0.93
92 INT200272 Localization of Sp1 3 0.57 0.06 0.93
93 INT169235 Negative_regulation of USF1 4 0.37 2.69 0.91
94 INT102677 Negative_regulation of TCF21 2 0.41 0.22 0.89
95 INT206673 Positive_regulation of Arntl 12 0.67 0.45 0.85
96 INT173472 Positive_regulation of Isl1 1 0.03 0.2 0.83
97 INT123410 Negative_regulation of Gene_expression of Sp1 3 0.38 1.01 0.82
98 INT149817 Gene_expression of Bhlhe41 2 0.43 2.47 0.81
99 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
100 INT66992 Positive_regulation of Id3 2 0.43 0.23 0.78
101 INT30050 Gene_expression of Tcf3 13 0.48 2.57 0.77
102 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
103 INT184694 Gene_expression of Usf1 10 0.55 4.27 0.72
104 INT185049 Transcription of Hand1 5 0.47 1.84 0.71
105 INT149819 Regulation of Gene_expression of Bhlhe41 1 0.29 0 0.7
106 INT121606 Positive_regulation of Usf2 1 0.26 0.1 0.69
107 INT149804 Regulation of Bhlhe41 1 0.29 0 0.69
108 INT243779 Negative_regulation of Gene_expression of Isl1 2 0.30 2.62 0.68
109 INT98967 Localization of SP1 2 0.60 0.15 0.66
110 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
111 INT24905 Negative_regulation of Gene_expression of SP1 4 0.39 2.05 0.65
112 INT231131 Regulation of HAND1 5 0.27 1.81 0.63
113 INT248964 Positive_regulation of Transcription of Arntl 3 0.48 0.25 0.63
114 INT181529 Regulation of Positive_regulation of Hand1 2 0.16 2.62 0.61
115 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
116 INT226838 Transcription of Isl1 2 0.28 0.36 0.6
117 INT105266 Localization of Tcf3 3 0.32 1.08 0.59
118 INT281366 Regulation of Tcf21 1 0.09 0.23 0.59
119 INT325055 Binding of Hand1 1 0.04 2.15 0.58
120 INT126899 Regulation of SP1 5 0.43 2.53 0.57
121 INT148766 Positive_regulation of Gene_expression of Usf1 1 0.69 0.39 0.57
122 INT148768 Gene_expression of Usf2 1 0.57 0.39 0.57
123 INT316161 Negative_regulation of Gene_expression of TCF21 1 0.10 0.11 0.56
124 INT206674 Positive_regulation of Gene_expression of Arntl 6 0.67 0.6 0.52
125 INT279099 Regulation of Regulation of Hand1 3 0.20 1.31 0.5
126 INT89334 Negative_regulation of Binding of SP1 2 0.47 1.05 0.5
127 INT135747 Gene_expression of Id3 1 0.52 0 0.5
128 INT292834 Negative_regulation of Gene_expression of Arntl 6 0.43 0.87 0.49
129 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
130 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
131 INT231129 Positive_regulation of HAND1 5 0.30 2.73 0.45
132 INT222229 Localization of Tcf21 1 0.57 0.45 0.45
133 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
134 INT126896 Positive_regulation of Protein_catabolism of SP1 1 0.13 0.99 0.44
135 INT304570 Regulation of Binding of Arntl 2 0.26 0.35 0.43
136 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
137 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
138 INT204013 Phosphorylation of Arntl 2 0.63 1.02 0.41
139 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
140 INT126895 Protein_catabolism of SP1 3 0.96 3.59 0.38
141 INT30052 Positive_regulation of Tcf3 3 0.41 0.27 0.37
142 INT98963 Positive_regulation of Binding of SP1 1 0.43 0 0.37
143 INT17937 Gene_expression of Isl1 4 0.27 0.48 0.36
144 INT252590 Regulation of Transcription of Hand1 1 0.36 0.76 0.36
145 INT166959 Positive_regulation of Positive_regulation of SP1 3 0.46 2.23 0.35
146 INT187587 Binding of Ep300 11 0.35 2.37 0.34
147 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
148 INT190575 Positive_regulation of Usf1 2 0.27 1.21 0.33
149 INT192400 Positive_regulation of Binding of Hand1 2 0.25 0.24 0.33
150 INT209302 Gene_expression of Scx 1 0.20 0.05 0.33
151 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
152 INT271762 Binding of HAND1 3 0.10 3.66 0.31
153 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
154 INT136460 Negative_regulation of Sp1 2 0.30 0.99 0.3
155 INT172806 Localization of ISL1 4 0.26 2.64 0.29
156 INT339621 Regulation of Negative_regulation of Hand1 1 0.04 0.75 0.29
157 INT325048 Positive_regulation of Gene_expression of Hand1 1 0.05 1.16 0.28
158 INT212382 Positive_regulation of USF1 2 0.50 3.14 0.27
159 INT93215 Positive_regulation of Phosphorylation of Sp1 1 0.11 0.09 0.27
160 INT148769 Regulation of Usf2 1 0.43 0.24 0.27
161 INT148767 Regulation of Usf1 1 0.45 0.24 0.27
162 INT78132 Binding of Isl1 1 0.16 0 0.27
163 INT25465 Positive_regulation of ISL1 6 0.15 3.59 0.26
164 INT173797 Negative_regulation of Isl1 3 0.37 0.15 0.26
165 INT173792 Negative_regulation of Negative_regulation of Isl1 1 0.08 0.15 0.26
166 INT114369 Positive_regulation of Tcf4 6 0.40 2.7 0.25
167 INT231128 Gene_expression of HAND1 4 0.40 1.32 0.25
168 INT281018 Regulation of Arntl 12 0.47 0.81 0.24
169 INT253556 Phosphorylation of Sp1 6 0.44 2.93 0.24
170 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
171 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
172 INT142117 Regulation of Runx2 6 0.61 2.75 0.22
173 INT310471 Regulation of Ascl1 1 0.34 0.19 0.22
174 INT271929 Protein_catabolism of Psmd9 4 0.11 1.69 0.21
175 INT290800 Protein_catabolism of Arntl 1 0.76 0.84 0.21
176 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
177 INT271486 Negative_regulation of Negative_regulation of Hand1 2 0.16 1.07 0.2
178 INT114372 Negative_regulation of Tcf4 2 0.25 0.7 0.2
179 INT136457 Negative_regulation of Negative_regulation of Sp1 1 0.30 0.65 0.2
180 INT253542 Positive_regulation of Phosphorylation of Sp1 1 0.27 1.16 0.2
181 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19
182 INT205087 Positive_regulation of Gene_expression of ISL1 4 0.26 3.86 0.19
183 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
184 INT243778 Binding of Isl1 1 0.26 0 0.19
185 INT171605 Negative_regulation of Runx2 4 0.46 2.14 0.17
186 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
187 INT190607 Localization of Usf1 2 0.29 0.6 0.17
188 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
189 INT190551 Localization of Lmo2 1 0.21 0.6 0.17
190 INT190547 Negative_regulation of Localization of Usf1 1 0.17 0.61 0.17
191 INT310462 Positive_regulation of Gene_expression of Ascl1 1 0.37 0.52 0.17
192 INT114370 Negative_regulation of Positive_regulation of Tcf4 1 0.10 0.63 0.17
193 INT210249 Gene_expression of Tcf4 14 0.66 4.32 0.16
194 INT98772 Localization of Isl1 2 0.65 0 0.16
195 INT201210 Negative_regulation of ISL1 2 0.02 0.4 0.16
196 INT310488 Binding of Ascl1 1 0.28 0.25 0.16
197 INT178673 Positive_regulation of Gene_expression of SP1 1 0.08 0.14 0.16
198 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
199 INT190550 Positive_regulation of Binding of Usf1 1 0.19 0.79 0.15
200 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
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