GO:0043433

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Name negative regulation of sequence-specific DNA binding transcription factor activity
Categary Process
Go Slim No
Go Link GO:0043433
Unique Molecular Interactions 781
Total Molecular Interactions 1034
Total Single Events 8588
Pain Genes Associated 76

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of sequence-specific DNA binding transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of sequence-specific DNA binding transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
4 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
5 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
6 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
7 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
8 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
9 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
10 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
11 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 0.15 1.14 1.27
12 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
13 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
14 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
15 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
16 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99
17 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
18 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98
19 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
20 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
21 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
22 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92
23 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
24 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
25 INT328501 Sumo1 Negative_regulation of Gene_expression of Pglyrp1 1 0.00 1.54 0.83
26 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
27 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
28 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
29 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
30 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
31 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
32 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
33 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
34 INT99743 Olr1742 Regulation of Gene_expression of Hmox1 1 0.00 0 0.68
35 INT118568 Binding of Ddit3 and Atf6 1 0.33 0.85 0.66
36 INT86519 Binding of Hmox1 and Hmox2 1 0.08 0.1 0.66
37 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
38 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
39 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
40 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
41 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
42 INT2687 Negative_regulation of Binding of Thra and SGSM3 1 0.43 0.1 0.62
43 INT2686 Binding of Thra and SGSM3 1 0.36 0.1 0.61
44 INT66766 Casp1 Positive_regulation of Transcription of Pla2g10 1 0.06 0.19 0.6
45 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
46 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
47 INT2685 S100A6 Positive_regulation of Regulation of Thra 1 0.47 0.09 0.58
48 INT2684 S100A6 Regulation of Regulation of Thra 1 0.45 0.09 0.58
49 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
50 INT112025 Binding of Hand1 and Il10 2 0.15 0.56 0.55
51 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55
52 INT355881 Il17a Regulation of Gene_expression of Hand1 1 0.18 1.51 0.54
53 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
54 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53
55 INT66769 Negative_regulation of Il1b Positive_regulation of Pla2g10 1 0.04 0.25 0.53
56 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
57 INT135755 Pomc Positive_regulation of Positive_regulation of Id3 1 0.17 0 0.5
58 INT135751 Pomc Positive_regulation of Positive_regulation of Id1 1 0.19 0 0.5
59 INT135752 Pomc Positive_regulation of Id3 1 0.16 0 0.5
60 INT350076 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 1.29 0.5
61 INT135753 Pomc Positive_regulation of Gene_expression of Id1 1 0.17 0 0.5
62 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
63 INT135754 Pomc Positive_regulation of Id1 1 0.17 0 0.5
64 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
65 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
66 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
67 INT300551 TBX21 Regulation of Hand1 2 0.10 0.44 0.48
68 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
69 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
70 INT148466 Ccl4 Positive_regulation of Hmox1 1 0.28 0.06 0.47
71 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
72 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
73 INT233668 Cebpd Negative_regulation of Cebpg 1 0.43 0.66 0.46
74 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
75 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
76 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
77 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45
78 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
79 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
80 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43
81 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
82 INT292634 IL4 Positive_regulation of Gene_expression of FOXP3 1 0.10 0.42 0.43
83 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
84 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
85 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
86 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
87 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
88 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
89 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
90 INT216881 Binding of Apoc4 and Hmox1 1 0.01 1.78 0.4
91 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
92 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4
93 INT147473 Nfe2l2 Positive_regulation of Gene_expression of Hmox1 1 0.74 0.49 0.39
94 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38
95 INT147472 co Positive_regulation of Gene_expression of Hmox1 1 0.01 0.57 0.36
96 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
97 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
98 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
99 INT112024 Binding of Hand1 and Ighg1 2 0.30 0.84 0.33
100 INT112018 Binding of Hand1 and IgG2a 2 0.22 0.84 0.32
101 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
102 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
103 INT189494 Negative_regulation of Ccr5 Negative_regulation of Gene_expression of Hand1 1 0.16 0.66 0.32
104 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
105 INT113950 FLNA Regulation of Oprd1 1 0.00 0.16 0.32
106 INT112022 Binding of Hand1 and Ifng 1 0.09 0.3 0.32
107 INT241138 Ighg1 Positive_regulation of Hand1 1 0.06 0.64 0.32
108 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
109 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
110 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
111 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
112 INT188707 Binding of IFNA1 and Hand1 1 0.01 0.56 0.32
113 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
114 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
115 INT51859 Pim1 Positive_regulation of Positive_regulation of Pdyn 1 0.02 0 0.31
116 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
117 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
118 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
119 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
120 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
121 INT243631 Binding of Hand1 and Nfatc1 1 0.04 0.76 0.3
122 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
123 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
124 INT328500 Sumo1 Positive_regulation of Negative_regulation of Cebpz 1 0.11 1.06 0.29
125 INT252604 Negative_regulation of Cxcl10 Negative_regulation of Gene_expression of Hand1 1 0.24 0.5 0.29
126 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
127 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
128 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
129 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
130 INT18499 Binding of SUMO1 and SEC1 1 0.12 0 0.28
131 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
132 INT321288 Fig4 Positive_regulation of Nr0b2 1 0.15 0.47 0.27
133 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
134 INT246439 Hand1 Positive_regulation of Gene_expression of Cd79a 1 0.04 0.78 0.27
135 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
136 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
137 INT328499 Binding of Cebpz and Sumo1 1 0.08 0.84 0.27
138 INT246435 Xcl1 Positive_regulation of Gene_expression of Cd79a 1 0.07 0.83 0.27
139 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27
140 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
141 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
142 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
143 INT216880 Apoc4 Positive_regulation of Hmox1 1 0.03 1.06 0.25
144 INT294514 Safb Positive_regulation of Localization of Hand1 1 0.08 0.38 0.25
145 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25
146 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
147 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25
148 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
149 INT350099 Gene_expression of Hmox1 Positive_regulation of Gene_expression of MRXS5 1 0.01 0.51 0.24
150 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24
151 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
152 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
153 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
154 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
155 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
156 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23
157 INT318174 Binding of Crp and Xcl1 1 0.03 1.9 0.22
158 INT181445 Binding of Ccr5 and Hand1 1 0.12 1.01 0.22
159 INT172826 Binding of Tnfsf4 and T2dm2 1 0.00 5.97 0.22
160 INT333758 Hand1 Positive_regulation of Eae1 1 0.05 1.6 0.22
161 INT350065 Gene_expression of Hmox1 Negative_regulation of Gene_expression of Tlr4 1 0.18 0.35 0.22
162 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
163 INT103867 SFTPA1 Positive_regulation of Hmox1 1 0.00 0.35 0.22
164 INT64340 Zc3h15 Negative_regulation of Hmox1 1 0.12 0.47 0.22
165 INT350078 Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 0.35 0.22
166 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22
167 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
168 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
169 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
170 INT311987 Binding of Cd40 and Negative_regulation of Regulation of Hand1 1 0.28 0.27 0.21
171 INT276241 Slc11a1 Positive_regulation of Gene_expression of Hand1 1 0.02 1.24 0.21
172 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
173 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2
174 INT348970 Binding of MOG and HAND1 1 0.03 1.28 0.2
175 INT350096 Hmox1 Negative_regulation of Gene_expression of MRXS5 1 0.01 0.32 0.2
176 INT188698 Hand1 Positive_regulation of Localization of Mthfd1 1 0.06 0.71 0.2
177 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
178 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2
179 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
180 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
181 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
182 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
183 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2
184 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2
185 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
186 INT238010 Binding of Cxcr3 and Hand1 1 0.12 1.55 0.19
187 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
188 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
189 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
190 INT199192 Gnat3 Positive_regulation of Hmox1 1 0.27 0.23 0.19
191 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19
192 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
193 INT264189 HR Positive_regulation of Gene_expression of IL10 1 0.00 1.48 0.19
194 INT286965 Binding of STAT3 and FOXP3 1 0.27 1.84 0.19
195 INT284889 Gene_expression of Hand1 Positive_regulation of Gene_expression of Il4 1 0.21 0.4 0.18
196 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18
197 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
198 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
199 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
200 INT245183 Binding of CTSB and TCF7L2 1 0.39 6.39 0.18

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of sequence-specific DNA binding transcription factor activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of sequence-specific DNA binding transcription factor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
2 INT221172 Binding of Flna 32 0.42 1.37 51.59
3 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
4 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
5 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
6 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
7 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
8 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
9 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
10 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
11 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
12 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96
13 INT104045 Regulation of Hand1 65 0.35 51.32 16.26
14 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
15 INT173505 Localization of Hand2 63 0.57 45.32 13.66
16 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
17 INT20378 Localization of Hand1 53 0.71 41.96 13.31
18 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
19 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39
20 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
21 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
22 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
23 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88
24 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
25 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
26 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
27 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
28 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12
29 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
30 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
31 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
32 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4
33 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
34 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
35 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
36 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
37 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
38 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
39 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
40 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
41 INT69572 Localization of Prnp 96 0.81 38.11 5.45
42 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
43 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
44 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
45 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13
46 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05
47 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01
48 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
49 INT66760 Gene_expression of Pla2g10 8 0.76 4.43 4.83
50 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
51 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81
52 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73
53 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
54 INT66762 Negative_regulation of Pla2g10 6 0.48 7.8 4.54
55 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
56 INT69570 Binding of Prnp 75 0.48 44.26 4.37
57 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32
58 INT39948 Binding of FLNA 45 0.42 58.05 4.27
59 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2
60 INT221168 Localization of Flna 1 0.58 0.05 4.05
61 INT151736 Binding of Hand1 15 0.26 9.77 4.04
62 INT156131 Binding of Hand2 14 0.25 10.35 3.99
63 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97
64 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9
65 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
66 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69
67 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52
68 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47
69 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
70 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
71 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
72 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3
73 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
74 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
75 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01
76 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
77 INT54749 Binding of BTRC 7 0.09 0.88 2.9
78 INT221171 Positive_regulation of Localization of Flna 1 0.39 0.05 2.9
79 INT116540 Binding of Twist1 35 0.48 16.32 2.85
80 INT127904 Negative_regulation of Gene_expression of Hmox1 11 0.42 9.54 2.8
81 INT94463 Regulation of Gene_expression of Hand1 10 0.36 5.17 2.72
82 INT60750 Gene_expression of HNF4A 12 0.65 8.29 2.68
83 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
84 INT99550 Regulation of FLNA 51 0.54 27.88 2.58
85 INT17039 Regulation of Hr 11 0.27 5.22 2.58
86 INT188344 Positive_regulation of Gene_expression of Foxp3 10 0.36 5.97 2.56
87 INT118251 Localization of Pla2g10 5 0.73 3.07 2.55
88 INT46646 Localization of FLNA 19 0.73 18.83 2.53
89 INT259224 Negative_regulation of Flna 1 0.23 0.15 2.51
90 INT81291 Regulation of Gene_expression of Hmox1 11 0.60 8.78 2.46
91 INT17037 Negative_regulation of Hr 11 0.22 11.81 2.46
92 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
93 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
94 INT221177 Negative_regulation of Gene_expression of Flna 2 0.33 0 2.22
95 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
96 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
97 INT228061 Positive_regulation of Localization of Hand1 8 0.26 6.39 2.06
98 INT112015 Negative_regulation of Regulation of Hand1 5 0.33 3.48 2.05
99 INT221179 Regulation of Flna 1 0.24 0.13 2.04
100 INT2844 Positive_regulation of ID1 6 0.70 3.92 2.03
101 INT135744 Positive_regulation of Id1 4 0.49 3.08 2.02
102 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
103 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98
104 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
105 INT118250 Positive_regulation of Gene_expression of Pla2g10 3 0.49 2.47 1.93
106 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92
107 INT248677 Positive_regulation of Nr0b2 3 0.42 4.49 1.91
108 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
109 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
110 INT167203 Binding of PRNP 25 0.48 20.09 1.84
111 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
112 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
113 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
114 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77
115 INT174924 Gene_expression of Smad7 6 0.41 3.59 1.76
116 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
117 INT174923 Positive_regulation of Gene_expression of Smad7 3 0.37 2.3 1.73
118 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72
119 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
120 INT221166 Positive_regulation of Flna 2 0.39 0.09 1.7
121 INT129610 Gene_expression of Id2 7 0.74 17.07 1.69
122 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
123 INT80227 Regulation of Gene_expression of Hmox1 12 0.44 11.04 1.61
124 INT285510 Regulation of Localization of Hand1 6 0.14 6.13 1.61
125 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
126 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
127 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
128 INT91232 Regulation of Positive_regulation of Hmox1 5 0.45 2.43 1.55
129 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
130 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
131 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
132 INT103305 Positive_regulation of Positive_regulation of Hmox1 8 0.49 4.81 1.49
133 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
134 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
135 INT18503 Binding of SUMO1 7 0.27 6.21 1.48
136 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
137 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
138 INT259219 Negative_regulation of Negative_regulation of Flna 1 0.23 0 1.47
139 INT167872 Negative_regulation of Gene_expression of Foxp3 8 0.50 4.14 1.46
140 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
141 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
142 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
143 INT10873 Localization of Twist1 21 0.74 10.43 1.37
144 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
145 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
146 INT26658 Localization of ID1 1 0.32 0.18 1.33
147 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
148 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29
149 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
150 INT63905 Regulation of RB1 13 0.62 12.67 1.28
151 INT91320 Localization of Hmox1 8 0.81 4.06 1.28
152 INT2681 Binding of Thra 11 0.32 5.98 1.27
153 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
154 INT120076 Positive_regulation of Gene_expression of Smad7 16 0.65 11.33 1.25
155 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
156 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
157 INT172630 Binding of HNF4A 16 0.05 7.78 1.22
158 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
159 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
160 INT2682 Regulation of Thra 4 0.55 0.49 1.21
161 INT116144 Positive_regulation of Positive_regulation of Ddit3 2 0.41 2.95 1.2
162 INT66759 Transcription of Pla2g10 1 0.59 0.41 1.19
163 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
164 INT137860 Positive_regulation of Hr 2 0.14 3.9 1.16
165 INT85621 Regulation of PRNP 16 0.60 8.7 1.15
166 INT115831 Transcription of Hmox1 16 0.66 5.31 1.14
167 INT229562 Negative_regulation of Foxp3 6 0.36 3.7 1.14
168 INT238377 Gene_expression of SIGIRR 1 0.65 8.59 1.12
169 INT199187 Localization of Hmox1 2 0.78 3.36 1.11
170 INT19277 Gene_expression of Thra 4 0.58 0.68 1.1
171 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
172 INT237904 Negative_regulation of Localization of Hand1 5 0.24 3.52 1.09
173 INT325047 Gene_expression of Hand1 1 0.07 6.42 1.06
174 INT116529 Binding of HMOX1 10 0.47 15.38 1.04
175 INT204737 Negative_regulation of Gene_expression of Prnp 32 0.59 18.96 1.03
176 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
177 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
178 INT172616 Regulation of HNF4A 9 0.06 4.25 1.02
179 INT152407 Negative_regulation of Gene_expression of DDIT3 3 0.40 0.87 1.02
180 INT238596 Gene_expression of Sumo1 1 0.44 0.25 1.02
181 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
182 INT152408 Binding of DDIT3 3 0.35 2.06 1
183 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
184 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
185 INT105445 Localization of HMOX1 5 0.71 3.11 0.98
186 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
187 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
188 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
189 INT116140 Localization of Ddit3 2 0.57 1.94 0.96
190 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94
191 INT201454 Positive_regulation of Positive_regulation of Hmox1 6 0.35 5.2 0.94
192 INT148461 Positive_regulation of Transcription of Hmox1 6 0.33 1.83 0.93
193 INT66273 Positive_regulation of Pim1 3 0.12 0.37 0.93
194 INT66272 Gene_expression of Pim1 3 0.18 0.36 0.92
195 INT114824 Binding of PTHLH 12 0.42 9.5 0.9
196 INT171851 Gene_expression of Sumo1 13 0.30 10.7 0.89
197 INT142423 Negative_regulation of Positive_regulation of FLNA 2 0.05 0.99 0.89
198 INT312362 Gene_expression of PBX1 1 0.56 4.48 0.87
199 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
200 INT101892 Gene_expression of PIM1 10 0.65 7.19 0.85
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