GO:0043497

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Name regulation of protein heterodimerization activity
Categary Process
Go Slim No
Go Link GO:0043497
Unique Molecular Interactions 390
Total Molecular Interactions 506
Total Single Events 5186
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of protein heterodimerization activity. They are ordered first by their pain relevance and then by number of times they were reported for regulation of protein heterodimerization activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
2 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
3 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
4 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
5 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
6 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
7 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
8 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
9 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
10 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
11 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
12 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
13 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
14 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
15 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
16 INT112699 Bid Regulation of Bax 1 0.25 0.51 0.61
17 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
18 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
19 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47
20 INT41174 Bak1 Regulation of Localization of Prl 1 0.02 0 0.46
21 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46
22 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
23 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
24 INT116613 Lnpep Negative_regulation of Gene_expression of BAX 1 0.42 0.62 0.43
25 INT116609 Lnpep Negative_regulation of Bcl2 1 0.05 0.62 0.43
26 INT116606 Lnpep Regulation of Gene_expression of Bcl2 1 0.07 0.62 0.43
27 INT116607 Lnpep Negative_regulation of Gene_expression of Bcl2 1 0.10 0.62 0.43
28 INT116612 Lnpep Negative_regulation of BAX 1 0.42 0.62 0.42
29 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
30 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
31 INT235878 Creb1 Positive_regulation of Gene_expression of Bcl2 1 0.05 0.17 0.38
32 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
33 INT172213 Binding of BAX and BCL2L1 3 0.22 4.02 0.35
34 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
35 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
36 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34
37 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
38 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
39 INT242398 Cyp19a1 Positive_regulation of Bcl2 1 0.00 1.28 0.3
40 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
41 INT218928 Cyp3a23/3a1 Regulation of Transcription of Bcl2 1 0.00 0.56 0.28
42 INT260837 NRP2 Negative_regulation of Negative_regulation of Bcl2 1 0.00 0.9 0.28
43 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
44 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26
45 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26
46 INT272157 Gh1 Negative_regulation of Bcl2 1 0.23 1.2 0.26
47 INT272158 Gh1 Regulation of Bcl2 1 0.15 1.2 0.26
48 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26
49 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26
50 INT141634 Binding of Alb and Nrg1 1 0.00 0.3 0.26
51 INT134522 Nrg1 Regulation of Gene_expression of Mpz 1 0.60 0.29 0.25
52 INT260840 NRP2 Positive_regulation of Gene_expression of Bcl2 1 0.00 0.85 0.24
53 INT134523 Nrg1 Positive_regulation of Gene_expression of Mpz 1 0.49 0.32 0.23
54 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
55 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23
56 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2
57 INT155063 Csf2 Negative_regulation of Gene_expression of Bax 1 0.27 1.46 0.18
58 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
59 INT285026 Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
60 INT285022 Regulation of Bak1 Regulation of Bcl2 1 0.09 0.71 0.17
61 INT155066 Csf2 Negative_regulation of Bax 1 0.12 1.89 0.17
62 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17
63 INT155233 TXNIP Regulation of BCL2 1 0.23 0.15 0.17
64 INT285024 Bcl2 Regulation of Bak1 1 0.09 0.71 0.17
65 INT229203 Binding of Bcl2 and Cyp2c11 1 0.36 1.2 0.17
66 INT155068 Csf2 Negative_regulation of Bcl2 1 0.12 1.88 0.17
67 INT155232 TXNIP Regulation of BAX 1 0.23 0.15 0.17
68 INT347445 CD99 Positive_regulation of BCL2 1 0.17 0.95 0.16
69 INT336891 Epo Negative_regulation of Transcription of Bax 1 0.10 0.68 0.16
70 INT292750 Akt1 Positive_regulation of Bcl2 1 0.01 1.67 0.15
71 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15
72 INT130918 HMHA1 Positive_regulation of BAX 1 0.04 1.37 0.14
73 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
74 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
75 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
76 INT273040 Vip Regulation of Bax 1 0.23 1.69 0.13
77 INT309139 Edc4 Positive_regulation of Bcl2 1 0.03 0.12 0.13
78 INT148594 Binding of BCL2 and CD34 1 0.39 1.17 0.13
79 INT309142 Edc4 Regulation of Bcl2 1 0.02 0.12 0.13
80 INT246016 Negative_regulation of Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
81 INT273041 Adcyap1 Regulation of Bax 1 0.21 1.69 0.13
82 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
83 INT348542 BCL2 Negative_regulation of NLRP1 1 0.07 2.02 0.13
84 INT246017 Timp1 Negative_regulation of Gene_expression of Bcl2 1 0.03 1.07 0.13
85 INT172899 Binding of Bcl2 and Bcl2l1 3 0.02 5.54 0.12
86 INT226192 Protein_catabolism of Bax Positive_regulation of Gtf3a 1 0.00 0.53 0.12
87 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
88 INT305194 Bcl2 Positive_regulation of Epo 1 0.06 0.29 0.12
89 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
90 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11
91 INT285030 Binding of Bax and Slc25a4 1 0.03 0.84 0.11
92 INT221684 Binding of Bcl2 and FRTS 1 0.01 1.19 0.11
93 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
94 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
95 INT265890 BCL2 Regulation of Gene_expression of BAX 1 0.04 1.08 0.1
96 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
97 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
98 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09
99 INT282094 Apoa2 Negative_regulation of BCL2 1 0.06 1.15 0.09
100 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
101 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
102 INT265887 IGF1 Negative_regulation of BCL2 1 0.09 1.02 0.09
103 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
104 INT294637 Bcl2a1a Positive_regulation of Gene_expression of Bcl2 1 0.15 0.97 0.09
105 INT54096 NRG1 Regulation of Protein_catabolism of Fgg 1 0.01 0 0.09
106 INT204300 Bcl2 Negative_regulation of Positive_regulation of Bak1 1 0.02 1.13 0.09
107 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
108 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 0.06 0.74 0.08
109 INT302290 Birc5 Regulation of BAK1 1 0.21 1.22 0.07
110 INT204301 Positive_regulation of Hrk Positive_regulation of Positive_regulation of Bak1 1 0.00 1.17 0.07
111 INT302131 Negative_regulation of SOD2 Regulation of BAK1 1 0.09 1.22 0.07
112 INT302289 Negative_regulation of Birc5 Regulation of BAK1 1 0.20 1.22 0.07
113 INT285025 Bnip3 Positive_regulation of Bak1 1 0.11 0.78 0.07
114 INT204299 Bcl2 Negative_regulation of Localization of Aifm1 1 0.06 1.22 0.07
115 INT285032 Bnip3 Positive_regulation of Bax 1 0.28 0.77 0.07
116 INT340401 Positive_regulation of Bax Positive_regulation of Binding of Hrk 1 0.01 0.79 0.07
117 INT302128 SOD2 Regulation of BAK1 1 0.09 1.22 0.07
118 INT297733 Cbr1 Regulation of Gene_expression of Bcl2 1 0.05 0.94 0.07
119 INT340395 Binding of Bax and Tg(CAG-EGFP)D4Nagy 1 0.02 0.43 0.07
120 INT302147 PTGER2 Positive_regulation of BAK1 1 0.06 2.08 0.06
121 INT302177 PTGER2 Positive_regulation of BCL2 1 0.04 2.08 0.06
122 INT302175 BAX Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
123 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
124 INT352299 Regulation of Binding of BCL2 and VIM 1 0.10 1.07 0.06
125 INT352298 Binding of BCL2 and VIM 1 0.09 1.06 0.06
126 INT302138 PTGER2 Positive_regulation of Gene_expression of BAK1 1 0.06 2.08 0.06
127 INT341375 Sod2 Regulation of Bcl2 1 0.08 1.96 0.05
128 INT190824 Binding of Cl and Bcl2 1 0.02 1.4 0.05
129 INT333252 Positive_regulation of Binding of Bcl2 and Mcl1 1 0.03 0.88 0.04
130 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04
131 INT268664 Ptger2 Positive_regulation of Bcl2 1 0.02 0.9 0.04
132 INT172214 BAX Positive_regulation of TP53 1 0.09 0.37 0.04
133 INT333245 Binding of Bcl2 and Bcl2l11 1 0.03 0.87 0.04
134 INT268666 Ptger2 Positive_regulation of Gene_expression of Bcl2 1 0.02 0.9 0.04
135 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
136 INT204298 Bid Positive_regulation of Binding of Bak1 1 0.05 0.57 0.04
137 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04
138 INT333253 Binding of Bcl2 and Mcl1 1 0.02 2.14 0.04
139 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
140 INT341009 Nrg1 Positive_regulation of Gene_expression of Fabp7 1 0.10 0.49 0.04
141 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03
142 INT192164 Binding of BAK1 and BCL2 3 0.04 2.8 0.03
143 INT192167 Negative_regulation of Binding of BAK1 and BCL2 2 0.05 1.89 0.03
144 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
145 INT192165 Binding of BAK1 and BCL2L1 2 0.06 1.35 0.03
146 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
147 INT288538 Il2 Positive_regulation of Gene_expression of Bcl2 1 0.04 1.96 0.03
148 INT192166 Negative_regulation of Binding of BAK1 and BCL2L1 1 0.05 1.06 0.03
149 INT297737 Cbr1 Positive_regulation of Bax 1 0.06 0.53 0.03
150 INT224682 Mcl1 Regulation of Bak1 1 0.01 1.09 0.03
151 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
152 INT217148 MIR21 Regulation of BCL2 1 0.32 0.98 0.03
153 INT238395 BAX Regulation of CDKN1A 1 0.03 0.31 0.03
154 INT101159 Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT 1 0.31 0.96 0.03
155 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
156 INT181083 Binding of Akt1 and Cdc42 1 0.00 0.79 0.03
157 INT229204 Olr1254 Negative_regulation of Gene_expression of Bcl2 1 0.02 0.18 0.03
158 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
159 INT333259 Bcl2 Regulation of Bax 1 0.03 0.32 0.03
160 INT172894 Negative_regulation of Lox Negative_regulation of Gene_expression of Bcl2 1 0.03 1.12 0.03
161 INT220445 Bcl2 Negative_regulation of Positive_regulation of Casp9 1 0.01 1.37 0.03
162 INT224689 Binding of Bak1 and Mcl1 1 0.01 1.09 0.03
163 INT224676 Binding of Bax and Mcl1 1 0.01 1.09 0.03
164 INT333249 Cxcl12 Positive_regulation of Positive_regulation of Bak1 1 0.30 0.32 0.03
165 INT224690 Mcl1 Regulation of Bax 1 0.00 1.09 0.03
166 INT333262 Bcl2 Regulation of Bak1 1 0.04 0.31 0.03
167 INT341376 Sod2 Regulation of Bax 1 0.09 0.99 0.03
168 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0
169 INT283013 Binding of Bak1 and Bcl2 4 0.06 1.03 0
170 INT185852 Binding of BAK1 and BAX 3 0.29 2.5 0
171 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0
172 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0
173 INT198011 Binding of BAX and MCL1 2 0.20 3.04 0
174 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0
175 INT144032 STAT3 Regulation of BCL2 2 0.07 0.86 0
176 INT217150 MIR16-2 Regulation of BCL2 2 0.09 1.89 0
177 INT217137 MIR15B Regulation of BCL2 2 0.15 1.88 0
178 INT185851 BID Positive_regulation of BAK1 1 0.43 0.73 0
179 INT295047 Binding of Bcl2 and Nr4a1 1 0.04 0.96 0
180 INT254089 EPO Regulation of Gene_expression of Bcl2 1 0.03 0.63 0
181 INT285031 Binding of Bcl2 and Bcl2l1 1 0.27 0.1 0
182 INT321406 VEGFA Regulation of BCL2 1 0.01 0.75 0
183 INT295046 Bcl2 Regulation of Gene_expression of Nr4a1 1 0.02 0.92 0
184 INT292503 Mlph Regulation of Gene_expression of BCL2 1 0.00 0.4 0
185 INT253474 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Bcl2 1 0.04 1.27 0
186 INT285029 Binding of Bax and Bcl2l1 1 0.25 0.1 0
187 INT330047 Binding of Bax and Bcl2l11 1 0.13 0.62 0
188 INT191058 Binding of Bcl2 and Positive_regulation of Gene_expression of Bax 1 0.21 0.49 0
189 INT333258 Gene_expression of Cxcl12 Positive_regulation of Positive_regulation of Bak1 1 0.15 0.55 0
190 INT333688 Trp53 Positive_regulation of Bcl2 1 0.45 2.51 0
191 INT254707 Positive_regulation of Map2k1 Regulation of Gene_expression of BAK1 1 0.05 0.67 0
192 INT341005 Binding of Vim and Nrg1 1 0.05 0.14 0
193 INT327971 PNLIP Positive_regulation of Gene_expression of BAX 1 0.43 1.95 0
194 INT292500 Mlph Regulation of Gene_expression of BAX 1 0.00 0.4 0
195 INT322658 Binding of Bak1 and Prdm8 1 0.02 0.89 0
196 INT106380 ARSA Regulation of Gene_expression of BAX 1 0.06 0.12 0
197 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0
198 INT321400 VEGFA Negative_regulation of Gene_expression of BAX 1 0.03 0.75 0
199 INT348531 Binding of BCL2 and BECN1 1 0.06 0.43 0
200 INT221240 Akt1 Positive_regulation of Phosphorylation of Bcl2 1 0.00 0.89 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of protein heterodimerization activity. They are ordered first by their pain relevance and then by number of times they were reported in regulation of protein heterodimerization activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
2 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
3 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
4 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
5 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94
6 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
7 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
8 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36
9 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
10 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
11 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
12 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
13 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22
14 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08
15 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
16 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
17 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
18 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
19 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82
20 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
21 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
22 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
23 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
24 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
25 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41
26 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
27 INT145929 Regulation of Bax 20 0.60 18.12 5.35
28 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
29 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
30 INT109513 Positive_regulation of Gene_expression of Bax 37 0.67 29.52 5.06
31 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
32 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
33 INT103345 Positive_regulation of Gene_expression of BAK1 10 0.57 6.4 4.19
34 INT101858 Negative_regulation of BAX 25 0.57 23.77 4.16
35 INT84686 Regulation of BAX 26 0.49 28.54 4.13
36 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
37 INT123752 Regulation of Bax 19 0.60 16.45 4
38 INT112692 Localization of Bax 31 0.80 20.97 3.98
39 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
40 INT124579 Localization of BAX 35 0.78 30.31 3.43
41 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
42 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
43 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
44 INT105884 Binding of Bcl2 19 0.35 15.67 3
45 INT74293 Positive_regulation of BAK1 13 0.60 14.13 2.73
46 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
47 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
48 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
49 INT103966 Negative_regulation of Gene_expression of BAX 9 0.56 7.95 2.14
50 INT77627 Regulation of Gene_expression of BAX 14 0.44 15.09 2.12
51 INT154970 Localization of Bax 15 0.74 11.12 2.11
52 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
53 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
54 INT98836 Transcription of Bax 6 0.69 5.04 1.96
55 INT134442 Transcription of Bax 14 0.67 7.6 1.9
56 INT135540 Negative_regulation of Bax 16 0.48 11.8 1.89
57 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
58 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
59 INT134443 Binding of Bax 10 0.47 5.62 1.84
60 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
61 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
62 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
63 INT103967 Negative_regulation of Gene_expression of BAK1 8 0.42 7.02 1.54
64 INT105784 Binding of Nrg1 7 0.37 1.29 1.52
65 INT62800 Regulation of BAK1 7 0.41 10.12 1.47
66 INT146785 Positive_regulation of Localization of Bax 7 0.69 6.16 1.47
67 INT109512 Negative_regulation of Gene_expression of Bax 12 0.42 8.04 1.44
68 INT112695 Negative_regulation of Protein_catabolism of Bax 3 0.36 1.72 1.3
69 INT142017 Positive_regulation of Positive_regulation of BAK1 2 0.52 1.74 1.3
70 INT158056 Localization of Nrg1 13 0.79 3.11 1.28
71 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
72 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
73 INT112693 Protein_catabolism of Bax 5 0.74 3.17 1.2
74 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
75 INT141189 Negative_regulation of Transcription of Bax 1 0.41 1.42 1.14
76 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12
77 INT172855 Binding of Bcl2 37 0.32 23.41 1.09
78 INT70021 Localization of BCL2 23 0.74 21.6 1.09
79 INT101994 Positive_regulation of Nrg1 10 0.50 1.24 1.05
80 INT93094 Gene_expression of Bak1 13 0.52 13.94 1.02
81 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96
82 INT175507 Regulation of Gene_expression of Bax 13 0.50 10.91 0.95
83 INT98134 Binding of BAX 17 0.39 11.45 0.93
84 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
85 INT135542 Positive_regulation of Bak1 17 0.43 16.12 0.88
86 INT151115 Regulation of Regulation of Bcl2 4 0.21 4.12 0.88
87 INT92117 Phosphorylation of BCL2 26 0.80 9.93 0.86
88 INT137512 Positive_regulation of Positive_regulation of BAX 5 0.49 4.91 0.85
89 INT144697 Regulation of Gene_expression of Bax 8 0.37 9.5 0.81
90 INT82896 Transcription of BAX 3 0.67 4.61 0.8
91 INT70019 Binding of BCL2 25 0.47 17.55 0.79
92 INT109404 Transcription of BCL2 6 0.69 4.49 0.77
93 INT148984 Positive_regulation of Localization of BAX 6 0.48 5.29 0.77
94 INT124844 Regulation of Positive_regulation of Bcl2 3 0.43 2.55 0.75
95 INT139846 Protein_catabolism of Nrg1 5 0.60 1.78 0.74
96 INT155392 Negative_regulation of Negative_regulation of Bcl2 3 0.21 1.64 0.74
97 INT134444 Positive_regulation of Binding of Bcl2 3 0.47 2.67 0.72
98 INT14040 Binding of Bak1 2 0.30 0.55 0.72
99 INT126736 Positive_regulation of Gene_expression of Nrg1 3 0.50 0.42 0.71
100 INT14041 Regulation of Binding of Bak1 1 0.23 0 0.68
101 INT204290 Positive_regulation of Bak1 3 0.22 5.19 0.66
102 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
103 INT290081 Regulation of NRG1 7 0.26 5.24 0.59
104 INT70025 Positive_regulation of Positive_regulation of BCL2 3 0.27 0.96 0.58
105 INT178128 Negative_regulation of Phosphorylation of BCL2 7 0.27 3.94 0.56
106 INT285007 Regulation of Bak1 1 0.20 3.46 0.56
107 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
108 INT155090 Regulation of Positive_regulation of BCL2 3 0.26 1.78 0.54
109 INT176242 Binding of Bax 10 0.42 10.18 0.52
110 INT144696 Regulation of Transcription of Bcl2 5 0.44 2.96 0.51
111 INT15770 Negative_regulation of Gene_expression of Nrg1 3 0.43 1.27 0.5
112 INT135541 Negative_regulation of Bak1 6 0.30 4.52 0.49
113 INT134445 Positive_regulation of Positive_regulation of Bcl2 3 0.47 2.43 0.49
114 INT102108 Protein_catabolism of Bax 8 0.64 5.69 0.48
115 INT221676 Protein_catabolism of Bcl2 4 0.24 2.77 0.48
116 INT19083 Positive_regulation of NRG1 3 0.20 0.65 0.48
117 INT134446 Positive_regulation of Binding of Bax 1 0.49 0.72 0.48
118 INT229243 Negative_regulation of Phosphorylation of BAX 1 0.18 2.32 0.47
119 INT204052 Transcription of Bcl2 5 0.51 3.25 0.45
120 INT140295 Protein_catabolism of BCL2 4 0.64 5.7 0.44
121 INT220424 Positive_regulation of Negative_regulation of Bcl2 2 0.14 1.81 0.44
122 INT152059 Regulation of Transcription of Bax 1 0.26 0.07 0.42
123 INT105888 Phosphorylation of BAX 9 0.80 4.78 0.4
124 INT150946 Negative_regulation of Positive_regulation of Bak1 2 0.29 3.02 0.4
125 INT135802 Positive_regulation of Negative_regulation of Bax 2 0.41 0.57 0.4
126 INT229233 Positive_regulation of Phosphorylation of BAX 1 0.21 1.94 0.38
127 INT155724 Negative_regulation of Transcription of Bcl2 6 0.53 2.35 0.37
128 INT290096 Regulation of Gene_expression of NRG1 2 0.06 2.21 0.35
129 INT204069 Negative_regulation of Positive_regulation of Bax 5 0.31 3.08 0.34
130 INT169538 Negative_regulation of Localization of Bax 3 0.49 1.41 0.34
131 INT334851 Positive_regulation of Localization of Nrg1 1 0.30 0.68 0.34
132 INT184482 Positive_regulation of Positive_regulation of Bax 5 0.41 4.7 0.33
133 INT172216 Binding of Bak1 5 0.25 8.48 0.33
134 INT221191 Negative_regulation of Localization of Bax 4 0.38 2.85 0.33
135 INT93093 Regulation of Gene_expression of Bak1 3 0.30 2.09 0.32
136 INT122950 Binding of BAK1 16 0.41 12.85 0.31
137 INT140379 Positive_regulation of Gene_expression of Bak1 4 0.27 2.27 0.31
138 INT109530 Negative_regulation of Positive_regulation of BAX 3 0.42 3.01 0.3
139 INT82900 Positive_regulation of Transcription of BAX 2 0.49 1.86 0.29
140 INT229853 Gene_expression of Bak1 2 0.25 2.04 0.29
141 INT178114 Positive_regulation of Phosphorylation of BCL2 11 0.49 4.44 0.28
142 INT102111 Positive_regulation of Protein_catabolism of Bax 2 0.45 1.14 0.27
143 INT150947 Positive_regulation of Positive_regulation of Bak1 1 0.05 0.6 0.25
144 INT172227 Regulation of Localization of BAX 3 0.26 4.79 0.24
145 INT203557 Transcription of NRG1 2 0.31 0.7 0.24
146 INT292743 Negative_regulation of Binding of Bcl2 1 0.05 1.97 0.24
147 INT135543 Negative_regulation of Positive_regulation of Bax 5 0.30 6.4 0.23
148 INT183881 Localization of CDC42 3 0.49 1.92 0.23
149 INT285003 Positive_regulation of Regulation of Bcl2 1 0.46 0.68 0.23
150 INT108563 Negative_regulation of Regulation of Bcl2 1 0.32 0.74 0.22
151 INT187555 Transcription of BAK1 3 0.19 2.6 0.21
152 INT187556 Regulation of Transcription of BAK1 1 0.02 1.22 0.21
153 INT187553 Regulation of Transcription of BAX 1 0.37 1.21 0.21
154 INT282088 Localization of Bak1 6 0.54 3.78 0.19
155 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
156 INT220426 Regulation of Negative_regulation of Bcl2 1 0.05 0.81 0.18
157 INT300463 Regulation of Regulation of Bax 1 0.29 1.33 0.18
158 INT198036 Negative_regulation of BAK1 5 0.27 5.98 0.17
159 INT238507 Regulation of Regulation of BCL2 3 0.44 5.14 0.16
160 INT101109 Negative_regulation of Localization of Bcl2 1 0.03 0.62 0.16
161 INT54093 Protein_catabolism of NRG1 1 0.26 0 0.16
162 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15
163 INT231261 Regulation of Nrg1 3 0.31 1.32 0.15
164 INT229235 Regulation of Localization of BCL2 2 0.29 3.7 0.15
165 INT102109 Protein_catabolism of Bcl2 1 0.65 0.55 0.15
166 INT220571 Positive_regulation of Protein_catabolism of Nrg1 1 0.30 0.08 0.15
167 INT110957 Positive_regulation of Positive_regulation of Bcl2 3 0.35 2.3 0.13
168 INT320315 Protein_catabolism of BAK1 3 0.76 3.13 0.13
169 INT285005 Negative_regulation of Bak1 1 0.14 0.16 0.13
170 INT185872 Localization of BAK1 6 0.74 11.28 0.12
171 INT265485 Positive_regulation of Localization of BAK1 4 0.50 5.17 0.12
172 INT206133 Binding of CDC42 3 0.25 0.8 0.12
173 INT185907 Positive_regulation of Binding of BAK1 2 0.60 1.59 0.12
174 INT179038 Positive_regulation of Regulation of Bcl2 1 0.39 3.49 0.12
175 INT238490 Regulation of Regulation of BAK1 1 0.19 2.56 0.12
176 INT133486 Negative_regulation of Binding of BAX 1 0.15 0.62 0.12
177 INT203559 Positive_regulation of Transcription of NRG1 1 0.22 0 0.11
178 INT336888 Negative_regulation of Transcription of Bax 1 0.07 0.68 0.11
179 INT304137 Regulation of Localization of Bax 2 0.24 1.7 0.09
180 INT54092 Regulation of Protein_catabolism of NRG1 1 0.13 0 0.09
181 INT197282 Positive_regulation of Gene_expression of Cdc42 3 0.26 0.12 0.08
182 INT329735 Negative_regulation of Protein_catabolism of Nrg1 1 0.36 0.49 0.08
183 INT327140 Regulation of Localization of BAK1 1 0.45 0.71 0.07
184 INT303976 Negative_regulation of Protein_catabolism of BAX 1 0.09 0.24 0.07
185 INT285012 Positive_regulation of Positive_regulation of Bak1 1 0.16 0.77 0.07
186 INT54094 Positive_regulation of Protein_catabolism of NRG1 1 0.14 0 0.07
187 INT322649 Positive_regulation of Localization of Bak1 1 0.47 1.04 0.07
188 INT303978 Protein_catabolism of BAX 1 0.13 0.24 0.07
189 INT307466 Positive_regulation of Phosphorylation of Bax 1 0.15 0.76 0.07
190 INT285008 Negative_regulation of Regulation of Bak1 1 0.14 0.87 0.07
191 INT334840 Positive_regulation of Phosphorylation of Nrg1 1 0.30 0 0.06
192 INT290102 Localization of NRG1 1 0.15 0.76 0.06
193 INT333214 Regulation of Bak1 1 0.18 1.1 0.06
194 INT268304 Negative_regulation of Gene_expression of Bak1 3 0.28 1.95 0.05
195 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
196 INT268622 Regulation of Negative_regulation of Bax 1 0.12 0.81 0.05
197 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
198 INT302229 Negative_regulation of Negative_regulation of BCL2 3 0.21 2.69 0.04
199 INT309494 Negative_regulation of Binding of Bax 2 0.38 1.31 0.04
200 INT172226 Positive_regulation of Negative_regulation of BAX 2 0.48 1.51 0.04
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