GO:0043507

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Name positive regulation of JUN kinase activity
Categary Process
Go Slim No
Go Link GO:0043507
Unique Molecular Interactions 904
Total Molecular Interactions 1325
Total Single Events 7943
Pain Genes Associated 43

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of JUN kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of JUN kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
6 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
7 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
8 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
9 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
10 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
11 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
12 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
13 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
14 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
15 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
16 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
17 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
18 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
19 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
20 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
21 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
22 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
23 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
24 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
25 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
26 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
27 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
28 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
29 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
30 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
31 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
32 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
33 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
34 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
35 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
36 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
37 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
38 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
39 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
40 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
41 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
42 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
43 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
44 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
45 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
46 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
47 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
48 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
49 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
50 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
51 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
52 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
53 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
54 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
55 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
56 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
57 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
58 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
59 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
60 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
61 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
62 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
63 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
64 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
65 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
66 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
67 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
68 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
69 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
70 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
71 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
72 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
73 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
74 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
75 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
76 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
77 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
78 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
79 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
80 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
81 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
82 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
83 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
84 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
85 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
86 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
87 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
88 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
89 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
90 INT151630 Il1rn Negative_regulation of Dock9 1 0.03 1.33 0.88
91 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
92 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
93 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
94 INT187225 Vip Negative_regulation of Gene_expression of Tnfrsf11a 1 0.27 1.92 0.87
95 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
96 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
97 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
98 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
99 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
100 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
101 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
102 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
103 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
104 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
105 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
106 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
107 INT187226 Vip Positive_regulation of Gene_expression of Il1rn 1 0.04 0.96 0.82
108 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
109 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
110 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
111 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
112 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
113 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
114 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
115 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
116 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
117 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
118 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77
119 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
120 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
121 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
122 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76
123 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
124 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
125 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
126 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
127 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
128 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
129 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
130 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
131 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
132 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
133 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
134 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
135 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
136 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
137 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
138 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
139 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
140 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
141 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
142 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
143 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
144 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
145 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
146 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
147 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
148 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
149 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
150 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
151 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
152 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
153 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
154 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
155 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
156 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
157 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
158 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
159 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
160 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
161 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
162 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
163 INT279398 Binding of IL1RN and Il1rn 1 0.00 0.51 0.63
164 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
165 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
166 INT255997 Binding of Il1rn and H7 1 0.01 1.21 0.63
167 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
168 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
169 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
170 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
171 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
172 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
173 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
174 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
175 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
176 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
177 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
178 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
179 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
180 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
181 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
182 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
183 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
184 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
185 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59
186 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59
187 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
188 INT168416 MIR146A Regulation of Irak1 1 0.24 0.99 0.59
189 INT96240 Il13 Negative_regulation of Il1b 1 0.17 0.6 0.59
190 INT96242 Il13 Negative_regulation of Gene_expression of Il1b 1 0.15 0.67 0.59
191 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
192 INT128603 Il1b Positive_regulation of Gene_expression of Fos 1 0.50 0.59 0.58
193 INT58342 Calca Negative_regulation of Localization of IL1B 1 0.00 0.6 0.58
194 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
195 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57
196 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57
197 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
198 INT143940 Il1rn Negative_regulation of Il1f5 1 0.00 0.51 0.57
199 INT60665 Il1b Regulation of Oprd1 1 0.05 0 0.57
200 INT58805 Il1b Negative_regulation of LH 1 0.24 0 0.56

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of JUN kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of JUN kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
3 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
4 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
5 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
6 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
7 INT6849 Localization of IL1B 229 0.81 112.56 69.63
8 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
9 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
10 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
11 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
12 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
13 INT6484 Binding of IL1B 122 0.47 75.84 35.07
14 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
15 INT9347 Localization of Il1b 58 0.81 26.13 31.53
16 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
17 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
18 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
19 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
20 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
21 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
22 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
23 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
24 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
25 INT48081 Localization of Il1b 46 0.80 21.59 22.4
26 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
27 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
28 INT5048 Binding of Edn1 55 0.47 18.86 19.16
29 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08
30 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
31 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82
32 INT9191 Localization of EDN1 94 0.81 57.01 14.78
33 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
34 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
35 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
36 INT6365 Localization of Edn1 56 0.81 18.84 13.83
37 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
38 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
39 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
40 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
41 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
42 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
43 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
44 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
45 INT6361 Localization of Edn1 30 0.81 19.09 9.7
46 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
47 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
48 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
49 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
50 INT10237 Binding of EDN1 40 0.48 16 8.48
51 INT171962 Gene_expression of Tnfrsf11a 40 0.72 31.1 7.84
52 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
53 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
54 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
55 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
56 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
57 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
58 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
59 INT69980 Negative_regulation of Il1rn 11 0.33 7.75 6.7
60 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
61 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
62 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
63 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
64 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
65 INT126395 Positive_regulation of Gene_expression of Il1rn 11 0.41 7.66 6.25
66 INT80750 Binding of Il1b 11 0.47 7.97 5.95
67 INT107441 Positive_regulation of Gene_expression of Il1rn 7 0.46 3.24 5.95
68 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
69 INT10705 Binding of Il1b 9 0.36 2.8 5.53
70 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44
71 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
72 INT114183 Positive_regulation of Il1rn 17 0.55 11.31 4.83
73 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75
74 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
75 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
76 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
77 INT76683 Positive_regulation of Il1rn 9 0.51 9.3 4.41
78 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
79 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
80 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17
81 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
82 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
83 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
84 INT83646 Binding of Il1rn 12 0.37 4.41 3.51
85 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
86 INT40232 Transcription of Il1rn 8 0.53 9.6 3.37
87 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
88 INT171888 Binding of Il1rn 13 0.38 5.53 3.13
89 INT171959 Binding of Tnfrsf11a 15 0.34 11.03 3.02
90 INT53374 Binding of Edn1 17 0.43 11.66 2.98
91 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
92 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9
93 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
94 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
95 INT204524 Binding of TLR9 17 0.43 11.69 2.76
96 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
97 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
98 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
99 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
100 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
101 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
102 INT76679 Positive_regulation of Transcription of Il1rn 1 0.37 9.13 2.55
103 INT62064 Negative_regulation of Gene_expression of Il1rn 6 0.32 4.81 2.53
104 INT69981 Positive_regulation of Negative_regulation of Il1rn 2 0.09 3.28 2.48
105 INT131928 Localization of Il1rn 3 0.74 2.22 2.24
106 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
107 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
108 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
109 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
110 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
111 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
112 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
113 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
114 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
115 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
116 INT97019 Negative_regulation of Binding of TNFRSF11A 4 0.17 1.8 1.89
117 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
118 INT208890 Gene_expression of Irak1 7 0.65 2.42 1.87
119 INT134890 Localization of TNFRSF11A 1 0.79 3.75 1.86
120 INT173931 Regulation of Gene_expression of Il1rn 3 0.60 2.68 1.84
121 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
122 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
123 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
124 INT134889 Negative_regulation of TNFRSF11A 9 0.42 12.65 1.76
125 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
126 INT171964 Positive_regulation of Gene_expression of Tnfrsf11a 5 0.37 4.11 1.73
127 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
128 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
129 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
130 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
131 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
132 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
133 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
134 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
135 INT95668 Positive_regulation of Tnfrsf11a 12 0.47 10.14 1.34
136 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
137 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
138 INT190067 Binding of Traf2 5 0.20 3.28 1.27
139 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
140 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
141 INT319293 Phosphorylation of Ptk2b 9 0.80 3.14 1.24
142 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
143 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
144 INT101022 Regulation of Il1rn 5 0.44 2.15 1.21
145 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
146 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
147 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
148 INT209895 Transcription of TNFRSF11A 4 0.52 2.56 1.09
149 INT153769 Negative_regulation of Tnfrsf11a 4 0.39 2.13 1.05
150 INT9348 Regulation of Localization of Il1b 2 0.27 0.14 1.04
151 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02
152 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02
153 INT290411 Gene_expression of Ptk2b 10 0.65 3.72 1.01
154 INT346201 Negative_regulation of Phosphorylation of IL1B 1 0.20 1.69 1.01
155 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
156 INT292529 Phosphorylation of Il1rn 1 0.09 1 0.97
157 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
158 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
159 INT145851 Negative_regulation of Positive_regulation of Il1rn 1 0.08 0.7 0.95
160 INT236927 Positive_regulation of Ptk2b 9 0.67 3.41 0.94
161 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94
162 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
163 INT173929 Regulation of Il1rn 5 0.26 3.02 0.93
164 INT145852 Negative_regulation of Negative_regulation of Il1rn 1 0.08 0.69 0.93
165 INT168280 Positive_regulation of Phosphorylation of Il1b 1 0.49 1.1 0.93
166 INT255990 Localization of Il1rn 6 0.73 1.74 0.9
167 INT171889 Negative_regulation of Gene_expression of Il1rn 3 0.08 2.31 0.9
168 INT152081 Phosphorylation of Edn1 1 0.53 0.39 0.9
169 INT254188 Positive_regulation of Irak1 7 0.44 3.46 0.87
170 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
171 INT116032 Transcription of Il1rn 4 0.70 2.19 0.84
172 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
173 INT167424 Positive_regulation of Pak1 1 0.14 1.43 0.83
174 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
175 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
176 INT187218 Negative_regulation of Gene_expression of Tnfrsf11a 1 0.31 1.65 0.8
177 INT294787 Localization of TLR9 2 0.67 2.35 0.75
178 INT61121 Regulation of Regulation of Edn1 1 0.43 0.2 0.75
179 INT127822 Negative_regulation of Transcription of Il1b 2 0.42 1.2 0.72
180 INT59970 Positive_regulation of Binding of Edn1 2 0.40 1.11 0.71
181 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
182 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
183 INT187210 Negative_regulation of Binding of Tnfrsf11a 1 0.23 1.77 0.7
184 INT21957 Negative_regulation of Negative_regulation of Edn1 5 0.43 1.34 0.69
185 INT88190 Negative_regulation of Binding of Il1rn 1 0.36 0.46 0.68
186 INT168411 Binding of Irak1 1 0.18 1.08 0.68
187 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
188 INT100396 Transcription of Edn1 7 0.69 2.48 0.66
189 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
190 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
191 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
192 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
193 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
194 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
195 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
196 INT83618 Regulation of Positive_regulation of Il1b 2 0.44 1.04 0.58
197 INT81352 Negative_regulation of Regulation of IL1B 2 0.41 0.51 0.58
198 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
199 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57
200 INT135715 Negative_regulation of Localization of Edn1 5 0.42 1.7 0.56
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