GO:0043514

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Name interleukin-12 complex
Categary Component
Go Slim No
Go Link GO:0043514
Unique Molecular Interactions 359
Total Molecular Interactions 449
Total Single Events 4129
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-12 complex. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-12 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
2 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26
3 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56
4 INT69031 IL12A Positive_regulation of IFNA1 9 0.13 4.23 1.52
5 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
6 INT70046 IL12A Regulation of IL10 1 0.07 1.42 1.21
7 INT70045 IL12A Regulation of Negative_regulation of PRF1 1 0.04 1.42 1.21
8 INT70044 IL12A Regulation of PRF1 1 0.04 1.42 1.21
9 INT70034 IL12A Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
10 INT156545 Il13 Positive_regulation of Gene_expression of Il12a 1 0.27 1.56 1.13
11 INT128700 BBS9 Negative_regulation of Il12a 1 0.47 0.76 1.03
12 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
13 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92
14 INT133176 Regulation of Mastl Negative_regulation of Il12a 1 0.01 0.24 0.86
15 INT133177 Mastl Negative_regulation of Il12a 1 0.01 0.24 0.86
16 INT249656 tm Positive_regulation of Il12a 1 0.07 1.17 0.84
17 INT113240 Il12a Regulation of Transcription of Tacr1 1 0.21 0.79 0.82
18 INT113238 Il12a Positive_regulation of Transcription of Tacr1 1 0.38 0.78 0.79
19 INT209029 Il12b Positive_regulation of Elf1 1 0.24 0.37 0.72
20 INT209031 Il12b Positive_regulation of Ccr1 1 0.02 0.37 0.72
21 INT209030 Il12b Positive_regulation of Cxcl1 1 0.16 0.37 0.72
22 INT209028 Il12b Positive_regulation of Il17a 1 0.12 0.37 0.72
23 INT209032 Il12b Positive_regulation of Csf2 1 0.08 0.37 0.72
24 INT184125 Il12a Positive_regulation of Stat4 2 0.11 1.04 0.7
25 INT176365 IL12A Positive_regulation of Gene_expression of IFNA1 1 0.13 1.35 0.6
26 INT250326 Binding of Il12a and Rpsa 1 0.09 0.93 0.59
27 INT283980 Binding of IL12A and IL23A 2 0.24 1.33 0.57
28 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57
29 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
30 INT176371 LBR Positive_regulation of IL12A 1 0.04 1.22 0.55
31 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
32 INT240537 Binding of Il12a and Ebi3 1 0.08 1.23 0.49
33 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48
34 INT176364 IL12A Regulation of Positive_regulation of IFNA1 1 0.12 0.59 0.46
35 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
36 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
37 INT222924 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il12a 1 0.01 0.59 0.45
38 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44
39 INT209049 Slc11a1 Positive_regulation of Localization of Il12a 1 0.04 0.09 0.44
40 INT292887 IL4 Regulation of IL12A 1 0.01 0.25 0.39
41 INT237778 Il12b Positive_regulation of Gene_expression of Eae1 1 0.01 1.51 0.39
42 INT292889 IL2 Regulation of IL12A 1 0.01 0.25 0.39
43 INT292888 TNF Regulation of IL12A 1 0.02 0.25 0.39
44 INT217028 Adp Negative_regulation of Il12b 1 0.00 0 0.37
45 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36
46 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34
47 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34
48 INT346915 Il12a Positive_regulation of Positive_regulation of IFN1@ 1 0.20 1.26 0.34
49 INT73494 PTGER2 Positive_regulation of Gene_expression of IL12A 1 0.05 0.51 0.33
50 INT73493 PTGER2 Negative_regulation of Gene_expression of IL12A 1 0.04 0.51 0.33
51 INT221417 IL12A Positive_regulation of Binding of IFN1@ 1 0.14 0.98 0.33
52 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31
53 INT93989 Rab8a Positive_regulation of Gene_expression of Il12a 1 0.10 0.48 0.3
54 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
55 INT164433 Il12a Positive_regulation of Il6 1 0.01 1.71 0.29
56 INT164434 Il12a Positive_regulation of Tnf 1 0.00 1.7 0.29
57 INT213808 Il12a Regulation of Gene_expression of Insrr 1 0.00 0.76 0.28
58 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27
59 INT120855 PRL Positive_regulation of Localization of IL12A 1 0.43 0.5 0.26
60 INT237380 Binding of Cdkn2d and Il12b 1 0.01 0.45 0.26
61 INT254598 Il12a Positive_regulation of Gene_expression of IFNA1 1 0.11 0.4 0.25
62 INT304582 IL12A Positive_regulation of Gene_expression of TH1L 1 0.21 0.83 0.25
63 INT304580 IL12A Regulation of Gene_expression of TH1L 1 0.19 0.82 0.25
64 INT225652 Gene_expression of IL4 Positive_regulation of Positive_regulation of IL12A 1 0.06 1.2 0.25
65 INT289406 C3ar1 Positive_regulation of Gene_expression of Il12a 1 0.01 1.04 0.25
66 INT189142 MTNR1B Positive_regulation of Gene_expression of IL12A 1 0.01 0.29 0.24
67 INT186368 Il10 Negative_regulation of Gene_expression of Il12a 1 0.06 0.17 0.24
68 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
69 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
70 INT186374 Il13 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23
71 INT186371 Il4 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23
72 INT329306 Spp1 Positive_regulation of Il12a 1 0.08 1.19 0.23
73 INT350146 Binding of IL12A and RS1 1 0.01 0.97 0.23
74 INT240539 Il12a Positive_regulation of Stat3 1 0.11 0.75 0.22
75 INT325314 Binding of IL12A and STAT3 1 0.19 0.6 0.22
76 INT240538 Il12a Positive_regulation of Phosphorylation of Stat4 1 0.11 0.76 0.22
77 INT325317 Binding of IL12A and TH1L 1 0.18 0.59 0.22
78 INT104833 IGKV2OR2-1 Negative_regulation of Gene_expression of IL12A 1 0.00 0 0.22
79 INT260437 Positive_regulation of Tlr7 Positive_regulation of Positive_regulation of Il12a 1 0.03 0.27 0.21
80 INT240535 Il12a Positive_regulation of Tyk2 1 0.10 0.75 0.21
81 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
82 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21
83 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2
84 INT186353 Binding of Il12a and Il1 1 0.21 0.38 0.2
85 INT252821 Binding of CD4 and IL12A 1 0.02 1.36 0.19
86 INT237777 Il23a Regulation of Localization of Il12a 1 0.19 0.93 0.19
87 INT252817 Binding of CD8A and IL12A 1 0.02 1.36 0.19
88 INT252788 Binding of IL12A and IL18 1 0.01 1.33 0.19
89 INT323134 Binding of IL10 and IL12A 1 0.06 0.55 0.18
90 INT355882 TNF Positive_regulation of Gene_expression of Il12b 1 0.03 0.21 0.18
91 INT266616 Il4 Positive_regulation of Il12a 1 0.01 0.4 0.17
92 INT104827 IRF6 Positive_regulation of IL12A 2 0.07 0.13 0.16
93 INT329305 Spp1 Positive_regulation of Gene_expression of Il12a 1 0.12 0.88 0.16
94 INT243632 Il12a Positive_regulation of Nfatc1 1 0.03 0.44 0.16
95 INT273251 Binding of IL6 and IL12A 1 0.00 1.15 0.16
96 INT224797 IL12A Regulation of Gene_expression of TNF 1 0.26 1.59 0.15
97 INT233386 Binding of Il12a and Il12b 1 0.01 0.48 0.15
98 INT316535 Il23a Regulation of Il12a 1 0.07 1.15 0.15
99 INT274474 IL12A Regulation of Gene_expression of VEGFA 1 0.04 0.36 0.14
100 INT274472 IL12A Negative_regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
101 INT330467 IL12A Positive_regulation of Localization of TH1L 1 0.16 0.3 0.14
102 INT274473 IL12A Regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
103 INT237774 Il12b Positive_regulation of Eae1 1 0.01 0.58 0.13
104 INT313914 Binding of Il12a and Il23r 1 0.14 0.44 0.13
105 INT247157 Tas2r129 Positive_regulation of Gene_expression of Il12a 1 0.00 1.23 0.13
106 INT329303 Spp1 Positive_regulation of Localization of Il12a 1 0.12 0.92 0.12
107 INT186379 Il12a Positive_regulation of Binding of IFNA1 1 0.03 0.07 0.12
108 INT292628 IL12A Positive_regulation of Gene_expression of IL9 1 0.07 0.15 0.12
109 INT338434 Binding of Il12a and TBX21 1 0.07 0.58 0.11
110 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
111 INT233384 Il10 Negative_regulation of Il12a 1 0.01 0.54 0.11
112 INT259852 Binding of Il12a and Retnlb 1 0.01 0.59 0.11
113 INT274471 IL12A Negative_regulation of Gene_expression of IL10 1 0.02 0.99 0.1
114 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
115 INT274470 Binding of IL12A and GOPC 1 0.02 0.6 0.09
116 INT243652 Gk Negative_regulation of Gene_expression of Il12a 1 0.01 0 0.09
117 INT194828 IL12A Positive_regulation of Phosphorylation of Stat4 1 0.03 0.08 0.09
118 INT349331 Tlr4 Positive_regulation of Positive_regulation of Il12a 1 0.01 0.19 0.08
119 INT294679 GPI Positive_regulation of Gene_expression of Il12a 1 0.00 0.69 0.08
120 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
121 INT247156 Tas2r129 Positive_regulation of Il12a 1 0.00 0.8 0.07
122 INT233502 Fzd5 Positive_regulation of Gene_expression of Il12a 1 0.04 0.33 0.07
123 INT292629 IL21 Positive_regulation of IL12A 1 0.06 0.05 0.06
124 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
125 INT186375 TNF Negative_regulation of Gene_expression of Il12b 1 0.03 0.78 0.06
126 INT292624 IL21 Positive_regulation of Binding of IL12A 1 0.06 0.05 0.06
127 INT274469 IL12A Positive_regulation of Gene_expression of IL6 1 0.04 1.39 0.06
128 INT110751 IL12A Negative_regulation of KRR1 1 0.64 0.57 0.05
129 INT194665 IL12A Positive_regulation of MAPK1 1 0.06 0 0.05
130 INT294771 IL6 Positive_regulation of IL12A 1 0.05 0.15 0.04
131 INT285863 Positive_regulation of IL12A Regulation of TH1L 1 0.01 0.25 0.04
132 INT303996 Lep Positive_regulation of Gene_expression of IL12A 1 0.08 0.29 0.04
133 INT194679 IL12A Positive_regulation of GADD45A 1 0.04 0 0.04
134 INT285864 IL12A Regulation of TH1L 1 0.00 0.25 0.04
135 INT186382 TNF Regulation of Il12a 1 0.06 0.72 0.03
136 INT225648 IL4 Positive_regulation of Gene_expression of IL12A 1 0.06 0.89 0.03
137 INT186386 Il12a Regulation of Gene_expression of TNF 1 0.06 0.66 0.03
138 INT233387 Binding of SPINK1 and Il12b 1 0.04 0.33 0
139 INT186378 IFNA1 Positive_regulation of Il12a 1 0.03 0.76 0
140 INT300079 IL12A Positive_regulation of Positive_regulation of IFNA1 1 0.05 2.14 0
141 INT191059 Bcl2 Positive_regulation of Localization of Il12a 1 0.16 0.77 0
142 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
143 INT274475 IL12A Regulation of Gene_expression of IL6 1 0.04 0.68 0
144 INT317857 Tlr4 Positive_regulation of Il12a 1 0.11 1.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-12 complex. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-12 complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96
2 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97
3 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85
4 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98
5 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87
6 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38
7 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07
8 INT87239 Localization of Il12a 51 0.75 31.95 12.05
9 INT67401 Gene_expression of Il12a 25 0.55 20.04 11.12
10 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68
11 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16
12 INT91667 Localization of IL12A 39 0.74 25.51 7.36
13 INT77945 Regulation of Gene_expression of Il12a 19 0.58 6.55 6.4
14 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69
15 INT106189 Regulation of Il12a 18 0.44 12.4 5.3
16 INT98251 Binding of IL12A 20 0.37 16.03 4.51
17 INT92653 Gene_expression of IL12B 21 0.75 17.28 3.89
18 INT71374 Positive_regulation of Gene_expression of Il12a 5 0.22 7.49 3.8
19 INT144231 Gene_expression of Il12b 18 0.75 12.93 3.65
20 INT133169 Positive_regulation of Il12b 25 0.49 13 3.64
21 INT174160 Binding of Il12a 19 0.24 12.61 3.4
22 INT70051 Transcription of IL12A 7 0.25 5.61 3.39
23 INT79553 Localization of Il12a 9 0.31 5.85 3.16
24 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98
25 INT133174 Positive_regulation of Gene_expression of Il12b 29 0.15 13.04 2.92
26 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82
27 INT85878 Negative_regulation of Il12a 4 0.58 2.88 2.21
28 INT92648 Positive_regulation of IL12B 7 0.20 4.55 2.19
29 INT105378 Regulation of IL12A 6 0.26 8.82 2.15
30 INT85877 Positive_regulation of Il12a 6 0.43 4.87 2.11
31 INT74156 Positive_regulation of Il12b 3 0.49 1.54 2.04
32 INT91663 Positive_regulation of Localization of IL12A 9 0.27 5.91 1.95
33 INT92056 Transcription of Il12b 8 0.69 4.75 1.95
34 INT258781 Regulation of Regulation of Il12a 1 0.17 1.54 1.87
35 INT133170 Negative_regulation of Il12b 12 0.05 5.32 1.86
36 INT140906 Negative_regulation of Gene_expression of Il12a 4 0.38 5.28 1.86
37 INT91659 Negative_regulation of Localization of IL12A 8 0.14 3.9 1.75
38 INT110950 Positive_regulation of Negative_regulation of Il12a 2 0.44 1.75 1.73
39 INT128699 Regulation of Il12a 3 0.45 3.36 1.59
40 INT87241 Positive_regulation of Localization of Il12a 8 0.50 1.3 1.58
41 INT174230 Positive_regulation of Gene_expression of IL12B 6 0.49 3.2 1.56
42 INT110028 Transcription of Il12a 6 0.49 1.48 1.51
43 INT67398 Transcription of Il12a 3 0.26 3.16 1.49
44 INT97142 Localization of IL12B 5 0.73 1.73 1.46
45 INT95566 Positive_regulation of Positive_regulation of IL12A 10 0.41 7.47 1.43
46 INT79554 Negative_regulation of Localization of Il12a 2 0.09 1.14 1.24
47 INT236329 Regulation of IL12B 3 0.02 0.78 1.2
48 INT92055 Positive_regulation of Transcription of Il12b 4 0.49 2.77 1.16
49 INT233357 Localization of Il12b 7 0.16 3.4 1.12
50 INT67399 Negative_regulation of Transcription of Il12a 2 0.03 2.63 1.05
51 INT144232 Negative_regulation of Gene_expression of Il12b 4 0.41 2.26 1.01
52 INT233349 Regulation of Il12b 5 0.05 3.71 0.98
53 INT110949 Negative_regulation of Negative_regulation of Il12a 1 0.41 0 0.98
54 INT133173 Regulation of Negative_regulation of Il12b 2 0.04 0.52 0.97
55 INT77947 Regulation of Gene_expression of IL12A 6 0.24 5.23 0.94
56 INT92649 Negative_regulation of Gene_expression of IL12B 3 0.03 2.23 0.86
57 INT110027 Regulation of Localization of Il12a 3 0.41 0.6 0.85
58 INT186283 Negative_regulation of Gene_expression of Il12b 2 0.13 7.92 0.74
59 INT240523 Phosphorylation of Il12a 2 0.29 1.32 0.7
60 INT74155 Transcription of Il12b 3 0.60 1.45 0.66
61 INT156544 Regulation of Il12b 2 0.44 1.29 0.66
62 INT95567 Negative_regulation of Positive_regulation of IL12A 2 0.34 1.83 0.59
63 INT226482 Phosphorylation of IL12A 3 0.10 1.47 0.57
64 INT186277 Binding of Il12b 4 0.20 2.15 0.55
65 INT237764 Regulation of Binding of Il12a 1 0.29 0.82 0.52
66 INT252282 Positive_regulation of Phosphorylation of Il12a 1 0.08 0.59 0.49
67 INT174157 Negative_regulation of Localization of Il12a 4 0.09 1.54 0.48
68 INT330393 Positive_regulation of Gene_expression of Il12b 2 0.49 1.24 0.48
69 INT290393 Regulation of Localization of IL12A 1 0.16 1.02 0.48
70 INT110022 Positive_regulation of Transcription of Il12a 2 0.43 0.13 0.45
71 INT233355 Positive_regulation of Localization of Il12b 2 0.11 0.99 0.43
72 INT185318 Negative_regulation of Transcription of Il12b 2 0.06 1.03 0.43
73 INT233356 Negative_regulation of Positive_regulation of Il12b 3 0.13 0.85 0.38
74 INT233350 Regulation of Gene_expression of Il12b 1 0.06 3.03 0.37
75 INT301687 Negative_regulation of Phosphorylation of IL12A 1 0.05 0.94 0.37
76 INT186272 Positive_regulation of Positive_regulation of Il12a 7 0.26 4.45 0.36
77 INT237901 Protein_catabolism of Il12a 2 1.00 0.79 0.36
78 INT92652 Negative_regulation of Positive_regulation of IL12B 1 0.03 0.99 0.36
79 INT348183 Binding of IL12B 1 0.46 0.97 0.33
80 INT329823 Negative_regulation of Il12b 1 0.42 0.57 0.27
81 INT77946 Positive_regulation of Transcription of IL12A 1 0.24 0 0.24
82 INT294675 Localization of Il12b 2 0.78 1.15 0.19
83 INT119167 Positive_regulation of Transcription of Il12b 1 0.09 0.77 0.17
84 INT216975 Regulation of Negative_regulation of Il12a 1 0.16 0 0.14
85 INT237761 Phosphorylation of Il12b 1 0.09 0.49 0.11
86 INT323145 Regulation of Positive_regulation of IL12A 1 0.12 0.42 0.11
87 INT306724 Negative_regulation of Transcription of Il12a 1 0.18 0.3 0.1
88 INT233354 Positive_regulation of Positive_regulation of Il12b 1 0.06 2.91 0.07
89 INT186310 Positive_regulation of Binding of Il12b 1 0.15 1.07 0.07
90 INT97135 Positive_regulation of Localization of IL12B 2 0.49 0.92 0.05
91 INT274483 Positive_regulation of Binding of IL12A 1 0.16 1.08 0.05
92 INT350811 Regulation of Transcription of Il12a 1 0.11 0.2 0.04
93 INT305355 Transcription of IL12B 1 0.52 0.46 0.03
94 INT186281 Positive_regulation of Binding of Il12a 2 0.26 2.09 0
95 INT274486 Protein_catabolism of IL12A 1 0.28 0.98 0
96 INT300093 Positive_regulation of Negative_regulation of IL12A 1 0.26 1.28 0
97 INT97143 Regulation of Localization of IL12B 1 0.08 0 0
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