GO:0043517

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Name positive regulation of DNA damage response, signal transduction by p53 class mediator
Categary Process
Go Slim No
Go Link GO:0043517
Unique Molecular Interactions 88
Total Molecular Interactions 123
Total Single Events 1009
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of DNA damage response, signal transduction by p53 class mediator. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of DNA damage response, signal transduction by p53 class mediator. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
3 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
4 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
5 INT228449 PMAIP1 Negative_regulation of Fgf2 1 0.00 0.07 0.49
6 INT228448 PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
7 INT228447 Negative_regulation of PMAIP1 Negative_regulation of Cntf 1 0.00 0.07 0.49
8 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
9 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
10 INT228446 PMAIP1 Regulation of Transcription of Mtpn 1 0.00 0 0.34
11 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
12 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
13 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
14 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
15 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
16 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
17 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
18 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
19 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17
20 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
21 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
22 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
23 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
24 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
25 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14
26 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
27 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
28 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
29 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
30 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
31 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
32 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05
33 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05
34 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
35 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05
36 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
37 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
38 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
39 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
40 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
41 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
42 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
43 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
44 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
45 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
46 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
47 INT249169 PMAIP1 Positive_regulation of PRKDC 1 0.00 0 0
48 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0
49 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
50 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0
51 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
52 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
53 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
54 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
55 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
56 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
57 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
58 INT345484 Binding of MCL1 and PMAIP1 1 0.04 0.8 0
59 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
60 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
61 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
62 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
63 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
64 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
65 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
66 INT345486 PMAIP1 Positive_regulation of Localization of CYC1 1 0.18 0.96 0
67 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
68 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
69 INT345483 Binding of MYC and PMAIP1 1 0.16 0.63 0
70 INT105017 Binding of Slc25a31 and Atr 1 0.16 0.13 0
71 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
72 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
73 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
74 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
75 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
76 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
77 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
78 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
79 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
80 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
81 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
82 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0
83 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of DNA damage response, signal transduction by p53 class mediator. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of DNA damage response, signal transduction by p53 class mediator. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
2 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
3 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
4 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
5 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
6 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
7 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
8 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
9 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
10 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
11 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
12 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
13 INT69702 Positive_regulation of PMAIP1 7 0.35 8.81 1.98
14 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
15 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
16 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
17 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
18 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
19 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
20 INT25663 Localization of PMAIP1 3 0.38 2.47 0.71
21 INT28118 Binding of Atm 13 0.38 12.24 0.68
22 INT25664 Negative_regulation of Localization of PMAIP1 1 0.09 0.09 0.66
23 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
24 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
25 INT164585 Regulation of PMAIP1 2 0.20 2.07 0.61
26 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
27 INT48212 Binding of ATM 5 0.47 3.89 0.57
28 INT160778 Transcription of ATM 1 0.40 1.03 0.57
29 INT291268 Gene_expression of Atr 1 0.06 1.48 0.57
30 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
31 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
32 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
33 INT192946 Gene_expression of PMAIP1 2 0.27 1.77 0.52
34 INT164584 Positive_regulation of Positive_regulation of PMAIP1 1 0.20 0.9 0.52
35 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
36 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
37 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
38 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
39 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
40 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
41 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
42 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
43 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
44 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
45 INT245337 Gene_expression of ATR 3 0.27 2.06 0.29
46 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
47 INT167438 Localization of ATM 3 0.55 1.61 0.27
48 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
49 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
50 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
51 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
52 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
53 INT105012 Negative_regulation of Atr 1 0.34 0.35 0.16
54 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
55 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
56 INT245341 Regulation of Gene_expression of ATR 1 0.18 0.94 0.14
57 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
58 INT167440 Regulation of ATM 2 0.20 0.68 0.12
59 INT245339 Regulation of ATR 1 0.18 0.92 0.11
60 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
61 INT345504 Binding of PMAIP1 1 0.15 1.7 0.1
62 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
63 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
64 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
65 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
66 INT265487 Positive_regulation of Localization of PMAIP1 1 0.25 1.17 0.05
67 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
68 INT207803 Regulation of Atm 3 0.41 1.15 0.03
69 INT207807 Localization of Atm 4 0.74 0.21 0
70 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
71 INT208213 Localization of ATR 2 0.50 0.19 0
72 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
73 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
74 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
75 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
76 INT252642 Transcription of Atm 1 0.53 0.18 0
77 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
78 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
79 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
80 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
81 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
82 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
83 INT235140 Binding of Atr 1 0.00 1.28 0
84 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0
85 INT184623 Positive_regulation of Localization of CDKN2A 1 0.04 0.86 0
86 INT247424 Transcription of Cdkn2a 1 0.47 0.82 0
87 INT345501 Negative_regulation of PMAIP1 1 0.17 0.46 0
88 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
89 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0
90 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
91 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
92 INT252554 Positive_regulation of ATR 1 0.13 0 0
93 INT247425 Regulation of Transcription of Cdkn2a 1 0.18 0.82 0
94 INT345499 Negative_regulation of Positive_regulation of PMAIP1 1 0.21 1.65 0
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