GO:0043518

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Name negative regulation of DNA damage response, signal transduction by p53 class mediator
Categary Process
Go Slim No
Go Link GO:0043518
Unique Molecular Interactions 285
Total Molecular Interactions 443
Total Single Events 2785
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of DNA damage response, signal transduction by p53 class mediator. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of DNA damage response, signal transduction by p53 class mediator. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
3 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
4 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
5 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
6 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
7 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
8 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
9 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
10 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
11 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
12 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
13 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
14 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87
15 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
16 INT63594 Snai1 Negative_regulation of Binding of Ugt1a2 1 0.05 0.32 0.82
17 INT63596 Snai1 Negative_regulation of ITS 1 0.00 0.31 0.81
18 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
19 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
20 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
21 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
22 INT164990 Mif Positive_regulation of Gene_expression of Grina 1 0.24 0.53 0.6
23 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
24 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
25 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
26 INT91428 CD44 Positive_regulation of Binding of MMRN1 1 0.24 0.85 0.55
27 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
28 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
29 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48
30 INT187100 Binding of Cd4 and Cd44 1 0.02 1.09 0.47
31 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
32 INT195769 MIF Regulation of Gene_expression of TP53I11 1 0.19 1.24 0.47
33 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
34 INT253997 Binding of Cd200r1 and Mif 1 0.03 1.02 0.46
35 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
36 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
37 INT355571 MIF Positive_regulation of IL8 1 0.04 1.05 0.44
38 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44
39 INT121364 ZNF398 Negative_regulation of Transcription of MIF 1 0.00 0.9 0.43
40 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
41 INT148548 Cd44 Positive_regulation of Regulation of NPEPPS 1 0.00 0.29 0.42
42 INT121378 Fancl Positive_regulation of MIF 1 0.01 0.92 0.42
43 INT148547 Cd44 Positive_regulation of NPEPPS 1 0.00 0.29 0.41
44 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
45 INT121365 ZNF398 Negative_regulation of Gene_expression of MIF 1 0.00 0.73 0.38
46 INT166792 Binding of CD44 and HRAS 3 0.12 1.49 0.37
47 INT355570 MIF Positive_regulation of Gene_expression of IL8 1 0.07 1.11 0.36
48 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
49 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
50 INT32212 POMC Regulation of Gene_expression of Mif 1 0.00 1.01 0.35
51 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
52 INT72953 Mif Positive_regulation of Localization of Prl 1 0.42 0 0.34
53 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
54 INT72951 Mif Regulation of Prl 1 0.41 0 0.32
55 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
56 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
57 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
58 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
59 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
60 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
61 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
62 INT337085 Binding of Cxcr4 and Mif 1 0.21 1.89 0.3
63 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
64 INT163762 MDM2 Positive_regulation of Gene_expression of BAX 1 0.27 0.86 0.3
65 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
66 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
67 INT72952 Mif Regulation of Localization of Prl 1 0.28 0 0.27
68 INT254000 Regulation of Binding of Cxcr4 and Mif 1 0.29 0.56 0.27
69 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
70 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
71 INT355567 IRF6 Positive_regulation of MIF 1 0.01 0.29 0.25
72 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
73 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
74 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
75 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
76 INT205155 Negative_regulation of Binding of CD44 and MMP9 1 0.32 1.98 0.23
77 INT166791 CD44 Positive_regulation of Gene_expression of PTGER1 1 0.05 0.15 0.2
78 INT166787 CD44 Negative_regulation of Gene_expression of PTGER1 1 0.04 0.15 0.2
79 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
80 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
81 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
82 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
83 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
84 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
85 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
86 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
87 INT316479 Il6 Positive_regulation of Snai1 1 0.24 0.33 0.15
88 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
89 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
90 INT195770 Binding of CPB1 and MIF 1 0.01 0.47 0.15
91 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
92 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
93 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13
94 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
95 INT87839 Binding of Cd74 and Dcn 1 0.36 0.21 0.13
96 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
97 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
98 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
99 INT204899 Tlr4 Positive_regulation of Cd44 1 0.23 0.09 0.09
100 INT222425 Mif Regulation of Tlr4 1 0.01 0.24 0.09
101 INT204885 Tlr4 Negative_regulation of Positive_regulation of Cd44 1 0.21 0.09 0.09
102 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
103 INT204889 Tlr4 Negative_regulation of Cd44 1 0.10 0.09 0.09
104 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
105 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
106 INT337090 Mif Positive_regulation of Gene_expression of Mapk1 1 0.10 1.11 0.08
107 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
108 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
109 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08
110 INT222514 Mif Regulation of Localization of Il6 1 0.04 0.23 0.08
111 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08
112 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
113 INT27290 Cytl1 Positive_regulation of CD44 1 0.00 0.99 0.08
114 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
115 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
116 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
117 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
118 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
119 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
120 INT1226 Fabp6 Negative_regulation of Snai1 1 0.03 0.49 0.07
121 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
122 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
123 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
124 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
125 INT133306 Positive_regulation of Binding of CD44 and SPP1 1 0.16 0.83 0.07
126 INT193790 ITIH4 Regulation of Gene_expression of MDM2 1 0.06 0.45 0.07
127 INT205160 Binding of CD44 and MMP2 1 0.09 0.61 0.07
128 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
129 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
130 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
131 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
132 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
133 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
134 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
135 INT352612 Trp53 Negative_regulation of Cd44 1 0.24 1.01 0.04
136 INT269214 SNAI1 Positive_regulation of Positive_regulation of CDH1 1 0.35 0.71 0.04
137 INT269211 SNAI1 Positive_regulation of Gene_expression of CDH1 1 0.40 0.73 0.04
138 INT276381 Timp1 Positive_regulation of CD44 1 0.07 0.72 0.04
139 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
140 INT233848 Zeb1 Positive_regulation of Snai1 1 0.07 0.58 0.04
141 INT233853 Zeb1 Positive_regulation of Snai2 1 0.09 0.58 0.04
142 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
143 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
144 INT276376 Gtf3a Regulation of CD44 1 0.00 0.86 0.04
145 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
146 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
147 INT348820 Cd74 Regulation of Gene_expression of TFDP3 1 0.07 0.16 0.04
148 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
149 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
150 INT276385 Timp1 Regulation of CD44 1 0.04 0.87 0.04
151 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
152 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
153 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
154 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
155 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
156 INT314686 TP53 Regulation of Gene_expression of MDM2 1 0.21 0.96 0.03
157 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
158 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
159 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
160 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
161 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
162 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
163 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0
164 INT267136 Binding of CD44 and FN1 2 0.04 0.56 0
165 INT176543 Binding of Cd44 and Spp1 2 0.31 0.57 0
166 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
167 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
168 INT325945 Binding of Cd44 and Ezr 1 0.25 0.39 0
169 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
170 INT121545 Mif Negative_regulation of Regulation of Ptgs2 1 0.13 0.15 0
171 INT170121 ITGAL Regulation of CD44 1 0.07 1.07 0
172 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
173 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
174 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
175 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
176 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
177 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
178 INT127731 Binding of A2m and Mif 1 0.19 0 0
179 INT347162 MDM2 Negative_regulation of TP53 1 0.02 1.09 0
180 INT320714 Gene_expression of MDM2 Negative_regulation of TP53 1 0.16 0.88 0
181 INT298451 Binding of SNAI1 and Vim 1 0.07 1.45 0
182 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
183 INT298437 Binding of ITK and SNAI1 1 0.05 1.16 0
184 INT304028 MDM2 Regulation of TP53 1 0.19 1.11 0
185 INT306256 MDM2 Negative_regulation of Positive_regulation of TP53 1 0.23 0.44 0
186 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
187 INT312225 Positive_regulation of INPP5K Positive_regulation of CD44 1 0.15 0.1 0
188 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
189 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
190 INT269209 SNAI1 Regulation of Gene_expression of LOXL2 1 0.07 1.14 0
191 INT170118 PECAM1 Regulation of CD44 1 0.01 1.07 0
192 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
193 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
194 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
195 INT352617 Mdm2 Positive_regulation of Positive_regulation of Trp53 1 0.20 2.56 0
196 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
197 INT253993 Positive_regulation of Binding of Cxcr4 and Mif 1 0.50 0 0
198 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
199 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
200 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of DNA damage response, signal transduction by p53 class mediator. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of DNA damage response, signal transduction by p53 class mediator. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116737 Localization of Mif 63 0.81 52.97 28.11
2 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
3 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
4 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
5 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96
6 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
7 INT114674 Gene_expression of Mdm2 15 0.78 3.51 11.85
8 INT72949 Binding of Mif 31 0.46 23.12 11.65
9 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
10 INT117553 Regulation of MIF 10 0.56 12.76 8.67
11 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
12 INT1223 Negative_regulation of Snai1 15 0.38 2.05 8.46
13 INT114675 Positive_regulation of Gene_expression of Mdm2 1 0.70 1.98 7.9
14 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
15 INT20914 Positive_regulation of Snai1 13 0.41 3.41 7.69
16 INT517 Regulation of Mif 16 0.62 5.43 6.55
17 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08
18 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08
19 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
20 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
21 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
22 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12
23 INT174339 Positive_regulation of Localization of Mif 7 0.61 8.27 4.95
24 INT121372 Positive_regulation of Gene_expression of MIF 17 0.60 14.78 4.73
25 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
26 INT67144 Gene_expression of Cd44 17 0.76 8.94 4.48
27 INT48411 Gene_expression of Cd44 35 0.77 27.05 4.29
28 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
29 INT116738 Positive_regulation of Gene_expression of Mif 14 0.68 10.99 3.8
30 INT187168 Binding of Cd74 13 0.27 11.2 3.44
31 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
32 INT130226 Positive_regulation of Gene_expression of Mif 4 0.58 15.75 3.03
33 INT116540 Binding of Twist1 35 0.48 16.32 2.85
34 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
35 INT163290 Binding of MIF 9 0.31 7.57 2.8
36 INT1225 Regulation of Snai1 10 0.30 1.05 2.72
37 INT243350 Binding of CD74 2 0.11 4.86 2.72
38 INT203137 Binding of Mif 6 0.31 9.46 2.71
39 INT120011 Localization of MIF 6 0.58 5.72 2.6
40 INT91429 Binding of CD44 34 0.41 17.67 2.51
41 INT40748 Negative_regulation of Mif 6 0.56 8.33 2.46
42 INT269217 Gene_expression of SNAI1 81 0.76 80.49 2.26
43 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
44 INT103304 Positive_regulation of Mif 6 0.48 8.66 2.05
45 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
46 INT253975 Binding of Cd74 4 0.27 4.57 1.88
47 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
48 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76
49 INT32024 Positive_regulation of Positive_regulation of Snai1 2 0.25 0.32 1.7
50 INT44149 Regulation of Gene_expression of Mif 6 0.54 2.45 1.63
51 INT55302 Binding of Snai1 2 0.31 1.94 1.63
52 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
53 INT353326 Negative_regulation of Localization of Mif 1 0.45 1.28 1.59
54 INT65684 Gene_expression of MDM2 30 0.62 24.94 1.55
55 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
56 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
57 INT173716 Positive_regulation of Cd44 7 0.44 4.65 1.45
58 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
59 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
60 INT114671 Positive_regulation of Mdm2 1 0.61 0.5 1.38
61 INT10873 Localization of Twist1 21 0.74 10.43 1.37
62 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
63 INT253987 Regulation of Localization of Mif 3 0.43 1.65 1.27
64 INT123924 Positive_regulation of Gene_expression of Cd44 2 0.46 1.11 1.25
65 INT41418 Regulation of Mif 2 0.40 3.86 1.24
66 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
67 INT121368 Transcription of Mif 5 0.72 2.71 1.15
68 INT91431 Positive_regulation of Gene_expression of CD44 18 0.69 9.25 1.12
69 INT121375 Transcription of MIF 4 0.62 2.85 1.1
70 INT135390 Binding of Cd44 3 0.45 1.91 1.09
71 INT102827 Protein_catabolism of Mif 1 0.33 0 1.06
72 INT97032 Gene_expression of Snai1 3 0.52 0.58 1.04
73 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
74 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
75 INT114673 Regulation of Gene_expression of Mdm2 1 0.62 0.23 1.02
76 INT63354 Negative_regulation of Gene_expression of CD44 4 0.50 4.76 1.01
77 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
78 INT106386 Regulation of Gene_expression of CD44 8 0.27 3.66 0.96
79 INT135392 Localization of Cd44 1 0.75 1.74 0.93
80 INT121369 Negative_regulation of Gene_expression of MIF 3 0.50 2.48 0.92
81 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
82 INT121376 Negative_regulation of Transcription of MIF 3 0.37 2.26 0.87
83 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
84 INT353328 Regulation of Positive_regulation of Mif 1 0.40 0.89 0.81
85 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
86 INT204842 Positive_regulation of Cd44 9 0.49 6.6 0.77
87 INT2108 Localization of Mif 5 0.77 2.7 0.73
88 INT187096 Negative_regulation of Cd44 6 0.30 5.92 0.7
89 INT187087 Binding of Cd44 5 0.47 2.79 0.66
90 INT32209 Regulation of Gene_expression of Mif 3 0.59 3.41 0.66
91 INT130229 Regulation of Negative_regulation of Mif 1 0.39 1.36 0.66
92 INT353322 Negative_regulation of Positive_regulation of Mif 1 0.38 0.35 0.66
93 INT44148 Negative_regulation of Gene_expression of Mif 6 0.41 0.95 0.64
94 INT63356 Regulation of CD44 6 0.23 6.29 0.61
95 INT116060 Negative_regulation of Gene_expression of Cd74 1 0.12 0 0.61
96 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
97 INT288158 Negative_regulation of Gene_expression of Cd44 5 0.30 5.73 0.59
98 INT54000 Positive_regulation of SNAI1 7 0.49 5.37 0.58
99 INT271439 Positive_regulation of Localization of Cd74 1 0.36 1.01 0.52
100 INT337079 Negative_regulation of Gene_expression of Mif 1 0.41 4.17 0.51
101 INT271435 Localization of Cd74 1 0.54 0.95 0.49
102 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
103 INT106384 Negative_regulation of CD44 7 0.42 2.14 0.47
104 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
105 INT174418 Regulation of Gene_expression of Cd74 1 0.04 0.9 0.46
106 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
107 INT254172 Negative_regulation of Gene_expression of Cd74 1 0.24 1.03 0.44
108 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
109 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
110 INT205169 Localization of CD44 7 0.64 2.3 0.41
111 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
112 INT116735 Positive_regulation of Positive_regulation of Mif 1 0.70 0.61 0.38
113 INT62874 Gene_expression of CD74 1 0.00 0.64 0.37
114 INT123578 Negative_regulation of Gene_expression of Snai1 1 0.33 0.5 0.36
115 INT123579 Negative_regulation of Positive_regulation of Snai1 1 0.33 0.51 0.36
116 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
117 INT135495 Regulation of Positive_regulation of Snai1 1 0.23 0 0.33
118 INT253977 Positive_regulation of Binding of Mif 1 0.48 0.97 0.32
119 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
120 INT205172 Negative_regulation of Binding of CD44 1 0.36 1.97 0.31
121 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
122 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3
123 INT121374 Regulation of Gene_expression of MIF 2 0.39 1.01 0.29
124 INT103070 Negative_regulation of Gene_expression of Cd44 1 0.38 0.43 0.29
125 INT269225 Negative_regulation of Gene_expression of SNAI1 4 0.58 9.11 0.28
126 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
127 INT185824 Negative_regulation of Negative_regulation of CD44 1 0.28 0.42 0.24
128 INT203080 Negative_regulation of Cd44 1 0.14 0.3 0.24
129 INT121366 Regulation of Transcription of Mif 1 0.02 0.61 0.24
130 INT121367 Negative_regulation of Transcription of Mif 1 0.02 0.59 0.24
131 INT48656 Positive_regulation of Gene_expression of Cd44 7 0.69 5.93 0.21
132 INT337077 Positive_regulation of Localization of Mif 1 0.58 0.96 0.21
133 INT167250 Regulation of Gene_expression of MDM2 1 0.06 0.86 0.21
134 INT88744 Positive_regulation of Gene_expression of MDM2 9 0.43 7.82 0.2
135 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
136 INT58734 Regulation of SNAI1 3 0.60 1.26 0.2
137 INT172958 Positive_regulation of Mdm2 4 0.56 2.43 0.19
138 INT162483 Localization of Snai1 1 0.43 0 0.19
139 INT162484 Regulation of Localization of Snai1 1 0.33 0 0.19
140 INT246630 Positive_regulation of Positive_regulation of CD44 1 0.51 0.34 0.18
141 INT269228 Binding of SNAI1 1 0.47 2.28 0.18
142 INT214464 Regulation of Gene_expression of Cd44 3 0.34 2.95 0.17
143 INT181783 Transcription of SNAI1 3 0.71 2.44 0.17
144 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
145 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
146 INT58735 Negative_regulation of Regulation of SNAI1 1 0.33 0.24 0.17
147 INT126733 Regulation of MDM2 2 0.36 0.73 0.16
148 INT113346 Binding of MDM2 10 0.35 5.73 0.15
149 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
150 INT266010 Localization of Mdm2 2 0.75 2.64 0.15
151 INT204054 Negative_regulation of Negative_regulation of Mdm2 2 0.14 2.23 0.15
152 INT286764 Regulation of Localization of Mdm2 1 0.14 1.38 0.15
153 INT286748 Regulation of Mdm2 1 0.14 1.37 0.15
154 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
155 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
156 INT175517 Gene_expression of Mdm2 18 0.78 16.28 0.13
157 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
158 INT307932 Localization of Snai1 3 0.78 2.28 0.13
159 INT316436 Positive_regulation of Snai1 1 0.22 0.35 0.13
160 INT131015 Negative_regulation of Cd74 1 0.17 0.25 0.12
161 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
162 INT337076 Positive_regulation of Negative_regulation of Mif 1 0.48 1.44 0.12
163 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
164 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
165 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
166 INT288160 Regulation of Cd44 1 0.42 0.67 0.1
167 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
168 INT203611 Positive_regulation of Negative_regulation of CD44 1 0.24 0.31 0.09
169 INT269218 Localization of SNAI1 4 0.79 3.1 0.07
170 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
171 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
172 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
173 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
174 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
175 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
176 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
177 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
178 INT273406 Positive_regulation of Gene_expression of TWIST1 4 0.57 8.42 0.04
179 INT298445 Positive_regulation of Gene_expression of SNAI1 4 0.59 5.07 0.04
180 INT141476 Regulation of Gene_expression of TWIST1 2 0.50 2.57 0.04
181 INT324127 Positive_regulation of Cd74 2 0.07 1.34 0.04
182 INT200859 Transcription of Cd44 2 0.41 0.71 0.04
183 INT269219 Phosphorylation of SNAI1 1 0.62 0.38 0.04
184 INT287282 Regulation of Binding of MDM2 1 0.04 0.63 0.04
185 INT174340 Protein_catabolism of Mif 1 0.89 0.09 0.04
186 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
187 INT176240 Phosphorylation of Mdm2 2 0.22 1.28 0.03
188 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
189 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
190 INT204861 Localization of Cd44 1 0.46 0.06 0.03
191 INT176252 Positive_regulation of Phosphorylation of Mdm2 1 0.14 0.42 0.03
192 INT205162 Regulation of Binding of CD44 1 0.38 0.26 0.03
193 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
194 INT204349 Regulation of SIRT1 8 0.61 1.99 0
195 INT126734 Positive_regulation of MDM2 8 0.49 5.56 0
196 INT133317 Positive_regulation of Binding of CD44 6 0.55 6.28 0
197 INT256134 Localization of Sirt1 5 0.50 2.99 0
198 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0
199 INT204353 Transcription of SIRT1 3 0.68 0.67 0
200 INT266011 Positive_regulation of Gene_expression of Mdm2 3 0.47 4.61 0
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