GO:0043522

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Name leucine zipper domain binding
Categary Function
Go Slim No
Go Link GO:0043522
Unique Molecular Interactions 55
Total Molecular Interactions 75
Total Single Events 417
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leucine zipper domain binding. They are ordered first by their pain relevance and then by number of times they were reported for leucine zipper domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
2 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
3 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7
4 INT161189 CRX Regulation of Gene_expression of Rvm 1 0.00 2 1.39
5 INT161191 CRX Regulation of Gene_expression of Trib3 1 0.00 2 1.38
6 INT146879 CRX Regulation of NMS 2 0.02 1.86 1.17
7 INT100564 CRX Positive_regulation of Fos 1 0.04 0.89 1.06
8 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9
9 INT341370 CRX Positive_regulation of Gene_expression of Ceacam3 1 0.04 0.99 0.9
10 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
11 INT145646 Binding of Scn2a1 and Scn5a 1 0.36 0 0.76
12 INT190986 Per1 Positive_regulation of Scn2a1 1 0.17 0 0.74
13 INT190979 Per2 Positive_regulation of Scn2a1 1 0.20 0 0.74
14 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
15 INT82497 Binding of CRX and Nts 1 0.05 1.54 0.7
16 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
17 INT28845 su Negative_regulation of Positive_regulation of Scn2a1 1 0.27 1.27 0.61
18 INT190987 Abat Regulation of Scn2a1 1 0.03 0.07 0.59
19 INT190988 Vip Positive_regulation of Gene_expression of Scn2a1 1 0.16 0.1 0.57
20 INT146880 CRX Positive_regulation of Ngf 1 0.03 0.78 0.52
21 INT157709 CRX Positive_regulation of Mpo 1 0.08 1.11 0.5
22 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
23 INT248310 Crx Regulation of MATN3 1 0.07 0.65 0.45
24 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
25 INT158878 CRX Positive_regulation of Gene_expression of Fos 1 0.02 1.49 0.41
26 INT290821 CRX Positive_regulation of Cort 1 0.14 0.51 0.41
27 INT190977 Npy Regulation of Scn2a1 1 0.16 0 0.4
28 INT68066 Binding of MAOA and NRL 1 0.34 0 0.39
29 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
30 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
31 INT316676 Binding of CRX and SFTPD 1 0.05 0.65 0.33
32 INT190998 ADCYAP1 Positive_regulation of Scn2a1 1 0.07 0.45 0.27
33 INT328896 Scn2a1 Regulation of hb 1 0.02 0.27 0.23
34 INT190985 Vip Regulation of Scn2a1 1 0.09 0 0.18
35 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
36 INT330156 Scn2a1 Regulation of Transcription of Pcsk1n 1 0.13 0 0.13
37 INT190982 Avp Positive_regulation of Scn2a1 1 0.17 0.17 0.1
38 INT190976 Binding of Scn2a1 and Gal 1 0.06 0 0.05
39 INT163410 CRX Positive_regulation of Gene_expression of Crhr2 1 0.02 0.94 0.05
40 INT178430 Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
41 INT163411 CRX Negative_regulation of Gene_expression of Crhr2 1 0.02 0.94 0.05
42 INT178447 Negative_regulation of Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
43 INT235168 Binding of Crx and Atxn7 1 0.11 0.81 0.03
44 INT220634 Binding of Bace1 and Pawr 2 0.06 0.2 0
45 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0
46 INT87160 Prkcg Regulation of Pmf1 1 0.39 0 0
47 INT330155 Pcsk1n Regulation of Gene_expression of Scn2a1 1 0.15 0 0
48 INT306339 Binding of CRX and PAX6 1 0.53 0.27 0
49 INT190980 Binding of Avp and Scn2a1 1 0.12 0 0
50 INT283718 Binding of Id2 and Aatf 1 0.03 0.19 0
51 INT87158 Pmf1 Positive_regulation of Gene_expression of Oprd1 1 0.08 0 0
52 INT184468 Negative_regulation of CRX Negative_regulation of Vwf 1 0.02 0.1 0
53 INT189992 Binding of Ptger2 and Pawr 1 0.00 2.89 0
54 INT207462 CRX Negative_regulation of Gene_expression of BGLAP 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leucine zipper domain binding. They are ordered first by their pain relevance and then by number of times they were reported in leucine zipper domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94
2 INT28843 Positive_regulation of Scn2a1 31 0.68 5.35 10.7
3 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5
4 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13
5 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79
6 INT56159 Regulation of Scn2a1 17 0.51 3.23 4.27
7 INT190722 Positive_regulation of Gene_expression of Scn2a1 15 0.36 0.5 3.78
8 INT28844 Negative_regulation of Scn2a1 15 0.37 3.84 3.65
9 INT82846 Negative_regulation of CRX 9 0.37 5.93 3.64
10 INT162140 Negative_regulation of Gene_expression of CRX 1 0.06 1.26 2.49
11 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3
12 INT7521 Binding of NRL 4 0.40 0.21 2.22
13 INT34860 Negative_regulation of Gene_expression of Scn2a1 8 0.30 0.97 1.94
14 INT10671 Regulation of CRX 4 0.53 6.29 1.78
15 INT162139 Positive_regulation of Gene_expression of CRX 2 0.14 1.51 1.71
16 INT79001 Positive_regulation of Localization of Scn2a1 3 0.36 0.22 1.48
17 INT162141 Localization of CRX 3 0.11 4.24 1.16
18 INT162138 Negative_regulation of Localization of CRX 1 0.04 0.5 1.16
19 INT141116 Transcription of Scn2a1 9 0.45 1.1 1.1
20 INT207091 Positive_regulation of Pawr 2 0.36 1.95 1.1
21 INT248303 Gene_expression of Crx 1 0.61 2.06 1.04
22 INT190964 Regulation of Gene_expression of Scn2a1 7 0.29 1.29 1.02
23 INT163409 Negative_regulation of Positive_regulation of CRX 2 0.03 1.85 0.99
24 INT207103 Positive_regulation of Positive_regulation of Pawr 2 0.36 1.45 0.85
25 INT207108 Gene_expression of Pawr 5 0.40 1.61 0.77
26 INT7520 Negative_regulation of NRL 1 0.43 0.37 0.69
27 INT190961 Negative_regulation of Positive_regulation of Scn2a1 2 0.27 0.15 0.64
28 INT248307 Negative_regulation of Crx 1 0.33 1.13 0.64
29 INT154986 Binding of CRX 3 0.24 3.87 0.53
30 INT141114 Positive_regulation of Positive_regulation of Scn2a1 1 0.30 0 0.53
31 INT207074 Binding of Pawr 2 0.18 0.87 0.48
32 INT248306 Positive_regulation of Gene_expression of Crx 1 0.39 0.88 0.44
33 INT290820 Positive_regulation of Positive_regulation of CRX 1 0.14 1.09 0.39
34 INT141118 Negative_regulation of Transcription of Scn2a1 1 0.28 0 0.36
35 INT235142 Gene_expression of Crx 2 0.17 0.82 0.34
36 INT248305 Regulation of Crx 1 0.21 0.74 0.31
37 INT277757 Gene_expression of Pmf1 3 0.12 4.14 0.23
38 INT54722 Protein_catabolism of CRX 1 0.56 0.67 0.21
39 INT68069 Regulation of Binding of NRL 1 0.38 0 0.17
40 INT189988 Regulation of Pawr 3 0.13 3.26 0.05
41 INT178410 Negative_regulation of Pawr 1 0.12 0.29 0.05
42 INT190959 Positive_regulation of Negative_regulation of Scn2a1 1 0.31 0.1 0.04
43 INT235159 Positive_regulation of Crx 1 0.14 0.7 0.03
44 INT235133 Localization of Crx 1 0.21 0.71 0.03
45 INT283691 Binding of Aatf 2 0.03 0.19 0
46 INT283704 Phosphorylation of Aatf 1 0.05 0.19 0
47 INT256679 Gene_expression of Aatf 1 0.65 0.71 0
48 INT350502 Positive_regulation of Pmf1 1 0.02 1.26 0
49 INT286557 Regulation of Binding of Aatf 1 0.02 0 0
50 INT347888 Regulation of Binding of Scn2a1 1 0.03 0.05 0
51 INT87155 Positive_regulation of Pmf1 1 0.38 0 0
52 INT338075 Regulation of Localization of CRX 1 0.06 1 0
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