GO:0043539

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Name protein serine/threonine kinase activator activity
Categary Function
Go Slim No
Go Link GO:0043539
Unique Molecular Interactions 237
Total Molecular Interactions 305
Total Single Events 2831
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein serine/threonine kinase activator activity. They are ordered first by their pain relevance and then by number of times they were reported for protein serine/threonine kinase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
3 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
4 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
5 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
6 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
7 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
8 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
9 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
10 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
11 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
12 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
13 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
14 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
15 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
16 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
17 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
18 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
19 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
20 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
21 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
22 INT273235 Binding of Cdk5 and Cdk5r1 1 0.24 6.06 0.46
23 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
24 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
25 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
26 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
27 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
28 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
29 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
30 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
31 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
32 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
33 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
34 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
35 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
36 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
37 INT339645 Binding of Cdk5r1 and Ebi3 1 0.01 0.78 0.31
38 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
39 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
40 INT298996 Il18 Positive_regulation of Gene_expression of Cdk5r1 1 0.03 1.65 0.29
41 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
42 INT299011 Il18 Positive_regulation of Transcription of Cdk5r1 1 0.03 1.65 0.29
43 INT247949 Cdk5r1 Positive_regulation of Cdk5 1 0.26 1.12 0.28
44 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
45 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
46 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
47 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
48 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
49 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
50 INT273232 Negative_regulation of Binding of Cdk5 and Cdk5r1 1 0.28 3.16 0.23
51 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
52 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
53 INT34773 GH1 Regulation of IGF2 1 0.31 0.05 0.22
54 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
55 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
56 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
57 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
58 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
59 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
60 INT326831 Cdk5r2 Positive_regulation of Binding of Cdk5r1 1 0.01 0.95 0.21
61 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
62 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
63 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
64 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
65 INT221955 Binding of ELAVL1 and CDK5R1 1 0.01 0.93 0.19
66 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
67 INT221956 CDK5R1 Regulation of Positive_regulation of CDK5 1 0.21 0.62 0.19
68 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
69 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
70 INT164791 Cdk5r1 Positive_regulation of Cdk5 1 0.30 0.25 0.17
71 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
72 INT164790 Cdk5r1 Positive_regulation of Trib3 1 0.02 0.25 0.17
73 INT299001 Il18 Positive_regulation of Cdk5r1 1 0.03 0.36 0.17
74 INT92580 IGF2 Positive_regulation of Gene_expression of PTGER2 1 0.07 0.43 0.15
75 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
76 INT92583 IGF2 Positive_regulation of Transcription of PTGER2 1 0.07 0.43 0.15
77 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
78 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
79 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
80 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
81 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
82 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
83 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
84 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
85 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
86 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
87 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
88 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
89 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
90 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
91 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
92 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
93 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
94 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
95 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
96 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
97 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
98 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
99 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
100 INT51720 Negative_regulation of Ins1 Negative_regulation of Igf1 1 0.12 0.85 0.11
101 INT221958 CDK5R1 Positive_regulation of Positive_regulation of CDK5 1 0.36 0.38 0.1
102 INT277657 Igfbp1 Negative_regulation of Negative_regulation of Igf1 1 0.02 0.26 0.1
103 INT161741 Gh1 Positive_regulation of Gene_expression of Igf1 1 0.35 0.55 0.1
104 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1
105 INT25501 Gnrhr Positive_regulation of Igf1 1 0.12 0.09 0.1
106 INT161742 Gnrhr Positive_regulation of Gene_expression of Igf1 1 0.25 0.55 0.1
107 INT221959 Binding of CDK5 and CDK5R1 1 0.28 0.53 0.1
108 INT201748 Car2 Positive_regulation of Cdk5r1 1 0.00 0.67 0.09
109 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
110 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
111 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
112 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09
113 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09
114 INT340555 Igf1 Positive_regulation of Mapk1 1 0.24 0.65 0.09
115 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
116 INT276141 Binding of Gh and Igf1 2 0.34 0.66 0.08
117 INT49363 Gh Positive_regulation of Igf1 1 0.00 0.49 0.08
118 INT175984 Igf1 Regulation of Localization of Serpina1c 1 0.14 0.54 0.08
119 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
120 INT9497 Gh Positive_regulation of Gene_expression of Igf1 1 0.08 0.31 0.08
121 INT325058 Igf1 Positive_regulation of Ang 1 0.04 1.4 0.08
122 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
123 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
124 INT247948 Positive_regulation of Cdk5r1 Positive_regulation of Cdk5 1 0.26 0.16 0.07
125 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
126 INT315987 Rhd Positive_regulation of Gene_expression of Igf1 1 0.10 0.47 0.07
127 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
128 INT142346 Igf1 Positive_regulation of Mapk3 1 0.75 0.33 0.06
129 INT295130 Igf1 Regulation of Grxcr1 1 0.02 0.64 0.06
130 INT343481 Epo Positive_regulation of Igf1 1 0.15 0.31 0.06
131 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
132 INT295128 Igf1 Regulation of Transcription of Pou1f1 1 0.16 0.64 0.06
133 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06
134 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
135 INT142347 Negative_regulation of Igf1 Positive_regulation of Mapk3 1 0.46 0.33 0.06
136 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05
137 INT335023 Fgf21 Positive_regulation of Gene_expression of Igf1 1 0.49 0.65 0.05
138 INT112282 Ntf3 Regulation of Igf1 1 0.07 0.14 0.05
139 INT206619 Mtpn Positive_regulation of Igf1 1 0.04 0.17 0.05
140 INT112281 Cntf Regulation of Igf1 1 0.22 0.14 0.05
141 INT198358 GH1 Regulation of Igf1 1 0.00 0.09 0.05
142 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
143 INT315986 Igf1 Positive_regulation of Pik3c3 1 0.00 0.48 0.05
144 INT184083 Positive_regulation of Gh Positive_regulation of Igf1 1 0.09 0.7 0.04
145 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
146 INT184115 Igf1 Positive_regulation of Gene_expression of Socs2 1 0.16 0.62 0.04
147 INT221952 UTS2R Regulation of Protein_catabolism of CDK5R1 1 0.10 0.3 0.04
148 INT326830 Cdk5r1 Positive_regulation of Positive_regulation of Cdk5 1 0.09 0.16 0.04
149 INT206620 Gh1 Positive_regulation of Igf1 1 0.25 0.17 0.04
150 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04
151 INT221962 UTS2R Regulation of Gene_expression of CDK5R1 1 0.09 0.43 0.03
152 INT221963 ELAVL1 Regulation of Gene_expression of CDK5R1 1 0.01 0.58 0.03
153 INT295573 Igf1 Positive_regulation of Gene_expression of Mstn 1 0.19 0 0
154 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
155 INT315984 Rhd Positive_regulation of Localization of Igf1 1 0.07 0.25 0
156 INT226190 Binding of Igf1 and Positive_regulation of Pik3cb 1 0.17 1.04 0
157 INT295868 Igf1 Positive_regulation of VEGFA 1 0.16 0.19 0
158 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0
159 INT199365 Igf2 Positive_regulation of Phosphorylation of Macf1 1 0.13 1.84 0
160 INT218952 Dlst Negative_regulation of Igf1 1 0.03 0.1 0
161 INT295574 Binding of Igf1 and Mstn 1 0.16 0.08 0
162 INT199359 Igf2 Regulation of Macf1 1 0.11 3.11 0
163 INT284370 Igf1 Regulation of Gene_expression of VEGFA 1 0.37 0.05 0
164 INT199361 Regulation of Igf2 Regulation of Macf1 1 0.11 1.59 0
165 INT199367 DST Regulation of Igf2 1 0.03 1.03 0
166 INT295857 Igf1 Regulation of Localization of Srsf1 1 0.50 0 0
167 INT253007 Igf1 Regulation of Gene_expression of PTTG1 1 0.03 0.46 0
168 INT218954 Dlst Regulation of Gene_expression of Igf1 1 0.03 0 0
169 INT300901 Binding of IGF2 and IGF2BP1 1 0.04 0.71 0
170 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0
171 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0
172 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
173 INT178639 Binding of ESR1 and Igf1 1 0.02 0.39 0
174 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0
175 INT218951 Negative_regulation of Dlst Negative_regulation of Igf1 1 0.03 0.1 0
176 INT215206 Gh Positive_regulation of Transcription of Igf1 1 0.03 0 0
177 INT202431 Binding of IGF2 and INSRR 1 0.01 0.85 0
178 INT17529 Igf1 Regulation of Gh 1 0.01 0.07 0
179 INT215209 Binding of Igf1 and Igfbp3 1 0.11 0 0
180 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
181 INT17537 Igf1 Regulation of Prl 1 0.00 0 0
182 INT333845 Igf1 Positive_regulation of Gene_expression of Creb1 1 0.21 0.13 0
183 INT17527 Igf1 Regulation of Lhb 1 0.00 0 0
184 INT199360 Igf2 Regulation of Gene_expression of Lyve1 1 0.30 1.13 0
185 INT199363 Igf2 Regulation of Gopc 1 0.15 1.61 0
186 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0
187 INT199369 DST Regulation of Igf1 1 0.02 0.8 0
188 INT215205 Binding of Igf2 and Igfbp3 1 0.04 0 0
189 INT74032 Igf1 Positive_regulation of Jun 1 0.48 0.11 0
190 INT141959 Binding of IGFBP3 and Igf2 1 0.01 0.09 0
191 INT300899 IGF2BP3 Positive_regulation of IGF2 1 0.37 1.06 0
192 INT162437 Binding of Igf1 and Igfals 1 0.10 1.45 0
193 INT289926 Ctrc Negative_regulation of Protein_catabolism of Igf1 1 0.01 0 0
194 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
195 INT132069 Binding of Igf1 and Igfbp3 1 0.38 0.08 0
196 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
197 INT178637 Igf1 Positive_regulation of ESR1 1 0.03 0.17 0
198 INT141950 Binding of Igf2 and Mb 1 0.00 0.1 0
199 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0
200 INT178628 Igf1 Regulation of Gene_expression of Pgr 1 0.24 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein serine/threonine kinase activator activity. They are ordered first by their pain relevance and then by number of times they were reported in protein serine/threonine kinase activator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
3 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
4 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
5 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
6 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
7 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
8 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
9 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
10 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
11 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
12 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
13 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
14 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
15 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
16 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
17 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
18 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
19 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
20 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
21 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
22 INT151032 Localization of Igf1 49 0.76 26.32 5.71
23 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
24 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2
25 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
26 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
27 INT49360 Localization of Igf1 22 0.76 6.96 4.26
28 INT109219 Negative_regulation of Cdk5r1 5 0.43 1.22 4.25
29 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
30 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
31 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
32 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
33 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
34 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
35 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
36 INT201632 Positive_regulation of Cdk5r1 20 0.40 21.6 2.75
37 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
38 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
39 INT66544 Binding of Igf1 23 0.46 8.33 2.44
40 INT9327 Localization of Igf2 8 0.80 5.07 2.36
41 INT101603 Positive_regulation of Cdk5r1 4 0.56 1.12 2.35
42 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
43 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
44 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
45 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
46 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
47 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
48 INT101599 Gene_expression of Cdk5r1 5 0.63 1.27 1.68
49 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
50 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
51 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
52 INT101601 Regulation of Cdk5r1 3 0.50 1.2 1.46
53 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
54 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
55 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
56 INT90491 Binding of Igf1 25 0.44 9.75 1.36
57 INT114969 Gene_expression of CDK5R1 3 0.75 11.24 1.33
58 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
59 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21
60 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
61 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
62 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
63 INT138783 Positive_regulation of Gene_expression of Cdk5r1 2 0.38 0.68 1.15
64 INT203890 Positive_regulation of Gene_expression of Cdk5r1 9 0.40 9.13 1.11
65 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07
66 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
67 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
68 INT109221 Positive_regulation of Negative_regulation of Cdk5r1 1 0.37 0.15 0.95
69 INT34779 Regulation of IGF2 7 0.38 4.34 0.9
70 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
71 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
72 INT77663 Positive_regulation of CDK5R1 3 0.67 0.43 0.79
73 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
74 INT58245 Regulation of Localization of Igf2 1 0.62 1.27 0.78
75 INT273220 Positive_regulation of Positive_regulation of Cdk5r1 4 0.40 5.3 0.75
76 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
77 INT134472 Binding of Cdk5r1 4 0.26 4.25 0.65
78 INT77662 Regulation of CDK5R1 2 0.60 1.93 0.63
79 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
80 INT221978 Regulation of Gene_expression of CDK5R1 1 0.59 5.08 0.61
81 INT34778 Localization of IGF2 5 0.62 4.78 0.59
82 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
83 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
84 INT277644 Negative_regulation of Localization of Igf2 1 0.02 0.69 0.56
85 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
86 INT273230 Negative_regulation of Cdk5r1 1 0.25 4.48 0.53
87 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
88 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
89 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
90 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
91 INT70893 Positive_regulation of Gene_expression of IGF2 5 0.67 6.13 0.44
92 INT201636 Protein_catabolism of Cdk5r1 3 0.18 2.79 0.44
93 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
94 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
95 INT9328 Regulation of Gene_expression of Igf2 1 0.39 0.91 0.42
96 INT326821 Positive_regulation of Protein_catabolism of Cdk5r1 1 0.13 1.9 0.41
97 INT199340 Localization of Igf2 4 0.75 4.47 0.39
98 INT48617 Negative_regulation of IGF2 4 0.25 0.22 0.36
99 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
100 INT57131 Negative_regulation of Positive_regulation of Igf2 1 0.36 0.67 0.35
101 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
102 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
103 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
104 INT199358 Negative_regulation of Gene_expression of Igf2 3 0.43 4.48 0.3
105 INT247937 Localization of Cdk5r1 3 0.41 1.21 0.3
106 INT202435 Transcription of IGF2 3 0.58 2.44 0.29
107 INT9329 Transcription of Igf2 2 0.58 1.28 0.29
108 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
109 INT298974 Transcription of Cdk5r1 1 0.04 1.64 0.28
110 INT273216 Negative_regulation of Gene_expression of Cdk5r1 1 0.25 1.73 0.25
111 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
112 INT215027 Regulation of Localization of Igf2 1 0.07 1.71 0.24
113 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
114 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
115 INT326823 Positive_regulation of Localization of Cdk5r1 1 0.09 0.9 0.2
116 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
117 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
118 INT134469 Positive_regulation of Binding of Cdk5r1 1 0.35 0.4 0.18
119 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
120 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
121 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
122 INT23890 Binding of CDK5R1 2 0.36 0.23 0.16
123 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
124 INT199349 Regulation of Gene_expression of Igf2 4 0.50 4.56 0.15
125 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
126 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
127 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
128 INT221969 Negative_regulation of CDK5R1 1 0.41 0.44 0.13
129 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
130 INT118235 Positive_regulation of Igf2 9 0.70 10.05 0.12
131 INT76311 Binding of Igf2 2 0.44 1.91 0.12
132 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
133 INT101600 Regulation of Gene_expression of Cdk5r1 1 0.50 0.16 0.1
134 INT199357 Negative_regulation of Igf2 1 0.38 1.91 0.09
135 INT221976 Phosphorylation of CDK5R1 1 0.61 0.4 0.09
136 INT199337 Binding of Igf2 1 0.37 1.55 0.09
137 INT175512 Positive_regulation of Gene_expression of Igf2 16 0.70 22.75 0.08
138 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
139 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
140 INT221965 Positive_regulation of Gene_expression of CDK5R1 1 0.67 0.29 0.08
141 INT221977 Transcription of CDK5R1 1 0.51 0.59 0.08
142 INT185028 Binding of IGF2 4 0.46 1.72 0.07
143 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
144 INT51277 Negative_regulation of Gene_expression of IGF2 1 0.25 0.07 0.06
145 INT92591 Negative_regulation of Positive_regulation of IGF2 1 0.28 0.45 0.06
146 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
147 INT300903 Negative_regulation of Localization of IGF2 1 0.40 1.45 0.05
148 INT221975 Regulation of Transcription of CDK5R1 1 0.26 0.15 0.05
149 INT300907 Negative_regulation of Transcription of IGF2 1 0.29 1.44 0.05
150 INT171650 Protein_catabolism of CDK5R1 2 0.63 0.47 0.04
151 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
152 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
153 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
154 INT201634 Negative_regulation of Positive_regulation of Cdk5r1 1 0.02 0.31 0
155 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
156 INT199347 Transcription of Igf2 1 0.72 1.41 0
157 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
158 INT311645 Gene_expression of Spry2 1 0.70 1.81 0
159 INT260764 Negative_regulation of Spry2 1 0.28 0.1 0
160 INT353186 Positive_regulation of Gene_expression of Igf2 1 0.37 0.08 0
161 INT202433 Positive_regulation of Transcription of IGF2 1 0.42 0.55 0
162 INT199353 Positive_regulation of Positive_regulation of Igf2 1 0.50 1.35 0
163 INT311634 Positive_regulation of Spry2 1 0.45 0.4 0
164 INT311633 Localization of Spry2 1 0.68 0.26 0
165 INT311628 Negative_regulation of Gene_expression of Spry2 1 0.39 0.43 0
166 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
167 INT274108 Phosphorylation of Cdk5r1 1 0.01 0.84 0
168 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
169 INT311654 Regulation of Spry2 1 0.21 0.75 0
170 INT112083 Negative_regulation of Negative_regulation of Igf1 1 0.31 0.22 0
171 INT199355 Negative_regulation of Positive_regulation of Igf2 1 0.43 0.86 0
172 INT300911 Regulation of Gene_expression of IGF2 1 0.31 0.38 0
173 INT246771 Negative_regulation of Phosphorylation of Igf1 1 0.09 0.37 0
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