GO:0043548

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Name phosphatidylinositol 3-kinase binding
Categary Function
Go Slim No
Go Link GO:0043548
Unique Molecular Interactions 1027
Total Molecular Interactions 1509
Total Single Events 8904
Pain Genes Associated 36

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol 3-kinase binding. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol 3-kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
5 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
6 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
7 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
8 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
9 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
10 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
11 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
12 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
13 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
14 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
15 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
16 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
17 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
18 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
19 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
20 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
21 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
22 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
23 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
24 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
25 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
26 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
27 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
28 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
29 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
30 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
31 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
32 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
33 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
34 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
35 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
36 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
37 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
38 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
39 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
40 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
41 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
42 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26
43 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
44 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
45 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
46 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
47 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
48 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
49 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
50 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
51 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
52 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
53 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
54 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
55 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
56 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
57 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
58 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
59 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
60 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
61 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
62 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
63 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
64 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
65 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
66 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
67 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96
68 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
69 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
70 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
71 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
72 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
73 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
74 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
75 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
76 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
77 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
78 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
79 INT151961 Rbm39 Positive_regulation of Insrr 1 0.17 0.26 0.89
80 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
81 INT60719 Insrr Positive_regulation of Fos 1 0.03 1.23 0.84
82 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
83 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
84 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
85 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
86 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
87 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
88 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
89 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
90 INT70058 Binding of Pnoc and Insrr 1 0.01 0.09 0.77
91 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
92 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
93 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
94 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
95 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
96 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
97 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
98 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
99 INT111904 Binding of Gabrg1 and Insrr 1 0.02 0 0.74
100 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
101 INT33479 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Insrr 1 0.17 0.15 0.73
102 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
103 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
104 INT70011 Binding of Hrh1 and Insrr 1 0.00 0.4 0.72
105 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
106 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
107 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
108 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
109 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
110 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
111 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
112 INT144459 Binding of GPM6A and INSRR 1 0.00 0 0.67
113 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
114 INT81407 Binding of Oprl1 and Insrr 1 0.02 0.13 0.66
115 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
116 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
117 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
118 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
119 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
120 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
121 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
122 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
123 INT267888 St13 Positive_regulation of Insrr 1 0.00 0.07 0.64
124 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
125 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
126 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
127 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
128 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
129 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
130 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
131 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
132 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
133 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
134 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
135 INT113163 Insrr Positive_regulation of Pscs 1 0.04 0 0.6
136 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
137 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
138 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
139 INT249029 Binding of Csn2 and Insrr 1 0.00 0 0.59
140 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
141 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
142 INT267887 St13 Positive_regulation of Localization of Insrr 1 0.00 0 0.58
143 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
144 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
145 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
146 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
147 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
148 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
149 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
150 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
151 INT81792 AGRP Negative_regulation of INSRR 3 0.01 0 0.55
152 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
153 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
154 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
155 INT267890 Arl10 Regulation of Insrr 1 0.00 0.43 0.54
156 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
157 INT85265 Binding of Il1rn and Insrr 1 0.01 0 0.54
158 INT267889 St13 Regulation of Insrr 1 0.00 0.43 0.54
159 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
160 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
161 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
162 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
163 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
164 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
165 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
166 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
167 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
168 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
169 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
170 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
171 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
172 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
173 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
174 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
175 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
176 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
177 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
178 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
179 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
180 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
181 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
182 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
183 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
184 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
185 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
186 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
187 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
188 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
189 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
190 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
191 INT151455 Binding of Insrr and Gtf3a 1 0.00 0.21 0.46
192 INT151456 Binding of KITLG and Insrr 1 0.00 0.21 0.46
193 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
194 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
195 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
196 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
197 INT126339 Pax3 Regulation of Insrr 1 0.00 0.56 0.44
198 INT126338 Insrr Regulation of Gene_expression of Ifng 1 0.00 0.56 0.43
199 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
200 INT60718 Negative_regulation of Insrr Positive_regulation of Fos 1 0.01 0.6 0.42

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol 3-kinase binding. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol 3-kinase binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
3 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
4 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
5 INT4153 Binding of Insrr 109 0.40 17.99 72.15
6 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
7 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
8 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
9 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
10 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
11 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
12 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
13 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
14 INT8691 Localization of Insr 85 0.80 9.27 30.32
15 INT5300 Regulation of Insr 54 0.60 11.33 29.26
16 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
17 INT9781 Binding of INSRR 64 0.31 19.1 25.2
18 INT134651 Binding of TLR4 89 0.48 66.96 23.19
19 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
20 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
21 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
22 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
23 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
24 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52
25 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
26 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
27 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
28 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38
29 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
30 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
31 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
32 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
33 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
34 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
35 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85
36 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
37 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
38 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
39 INT12859 Localization of Insrr 16 0.32 2.68 8.07
40 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
41 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
42 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
43 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
44 INT62260 Negative_regulation of Gene_expression of Insrr 10 0.06 1.36 6.92
45 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
46 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
47 INT12632 Negative_regulation of Binding of INSRR 13 0.38 6.54 6.39
48 INT12631 Positive_regulation of Binding of INSRR 11 0.45 6.13 6.04
49 INT97797 Localization of TLR4 18 0.77 13.78 6
50 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
51 INT97018 Binding of CALM3 7 0.43 0.13 5.82
52 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
53 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
54 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
55 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
56 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
57 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
58 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
59 INT83056 Transcription of Insrr 11 0.11 2.43 5.11
60 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
61 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
62 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
63 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
64 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
65 INT12474 Regulation of INSRR 18 0.29 6.29 4.81
66 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
67 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
68 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
69 INT29326 Gene_expression of Calm1 17 0.67 3.71 4.53
70 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
71 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24
72 INT51084 Binding of Insr 13 0.30 4.25 4.23
73 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
74 INT83035 Binding of INSR 16 0.47 9.29 4.11
75 INT25841 Regulation of Binding of Insrr 6 0.50 0.4 4.03
76 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
77 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94
78 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
79 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
80 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
81 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
82 INT10116 Localization of INSR 11 0.57 5.43 3.48
83 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
84 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
85 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
86 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
87 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
88 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
89 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
90 INT51178 Transcription of INSRR 9 0.17 2.09 3.09
91 INT33241 Localization of INSRR 10 0.10 1.24 3.08
92 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
93 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
94 INT140378 Negative_regulation of Irs2 4 0.57 1.77 2.86
95 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
96 INT95037 Negative_regulation of Regulation of Insrr 1 0.02 0 2.77
97 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74
98 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
99 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
100 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
101 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
102 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
103 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
104 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
105 INT83058 Regulation of Positive_regulation of Insrr 2 0.11 0.66 2.31
106 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
107 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
108 INT122671 Positive_regulation of LCK 4 0.13 2.69 2.14
109 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
110 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
111 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
112 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
113 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
114 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
115 INT137906 Positive_regulation of Phosphorylation of Pdgfrb 6 0.50 2.55 1.94
116 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92
117 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
118 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
119 INT114059 Localization of Insr 10 0.46 3.49 1.87
120 INT51149 Positive_regulation of Gene_expression of INSRR 5 0.17 2.94 1.86
121 INT88518 Negative_regulation of Positive_regulation of INSRR 4 0.27 2.26 1.86
122 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
123 INT121869 Negative_regulation of Calm1 2 0.57 0 1.83
124 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
125 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
126 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
127 INT232645 Transcription of INSR 2 0.09 1.19 1.71
128 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
129 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
130 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
131 INT89652 Phosphorylation of INSRR 4 0.01 1.36 1.6
132 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
133 INT7333 Localization of CALM3 4 0.72 0.4 1.55
134 INT19342 Regulation of Insr 12 0.24 6.11 1.54
135 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
136 INT345367 Negative_regulation of Phosphorylation of Insrr 2 0.01 2.9 1.53
137 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
138 INT99694 Negative_regulation of Positive_regulation of Insrr 1 0.08 0.54 1.5
139 INT125855 Regulation of Negative_regulation of Insrr 1 0.01 0.26 1.45
140 INT122672 Regulation of Positive_regulation of LCK 1 0.06 1.15 1.44
141 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
142 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
143 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
144 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
145 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
146 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
147 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
148 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26
149 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
150 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
151 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
152 INT130477 Negative_regulation of Fyn 3 0.29 1.59 1.14
153 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
154 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
155 INT16172 Protein_catabolism of Insrr 5 0.18 1.39 1.11
156 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
157 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
158 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
159 INT97017 Regulation of Binding of CALM3 2 0.40 0 1.06
160 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
161 INT72590 Regulation of Binding of INSRR 1 0.15 1.79 1.02
162 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
163 INT79889 Positive_regulation of Gene_expression of Insrr 4 0.24 1.01 1.01
164 INT7338 Negative_regulation of CALM3 5 0.34 0.19 1
165 INT118738 Transcription of Tlr4 4 0.70 1.39 1
166 INT248588 Gene_expression of LCK 9 0.28 4.9 0.98
167 INT97014 Regulation of CALM3 1 0.55 0 0.97
168 INT97020 Negative_regulation of Regulation of CALM3 1 0.52 0 0.97
169 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
170 INT169336 Binding of Jak2 2 0.42 1.31 0.93
171 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
172 INT12858 Negative_regulation of Localization of Insrr 2 0.18 0.26 0.92
173 INT57370 Gene_expression of Coro1a 4 0.58 1.36 0.91
174 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
175 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
176 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
177 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
178 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
179 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
180 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
181 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
182 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
183 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
184 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
185 INT146940 Gene_expression of Fyn 2 0.52 2.76 0.83
186 INT161311 Positive_regulation of Negative_regulation of LCK 2 0.45 0.74 0.83
187 INT146942 Gene_expression of Lck 1 0.46 1.3 0.83
188 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81
189 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
190 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
191 INT100097 Negative_regulation of Transcription of Insrr 3 0.03 0.24 0.8
192 INT7335 Positive_regulation of CALM3 6 0.36 0.28 0.79
193 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
194 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
195 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
196 INT83375 Gene_expression of CALM3 3 0.58 1.57 0.78
197 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
198 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
199 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
200 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
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