GO:0043559

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Name insulin binding
Categary Function
Go Slim No
Go Link GO:0043559
Unique Molecular Interactions 229
Total Molecular Interactions 314
Total Single Events 3683
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin binding. They are ordered first by their pain relevance and then by number of times they were reported for insulin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
8 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
9 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
10 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
11 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
12 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
13 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
14 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
15 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
16 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
17 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
18 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
19 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
20 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
21 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
22 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
23 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
24 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
25 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
26 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
27 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
28 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
29 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
30 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
31 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
32 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
33 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
34 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 0.00 1.59 0.5
35 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
36 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
37 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
38 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
39 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
40 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
41 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
42 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
43 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
44 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
45 INT324830 Hspd1 Positive_regulation of IFNA1 1 0.04 0.46 0.3
46 INT246690 exf Regulation of Localization of Ide 1 0.00 0.17 0.3
47 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
48 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27
49 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27
50 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
51 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
52 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
53 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
54 INT324835 Hspd1 Positive_regulation of Gene_expression of IFNA1 1 0.15 0.31 0.23
55 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
56 INT246686 Ide Regulation of Ros1 1 0.03 0.41 0.22
57 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
58 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
59 INT314038 THL Negative_regulation of Pik3r1 1 0.14 0.78 0.18
60 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
61 INT236339 Binding of PCSK1 and GOPC 1 0.05 0.14 0.17
62 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
63 INT72116 Binding of PCSK1 and POMC 1 0.32 0 0.15
64 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
65 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
66 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
67 INT324804 Binding of Hspd1 and Tlr4 1 0.14 0.36 0.13
68 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
69 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
70 INT129094 Binding of GRP and Pik3r1 1 0.00 0.49 0.12
71 INT129075 Binding of Pik3r1 and Lyn 1 0.00 0.47 0.12
72 INT166153 Pik3r1 Regulation of Gene_expression of Ccr9 1 0.36 0.78 0.12
73 INT317888 Binding of Eef1a1 and Pik3r1 1 0.01 1.04 0.11
74 INT317887 Binding of Mtf1 and Pik3r1 1 0.25 1.04 0.11
75 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
76 INT349660 Binding of INSR and PYCARD 1 0.01 0 0.09
77 INT213051 Hdl1 Positive_regulation of Pik3r1 1 0.13 1.93 0.09
78 INT325059 Insr Positive_regulation of Ang 1 0.02 1.4 0.08
79 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08
80 INT312547 Akt1 Positive_regulation of Phosphorylation of Ide 1 0.01 0.6 0.08
81 INT207310 Pik3r1 Positive_regulation of Prnp 1 0.36 0.65 0.08
82 INT331796 Akt1 Negative_regulation of Negative_regulation of Pik3r1 1 0.04 0.88 0.08
83 INT340553 Pik3r1 Regulation of Gene_expression of Fbxo32 1 0.04 0.52 0.07
84 INT340320 Binding of Shc1 and Positive_regulation of Pik3r1 1 0.23 0 0.07
85 INT120569 Binding of Egfr and Pik3r1 1 0.40 1.22 0.06
86 INT120570 Positive_regulation of Binding of Egfr and Pik3r1 1 0.55 1.22 0.06
87 INT17920 Penk Positive_regulation of Insr 1 0.05 0.14 0.06
88 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
89 INT246691 Ide Positive_regulation of Gene_expression of Nos3 1 0.03 0.26 0.05
90 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
91 INT184123 Socs3 Positive_regulation of Protein_catabolism of Insr 1 0.03 0.41 0.05
92 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05
93 INT325060 Binding of Insr and Hand1 1 0.00 0.16 0.05
94 INT184085 Socs1 Positive_regulation of Protein_catabolism of Insr 1 0.04 0.41 0.05
95 INT213016 Regulation of Hdl1 Positive_regulation of Pik3r1 1 0.09 0.97 0.05
96 INT276951 Hspd1 Positive_regulation of Il10 1 0.05 0.75 0.04
97 INT199106 Negative_regulation of Pik3r1 Negative_regulation of Gene_expression of Ros1 1 0.03 0.08 0.04
98 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
99 INT276949 Hspd1 Positive_regulation of Gene_expression of Socs3 1 0.15 0.71 0.04
100 INT213031 Positive_regulation of Pik3r1 Positive_regulation of Gene_expression of Nos3 1 0.10 0.8 0.04
101 INT276977 Hspd1 Positive_regulation of Gene_expression of Il13 1 0.07 0.75 0.04
102 INT276956 Hspd1 Positive_regulation of Il13 1 0.07 0.75 0.04
103 INT191980 Ide Regulation of Sit1 1 0.17 0 0.04
104 INT342170 Insr Regulation of Localization of Cd320 1 0.08 0.92 0.04
105 INT276954 Hspd1 Positive_regulation of Stat3 1 0.31 0.65 0.04
106 INT276967 Hspd1 Regulation of Gene_expression of Socs3 1 0.14 0.71 0.04
107 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04
108 INT234991 Binding of Dsg3 and Positive_regulation of Pik3r1 1 0.05 0.32 0.03
109 INT253573 Binding of Jak2 and Pik3r1 1 0.06 0 0.03
110 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
111 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
112 INT276970 Hspd1 Positive_regulation of Gene_expression of Il10 1 0.10 0.69 0.03
113 INT306646 Mapk1 Regulation of Pik3r1 1 0.03 0.39 0
114 INT350792 Binding of Hspd1 and Lsr1 1 0.00 0.25 0
115 INT144761 Binding of INSR and Insr 1 0.05 0 0
116 INT317393 Binding of Car2 and Ide 1 0.03 0.3 0
117 INT289672 Binding of GNRH1 and INSR 1 0.02 0 0
118 INT235623 Binding of INS and INSR 1 0.14 0.47 0
119 INT287676 Negative_regulation of Sphk1 Negative_regulation of Pik3r1 1 0.14 0.42 0
120 INT176551 Binding of Pik3r1 and Spp1 1 0.03 0.65 0
121 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0
122 INT144754 Negative_regulation of Binding of Insr and Slc2a2 1 0.01 0 0
123 INT277315 Binding of Insr and Mbnl1 1 0.18 1.1 0
124 INT191982 Sit1 Regulation of Gene_expression of Ide 1 0.25 0.09 0
125 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
126 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0
127 INT315065 IGF1R Regulation of Gene_expression of PAR4 1 0.37 0.53 0
128 INT253565 Akt1 Positive_regulation of Positive_regulation of Pik3r1 1 0.10 0 0
129 INT315049 IGF1R Regulation of MT1X 1 0.29 0.52 0
130 INT205387 Binding of PCSK1 and DCLK1 1 0.05 1.42 0
131 INT211572 Binding of Kit and Pik3r1 1 0.21 0.06 0
132 INT320632 Ptger2 Regulation of Gene_expression of Hspd1 1 0.00 0.41 0
133 INT235624 INS Regulation of Phosphorylation of INSR 1 0.08 0.26 0
134 INT176553 Pik3r1 Positive_regulation of Positive_regulation of Mapk14 1 0.02 0.41 0
135 INT176542 Pik3r1 Positive_regulation of Positive_regulation of Mapk1 1 0.01 0.41 0
136 INT225536 Ncoa6 Positive_regulation of Localization of Ide 1 0.02 0.41 0
137 INT146131 Binding of Gnrh1 and Hspd1 1 0.02 0.88 0
138 INT271281 Gene_expression of Stat1 Positive_regulation of Insr 1 0.19 0.51 0
139 INT176536 Binding of Pik3r1 and Mtv7 1 0.02 0.46 0
140 INT271287 Gene_expression of IFNA1 Positive_regulation of Insr 1 0.03 0.51 0
141 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 0.02 0.43 0
142 INT144760 Binding of ABCA1 and Insr 1 0.00 0 0
143 INT319320 Binding of EGI and IGF1R 1 0.02 0.85 0
144 INT191981 Ide Positive_regulation of Positive_regulation of Sit1 1 0.28 0.06 0
145 INT326118 Binding of BMI1 and PCSK1 1 0.09 0 0
146 INT211574 Regulation of Binding of Kit and Pik3r1 1 0.16 0.06 0
147 INT306618 Myoz1 Regulation of Pik3r1 1 0.00 0.39 0
148 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
149 INT205392 Binding of ANPEP and PCSK1 1 0.06 1.4 0
150 INT191984 Ide Positive_regulation of Nppc 1 0.04 0.13 0
151 INT176550 Pik3r1 Positive_regulation of Gene_expression of Spp1 1 0.05 0.47 0
152 INT218307 Grb10 Positive_regulation of Protein_catabolism of INSR 1 0.03 0 0
153 INT144753 Binding of Insr and Slc2a2 1 0.01 0 0
154 INT114540 Binding of Pcsk1 and Penk 1 0.06 0 0
155 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0
156 INT307210 Ide Positive_regulation of Ppara 1 0.02 0.18 0
157 INT253567 Binding of Pik3r1 and Sp3 1 0.11 0.06 0
158 INT225582 Asc2 Positive_regulation of Localization of Ide 1 0.01 0.41 0
159 INT144762 Negative_regulation of Binding of INSR and Insr 1 0.06 0 0
160 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0
161 INT307584 Binding of EGFR and IGF1R 1 0.03 0.52 0
162 INT350796 Binding of CEBPB and Hspd1 1 0.00 0.25 0
163 INT211571 Pik3r1 Positive_regulation of Gene_expression of Kit 1 0.30 0.3 0
164 INT307212 Ide Regulation of Lep 1 0.00 0.51 0
165 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin binding. They are ordered first by their pain relevance and then by number of times they were reported in insulin binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
2 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
3 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
4 INT8691 Localization of Insr 85 0.80 9.27 30.32
5 INT5300 Regulation of Insr 54 0.60 11.33 29.26
6 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
7 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
8 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
9 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
10 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
11 INT56494 Localization of Ide 73 0.68 22.9 11.26
12 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
13 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
14 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
15 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
16 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
17 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
18 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
19 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
20 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92
21 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
22 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
23 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
24 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
25 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47
26 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
27 INT57642 Gene_expression of PCSK1 26 0.76 5.09 4.28
28 INT51084 Binding of Insr 13 0.30 4.25 4.23
29 INT83035 Binding of INSR 16 0.47 9.29 4.11
30 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82
31 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
32 INT10116 Localization of INSR 11 0.57 5.43 3.48
33 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45
34 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
35 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
36 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
37 INT191974 Regulation of Ide 16 0.38 9.54 2.52
38 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
39 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
40 INT121543 Positive_regulation of Gene_expression of PCSK1 4 0.29 1.63 2.21
41 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
42 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
43 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
44 INT53668 Regulation of Pcsk1 6 0.53 2.52 2.07
45 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
46 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
47 INT114059 Localization of Insr 10 0.46 3.49 1.87
48 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
49 INT58210 Gene_expression of Pcsk1 11 0.70 5.63 1.71
50 INT232645 Transcription of INSR 2 0.09 1.19 1.71
51 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
52 INT19342 Regulation of Insr 12 0.24 6.11 1.54
53 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42
54 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4
55 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
56 INT53775 Gene_expression of Hspd1 21 0.78 31.25 1.38
57 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
58 INT125762 Negative_regulation of Pcsk1 4 0.42 3.62 1.37
59 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
60 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23
61 INT53674 Transcription of Pcsk1 4 0.45 1.48 1.23
62 INT53672 Positive_regulation of Pcsk1 4 0.42 0.61 1.23
63 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
64 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
65 INT73176 Positive_regulation of Hspd1 5 0.35 3.96 1.22
66 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
67 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
68 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
69 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
70 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
71 INT88032 Negative_regulation of PCSK1 4 0.32 1.27 0.92
72 INT72944 Positive_regulation of PCSK1 3 0.49 0 0.89
73 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
74 INT165345 Localization of PCSK1 2 0.48 0.39 0.87
75 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
76 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
77 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
78 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
79 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
80 INT188347 Localization of Hspd1 2 0.41 4.53 0.71
81 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7
82 INT117392 Binding of Insr 8 0.23 4.88 0.68
83 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
84 INT191978 Positive_regulation of Gene_expression of Ide 16 0.63 6.8 0.65
85 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
86 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
87 INT18446 Transcription of Insr 2 0.18 0.84 0.62
88 INT116838 Regulation of Gene_expression of Hspd1 1 0.18 0.19 0.62
89 INT53774 Positive_regulation of Gene_expression of Hspd1 7 0.70 6.99 0.6
90 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
91 INT132388 Regulation of Regulation of Pcsk1 1 0.13 0.77 0.56
92 INT210522 Protein_catabolism of Ide 16 0.79 7.73 0.55
93 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
94 INT37938 Localization of Pcsk1 4 0.12 3.74 0.54
95 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
96 INT210539 Binding of Ide 11 0.29 6.09 0.52
97 INT53778 Regulation of Gene_expression of Hspd1 2 0.58 3.61 0.52
98 INT207614 Binding of Hspd1 4 0.18 1.16 0.5
99 INT191968 Negative_regulation of Gene_expression of Ide 9 0.39 7.14 0.47
100 INT90762 Regulation of Gene_expression of Pcsk1 2 0.22 0.58 0.44
101 INT100082 Negative_regulation of Hspd1 3 0.54 1.91 0.42
102 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
103 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
104 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
105 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
106 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
107 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
108 INT212985 Negative_regulation of Positive_regulation of Pik3r1 3 0.19 3.28 0.3
109 INT185119 Regulation of Positive_regulation of Pik3r1 3 0.13 0.45 0.3
110 INT324772 Positive_regulation of Gene_expression of Hspd1 1 0.49 0.41 0.29
111 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
112 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
113 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
114 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
115 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
116 INT210525 Transcription of Ide 3 0.40 1.93 0.21
117 INT191971 Regulation of Gene_expression of Ide 5 0.45 1.97 0.2
118 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
119 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
120 INT236698 Transcription of Pik3r1 1 0.15 1.3 0.18
121 INT207611 Regulation of Hspd1 1 0.20 0.19 0.17
122 INT210533 Negative_regulation of Binding of Ide 3 0.25 1.93 0.16
123 INT204171 Negative_regulation of Positive_regulation of Ide 2 0.06 1.73 0.16
124 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
125 INT309653 Negative_regulation of Localization of Pik3r1 1 0.14 0.55 0.15
126 INT164161 Regulation of PCSK1 3 0.30 2.09 0.14
127 INT242135 Regulation of Transcription of Ide 1 0.03 0.62 0.14
128 INT242147 Positive_regulation of Transcription of Ide 1 0.03 0.63 0.13
129 INT242133 Negative_regulation of Transcription of Ide 1 0.03 0.62 0.13
130 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
131 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
132 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
133 INT92634 Negative_regulation of Binding of Insr 1 0.25 0.08 0.12
134 INT53777 Negative_regulation of Positive_regulation of Hspd1 1 0.59 0.58 0.12
135 INT331058 Regulation of Phosphorylation of Ide 1 0.03 0.36 0.12
136 INT92589 Positive_regulation of IGF1R 4 0.38 0.98 0.11
137 INT308981 Positive_regulation of Negative_regulation of Insr 1 0.27 0.95 0.11
138 INT323945 Positive_regulation of Binding of Insr 1 0.08 0.94 0.11
139 INT129082 Positive_regulation of Pik3r1 1 0.00 0.47 0.11
140 INT204168 Positive_regulation of Negative_regulation of Ide 2 0.29 1.34 0.1
141 INT109025 Negative_regulation of Hspd1 2 0.55 1.48 0.1
142 INT312954 Regulation of Binding of IGF1R 1 0.13 0 0.1
143 INT288190 Regulation of Localization of Pik3r1 1 0.04 0.07 0.1
144 INT109020 Positive_regulation of Negative_regulation of Hspd1 1 0.39 0.76 0.1
145 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09
146 INT92587 Positive_regulation of Positive_regulation of IGF1R 1 0.38 0.38 0.08
147 INT349623 Negative_regulation of Binding of Igf1r 1 0.39 0.51 0.08
148 INT250508 Negative_regulation of Gene_expression of Igf1r 1 0.42 2.01 0.08
149 INT349620 Binding of Igf1r 1 0.34 0.51 0.08
150 INT210532 Positive_regulation of Protein_catabolism of Ide 2 0.40 0.86 0.07
151 INT234462 Phosphorylation of IGF1R 2 0.42 0.99 0.06
152 INT308619 Regulation of Phosphorylation of Pik3r1 1 0.09 1.06 0.06
153 INT221986 Localization of Hspd1 1 0.52 1.8 0.06
154 INT354322 Negative_regulation of Regulation of Ide 1 0.16 0.69 0.05
155 INT258395 Positive_regulation of Positive_regulation of Hspd1 5 0.25 2.79 0.04
156 INT315099 Localization of IGF1R 2 0.55 0.36 0.04
157 INT184013 Protein_catabolism of Insr 1 0.05 0.4 0.04
158 INT269823 Transcription of Hspd1 1 0.30 1.66 0.04
159 INT234471 Negative_regulation of Phosphorylation of IGF1R 1 0.04 0.76 0.03
160 INT117362 Positive_regulation of Positive_regulation of INSR 1 0.22 0.1 0.03
161 INT334692 Localization of Igf1r 1 0.09 0.89 0.03
162 INT235634 Phosphorylation of INSR 24 0.70 3.64 0
163 INT232490 Binding of PCSK1 5 0.27 0.07 0
164 INT222308 Regulation of IGF1R 3 0.12 2.18 0
165 INT339214 Negative_regulation of Gene_expression of IGF1R 2 0.22 0.4 0
166 INT282728 Regulation of Igf1r 2 0.18 0.92 0
167 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0
168 INT230477 Binding of Hspd1 2 0.34 1.09 0
169 INT229769 Regulation of Transcription of Pcsk1 1 0.09 0.85 0
170 INT321694 Positive_regulation of Phosphorylation of Igf1r 1 0.27 0.2 0
171 INT338259 Positive_regulation of Binding of IGF1R 1 0.27 1.38 0
172 INT239161 Positive_regulation of Negative_regulation of Pik3r1 1 0.30 0.77 0
173 INT144758 Negative_regulation of Negative_regulation of INSR 1 0.41 0 0
174 INT319333 Transcription of IGF1R 1 0.31 0.85 0
175 INT321704 Positive_regulation of Positive_regulation of Igf1r 1 0.18 0.17 0
176 INT320629 Regulation of Hspd1 1 0.58 0.68 0
177 INT235628 Negative_regulation of Phosphorylation of INSR 1 0.16 0.25 0
178 INT326119 Positive_regulation of Binding of PCSK1 1 0.37 0 0
179 INT276945 Negative_regulation of Positive_regulation of Hspd1 1 0.22 0.9 0
180 INT230481 Positive_regulation of Regulation of Insr 1 0.01 0.24 0
181 INT144756 Positive_regulation of Negative_regulation of INSR 1 0.49 0 0
182 INT144757 Negative_regulation of Gene_expression of INSR 1 0.41 0 0
183 INT210521 Positive_regulation of Binding of Ide 1 0.29 0.6 0
184 INT320630 Negative_regulation of Gene_expression of Hspd1 1 0.55 1.3 0
185 INT354324 Positive_regulation of Phosphorylation of Ide 1 0.19 0.77 0
186 INT191967 Positive_regulation of Positive_regulation of Ide 1 0.37 0.08 0
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