GO:0043560

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Name insulin receptor substrate binding
Categary Function
Go Slim No
Go Link GO:0043560
Unique Molecular Interactions 466
Total Molecular Interactions 621
Total Single Events 4239
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin receptor substrate binding. They are ordered first by their pain relevance and then by number of times they were reported for insulin receptor substrate binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
4 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
5 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
6 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
7 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
8 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
9 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
10 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
11 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
12 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
13 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
14 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
15 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
16 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
17 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
18 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
19 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
20 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
21 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
22 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
23 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
24 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
25 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
26 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
27 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
28 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
29 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
30 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
31 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
32 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26
33 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
34 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
35 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
36 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
37 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
38 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
39 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
40 INT121725 Binding of Trpv1 and Pik3cb 1 0.35 0.62 1.15
41 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14
42 INT121728 Ngf Positive_regulation of Phosphorylation of Pik3cb 1 0.45 0.69 1.11
43 INT121730 Pik3cb Regulation of Trpv1 1 0.58 0.54 1.09
44 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
45 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
46 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
47 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
48 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96
49 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
50 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
51 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
52 INT151961 Rbm39 Positive_regulation of Insrr 1 0.17 0.26 0.89
53 INT60719 Insrr Positive_regulation of Fos 1 0.03 1.23 0.84
54 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
55 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
56 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
57 INT70058 Binding of Pnoc and Insrr 1 0.01 0.09 0.77
58 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
59 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
60 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
61 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
62 INT111904 Binding of Gabrg1 and Insrr 1 0.02 0 0.74
63 INT33479 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Insrr 1 0.17 0.15 0.73
64 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
65 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
66 INT70011 Binding of Hrh1 and Insrr 1 0.00 0.4 0.72
67 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
68 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
69 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68
70 INT144459 Binding of GPM6A and INSRR 1 0.00 0 0.67
71 INT81407 Binding of Oprl1 and Insrr 1 0.02 0.13 0.66
72 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
73 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
74 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
75 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
76 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
77 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
78 INT267888 St13 Positive_regulation of Insrr 1 0.00 0.07 0.64
79 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
80 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
81 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
82 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
83 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
84 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
85 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
86 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
87 INT113163 Insrr Positive_regulation of Pscs 1 0.04 0 0.6
88 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
89 INT249029 Binding of Csn2 and Insrr 1 0.00 0 0.59
90 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
91 INT267887 St13 Positive_regulation of Localization of Insrr 1 0.00 0 0.58
92 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
93 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
94 INT81792 AGRP Negative_regulation of INSRR 3 0.01 0 0.55
95 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
96 INT267890 Arl10 Regulation of Insrr 1 0.00 0.43 0.54
97 INT85265 Binding of Il1rn and Insrr 1 0.01 0 0.54
98 INT267889 St13 Regulation of Insrr 1 0.00 0.43 0.54
99 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
100 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
101 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
102 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
103 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
104 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
105 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
106 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
107 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
108 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
109 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
110 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
111 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
112 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
113 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
114 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
115 INT151455 Binding of Insrr and Gtf3a 1 0.00 0.21 0.46
116 INT151456 Binding of KITLG and Insrr 1 0.00 0.21 0.46
117 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
118 INT126339 Pax3 Regulation of Insrr 1 0.00 0.56 0.44
119 INT126338 Insrr Regulation of Gene_expression of Ifng 1 0.00 0.56 0.43
120 INT60718 Negative_regulation of Insrr Positive_regulation of Fos 1 0.01 0.6 0.42
121 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
122 INT322394 Hist1h1t Positive_regulation of Pik3cb 1 0.01 0 0.42
123 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
124 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
125 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
126 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
127 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
128 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
129 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
130 INT283842 Binding of hb and Insrr 1 0.01 1.35 0.38
131 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
132 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
133 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
134 INT70010 Binding of Neurod1 and Insrr 1 0.01 0.11 0.37
135 INT70009 Binding of Gabpb1 and Insrr 1 0.00 0.11 0.37
136 INT67288 Binding of Insrr and Positive_regulation of Localization of Abat 1 0.00 0.18 0.37
137 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
138 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
139 INT214374 Pik3cb Regulation of Gene_expression of Slc6a3 1 0.37 0.3 0.35
140 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
141 INT189687 INSRR Negative_regulation of Transcription of TERT 1 0.00 0.24 0.35
142 INT122755 Helt Positive_regulation of Pik3cb 1 0.00 0.19 0.35
143 INT71518 Binding of INSRR and Nisch 1 0.00 0.22 0.35
144 INT136008 Binding of BDKRB2 and INSRR 1 0.01 0.17 0.34
145 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
146 INT136007 Binding of INSRR and KNG1 1 0.00 0.17 0.34
147 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
148 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
149 INT99676 Cck Positive_regulation of Insrr 1 0.11 0.07 0.33
150 INT283841 Dlg4 Negative_regulation of Insrr 1 0.01 0.95 0.33
151 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
152 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
153 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
154 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
155 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
156 INT84426 Binding of TSPO and INSRR 1 0.01 0.22 0.3
157 INT70184 INSRR Positive_regulation of FOS 1 0.03 0.09 0.29
158 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
159 INT334668 Gria2 Regulation of Gene_expression of Insrr 1 0.01 0.27 0.29
160 INT213802 Il4 Regulation of Gene_expression of Insrr 1 0.00 0.76 0.29
161 INT70186 PRCP Positive_regulation of INSRR 1 0.01 0.09 0.29
162 INT120236 Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28
163 INT274946 Binding of Pick1 and Insrr 1 0.00 0 0.28
164 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
165 INT120237 Positive_regulation of Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28
166 INT213808 Il12a Regulation of Gene_expression of Insrr 1 0.00 0.76 0.28
167 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
168 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
169 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
170 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
171 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
172 INT41406 Binding of Insr and Thtpa 1 0.05 0 0.25
173 INT189692 INSRR Positive_regulation of PRKCA 1 0.00 0 0.24
174 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
175 INT50619 Positive_regulation of Insrr Positive_regulation of Fos 1 0.07 0 0.23
176 INT192331 UBR7 Negative_regulation of INSRR 1 0.00 0.54 0.23
177 INT267885 Binding of Insrr and St13 1 0.00 0.09 0.23
178 INT89158 Grpr Positive_regulation of Localization of Insr 1 0.02 0 0.23
179 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
180 INT352945 Fig4 Regulation of Negative_regulation of Pik3cb 1 0.03 0.38 0.19
181 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
182 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
183 INT58579 Binding of INSRR and RPA1 1 0.00 0 0.18
184 INT314038 THL Negative_regulation of Pik3r1 1 0.14 0.78 0.18
185 INT263774 Neto1 Regulation of Insrr 1 0.00 0.28 0.18
186 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
187 INT127734 Binding of Insrr and Ogfr 1 0.01 0.35 0.17
188 INT94017 Binding of EDN3 and INSRR 1 0.03 0 0.16
189 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
190 INT224308 INSRR Regulation of VEGFA 1 0.00 1.42 0.16
191 INT94013 Positive_regulation of Binding of EDN2 and INSRR 1 0.04 0 0.16
192 INT94019 Positive_regulation of Binding of EDN3 and INSRR 1 0.04 0 0.16
193 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
194 INT58403 INSRR Negative_regulation of RTCA 1 0.00 0.06 0.15
195 INT189694 Negative_regulation of INSRR Negative_regulation of CHKB 1 0.00 0.07 0.15
196 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
197 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
198 INT189695 INSRR Negative_regulation of CHKB 1 0.00 0.07 0.15
199 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
200 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin receptor substrate binding. They are ordered first by their pain relevance and then by number of times they were reported in insulin receptor substrate binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
2 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
3 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
4 INT4153 Binding of Insrr 109 0.40 17.99 72.15
5 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
6 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
7 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
8 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
9 INT8691 Localization of Insr 85 0.80 9.27 30.32
10 INT5300 Regulation of Insr 54 0.60 11.33 29.26
11 INT9781 Binding of INSRR 64 0.31 19.1 25.2
12 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
13 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59
14 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
15 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52
16 INT94573 Negative_regulation of Pik3cb 42 0.50 15.83 15.4
17 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38
18 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
19 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
20 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
21 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
22 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85
23 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
24 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
25 INT12859 Localization of Insrr 16 0.32 2.68 8.07
26 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
27 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
28 INT62260 Negative_regulation of Gene_expression of Insrr 10 0.06 1.36 6.92
29 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
30 INT12632 Negative_regulation of Binding of INSRR 13 0.38 6.54 6.39
31 INT12631 Positive_regulation of Binding of INSRR 11 0.45 6.13 6.04
32 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
33 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
34 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
35 INT83056 Transcription of Insrr 11 0.11 2.43 5.11
36 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
37 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
38 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
39 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
40 INT12474 Regulation of INSRR 18 0.29 6.29 4.81
41 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
42 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
43 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
44 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
45 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24
46 INT51084 Binding of Insr 13 0.30 4.25 4.23
47 INT83035 Binding of INSR 16 0.47 9.29 4.11
48 INT25841 Regulation of Binding of Insrr 6 0.50 0.4 4.03
49 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
50 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94
51 INT116643 Phosphorylation of Pik3cb 12 0.80 4.73 3.87
52 INT10116 Localization of INSR 11 0.57 5.43 3.48
53 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
54 INT116645 Regulation of Pik3cb 11 0.41 3.78 3.43
55 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
56 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
57 INT51178 Transcription of INSRR 9 0.17 2.09 3.09
58 INT33241 Localization of INSRR 10 0.10 1.24 3.08
59 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
60 INT95037 Negative_regulation of Regulation of Insrr 1 0.02 0 2.77
61 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
62 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
63 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
64 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
65 INT83058 Regulation of Positive_regulation of Insrr 2 0.11 0.66 2.31
66 INT128745 Positive_regulation of Positive_regulation of Pik3cb 4 0.56 0.95 2.24
67 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
68 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
69 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
70 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
71 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
72 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
73 INT114059 Localization of Insr 10 0.46 3.49 1.87
74 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
75 INT51149 Positive_regulation of Gene_expression of INSRR 5 0.17 2.94 1.86
76 INT88518 Negative_regulation of Positive_regulation of INSRR 4 0.27 2.26 1.86
77 INT149335 Gene_expression of Pik3cb 10 0.57 2.93 1.82
78 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
79 INT232645 Transcription of INSR 2 0.09 1.19 1.71
80 INT89652 Phosphorylation of INSRR 4 0.01 1.36 1.6
81 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
82 INT19342 Regulation of Insr 12 0.24 6.11 1.54
83 INT345367 Negative_regulation of Phosphorylation of Insrr 2 0.01 2.9 1.53
84 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
85 INT99694 Negative_regulation of Positive_regulation of Insrr 1 0.08 0.54 1.5
86 INT125855 Regulation of Negative_regulation of Insrr 1 0.01 0.26 1.45
87 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
88 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
89 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
90 INT250707 Gene_expression of PIK3CB 15 0.31 5.4 1.34
91 INT121723 Regulation of Positive_regulation of Pik3cb 1 0.44 0.61 1.29
92 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
93 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
94 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
95 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
96 INT106339 Positive_regulation of Phosphorylation of Insr 1 0.49 0 1.12
97 INT16172 Protein_catabolism of Insrr 5 0.18 1.39 1.11
98 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
99 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
100 INT32354 Negative_regulation of Regulation of Insr 3 0.33 0.13 1.08
101 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
102 INT72590 Regulation of Binding of INSRR 1 0.15 1.79 1.02
103 INT79889 Positive_regulation of Gene_expression of Insrr 4 0.24 1.01 1.01
104 INT250708 Negative_regulation of PIK3CB 17 0.30 3.09 0.94
105 INT171382 Phosphorylation of Insr 6 0.51 3.41 0.94
106 INT169336 Binding of Jak2 2 0.42 1.31 0.93
107 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
108 INT12858 Negative_regulation of Localization of Insrr 2 0.18 0.26 0.92
109 INT41911 Regulation of Positive_regulation of Insr 2 0.21 0.32 0.88
110 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
111 INT171376 Positive_regulation of Phosphorylation of Insr 3 0.31 3.05 0.86
112 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
113 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
114 INT91908 Regulation of Negative_regulation of Insr 1 0.03 0.81 0.86
115 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
116 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
117 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
118 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
119 INT100097 Negative_regulation of Transcription of Insrr 3 0.03 0.24 0.8
120 INT194633 Negative_regulation of Gene_expression of Pik3cb 3 0.21 1.83 0.79
121 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
122 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
123 INT144759 Regulation of Gene_expression of INSR 2 0.44 3.09 0.77
124 INT42722 Negative_regulation of Ptpn11 1 0.21 0 0.71
125 INT83057 Regulation of Transcription of Insrr 1 0.04 0.09 0.71
126 INT117392 Binding of Insr 8 0.23 4.88 0.68
127 INT163543 Positive_regulation of Localization of INSRR 1 0.03 0 0.68
128 INT171366 Positive_regulation of Localization of Insr 3 0.18 0.63 0.66
129 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
130 INT120963 Negative_regulation of Negative_regulation of Pik3cb 2 0.17 1.4 0.64
131 INT18445 Regulation of Transcription of Insr 1 0.12 0.84 0.63
132 INT18446 Transcription of Insr 2 0.18 0.84 0.62
133 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
134 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
135 INT120961 Positive_regulation of Phosphorylation of Pik3cb 3 0.26 1.02 0.53
136 INT308979 Regulation of Localization of Insr 1 0.24 0.44 0.53
137 INT230238 Binding of Pik3cb 6 0.21 2.27 0.51
138 INT89654 Positive_regulation of Negative_regulation of INSRR 2 0.01 0.37 0.49
139 INT120390 Phosphorylation of PRKCD 1 0.33 0.38 0.49
140 INT184062 Binding of Jak2 5 0.37 3.13 0.47
141 INT110477 Positive_regulation of Localization of PRKCZ 1 0.20 0.07 0.45
142 INT205890 Transcription of Jak2 1 0.41 0.22 0.43
143 INT110479 Localization of PRKCZ 1 0.35 0.07 0.43
144 INT145854 Gene_expression of Jak2 4 0.67 3.08 0.41
145 INT120394 Positive_regulation of PRKCD 2 0.26 1.58 0.41
146 INT107462 Localization of Jak2 2 0.60 0.78 0.4
147 INT120968 Negative_regulation of Phosphorylation of Pik3cb 1 0.12 0.89 0.39
148 INT229697 Negative_regulation of Phosphorylation of Jak2 1 0.15 0.54 0.39
149 INT114062 Negative_regulation of Localization of Insr 1 0.19 0.31 0.39
150 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
151 INT114740 Binding of GRB2 8 0.36 2.24 0.37
152 INT110478 Regulation of PRKCZ 1 0.20 0.1 0.37
153 INT144755 Negative_regulation of INSR 5 0.41 2.09 0.36
154 INT194629 Positive_regulation of Gene_expression of Pik3cb 4 0.24 0.67 0.36
155 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35
156 INT200786 Positive_regulation of Gene_expression of Jak2 9 0.69 6.03 0.35
157 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
158 INT205910 Negative_regulation of Positive_regulation of Jak2 1 0.33 0.26 0.35
159 INT120391 Negative_regulation of Localization of PRKCD 1 0.22 0 0.34
160 INT120398 Positive_regulation of Positive_regulation of PRKCD 1 0.26 0 0.33
161 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32
162 INT267882 Positive_regulation of Phosphorylation of Insrr 2 0.01 0.71 0.32
163 INT99674 Regulation of Localization of Insrr 1 0.09 0.1 0.32
164 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
165 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31
166 INT83030 Positive_regulation of Binding of INSR 2 0.49 2.35 0.31
167 INT212985 Negative_regulation of Positive_regulation of Pik3r1 3 0.19 3.28 0.3
168 INT185119 Regulation of Positive_regulation of Pik3r1 3 0.13 0.45 0.3
169 INT132488 Positive_regulation of Localization of Insrr 1 0.07 0.35 0.3
170 INT278530 Regulation of Positive_regulation of Insr 1 0.01 1.96 0.28
171 INT192345 Positive_regulation of Phosphorylation of INSRR 1 0.01 0.68 0.27
172 INT240034 Phosphorylation of GRB2 3 0.79 1.79 0.25
173 INT250712 Regulation of PIK3CB 2 0.15 0.88 0.25
174 INT124735 Positive_regulation of Positive_regulation of Insr 1 0.08 0 0.25
175 INT214364 Positive_regulation of Negative_regulation of Pik3cb 1 0.42 0.19 0.25
176 INT115253 Negative_regulation of Phosphorylation of Insr 1 0.27 0.56 0.25
177 INT250992 Regulation of Gene_expression of INSRR 2 0.00 1.22 0.24
178 INT120969 Negative_regulation of Positive_regulation of Pik3cb 2 0.19 0.69 0.24
179 INT89399 Negative_regulation of Positive_regulation of PIK3CA 3 0.57 1 0.22
180 INT183683 Negative_regulation of Negative_regulation of Insrr 1 0.01 0.69 0.22
181 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
182 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
183 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
184 INT147732 Binding of PIK3CA 3 0.36 1.13 0.2
185 INT304145 Phosphorylation of Grb2 1 0.03 0.72 0.2
186 INT178118 Positive_regulation of PIK3CB 12 0.32 5.06 0.19
187 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
188 INT236698 Transcription of Pik3r1 1 0.15 1.3 0.18
189 INT289228 Localization of Ptpn11 1 0.15 0.87 0.18
190 INT328811 Negative_regulation of Localization of Jak2 1 0.34 0.13 0.17
191 INT200802 Regulation of Jak2 5 0.61 2.86 0.16
192 INT246833 Positive_regulation of Binding of PIK3CA 1 0.49 0.29 0.16
193 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
194 INT309653 Negative_regulation of Localization of Pik3r1 1 0.14 0.55 0.15
195 INT147731 Phosphorylation of PIK3CA 3 0.44 1.93 0.14
196 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
197 INT95659 Negative_regulation of Gene_expression of INSRR 1 0.02 0.51 0.13
198 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
199 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
200 INT184029 Binding of Ptpn11 2 0.19 0.18 0.12
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