GO:0043586

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Name tongue development
Categary Process
Go Slim No
Go Link GO:0043586
Unique Molecular Interactions 182
Total Molecular Interactions 255
Total Single Events 2457
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tongue development. They are ordered first by their pain relevance and then by number of times they were reported for tongue development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
2 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
3 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
4 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
5 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
6 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
7 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
8 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
9 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
10 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
11 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
12 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
13 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
14 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
15 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
16 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
17 INT163831 ERBB2 Positive_regulation of CCND1 1 0.03 0.82 0.38
18 INT342783 Prdm16 Positive_regulation of Gene_expression of Gal 1 0.02 0.72 0.37
19 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
20 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
21 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
22 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
23 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
24 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
25 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
26 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
27 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
28 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
29 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
30 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
31 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29
32 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
33 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
34 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
35 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
36 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
37 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
38 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
39 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
40 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
41 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
42 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
43 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
44 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
45 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
46 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
47 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
48 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19
49 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
50 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18
51 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
52 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
53 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17
54 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
55 INT115610 Binding of ERBB2 and KLF1 1 0.02 2.12 0.17
56 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
57 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
58 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
59 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
60 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
61 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13
62 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
63 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
64 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
65 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
66 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
67 INT279799 ATP6V0A2 Regulation of ERBB3 1 0.00 1.77 0.12
68 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
69 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
70 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
71 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
72 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
73 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
74 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
75 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09
76 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
77 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
78 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
79 INT309904 Binding of ERBB2 and TXK 1 0.01 0.23 0.08
80 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
81 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
82 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
83 INT201173 Sox2 Positive_regulation of Localization of Ryr2 1 0.40 0.9 0.07
84 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
85 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
86 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
87 INT293813 ERBB2 Positive_regulation of Positive_regulation of AR 1 0.09 0.45 0.07
88 INT201172 Sox2 Positive_regulation of Localization of Ca2 1 0.47 0.9 0.07
89 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
90 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
91 INT339099 ERBB2 Positive_regulation of IGF2R 1 0.33 0.67 0.06
92 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
93 INT339110 ERBB2 Positive_regulation of GATA6 1 0.31 0.67 0.06
94 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
95 INT213562 Ctnnd2 Regulation of Gene_expression of Sox2 1 0.35 0.07 0.05
96 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
97 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
98 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
99 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
100 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
101 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
102 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
103 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
104 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
105 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
106 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
107 INT341847 ERBB2 Positive_regulation of Gene_expression of ESYT1 1 0.02 1.42 0.03
108 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
109 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
110 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
111 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
112 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
113 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0
114 INT115609 Binding of ERBB2 and SFRP5 3 0.15 1.83 0
115 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0
116 INT294089 Negative_regulation of Binding of ERBB2 and ERBB4 1 0.08 0.6 0
117 INT115611 Binding of EDNRA and ERBB2 1 0.08 0.78 0
118 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
119 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
120 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
121 INT351602 TXK Positive_regulation of ERBB2 1 0.02 0.58 0
122 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
123 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
124 INT186603 Binding of ERBB2 and Ednra 1 0.02 0.53 0
125 INT339113 Binding of ASIP and ERBB2 1 0.00 0.64 0
126 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
127 INT339104 Binding of ERBB2 and GRB7 1 0.30 1.29 0
128 INT279802 ATP6V0A2 Negative_regulation of ERBB3 1 0.00 1.96 0
129 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
130 INT335215 RDH5 Positive_regulation of Negative_regulation of ERBB3 1 0.03 0.98 0
131 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
132 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
133 INT186589 Binding of ERBB2 and SCFV 1 0.13 0.65 0
134 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0
135 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 0.03 0.25 0
136 INT293807 Positive_regulation of Binding of ERBB2 and RORC 1 0.02 0.12 0
137 INT337405 MIR203 Regulation of LEF1 1 0.02 0.31 0
138 INT250667 KLF1 Regulation of ERBB2 1 0.00 1.16 0
139 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
140 INT293803 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of AR 1 0.10 0 0
141 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
142 INT337411 Negative_regulation of MIR203 Positive_regulation of Gene_expression of LEF1 1 0.04 0.25 0
143 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
144 INT294090 Negative_regulation of Binding of EGFR and ERBB2 1 0.14 0.6 0
145 INT250666 ERBB2 Positive_regulation of PIK3CB 1 0.15 0.69 0
146 INT293814 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of GOPC 1 0.02 0 0
147 INT161454 Mmp8 Positive_regulation of Egfr 1 0.36 0 0
148 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0
149 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0
150 INT287269 Binding of ERBB3 and PIK3CG 1 0.11 0.74 0
151 INT277860 MUC4 Negative_regulation of ERBB2 1 0.19 0.29 0
152 INT223583 TXK Negative_regulation of ERBB2 1 0.07 0.18 0
153 INT337417 MIR203 Negative_regulation of LEF1 1 0.04 0.57 0
154 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
155 INT277864 Binding of ERBB2 and Ralbp1 1 0.28 0.57 0
156 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
157 INT220822 Binding of Myc and LEF1 1 0.26 0.08 0
158 INT339115 Binding of ERBB2 and PVT1 1 0.43 1.11 0
159 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
160 INT220766 Binding of MAX and LEF1 1 0.40 0.08 0
161 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
162 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0
163 INT293799 Binding of ERBB2 and RORC 1 0.02 0.12 0
164 INT314691 ERBB2 Negative_regulation of TP53 1 0.28 1.23 0
165 INT294087 Negative_regulation of Binding of ERBB2 and ERBB3 1 0.08 0.6 0
166 INT339103 Binding of ERBB2 and TRPS1 1 0.39 0.3 0
167 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
168 INT339106 Binding of BCS1L and ERBB2 1 0.04 0.17 0
169 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
170 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
171 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
172 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
173 INT339114 Binding of ERBB2 and MYC 1 0.22 0.81 0
174 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
175 INT277863 Binding of ERBB2 and Abcc3 1 0.01 0.28 0
176 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0
177 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
178 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
179 INT339120 Binding of ERBB2 and MIEN1 1 0.31 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tongue development. They are ordered first by their pain relevance and then by number of times they were reported in tongue development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
3 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
4 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
5 INT173505 Localization of Hand2 63 0.57 45.32 13.66
6 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
7 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
8 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
9 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
10 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
11 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
12 INT156131 Binding of Hand2 14 0.25 10.35 3.99
13 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
14 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
15 INT64919 Gene_expression of Prdm16 6 0.75 11.63 3.5
16 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
17 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
18 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
19 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
20 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
21 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
22 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8
23 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
24 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
25 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68
26 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
27 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
28 INT52962 Binding of ERBB2 77 0.47 50.03 1.49
29 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48
30 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
31 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
32 INT140245 Binding of Gli3 3 0.36 2.65 1.46
33 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34
34 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
35 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
36 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
37 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
38 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
39 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
40 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
41 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91
42 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
43 INT144415 Regulation of Positive_regulation of Egfr 2 0.27 0.42 0.86
44 INT71649 Localization of ERBB2 23 0.78 13.63 0.83
45 INT144416 Regulation of Egfr 5 0.57 4.97 0.83
46 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
47 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81
48 INT144414 Positive_regulation of Positive_regulation of Egfr 1 0.49 0.65 0.8
49 INT159982 Negative_regulation of ERBB3 11 0.26 8.44 0.75
50 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74
51 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
52 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
53 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
54 INT185244 Gene_expression of Sox2 27 0.65 4.71 0.61
55 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
56 INT320644 Binding of Egfr 7 0.34 5.9 0.56
57 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
58 INT135062 Transcription of Gli3 1 0.05 0 0.52
59 INT206484 Localization of Shh 2 0.75 1.14 0.46
60 INT142943 Phosphorylation of Egfr 5 0.81 1.56 0.45
61 INT142942 Positive_regulation of Phosphorylation of Egfr 4 0.68 1.52 0.45
62 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
63 INT185255 Positive_regulation of Sox2 3 0.26 1.22 0.42
64 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
65 INT314126 Positive_regulation of Gene_expression of Prdm16 4 0.67 4.57 0.4
66 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
67 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
68 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
69 INT342781 Negative_regulation of Gene_expression of Prdm16 1 0.02 0.97 0.34
70 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
71 INT21789 Positive_regulation of ERBB3 7 0.47 4.26 0.29
72 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
73 INT201143 Regulation of Sox2 6 0.44 2.71 0.26
74 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
75 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
76 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
77 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
78 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
79 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
80 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
81 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
82 INT339167 Positive_regulation of Localization of ERBB2 2 0.49 1.49 0.17
83 INT181787 Transcription of ERBB2 13 0.71 10.03 0.16
84 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
85 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
86 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
87 INT144682 Negative_regulation of Regulation of Egfr 1 0.43 0.41 0.15
88 INT299514 Localization of Egfr 2 0.37 0.38 0.14
89 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
90 INT253190 Localization of Shh 2 0.77 1.06 0.13
91 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
92 INT233419 Negative_regulation of Positive_regulation of Egfr 2 0.40 0.97 0.12
93 INT201144 Regulation of Gene_expression of Sox2 3 0.44 0.82 0.11
94 INT314718 Negative_regulation of Localization of ERBB2 1 0.37 1.13 0.11
95 INT270451 Localization of Gli3 1 0.26 0.63 0.11
96 INT8098 Positive_regulation of Gene_expression of ERBB3 7 0.69 3.79 0.1
97 INT201140 Transcription of Sox2 4 0.67 1.31 0.1
98 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
99 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
100 INT219647 Negative_regulation of Negative_regulation of Egfr 1 0.19 0.13 0.1
101 INT220434 Negative_regulation of Gene_expression of ERBB3 1 0.03 0.4 0.1
102 INT184509 Regulation of Negative_regulation of ERBB3 1 0.01 0.47 0.1
103 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
104 INT270442 Transcription of Shh 1 0.53 0.25 0.09
105 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
106 INT213515 Binding of Shh 8 0.37 1.92 0.08
107 INT8099 Binding of ERBB3 7 0.36 3.09 0.08
108 INT270453 Regulation of Shh 1 0.27 0.83 0.08
109 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
110 INT256862 Regulation of Shh 1 0.25 0 0.07
111 INT185035 Regulation of ERBB3 3 0.42 6.5 0.06
112 INT314131 Positive_regulation of Prdm16 2 0.67 1.56 0.06
113 INT192961 Positive_regulation of Negative_regulation of ERBB2 2 0.64 3.53 0.06
114 INT299512 Regulation of Localization of Egfr 1 0.13 0.11 0.06
115 INT205021 Positive_regulation of Gene_expression of Egfr 3 0.64 4.15 0.05
116 INT213915 Negative_regulation of Positive_regulation of ERBB2 2 0.41 1.09 0.05
117 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
118 INT212270 Regulation of Localization of ERBB2 1 0.42 0.45 0.05
119 INT185260 Positive_regulation of Positive_regulation of Sox2 1 0.15 0 0.05
120 INT220802 Binding of LEF1 7 0.36 3.86 0.04
121 INT213537 Positive_regulation of Gene_expression of Sox2 3 0.48 1.34 0.04
122 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
123 INT289110 Localization of LEF1 2 0.32 1.19 0.04
124 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
125 INT213528 Negative_regulation of Gene_expression of Sox2 1 0.30 0.07 0.04
126 INT266927 Positive_regulation of Transcription of ERBB2 2 0.46 2.5 0.03
127 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
128 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
129 INT253181 Transcription of Shh 1 0.68 0.54 0.03
130 INT234210 Regulation of Negative_regulation of ERBB2 1 0.25 0.5 0.03
131 INT266932 Transcription of ERBB3 4 0.43 1.7 0
132 INT265512 Negative_regulation of Binding of ERBB2 4 0.40 1.43 0
133 INT201142 Negative_regulation of Sox2 4 0.57 0.59 0
134 INT279809 Localization of ERBB3 3 0.01 2.08 0
135 INT201141 Binding of Sox2 3 0.36 0.53 0
136 INT234204 Protein_catabolism of ERBB2 3 0.82 1.6 0
137 INT286987 Positive_regulation of Phosphorylation of ERBB2 2 0.23 0.91 0
138 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
139 INT279213 Positive_regulation of Binding of ERBB2 2 0.46 2.29 0
140 INT337456 Positive_regulation of Binding of LEF1 1 0.22 0 0
141 INT234916 Gene_expression of Lef1 1 0.04 0.25 0
142 INT277861 Positive_regulation of Positive_regulation of ERBB2 1 0.64 0.32 0
143 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0
144 INT286986 Phosphorylation of ERBB3 1 0.28 0.83 0
145 INT201146 Negative_regulation of Binding of Sox2 1 0.41 0.28 0
146 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
147 INT223291 Regulation of Transcription of ERBB2 1 0.25 0.21 0
148 INT337461 Positive_regulation of Transcription of LEF1 1 0.22 0.26 0
149 INT313602 Negative_regulation of Binding of ERBB3 1 0.18 0.58 0
150 INT341850 Positive_regulation of Protein_catabolism of ERBB2 1 0.42 0.97 0
151 INT201139 Localization of Sox2 1 0.73 0.15 0
152 INT293781 Regulation of Phosphorylation of ERBB2 1 0.24 0.13 0
153 INT289108 Negative_regulation of Transcription of LEF1 1 0.11 0.32 0
154 INT290929 Binding of Shh 1 0.31 0.1 0
155 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
156 INT220775 Binding of Lef1 1 0.20 0.06 0
157 INT213924 Regulation of Binding of ERBB2 1 0.43 0.46 0
158 INT289124 Negative_regulation of Positive_regulation of LEF1 1 0.11 0.34 0
159 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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