GO:0043588

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Name skin development
Categary Process
Go Slim No
Go Link GO:0043588
Unique Molecular Interactions 803
Total Molecular Interactions 1173
Total Single Events 6719
Pain Genes Associated 59

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for skin development. They are ordered first by their pain relevance and then by number of times they were reported for skin development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
3 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
4 INT138961 Dbi Positive_regulation of Chkb 1 0.00 3.05 3.99
5 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99
6 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
7 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
8 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
9 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
10 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
11 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2
12 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2
13 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
14 INT140013 Avp Positive_regulation of Gene_expression of Dbi 1 0.07 0.85 1.52
15 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
16 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
17 INT318491 IRF6 Positive_regulation of FPR2 1 0.10 6.14 1.44
18 INT140012 Avp Negative_regulation of Dbi 1 0.06 0.8 1.44
19 INT137958 Asprv1 Positive_regulation of Localization of Pdyn 1 0.21 0 1.43
20 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
21 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
22 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
23 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
24 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
25 INT271602 Binding of Pdgfa and Pdgfrl 1 0.02 0.86 1.25
26 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
27 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
28 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
29 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
30 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
31 INT145407 Oprd1 Regulation of Positive_regulation of Dbi 1 0.17 0 1.07
32 INT145408 H2-Ab1 Negative_regulation of Gene_expression of Dbi 1 0.05 0 1.06
33 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
34 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
35 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
36 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
37 INT88881 Negative_regulation of IRF6 Positive_regulation of Nfkb1 1 0.09 0.27 1.03
38 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
39 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
40 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
41 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
42 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
43 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
44 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
45 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
46 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
47 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
48 INT1654 Pomc Regulation of DSP 1 0.03 0 0.94
49 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
50 INT41093 Binding of Dbi and Nil 1 0.00 0 0.93
51 INT227325 Binding of IRF6 and Cd14 1 0.01 2.51 0.93
52 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
53 INT55204 Prl Positive_regulation of Localization of Dbi 1 0.02 0 0.91
54 INT271601 Pdgfa Positive_regulation of Pdgfrl 1 0.03 0.83 0.91
55 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
56 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9
57 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
58 INT343847 IRF6 Positive_regulation of TBCE 1 0.01 1.11 0.87
59 INT97795 IRF6 Positive_regulation of Localization of TNF 3 0.09 1.57 0.86
60 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85
61 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
62 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
63 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
64 INT286346 IRF6 Positive_regulation of IL8 3 0.03 0.88 0.8
65 INT140922 Btnl2 Negative_regulation of EDA 1 0.00 0.88 0.8
66 INT33059 Dsp Negative_regulation of Localization of LH 1 0.18 0 0.8
67 INT135781 Cyp3a23/3a1 Positive_regulation of Positive_regulation of Col1a1 1 0.01 0.78 0.8
68 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
69 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75
70 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
71 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
72 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
73 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
74 INT87646 Dbi Regulation of Olfr1507 1 0.00 0.69 0.72
75 INT289333 Binding of Ngfr and Rtn4r 1 0.03 2.35 0.72
76 INT289332 Binding of Ngfr and Lingo1 1 0.04 2.36 0.72
77 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
78 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
79 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7
80 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7
81 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
82 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69
83 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
84 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69
85 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
86 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69
87 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
88 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
89 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
90 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
91 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
92 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
93 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
94 INT27526 Binding of Sdcbp and Eda 1 0.13 0 0.65
95 INT318476 IRF6 Positive_regulation of Localization of RETNLB 1 0.00 1.42 0.65
96 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
97 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
98 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
99 INT115592 IRF6 Positive_regulation of Gene_expression of FAS 1 0.34 0.34 0.62
100 INT85489 IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
101 INT85488 Negative_regulation of IRF6 Negative_regulation of PLOD1 1 0.01 0.16 0.61
102 INT164990 Mif Positive_regulation of Gene_expression of Grina 1 0.24 0.53 0.6
103 INT318481 IRF6 Positive_regulation of Gene_expression of FPR2 1 0.14 5.09 0.59
104 INT318487 Negative_regulation of IRF6 Positive_regulation of FPR2 1 0.09 1.39 0.59
105 INT263454 Negative_regulation of IRF6 Positive_regulation of TNF 1 0.12 0.49 0.59
106 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
107 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
108 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
109 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
110 INT286349 IRF6 Positive_regulation of Localization of IL10 1 0.03 1.22 0.55
111 INT76002 Ngf Positive_regulation of Ngfr 1 0.05 0.48 0.53
112 INT49358 Binding of DHCR24 and Pdyn 1 0.00 0 0.53
113 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
114 INT318478 Negative_regulation of IRF6 Positive_regulation of LTB4R 1 0.01 2.38 0.53
115 INT192159 Mmp14 Regulation of Protein_catabolism of Col1a1 1 0.02 1.01 0.52
116 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
117 INT62898 Binding of Oprl1 and Dsp 1 0.35 0 0.52
118 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
119 INT32479 Gh1 Negative_regulation of Dbi 1 0.01 0 0.51
120 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51
121 INT97800 Gm5564 Regulation of IRF6 1 0.00 0.07 0.5
122 INT343825 IRF6 Regulation of Gene_expression of FUT1 1 0.00 1.74 0.5
123 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
124 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
125 INT169400 Negative_regulation of IRF6 Positive_regulation of Gene_expression of Il1b 1 0.50 0.62 0.5
126 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
127 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
128 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
129 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
130 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
131 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
132 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
133 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
134 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
135 INT289462 Negative_regulation of IRF6 Positive_regulation of IL1B 2 0.04 0.31 0.48
136 INT127663 IRF6 Positive_regulation of PDE4A 1 0.14 0.76 0.48
137 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
138 INT289463 IRF6 Positive_regulation of Localization of IL1B 1 0.05 0.52 0.48
139 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
140 INT34982 Trh Regulation of Dbi 1 0.12 0 0.47
141 INT217040 Negative_regulation of IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
142 INT34984 Negative_regulation of Trh Regulation of Dbi 1 0.19 0 0.47
143 INT217039 IRF6 Positive_regulation of CCL2 1 0.00 1.24 0.47
144 INT147444 PDGFA Positive_regulation of Gene_expression of Ros1 2 0.00 0.95 0.46
145 INT193480 Binding of ABCA1 and IRF6 1 0.00 1.08 0.46
146 INT253997 Binding of Cd200r1 and Mif 1 0.03 1.02 0.46
147 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
148 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
149 INT84517 IRF6 Positive_regulation of TF 1 0.14 0.19 0.44
150 INT314263 Binding of CPOX and PTGES3 1 0.01 1.7 0.44
151 INT188564 IRF6 Positive_regulation of Gene_expression of PRF1 1 0.01 0.44 0.44
152 INT120295 Ngf Positive_regulation of Positive_regulation of Ngfr 1 0.47 0.22 0.43
153 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
154 INT243682 IRF6 Positive_regulation of NEU2 1 0.01 0.18 0.43
155 INT343853 IRF6 Positive_regulation of PECAM1 1 0.00 0.53 0.43
156 INT188562 IRF6 Regulation of Gene_expression of PRF1 1 0.01 0.7 0.43
157 INT34983 Gene_expression of Dbi Positive_regulation of Localization of Trh 1 0.22 0 0.42
158 INT303857 DDR1 Positive_regulation of IL8 1 0.05 1.5 0.42
159 INT303858 DDR1 Positive_regulation of CXCR2 1 0.11 1.5 0.42
160 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
161 INT34981 Gene_expression of Dbi Positive_regulation of Localization of Prl 1 0.23 0 0.41
162 INT84518 IRF6 Positive_regulation of Gene_expression of TF 1 0.14 0.09 0.41
163 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
164 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
165 INT73537 Ntf3 Positive_regulation of Ngfr 1 0.21 0.1 0.38
166 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
167 INT318489 Positive_regulation of IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
168 INT318482 IRF6 Negative_regulation of Gene_expression of FPR2 1 0.09 1.18 0.38
169 INT149221 Binding of Ryr1 and Trpc3 5 0.40 0 0.37
170 INT73536 Ngf Regulation of Ngfr 1 0.22 0.08 0.37
171 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
172 INT144044 IRF6 Positive_regulation of PTGES 1 0.10 0.43 0.37
173 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
174 INT106511 Binding of Cpox and Ptges3 2 0.01 0.7 0.36
175 INT286351 IL8 Positive_regulation of Gene_expression of IRF6 1 0.03 0.71 0.36
176 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36
177 INT286350 IL6 Positive_regulation of Gene_expression of IRF6 1 0.04 0.71 0.36
178 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
179 INT250781 IRF6 Positive_regulation of AMIGO2 1 0.02 1.25 0.35
180 INT164371 Dbi Regulation of Pomc 1 0.19 0.17 0.35
181 INT318484 IRF6 Positive_regulation of Positive_regulation of LTB4R 1 0.01 1.38 0.35
182 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
183 INT144048 IRF6 Positive_regulation of Gene_expression of PTGES 1 0.12 0.46 0.35
184 INT318486 IRF6 Positive_regulation of Negative_regulation of FPR2 1 0.10 1.39 0.35
185 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
186 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
187 INT72953 Mif Positive_regulation of Localization of Prl 1 0.42 0 0.34
188 INT182126 IRF6 Positive_regulation of Gene_expression of SELE 1 0.03 0.86 0.34
189 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
190 INT188521 Binding of Hsp90aa1 and Ptges3 1 0.02 0.61 0.33
191 INT133021 IRF6 Positive_regulation of Gene_expression of IL8 1 0.11 0.51 0.32
192 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
193 INT72951 Mif Regulation of Prl 1 0.41 0 0.32
194 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
195 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
196 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
197 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32
198 INT76088 IFNA1 Positive_regulation of IRF6 1 0.19 0.18 0.31
199 INT76086 IRF6 Positive_regulation of ISYNA1 1 0.07 0.18 0.31
200 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31

Single Events

The table below shows the top 100 pain related interactions that have been reported for skin development. They are ordered first by their pain relevance and then by number of times they were reported in skin development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2
2 INT5989 Positive_regulation of Dbi 79 0.49 24.38 32.56
3 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
4 INT116737 Localization of Mif 63 0.81 52.97 28.11
5 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81
6 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51
7 INT5988 Localization of Dbi 74 0.81 17.52 24.09
8 INT78675 Gene_expression of Dbi 31 0.78 12.93 23.64
9 INT97798 Localization of IRF6 86 0.73 33.27 20.94
10 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
11 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
12 INT78670 Positive_regulation of Gene_expression of Dbi 26 0.70 6.72 19
13 INT96775 Gene_expression of Pdgfa 42 0.54 29.78 15.46
14 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
15 INT11762 Regulation of Dbi 40 0.62 7.83 14.48
16 INT22046 Negative_regulation of IRF6 52 0.43 25.69 14.13
17 INT99586 Binding of IRF6 60 0.36 27.87 13.2
18 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44
19 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
20 INT72949 Binding of Mif 31 0.46 23.12 11.65
21 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
22 INT5512 Negative_regulation of Dbi 32 0.36 7.33 9.1
23 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96
24 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
25 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
26 INT30638 Positive_regulation of Gene_expression of Dbi 17 0.69 4.63 8.28
27 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
28 INT78678 Positive_regulation of Dbi 12 0.70 2.13 7.71
29 INT18393 Negative_regulation of Ryr1 15 0.43 3.63 7.57
30 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
31 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
32 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9
33 INT4431 Negative_regulation of Eda 10 0.46 3.53 6.81
34 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
35 INT20343 Positive_regulation of Localization of Dbi 21 0.63 5.01 6.61
36 INT517 Regulation of Mif 16 0.62 5.43 6.55
37 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39
38 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
39 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
40 INT150417 Negative_regulation of Gene_expression of IRF6 20 0.41 11.48 6.28
41 INT516 Negative_regulation of Mif 13 0.59 6.69 6.08
42 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
43 INT19779 Binding of Dbi 41 0.36 8.8 5.87
44 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49
45 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48
46 INT96778 Positive_regulation of Pdgfa 22 0.46 12.7 5.31
47 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
48 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
49 INT174339 Positive_regulation of Localization of Mif 7 0.61 8.27 4.95
50 INT59555 Binding of RYR1 39 0.42 8.65 4.92
51 INT78671 Transcription of Dbi 7 0.72 0.77 4.83
52 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77
53 INT78672 Negative_regulation of Gene_expression of Dbi 6 0.43 0.67 4.75
54 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59
55 INT138779 Positive_regulation of Localization of IRF6 25 0.45 11.51 4.51
56 INT98357 Binding of Gnas 11 0.41 1.87 4.35
57 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33
58 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
59 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24
60 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
61 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94
62 INT96776 Positive_regulation of Gene_expression of Pdgfa 8 0.40 7.79 3.93
63 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
64 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89
65 INT63121 Binding of APC 29 0.41 23.02 3.8
66 INT116738 Positive_regulation of Gene_expression of Mif 14 0.68 10.99 3.8
67 INT97799 Regulation of IRF6 23 0.26 6.54 3.75
68 INT55907 Binding of Ngfr 13 0.47 5.79 3.75
69 INT27642 Regulation of Gene_expression of Dbi 10 0.44 2.55 3.66
70 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52
71 INT12385 Localization of NGFR 6 0.81 3.05 3.47
72 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43
73 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38
74 INT76098 Positive_regulation of Positive_regulation of IRF6 16 0.27 6.05 3.35
75 INT20344 Regulation of Localization of Dbi 8 0.49 1.97 3.31
76 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26
77 INT18394 Regulation of Ryr1 6 0.60 0.28 3.26
78 INT22375 Localization of PDGFA 21 0.75 15.46 3.25
79 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18
80 INT76838 Binding of Asprv1 7 0.36 1.42 3.13
81 INT67719 Positive_regulation of Col1a1 21 0.44 8.87 3.12
82 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11
83 INT94031 Regulation of Gene_expression of Dbi 4 0.24 3.36 3.08
84 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96
85 INT1653 Positive_regulation of DSP 8 0.49 3.3 2.93
86 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
87 INT14448 Localization of COL5A2 34 0.67 17.35 2.85
88 INT99129 Negative_regulation of LTB 5 0.57 0.7 2.84
89 INT271599 Phosphorylation of Pdgfa 1 0.11 2.55 2.81
90 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75
91 INT38872 Negative_regulation of Dsp 10 0.42 3.51 2.73
92 INT33057 Binding of Dsp 9 0.36 4.05 2.66
93 INT172963 Negative_regulation of Pdgfa 11 0.21 12.94 2.64
94 INT237700 Regulation of Negative_regulation of IRF6 2 0.11 1.08 2.58
95 INT237655 Binding of Sfn 1 0.42 3.62 2.55
96 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5
97 INT173592 Binding of COL5A2 32 0.33 9.14 2.48
98 INT8890 Transcription of Col1a1 10 0.63 4.02 2.48
99 INT78677 Regulation of Transcription of Dbi 1 0.62 0 2.48
100 INT223080 Binding of Pdgfa 8 0.18 7.21 2.44
101 INT75225 Transcription of Ngfr 4 0.60 1.95 2.44
102 INT106513 Gene_expression of Ptges3 7 0.73 3.57 2.42
103 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38
104 INT59287 Positive_regulation of Eda 5 0.40 1.25 2.36
105 INT91554 Positive_regulation of Transcription of Dbi 3 0.50 0.77 2.36
106 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32
107 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28
108 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26
109 INT74241 Positive_regulation of Gene_expression of EDA 3 0.49 4.93 2.24
110 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23
111 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18
112 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12
113 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
114 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04
115 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
116 INT145401 Positive_regulation of Positive_regulation of Dbi 1 0.44 0 2.03
117 INT43044 Gene_expression of Eda 3 0.75 0.69 2
118 INT91553 Regulation of Positive_regulation of Dbi 1 0.44 0 2
119 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
120 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
121 INT120857 Localization of Col1a1 10 0.71 2.33 1.93
122 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91
123 INT64712 Localization of Ngfr 4 0.78 1.19 1.91
124 INT59194 Gene_expression of STS 18 0.59 6.74 1.89
125 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85
126 INT113215 Negative_regulation of Asprv1 1 0.00 0 1.83
127 INT78676 Binding of Dbi 3 0.37 2.82 1.8
128 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78
129 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
130 INT8911 Regulation of DHCR24 1 0.05 1.91 1.71
131 INT3818 Regulation of Apc 13 0.39 12.52 1.68
132 INT32543 Negative_regulation of Gene_expression of Dbi 6 0.42 2.46 1.67
133 INT11713 Localization of RYR1 22 0.76 10.42 1.64
134 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
135 INT44149 Regulation of Gene_expression of Mif 6 0.54 2.45 1.63
136 INT26393 Localization of Eda 4 0.60 0.18 1.63
137 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
138 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59
139 INT353326 Negative_regulation of Localization of Mif 1 0.45 1.28 1.59
140 INT103767 Phosphorylation of DDR1 6 0.20 4.67 1.56
141 INT25771 Regulation of DSP 8 0.10 3.67 1.55
142 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
143 INT163594 Regulation of Ngfr 5 0.43 2.55 1.53
144 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52
145 INT42152 Gene_expression of Dsp 7 0.66 4.13 1.52
146 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
147 INT121347 Binding of GNAS 8 0.13 3.99 1.47
148 INT142719 Binding of Col1a1 7 0.34 5.83 1.47
149 INT188397 Regulation of Positive_regulation of IRF6 4 0.12 1.34 1.47
150 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
151 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
152 INT127679 Positive_regulation of Gene_expression of NGFR 7 0.67 4.98 1.43
153 INT49402 Positive_regulation of EDA 6 0.61 4.23 1.43
154 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
155 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39
156 INT220177 Binding of Apc 21 0.37 15.34 1.37
157 INT94825 Regulation of Dbi 3 0.45 1.73 1.37
158 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36
159 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36
160 INT120860 Positive_regulation of Gene_expression of Col1a1 12 0.44 4.84 1.34
161 INT95367 Negative_regulation of Positive_regulation of IRF6 7 0.21 3.5 1.34
162 INT55305 Regulation of RYR1 14 0.45 5.27 1.33
163 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
164 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
165 INT138939 Positive_regulation of Transcription of Ngfr 3 0.43 0.89 1.31
166 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
167 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3
168 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29
169 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28
170 INT139886 Gene_expression of PTGES3 11 0.72 1.5 1.27
171 INT56127 Positive_regulation of NGFR 8 0.49 5.3 1.27
172 INT253987 Regulation of Localization of Mif 3 0.43 1.65 1.27
173 INT124861 Positive_regulation of Col5a1 2 0.09 0.75 1.27
174 INT31804 Positive_regulation of Asprv1 5 0.40 1.92 1.26
175 INT29955 Regulation of Dsp 3 0.54 0.61 1.26
176 INT198840 Transcription of EDA 1 0.58 0.97 1.26
177 INT59473 Negative_regulation of Col1a1 4 0.25 1.33 1.24
178 INT4430 Regulation of Eda 2 0.23 0.38 1.24
179 INT71845 Positive_regulation of Positive_regulation of Col1a1 1 0.34 0.15 1.23
180 INT164372 Positive_regulation of Positive_regulation of Ngfr 6 0.62 4.1 1.22
181 INT12386 Binding of NGFR 6 0.48 2.15 1.22
182 INT99131 Regulation of LTB 1 0.26 0 1.22
183 INT9205 Binding of DSP 12 0.44 9.9 1.21
184 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
185 INT148321 Positive_regulation of Gene_expression of Pkd1 5 0.68 2.93 1.21
186 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2
187 INT110392 Transcription of Ngfr 3 0.52 2.48 1.19
188 INT103766 Positive_regulation of Phosphorylation of DDR1 2 0.13 1.94 1.19
189 INT59029 Positive_regulation of DHCR24 2 0.22 0.51 1.18
190 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
191 INT121368 Transcription of Mif 5 0.72 2.71 1.15
192 INT54044 Negative_regulation of EDA 7 0.42 2.54 1.14
193 INT32541 Positive_regulation of Positive_regulation of Dbi 2 0.39 0.5 1.14
194 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
195 INT142950 Protein_catabolism of ERCC2 2 0.25 1.45 1.14
196 INT123554 Transcription of Dbi 5 0.72 1.13 1.13
197 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12
198 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
199 INT13655 Binding of Eda 4 0.36 0.97 1.1
200 INT33475 Gene_expression of Ltb 4 0.58 2.45 1.09
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