GO:0043623

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Name cellular protein complex assembly
Categary Process
Go Slim No
Go Link GO:0043623
Unique Molecular Interactions 89
Total Molecular Interactions 154
Total Single Events 1260
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular protein complex assembly. They are ordered first by their pain relevance and then by number of times they were reported for cellular protein complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
2 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
3 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
4 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
5 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
6 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
7 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
8 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84
9 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
10 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
11 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
12 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
13 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
14 INT297313 Negative_regulation of Binding of Ccr1 and Ccl5 1 0.28 0.74 0.67
15 INT245299 Ccl5 Positive_regulation of Localization of IL8 1 0.11 2.87 0.66
16 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
17 INT804 Aap Negative_regulation of MBD2 1 0.01 0 0.57
18 INT254637 Bdkrb2 Regulation of Gene_expression of Ccl5 1 0.17 1.22 0.56
19 INT273350 Pde7a Positive_regulation of Localization of Pde4d 1 0.33 1.35 0.49
20 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
21 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
22 INT1066 Gm5720 Positive_regulation of MBD2 1 0.00 0.73 0.42
23 INT186758 Il13 Regulation of Ccl5 2 0.17 0.17 0.39
24 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39
25 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
26 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
27 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29
28 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
29 INT237088 Binding of Cxcl9 and Ccl5 1 0.29 1.51 0.26
30 INT246438 Ccl5 Positive_regulation of Gene_expression of Cd79a 1 0.13 0.83 0.26
31 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
32 INT252815 Binding of CCL5 and TNF 1 0.02 0.75 0.25
33 INT47600 Ccno Regulation of MBD2 1 0.00 0.22 0.24
34 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
35 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
36 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
37 INT295713 PTGER2 Positive_regulation of Regulation of CCL5 1 0.01 0.82 0.21
38 INT221785 Camk4 Positive_regulation of Atf1 1 0.12 0.14 0.19
39 INT170995 Binding of IFNA1 and Positive_regulation of Localization of CCL5 1 0.03 0.34 0.19
40 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
41 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
42 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18
43 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
44 INT246437 Ccl5 Positive_regulation of Regulation of Hand1 1 0.19 0.76 0.17
45 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
46 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17
47 INT87092 Binding of PPP4C and MBD2 1 0.05 0 0.16
48 INT246440 Ccl5 Positive_regulation of Positive_regulation of Xcl1 1 0.27 1.28 0.16
49 INT219597 Prkaca Positive_regulation of Pde4d 1 0.29 0 0.15
50 INT219599 Pde4d Regulation of Prkaca 1 0.28 0 0.12
51 INT171295 CXCL10 Positive_regulation of CCL5 1 0.04 0.06 0.12
52 INT286683 Gopc Positive_regulation of MBD2 1 0.01 1.07 0.11
53 INT219600 Pde4d Regulation of Binding of Prkaca 1 0.28 0 0.09
54 INT219602 Binding of Prkaca and Pde4d 1 0.23 0 0.09
55 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
56 INT186767 Ccl11 Regulation of Ccl5 1 0.01 0 0.07
57 INT171297 TNF Positive_regulation of Localization of CCL5 1 0.17 0.66 0.07
58 INT186766 Il5 Regulation of Ccl5 1 0.01 0 0.07
59 INT246441 Ccl5 Positive_regulation of Gene_expression of Aif1 1 0.03 0.71 0.06
60 INT246436 Ccl5 Regulation of Aif1 1 0.01 0.67 0.06
61 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
62 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04
63 INT247774 Binding of Ccl5 and Ccrl2 1 0.14 0.29 0.04
64 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04
65 INT171279 IL6 Positive_regulation of CCL5 1 0.04 0.38 0.04
66 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04
67 INT171301 TNF Positive_regulation of CCL5 1 0.16 0.38 0.04
68 INT247766 Binding of Ccl2 and Ccl5 1 0.14 0.28 0.04
69 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03
70 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03
71 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0
72 INT292553 Binding of TRAF2 and TRADD 1 0.09 0.1 0
73 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
74 INT219596 Binding of Pde4a and Pde4d 1 0.28 0.31 0
75 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
76 INT322413 Binding of ATF1 and EWSR1 1 0.26 1.3 0
77 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
78 INT127690 TNF Positive_regulation of Regulation of CCL5 1 0.33 0.17 0
79 INT327845 Binding of Aqp9 and Ooep 1 0.00 0 0
80 INT171282 TNFSF12 Positive_regulation of Gene_expression of CCL5 1 0.01 0 0
81 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
82 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
83 INT273941 Binding of Atf1 and Crem 1 0.15 0 0
84 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular protein complex assembly. They are ordered first by their pain relevance and then by number of times they were reported in cellular protein complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
2 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
3 INT78901 Localization of CCL5 67 0.78 40.79 20.59
4 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
5 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31
6 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83
7 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
8 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
9 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
10 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49
11 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
12 INT181348 Localization of Ccl5 24 0.65 19.55 6.8
13 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86
14 INT105775 Gene_expression of Pde4d 31 0.78 4.18 5.21
15 INT181363 Regulation of Ccl5 16 0.46 13.65 5.09
16 INT181362 Negative_regulation of Ccl5 21 0.40 15.63 4.96
17 INT82887 Positive_regulation of Ccl5 10 0.40 3.4 4.91
18 INT176614 Positive_regulation of Gene_expression of Ccl5 20 0.59 16.2 4.81
19 INT89590 Negative_regulation of Gene_expression of Ccl5 8 0.36 3.97 4.67
20 INT181042 Binding of Ccl5 18 0.41 9.34 4.51
21 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26
22 INT103281 Transcription of CCL5 10 0.67 5.95 3.7
23 INT89592 Localization of Ccl5 10 0.61 7.65 3.62
24 INT181378 Negative_regulation of Gene_expression of Ccl5 12 0.46 9.64 3.59
25 INT124123 Positive_regulation of Localization of CCL5 12 0.67 7 3.37
26 INT181418 Regulation of Gene_expression of Ccl5 11 0.52 9.86 3.37
27 INT82879 Regulation of Ccl5 9 0.30 6.19 3.17
28 INT78898 Regulation of Gene_expression of CCL5 9 0.42 5.7 3.11
29 INT115617 Binding of Ccl5 5 0.33 0.58 3.11
30 INT194661 Binding of CCL5 9 0.46 6.07 2.73
31 INT79399 Gene_expression of Pde4d 6 0.70 2.83 2.51
32 INT107489 Negative_regulation of Pde4d 3 0.42 0 2.47
33 INT107490 Positive_regulation of Pde4d 3 0.69 0.07 2.13
34 INT38374 Regulation of MBD2 8 0.10 0.72 2.09
35 INT115616 Positive_regulation of Binding of Ccl5 3 0.25 0.59 2.04
36 INT105776 Negative_regulation of Gene_expression of Pde4d 5 0.59 2.2 2.01
37 INT103061 Positive_regulation of Gene_expression of Ccl5 4 0.35 1.67 1.9
38 INT194660 Positive_regulation of Binding of CCL5 1 0.42 2.74 1.72
39 INT78896 Negative_regulation of Localization of CCL5 8 0.57 2.43 1.59
40 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51
41 INT115895 Phosphorylation of Ccl5 1 0.55 0 1.31
42 INT135924 Positive_regulation of Gene_expression of Pde4d 2 0.59 0 1.28
43 INT190067 Binding of Traf2 5 0.20 3.28 1.27
44 INT149924 Negative_regulation of Gene_expression of Pde4d 1 0.26 0.81 1.24
45 INT149554 Transcription of Ccl5 2 0.59 0.55 1.14
46 INT115893 Negative_regulation of Binding of Ccl5 1 0.37 0 1.14
47 INT219589 Binding of Pde4d 13 0.47 0.51 1.01
48 INT208244 Regulation of Gene_expression of Ccl5 1 0.26 1.92 1.01
49 INT219568 Positive_regulation of Pde4d 9 0.49 1.74 1
50 INT22946 Gene_expression of MBD2 4 0.25 0.26 0.98
51 INT181351 Transcription of Ccl5 5 0.64 2.19 0.9
52 INT103285 Regulation of Localization of CCL5 3 0.44 1.11 0.89
53 INT149555 Negative_regulation of Positive_regulation of Ccl5 1 0.15 0 0.88
54 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
55 INT219578 Negative_regulation of Pde4d 3 0.46 2.95 0.8
56 INT135923 Regulation of Gene_expression of Pde4d 2 0.44 0 0.8
57 INT118753 Regulation of Negative_regulation of Pde4d 1 0.02 0 0.8
58 INT181390 Negative_regulation of Positive_regulation of Ccl5 2 0.31 2.31 0.77
59 INT115897 Positive_regulation of Phosphorylation of Ccl5 1 0.41 0 0.66
60 INT104442 Transcription of ATF1 5 0.06 4.96 0.65
61 INT219580 Localization of Pde4d 5 0.73 2.07 0.64
62 INT181349 Positive_regulation of Localization of Ccl5 2 0.37 0.89 0.62
63 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
64 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
65 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
66 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
67 INT79397 Positive_regulation of Gene_expression of Pde4d 1 0.45 0.2 0.55
68 INT194225 Positive_regulation of Positive_regulation of Ccl5 1 0.07 1.13 0.55
69 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
70 INT219573 Positive_regulation of Localization of Pde4d 2 0.49 1.39 0.5
71 INT8053 Regulation of Negative_regulation of MBD2 1 0.16 0 0.5
72 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
73 INT194658 Positive_regulation of Transcription of CCL5 1 0.45 0.68 0.44
74 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43
75 INT219565 Regulation of Pde4d 3 0.44 0.5 0.39
76 INT268760 Positive_regulation of Binding of Ccl5 1 0.13 0.91 0.39
77 INT322698 Protein_catabolism of Ccl5 1 0.49 0.33 0.38
78 INT273330 Positive_regulation of Negative_regulation of Pde4d 1 0.39 1.25 0.35
79 INT195733 Phosphorylation of CCL5 2 0.10 1.04 0.33
80 INT264831 Regulation of Atf1 2 0.09 0.9 0.28
81 INT103283 Negative_regulation of Transcription of CCL5 1 0.50 0.28 0.27
82 INT322710 Positive_regulation of Transcription of Ccl5 1 0.43 0.56 0.26
83 INT273341 Transcription of Pde4d 2 0.54 0.68 0.24
84 INT273336 Regulation of Negative_regulation of Pde4d 1 0.35 0.68 0.24
85 INT282377 Regulation of Positive_regulation of CCL5 1 0.05 1.12 0.22
86 INT41148 Binding of MBD2 1 0.18 0 0.17
87 INT210123 Localization of Axin1 1 0.04 0.84 0.17
88 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
89 INT252702 Binding of TRAF2 3 0.23 2.21 0.16
90 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
91 INT89593 Negative_regulation of Localization of Ccl5 1 0.03 0.46 0.15
92 INT272026 Binding of Ooep 1 0.21 1.08 0.15
93 INT233838 Regulation of Binding of Ccl5 1 0.21 1 0.15
94 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
95 INT195730 Negative_regulation of Binding of CCL5 1 0.05 0.51 0.13
96 INT219593 Regulation of Binding of Pde4d 1 0.44 0 0.13
97 INT251559 Binding of Traf2 1 0.23 1.68 0.13
98 INT46899 Negative_regulation of Positive_regulation of MBD2 1 0.00 0 0.1
99 INT219574 Phosphorylation of Pde4d 1 0.79 0.33 0.1
100 INT246434 Negative_regulation of Negative_regulation of Ccl5 1 0.40 1.72 0.09
101 INT27567 Positive_regulation of Gene_expression of MBD2 1 0.01 0 0.09
102 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
103 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
104 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
105 INT47659 Localization of MBD2 2 0.70 0.72 0.08
106 INT120535 Positive_regulation of Negative_regulation of MBD2 1 0.01 0.22 0.07
107 INT219585 Positive_regulation of Positive_regulation of Pde4d 1 0.43 0 0.06
108 INT322421 Gene_expression of ATF1 2 0.39 1.41 0.05
109 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
110 INT269000 Gene_expression of Atf1 2 0.57 0.24 0
111 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
112 INT248265 Regulation of Pde4d 1 0.21 0.87 0
113 INT194799 Positive_regulation of ATF1 1 0.24 0.17 0
114 INT273928 Regulation of Gene_expression of Atf1 1 0.07 0.07 0
115 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
116 INT222849 Gene_expression of Traf2 1 0.12 0.38 0
117 INT219570 Negative_regulation of Positive_regulation of Pde4d 1 0.42 0 0
118 INT219575 Positive_regulation of Binding of Pde4d 1 0.49 0 0
119 INT252712 Phosphorylation of TRAF2 1 0.28 1.38 0
120 INT327835 Gene_expression of Ooep 1 0.01 0.12 0
121 INT348474 Regulation of Gene_expression of TRAF2 1 0.23 0.41 0
122 INT189478 Regulation of Transcription of Ccl5 1 0.38 0.63 0
123 INT269008 Transcription of Atf1 1 0.58 0.08 0
124 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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