GO:0043627

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Name response to estrogen stimulus
Categary Process
Go Slim No
Go Link GO:0043627
Unique Molecular Interactions 2396
Total Molecular Interactions 3287
Total Single Events 31198
Pain Genes Associated 112

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to estrogen stimulus. They are ordered first by their pain relevance and then by number of times they were reported for response to estrogen stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
2 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
3 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
4 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
5 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
6 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
7 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
8 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
9 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
10 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
11 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
12 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
13 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
14 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
15 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
16 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
17 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
18 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
19 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
20 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
21 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
22 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
23 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
24 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
25 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
26 INT30954 Crh Negative_regulation of LH 5 0.46 1.4 2.06
27 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
28 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
29 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
30 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
31 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
32 INT29715 Crh Negative_regulation of Localization of LH 5 0.43 0 1.78
33 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
34 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
35 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
36 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
37 INT341372 CRX Positive_regulation of Gene_expression of Crh 1 0.04 1.81 1.7
38 INT353717 Binding of Ghrl and Vta1 1 0.15 0 1.68
39 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
40 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
41 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
42 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
43 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59
44 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
45 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
46 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
47 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
48 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
49 INT209087 Crh Positive_regulation of Ceacam3 1 0.24 1.45 1.54
50 INT64628 Binding of Oxt and Gal 2 0.29 0.29 1.49
51 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
52 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
53 INT14375 Gal Positive_regulation of Localization of Prl 1 0.77 0 1.48
54 INT59547 Avp Positive_regulation of Crh 2 0.14 1.13 1.47
55 INT165450 Gal Regulation of Ceacam3 1 0.41 0.06 1.47
56 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
57 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
58 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
59 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
60 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
61 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
62 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4
63 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38
64 INT56093 FGFR1 Regulation of Gene_expression of SERPINE1 1 0.23 1.71 1.37
65 INT15277 Binding of Tac1 and Gal 1 0.39 0.19 1.35
66 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
67 INT158079 Binding of Esr1 and Gper 1 0.31 0.97 1.35
68 INT222182 Binding of ESR1 and HLA-DRB2 1 0.00 3.1 1.35
69 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
70 INT56087 TNF Regulation of Gene_expression of SERPINE1 1 0.43 1.67 1.33
71 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
72 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
73 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
74 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
75 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
76 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
77 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
78 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
79 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
80 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
81 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
82 INT62368 Gal Positive_regulation of Localization of LH 3 0.36 0 1.2
83 INT29714 Crh Regulation of Localization of LH 2 0.26 0 1.19
84 INT162419 Binding of Abpa and Cftr 1 0.04 1.66 1.19
85 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
86 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
87 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
88 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
89 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
90 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
91 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
92 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
93 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
94 INT29713 Crh Negative_regulation of Localization of Gnrhr 1 0.39 0 1.12
95 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
96 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
97 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
98 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
99 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07
100 INT62365 Gal Regulation of Localization of LH 1 0.33 0 1.07
101 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
102 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
103 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04
104 INT133650 Epo Negative_regulation of TNF 1 0.35 2.7 1.04
105 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
106 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
107 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
108 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
109 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
110 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
111 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
112 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
113 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
114 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
115 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
116 INT210015 Binding of Adcyap1 and Crh 1 0.47 0.88 1
117 INT5612 Cck Positive_regulation of Localization of Crh 1 0.65 0.16 1
118 INT91813 Binding of FAS and FASLG 4 0.23 9.89 0.99
119 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
120 INT175805 Crh Positive_regulation of Gene_expression of POMC 1 0.12 1.07 0.99
121 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
122 INT5107 Gal Positive_regulation of Localization of Sstr1 1 0.09 0 0.98
123 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
124 INT31494 Pomc Regulation of Crh 2 0.12 0.13 0.97
125 INT128602 Binding of Kcnma1 and Gtf2ird2 1 0.00 0 0.97
126 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
127 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96
128 INT36002 Negative_regulation of Crh Negative_regulation of LH 2 0.29 0.66 0.96
129 INT133617 Fas Positive_regulation of Fadd 1 0.48 0.07 0.96
130 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
131 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
132 INT133652 Epo Negative_regulation of Gene_expression of TNF 1 0.35 2.64 0.96
133 INT5108 Gal Positive_regulation of Ghrh 1 0.21 0 0.96
134 INT5104 Gal Positive_regulation of Sstr1 1 0.06 0 0.96
135 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
136 INT133071 STAT6 Positive_regulation of Gene_expression of GATA3 1 0.55 0 0.95
137 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
138 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
139 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
140 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
141 INT62449 Gnrh1 Regulation of Crh 1 0.40 0.34 0.91
142 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
143 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
144 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
145 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
146 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
147 INT137092 Ntf3 Negative_regulation of Gene_expression of Gal 1 0.47 1.01 0.9
148 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
149 INT64127 Igfbp2 Regulation of Localization of Avp 1 0.39 0.19 0.9
150 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
151 INT112642 Positive_regulation of Kcnma1 Positive_regulation of Nav1 1 0.02 0 0.89
152 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
153 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
154 INT66371 Pomc Regulation of Gene_expression of Crh 2 0.49 0 0.88
155 INT168019 Ldha Regulation of Gpt 1 0.01 0.15 0.88
156 INT168018 Positive_regulation of Ldha Regulation of Gpt 1 0.01 0.15 0.88
157 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
158 INT137563 Ghrl Positive_regulation of Gene_expression of Npy 1 0.59 0 0.87
159 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
160 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
161 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
162 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
163 INT130769 FASLG Negative_regulation of Binding of FAS 1 0.10 0.66 0.86
164 INT120293 RYBP Positive_regulation of Abcc2 1 0.04 0.14 0.86
165 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
166 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
167 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
168 INT21006 Oprl1 Regulation of Localization of Crh 1 0.19 0 0.84
169 INT192158 Binding of Mmp2 and Mmp9 1 0.21 0.94 0.83
170 INT64629 Binding of Gal and Crh 1 0.18 0.1 0.83
171 INT64627 Binding of Oxt and Crh 1 0.07 0.1 0.83
172 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
173 INT5103 Gal Regulation of Localization of Gh1 1 0.33 0.08 0.82
174 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
175 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
176 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
177 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
178 INT270217 Binding of C2 and Ca2 1 0.03 1.63 0.81
179 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 0.13 0.7 0.81
180 INT78348 Binding of GALR1 and GAL 4 0.41 1.47 0.8
181 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
182 INT36003 Crh Positive_regulation of Localization of LH 2 0.45 0 0.79
183 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
184 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
185 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
186 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
187 INT102161 Binding of TNF and Mmp2 1 0.10 0.88 0.78
188 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
189 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
190 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
191 INT79532 Crh Regulation of Ugt1a10 1 0.00 0 0.76
192 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
193 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
194 INT147251 Binding of Avp and Gal 1 0.15 0.19 0.76
195 INT226122 Ghrl Regulation of Cnr1 1 0.25 0.09 0.76
196 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
197 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
198 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
199 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
200 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to estrogen stimulus. They are ordered first by their pain relevance and then by number of times they were reported in response to estrogen stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1562 Localization of Crh 499 0.81 126.74 236.68
2 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
3 INT438 Gene_expression of Crh 376 0.78 159.11 169.17
4 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
5 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14
6 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
7 INT1898 Regulation of Crh 220 0.62 61.33 102.64
8 INT4822 Localization of Ca2 417 0.80 99.57 96.45
9 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
10 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
11 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
12 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
13 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72
14 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
15 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
16 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
17 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
18 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
19 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28
20 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
21 INT3920 Localization of Ldha 241 0.81 83.08 58.72
22 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
23 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
24 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92
25 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
26 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
27 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
28 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43
29 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
30 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
31 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
32 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23
33 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
34 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
35 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
36 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36
37 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
38 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
39 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
40 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
41 INT5489 Localization of CA2 172 0.80 39.46 33.56
42 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
43 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
44 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
45 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
46 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
47 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
48 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26
49 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56
50 INT5514 Negative_regulation of Localization of Crh 64 0.58 8.12 29.29
51 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02
52 INT16879 Binding of Crh 72 0.48 21.65 28.43
53 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97
54 INT21379 Transcription of Crh 65 0.72 15.64 27.92
55 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
56 INT37296 Binding of Esr1 117 0.43 62.51 27.33
57 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98
58 INT20462 Binding of ESR1 210 0.44 102.7 26.34
59 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
60 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
61 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
62 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25
63 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19
64 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
65 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
66 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45
67 INT103842 Gene_expression of Cftr 53 0.78 59.59 21.82
68 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73
69 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
70 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
71 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34
72 INT5040 Regulation of Gal 42 0.60 12.72 21.18
73 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73
74 INT78901 Localization of CCL5 67 0.78 40.79 20.59
75 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42
76 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67
77 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4
78 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36
79 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01
80 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
81 INT5099 Localization of Gal 46 0.81 10.66 18.93
82 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
83 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
84 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
85 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
86 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
87 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
88 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
89 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
90 INT77620 Gene_expression of Fas 146 0.78 72.4 16.61
91 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
92 INT4866 Positive_regulation of GAL 32 0.67 13.02 16.16
93 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66
94 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
95 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
96 INT92354 Localization of ESR1 77 0.75 33.04 15.51
97 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
98 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
99 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15
100 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14
101 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
102 INT11636 Positive_regulation of SERPINE1 85 0.69 68.73 14.8
103 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
104 INT2843 Gene_expression of Epo 100 0.78 62.01 14.66
105 INT14264 Binding of Gal 39 0.47 5.7 14.48
106 INT7587 Localization of GAL 27 0.78 4.79 14.29
107 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
108 INT8986 Positive_regulation of Gene_expression of Gal 24 0.67 10.96 14.09
109 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
110 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
111 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
112 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75
113 INT2336 Negative_regulation of Lct 51 0.58 33.79 13.73
114 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
115 INT2038 Localization of Esr1 104 0.79 40.12 13.27
116 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23
117 INT19799 Binding of Ca2 71 0.48 13.69 12.92
118 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
119 INT84307 Binding of Cftr 31 0.47 26.19 12.8
120 INT123779 Positive_regulation of MMP13 42 0.65 24.3 12.45
121 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
122 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35
123 INT12191 Negative_regulation of Localization of Ldha 35 0.59 13.71 12.35
124 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
125 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18
126 INT61706 Regulation of Gene_expression of Gal 17 0.62 10.09 11.96
127 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
128 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
129 INT14513 Localization of Ghrl 52 0.78 29.26 11.63
130 INT5011 Negative_regulation of Gal 30 0.57 9.88 11.49
131 INT373 Regulation of Ldha 37 0.61 17.86 11.41
132 INT80251 Binding of Nos1 21 0.30 8.24 11.31
133 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
134 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
135 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81
136 INT3535 Regulation of CA2 61 0.32 16.48 10.8
137 INT86291 Negative_regulation of Mmp2 33 0.57 20.38 10.76
138 INT74681 Positive_regulation of Gene_expression of Mmp2 23 0.55 15.58 10.74
139 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
140 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
141 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
142 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4
143 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
144 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
145 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
146 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97
147 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
148 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9
149 INT6516 Positive_regulation of BGLAP 45 0.67 26.61 9.9
150 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7
151 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68
152 INT104502 Gene_expression of Abcc2 26 0.78 8.37 9.65
153 INT77282 Positive_regulation of Cftr 23 0.69 21.8 9.65
154 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55
155 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
156 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43
157 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4
158 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
159 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
160 INT10597 Gene_expression of Cyp19a1 27 0.78 7.48 9.11
161 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
162 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
163 INT67612 Binding of PPARG 38 0.48 22.67 8.94
164 INT224964 Localization of Ghrl 30 0.59 7.71 8.77
165 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
166 INT48761 Transcription of Gal 13 0.69 8.53 8.61
167 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54
168 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51
169 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
170 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
171 INT4867 Positive_regulation of Gene_expression of GAL 17 0.70 6.65 8.28
172 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
173 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
174 INT17250 Negative_regulation of BGLAP 35 0.57 21 8.26
175 INT45234 Binding of Ldha 20 0.37 9.8 8.18
176 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
177 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
178 INT71381 Localization of Nos1 33 0.79 11.46 8.05
179 INT111903 Regulation of Mmp2 9 0.61 3.95 7.98
180 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97
181 INT15687 Regulation of ESR1 91 0.60 40.42 7.95
182 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87
183 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
184 INT1120 Gene_expression of C3 33 0.67 22.86 7.56
185 INT88014 Positive_regulation of Gene_expression of Fas 29 0.50 14.84 7.47
186 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
187 INT89589 Negative_regulation of Ccl5 9 0.40 4.62 7.39
188 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
189 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21
190 INT111398 Localization of Mmp2 37 0.76 23.78 7.17
191 INT10863 Positive_regulation of Ldlr 45 0.68 31.06 7.05
192 INT138802 Gene_expression of CFTR 36 0.70 18.8 7.02
193 INT3098 Positive_regulation of Epo 46 0.70 28.27 7
194 INT22336 Positive_regulation of Transcription of Crh 18 0.68 4.61 6.91
195 INT19146 Negative_regulation of Apoa2 19 0.36 5.34 6.73
196 INT110987 Transcription of ESR1 45 0.71 24.16 6.72
197 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
198 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67
199 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
200 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61
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