GO:0043652

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Name engulfment of apoptotic cell
Categary Process
Go Slim No
Go Link GO:0043652
Unique Molecular Interactions 76
Total Molecular Interactions 117
Total Single Events 953
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for engulfment of apoptotic cell. They are ordered first by their pain relevance and then by number of times they were reported for engulfment of apoptotic cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
2 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
3 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
4 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
5 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
6 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
7 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
8 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
9 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
10 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
11 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
12 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
13 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
14 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
15 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
16 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
17 INT131505 Rac1 Regulation of Gene_expression of Trpv1 1 0.55 0.39 0.42
18 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
19 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
20 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
21 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
22 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
23 INT330109 Binding of Racgap1 and Rac1 1 0.03 1.22 0.32
24 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
25 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
26 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
27 INT143973 Rac1 Positive_regulation of Vti1b 1 0.00 0.16 0.2
28 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
29 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
30 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
31 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
32 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
33 INT275157 Binding of Stat3 and Rac1 1 0.05 0.71 0.1
34 INT275158 Rac1 Positive_regulation of Stat3 1 0.07 0.72 0.1
35 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
36 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
37 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
38 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05
39 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05
40 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
41 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
42 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
43 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0
44 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
45 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
46 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
47 INT99770 Thbs1 Regulation of PGR 1 0.01 0 0
48 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
49 INT302641 Rac1 Regulation of TIE1 1 0.25 0.47 0
50 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
51 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
52 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
53 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
54 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
55 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
56 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
57 INT254847 Rac1 Positive_regulation of Fbrs 1 0.09 0.81 0
58 INT228112 Gene_expression of Chrm2 Positive_regulation of Positive_regulation of Rac1 1 0.14 0.26 0
59 INT288826 Binding of Rac1 and Vav1 1 0.25 0.68 0
60 INT334474 PGGT1B Regulation of Localization of Rac1 1 0.03 0.47 0
61 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
62 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
63 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0
64 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
65 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0
66 INT302633 Rac1 Regulation of Cdc42ep2 1 0.01 0 0
67 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
68 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
69 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
70 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
71 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
72 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
73 INT257340 Binding of Cyba and Rac1 1 0.09 0.29 0
74 INT254850 Setd1a Negative_regulation of Rac1 1 0.00 0 0
75 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for engulfment of apoptotic cell. They are ordered first by their pain relevance and then by number of times they were reported in engulfment of apoptotic cell. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
2 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
3 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
4 INT27627 Binding of Rac1 41 0.41 22.88 13.68
5 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
6 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
7 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
8 INT58475 Localization of Rac1 12 0.75 5.94 3.2
9 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
10 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
11 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
12 INT117980 Regulation of Rac1 10 0.45 3.72 1.88
13 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
14 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
15 INT150805 Localization of THBS1 4 0.46 2.88 1.23
16 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21
17 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21
18 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13
19 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
20 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
21 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
22 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99
23 INT81211 Transcription of Rac1 4 0.54 1.05 0.89
24 INT330097 Positive_regulation of Positive_regulation of Rac1 1 0.37 2.47 0.86
25 INT264629 Localization of Rac1 8 0.72 5.7 0.79
26 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
27 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7
28 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
29 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57
30 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
31 INT16012 Binding of Rac1 17 0.37 6.9 0.53
32 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
33 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
34 INT81212 Negative_regulation of Transcription of Rac1 1 0.01 0 0.46
35 INT87847 Regulation of Positive_regulation of Rac1 2 0.36 1.49 0.43
36 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
37 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
38 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
39 INT124986 Positive_regulation of Localization of Rac1 3 0.50 1.22 0.33
40 INT112551 Protein_catabolism of Rac1 2 0.66 0.29 0.3
41 INT116729 Regulation of Localization of Rac1 1 0.01 0.07 0.29
42 INT99682 Phosphorylation of Rac1 1 0.54 0.72 0.28
43 INT162873 Negative_regulation of Negative_regulation of Rac1 1 0.34 0.35 0.26
44 INT330090 Regulation of Negative_regulation of Rac1 1 0.36 0.53 0.25
45 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
46 INT330093 Negative_regulation of Positive_regulation of Rac1 1 0.34 0.88 0.23
47 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
48 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
49 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
50 INT231474 Binding of THBS1 4 0.34 2.04 0.16
51 INT168055 Regulation of Transcription of Rac1 1 0.36 0.34 0.16
52 INT133599 Positive_regulation of Binding of Rac1 2 0.40 0.4 0.15
53 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
54 INT330085 Regulation of Binding of Rac1 1 0.36 0.28 0.15
55 INT348149 Regulation of Gene_expression of Thbs1 1 0.31 1.94 0.1
56 INT348145 Localization of Thbs1 1 0.41 6.72 0.1
57 INT302613 Positive_regulation of Gene_expression of Rac1 14 0.67 3.7 0.08
58 INT334443 Positive_regulation of Positive_regulation of Rac1 1 0.33 1.1 0.08
59 INT222588 Negative_regulation of Gene_expression of Thbs1 2 0.30 7.93 0.07
60 INT302624 Negative_regulation of Gene_expression of Rac1 1 0.56 3.67 0.06
61 INT323949 Negative_regulation of Positive_regulation of Rac1 1 0.23 0.53 0.05
62 INT222624 Negative_regulation of Thbs1 2 0.30 8.42 0.04
63 INT99763 Regulation of Thbs1 2 0.23 2.08 0.04
64 INT334445 Regulation of Positive_regulation of Rac1 1 0.40 1.73 0.04
65 INT348152 Positive_regulation of Localization of Thbs1 1 0.24 0.85 0.04
66 INT348157 Regulation of Transcription of Thbs1 1 0.14 0.96 0.04
67 INT348147 Transcription of Thbs1 1 0.27 0.96 0.04
68 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
69 INT302611 Regulation of Gene_expression of Rac1 1 0.43 4.5 0.03
70 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
71 INT302615 Transcription of Rac1 5 0.66 1.1 0
72 INT334450 Regulation of Localization of Rac1 1 0.30 0.65 0
73 INT228095 Phosphorylation of Rac1 1 0.34 0.21 0
74 INT302609 Positive_regulation of Transcription of Rac1 1 0.48 0.27 0
75 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
76 INT277482 Negative_regulation of Transcription of Thbs1 1 0.43 0 0
77 INT302631 Regulation of Transcription of Rac1 1 0.43 0.47 0
78 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
79 INT348156 Positive_regulation of Gene_expression of Thbs1 1 0.24 0.9 0
80 INT302621 Regulation of Negative_regulation of Rac1 1 0.43 0 0
81 INT228789 Positive_regulation of Negative_regulation of Thbs1 1 0.26 0.07 0
82 INT302627 Negative_regulation of Localization of Rac1 1 0.41 0.28 0
83 INT302620 Negative_regulation of Transcription of Rac1 1 0.41 0 0
84 INT348146 Positive_regulation of Thbs1 1 0.25 2.41 0
85 INT277481 Negative_regulation of Negative_regulation of Thbs1 1 0.59 0 0
86 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
87 INT348158 Negative_regulation of Positive_regulation of Thbs1 1 0.22 0.65 0
88 INT334438 Positive_regulation of Localization of Rac1 1 0.33 2.37 0
89 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
90 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0
91 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
92 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
93 INT254786 Positive_regulation of Negative_regulation of Rac1 1 0.26 0.95 0
94 INT302614 Positive_regulation of Binding of Rac1 1 0.48 0.31 0
95 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
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