GO:0043931

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Name ossification involved in bone maturation
Categary Process
Go Slim No
Go Link GO:0043931
Unique Molecular Interactions 87
Total Molecular Interactions 130
Total Single Events 734
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ossification involved in bone maturation. They are ordered first by their pain relevance and then by number of times they were reported for ossification involved in bone maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT168866 Binding of RYR1 and Cd38 1 0.02 0.17 1.28
2 INT150784 ZNF398 Positive_regulation of Localization of THBS3 1 0.07 1.02 1.07
3 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
4 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
5 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
6 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
7 INT150800 THBS3 Negative_regulation of SPARC 1 0.23 0.51 0.53
8 INT150797 ZNF398 Positive_regulation of THBS3 1 0.07 0.5 0.52
9 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
10 INT150798 THBS3 Negative_regulation of TIMP2 1 0.18 0.49 0.52
11 INT150792 THBS3 Negative_regulation of MMP2 1 0.11 0.49 0.51
12 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
13 INT149221 Binding of Ryr1 and Trpc3 5 0.40 0 0.37
14 INT193029 CHRM2 Positive_regulation of RHOA 1 0.01 0.12 0.24
15 INT140376 TGM1 Positive_regulation of Rhoa 1 0.01 0 0.24
16 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
17 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
18 INT283373 Pcbd1 Regulation of RYR1 1 0.00 1.45 0.21
19 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
20 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
21 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
22 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
23 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
24 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
25 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
26 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13
27 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
28 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
29 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
30 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
31 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
32 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11
33 INT149219 Binding of Ryr1 and Trpc1 1 0.35 0 0.11
34 INT225740 RYR1 Positive_regulation of Binding of Entpd1 1 0.08 0.08 0.1
35 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
36 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
37 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
38 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
39 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
40 INT326377 Ezr Positive_regulation of Positive_regulation of Rhoa 1 0.05 0.16 0.06
41 INT326378 Binding of Rhoa and Ezr 1 0.04 0.17 0.06
42 INT170517 Binding of Ryr1 and Qdpr 2 0.15 0.36 0.05
43 INT326384 Slc9a3r2 Positive_regulation of Positive_regulation of Rhoa 1 0.03 0.16 0.05
44 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04
45 INT180438 Positive_regulation of Rhoa Positive_regulation of Car2 1 0.22 0.48 0.03
46 INT241450 Binding of Rhoa and Dpysl3 1 0.02 0 0.03
47 INT288829 Binding of Rhoa and Rac1 2 0.21 1.88 0
48 INT326383 Binding of Rhoa and Gopc 2 0.04 0.89 0
49 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
50 INT269586 Negative_regulation of TMPO Positive_regulation of RHOA 1 0.14 0 0
51 INT295704 Positive_regulation of Binding of RHOA and Racgap1 1 0.15 0.16 0
52 INT180446 Rhoa Regulation of Gene_expression of Car2 1 0.21 0.17 0
53 INT334472 Gopc Regulation of Positive_regulation of Rhoa 1 0.02 0.3 0
54 INT269547 PTGIR Regulation of Phosphorylation of RHOA 1 0.02 0 0
55 INT295706 PTGER2 Regulation of Regulation of RHOA 1 0.01 0.61 0
56 INT266704 Binding of RYR1 and TRDN 1 0.34 0 0
57 INT316647 Ryr1 Regulation of Qdpr 1 0.19 0.68 0
58 INT254851 C3 Negative_regulation of Rhoa 1 0.06 0 0
59 INT254848 Tgfb1 Negative_regulation of Rhoa 1 0.02 0 0
60 INT342432 Binding of Rhoa and Positive_regulation of Atp9a 1 0.20 0 0
61 INT334469 Gopc Regulation of Localization of Rhoa 1 0.02 0.3 0
62 INT269549 Regulation of GOPC Positive_regulation of RHOA 1 0.09 0 0
63 INT254854 Positive_regulation of C3 Negative_regulation of Rhoa 1 0.05 0 0
64 INT283372 Binding of RYR1 and Pcbd1 1 0.00 0.28 0
65 INT269581 PTGIR Regulation of RHOA 1 0.02 0 0
66 INT295714 PTGER2 Positive_regulation of RHOA 1 0.01 0.34 0
67 INT334473 PGGT1B Regulation of Localization of Rhoa 1 0.04 0.47 0
68 INT269571 Positive_regulation of GOPC Positive_regulation of RHOA 1 0.10 0 0
69 INT254865 Rhoa Positive_regulation of Fbrs 1 0.08 0.81 0
70 INT269555 GOPC Positive_regulation of RHOA 1 0.10 0 0
71 INT254864 Rhoa Positive_regulation of Egfl7 1 0.02 0.82 0
72 INT322843 Positive_regulation of PIK3CD Positive_regulation of Positive_regulation of RHOA 1 0.03 0 0
73 INT269564 MAPKAP1 Regulation of Positive_regulation of RHOA 1 0.03 0 0
74 INT269590 Positive_regulation of TMPO Positive_regulation of RHOA 1 0.16 0 0
75 INT269583 TMPO Positive_regulation of Gene_expression of RHOA 1 0.16 0.14 0
76 INT334468 Rhoa Regulation of Localization of Rac1 1 0.25 0.18 0
77 INT269574 Regulation of TMPO Positive_regulation of RHOA 1 0.20 0 0
78 INT295703 Binding of RHOA and Racgap1 1 0.11 0.16 0
79 INT254853 Rhoa Positive_regulation of Rac1 1 0.10 0.81 0
80 INT269576 Negative_regulation of GOPC Positive_regulation of RHOA 1 0.08 0 0
81 INT180125 Rhoa Positive_regulation of Rock1 1 0.14 0 0
82 INT344318 PDPN Positive_regulation of Positive_regulation of RHOA 1 0.11 0.92 0
83 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
84 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0
85 INT180439 Rhoa Regulation of Gene_expression of Acot1 1 0.07 0.17 0
86 INT266703 Binding of RYR1 and DIXDC1 1 0.26 0.1 0
87 INT296930 Casq1 Negative_regulation of RYR1 1 0.00 0.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ossification involved in bone maturation. They are ordered first by their pain relevance and then by number of times they were reported in ossification involved in bone maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
2 INT18393 Negative_regulation of Ryr1 15 0.43 3.63 7.57
3 INT59555 Binding of RYR1 39 0.42 8.65 4.92
4 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
5 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
6 INT18396 Positive_regulation of Ryr1 10 0.58 2.45 3.38
7 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26
8 INT18394 Regulation of Ryr1 6 0.60 0.28 3.26
9 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
10 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11
11 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
12 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
13 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
14 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
15 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
16 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
17 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04
18 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
19 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
20 INT85348 Localization of RHOA 12 0.59 4.81 1.83
21 INT11713 Localization of RYR1 22 0.76 10.42 1.64
22 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
23 INT55305 Regulation of RYR1 14 0.45 5.27 1.33
24 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
25 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
26 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
27 INT150803 Localization of THBS3 1 0.50 1 1.05
28 INT136817 Negative_regulation of Positive_regulation of RHOA 8 0.57 0 1.04
29 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
30 INT131824 Negative_regulation of RHOA 10 0.57 2.9 0.92
31 INT116831 Binding of Ryr1 11 0.47 0.12 0.9
32 INT38446 Localization of Ryr1 3 0.64 0.28 0.86
33 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
34 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
35 INT173338 Positive_regulation of Localization of RHOA 2 0.14 1.52 0.76
36 INT85347 Negative_regulation of Localization of RHOA 1 0.31 0 0.74
37 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
38 INT18395 Negative_regulation of Negative_regulation of Ryr1 1 0.00 0 0.59
39 INT316940 Positive_regulation of Phosphorylation of Rhoa 1 0.41 0.41 0.58
40 INT316931 Phosphorylation of Rhoa 1 0.48 0.41 0.57
41 INT140368 Positive_regulation of Positive_regulation of Rhoa 3 0.69 0.2 0.56
42 INT180420 Negative_regulation of Gene_expression of Rhoa 3 0.37 1.65 0.55
43 INT180422 Regulation of Gene_expression of Rhoa 2 0.39 0.6 0.55
44 INT140373 Binding of Rhoa 3 0.48 0.28 0.45
45 INT15647 Regulation of Positive_regulation of RYR1 1 0.26 0.23 0.45
46 INT183879 Binding of RHOA 6 0.34 2.1 0.31
47 INT131822 Positive_regulation of Positive_regulation of RHOA 2 0.45 0.33 0.29
48 INT80636 Positive_regulation of Localization of RYR1 2 0.47 0.78 0.29
49 INT140371 Positive_regulation of Negative_regulation of Rhoa 1 0.46 0 0.26
50 INT109859 Localization of Rhoa 3 0.54 1.09 0.24
51 INT289343 Regulation of Gene_expression of Rhoa 1 0.13 0.28 0.23
52 INT140365 Negative_regulation of Protein_catabolism of Rhoa 1 0.43 0 0.23
53 INT140358 Negative_regulation of Positive_regulation of Rhoa 1 0.43 0 0.23
54 INT289342 Negative_regulation of Gene_expression of Rhoa 1 0.20 0.28 0.23
55 INT59650 Regulation of Binding of RYR1 1 0.04 0 0.23
56 INT289353 Positive_regulation of Gene_expression of Rhoa 1 0.23 0.28 0.23
57 INT180415 Regulation of Rhoa 7 0.53 3.92 0.22
58 INT140359 Positive_regulation of Protein_catabolism of Rhoa 1 0.69 0 0.22
59 INT140369 Protein_catabolism of Rhoa 1 0.99 0 0.22
60 INT180418 Binding of Rhoa 16 0.32 7.05 0.2
61 INT49908 Regulation of Gene_expression of RYR1 3 0.45 0.32 0.19
62 INT140361 Regulation of Positive_regulation of Rhoa 1 0.45 0 0.17
63 INT60209 Transcription of RYR1 3 0.69 3.06 0.16
64 INT158175 Positive_regulation of Gene_expression of RYR1 2 0.48 1.35 0.13
65 INT170514 Gene_expression of Ryr1 4 0.49 0.56 0.12
66 INT269666 Regulation of Gene_expression of RHOA 1 0.32 0.38 0.1
67 INT282407 Transcription of Rhoa 1 0.15 0.52 0.1
68 INT109862 Negative_regulation of Localization of Rhoa 1 0.33 0.37 0.08
69 INT126629 Negative_regulation of Transcription of Rhoa 1 0.33 0 0.05
70 INT271024 Negative_regulation of Binding of RYR1 3 0.05 1.07 0.04
71 INT180419 Regulation of Positive_regulation of Rhoa 2 0.39 0.9 0.04
72 INT269659 Negative_regulation of Gene_expression of RHOA 1 0.42 0.26 0.04
73 INT316641 Positive_regulation of Localization of Ryr1 1 0.42 0 0.04
74 INT126630 Transcription of Rhoa 1 0.54 0 0.04
75 INT295675 Protein_catabolism of RHOA 2 0.24 0.21 0
76 INT211904 Negative_regulation of Localization of RYR1 1 0.37 0.64 0
77 INT322860 Regulation of Protein_catabolism of RHOA 1 0.08 0 0
78 INT269608 Regulation of Positive_regulation of RHOA 1 0.32 0.06 0
79 INT212954 Positive_regulation of Negative_regulation of Rhoa 1 0.19 1.18 0
80 INT191647 Regulation of Regulation of Rhoa 1 0.13 0.32 0
81 INT269627 Regulation of Phosphorylation of RHOA 1 0.32 0 0
82 INT269597 Negative_regulation of Phosphorylation of RHOA 1 0.31 0 0
83 INT269624 Positive_regulation of Phosphorylation of RHOA 1 0.36 0 0
84 INT334441 Regulation of Localization of Rhoa 1 0.33 0.88 0
85 INT80635 Regulation of Localization of RYR1 1 0.04 0.1 0
86 INT211903 Negative_regulation of Gene_expression of RYR1 1 0.37 0.06 0
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