GO:0043932

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Name ossification involved in bone remodeling
Categary Process
Go Slim No
Go Link GO:0043932
Unique Molecular Interactions 123
Total Molecular Interactions 158
Total Single Events 871
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ossification involved in bone remodeling. They are ordered first by their pain relevance and then by number of times they were reported for ossification involved in bone remodeling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
2 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
3 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
4 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
5 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
6 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
7 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
8 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
9 INT169477 TGFB3 Positive_regulation of Spink3 1 0.02 1.83 0.89
10 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
11 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
12 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
13 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
14 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
15 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
16 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
17 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
18 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
19 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
20 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
21 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
22 INT89145 TGFB1 Positive_regulation of Tcstv1 1 0.00 0.49 0.49
23 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
24 INT169478 TGFB3 Positive_regulation of Tgfa 1 0.01 0.9 0.44
25 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
26 INT169465 TGFB3 Positive_regulation of MTG1 1 0.03 0.89 0.43
27 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
28 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
29 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39
30 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
31 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
32 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
33 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
34 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
35 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
36 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
37 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
38 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
39 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
40 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
41 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
42 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
43 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
44 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
45 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
46 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
47 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
48 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25
49 INT225098 ZNF630 Regulation of Localization of TGFB1 1 0.01 0.44 0.24
50 INT225105 ZNF630 Regulation of TGFB1 1 0.01 0.44 0.24
51 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
52 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
53 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
54 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
55 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21
56 INT14869 Binding of EGF and TGFB3 1 0.14 0.69 0.19
57 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
58 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18
59 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18
60 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
61 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
62 INT160083 TGFB1 Positive_regulation of Gene_expression of L1CAM 1 0.16 1.53 0.16
63 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
64 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
65 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13
66 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
67 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
68 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
69 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
70 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11
71 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
72 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
73 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
74 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
75 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08
76 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08
77 INT134832 TGFB1 Regulation of YAP1 1 0.16 0.68 0.08
78 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
79 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
80 INT304330 TGFB1 Positive_regulation of ECM1 1 0.00 0.31 0.08
81 INT134835 TGFB1 Regulation of Gene_expression of YAP1 1 0.49 0.69 0.08
82 INT134834 TGFB1 Positive_regulation of YAP1 1 0.55 0.81 0.08
83 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
84 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
85 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07
86 INT94851 TGFB1 Regulation of Gene_expression of COL7A1 1 0.03 0.06 0.06
87 INT312228 INPP5K Regulation of TGFB1 1 0.06 0.08 0.05
88 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
89 INT271452 Binding of TGFB1 and Eln 1 0.00 0.38 0.04
90 INT271449 Binding of TGFB1 and Lox 1 0.01 0.38 0.04
91 INT157811 TGFB1 Positive_regulation of Timp2 1 0.02 0.06 0
92 INT312221 Binding of TGFB1 and INPP5K 1 0.09 0 0
93 INT180855 TGFB1 Regulation of S100A10 1 0.06 0.69 0
94 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0
95 INT184955 EGR1 Regulation of Regulation of TGFB1 1 0.39 0.3 0
96 INT180860 TGFB1 Regulation of Transcription of NID2 1 0.23 0.77 0
97 INT212770 Binding of CTD and TGFB1 1 0.01 3.95 0
98 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
99 INT157813 TGFB1 Positive_regulation of Gene_expression of Tagln 1 0.11 0.06 0
100 INT180849 TGFB1 Positive_regulation of COL4A2 1 0.10 1.28 0
101 INT147529 TGFB1 Negative_regulation of Gene_expression of Col2a1 1 0.05 0.32 0
102 INT137933 TGFB3 Regulation of Tgfb1 1 0.00 0 0
103 INT180857 TGFB1 Regulation of VCAN 1 0.04 0.69 0
104 INT180865 TGFB1 Positive_regulation of S100A10 1 0.24 1.22 0
105 INT269957 Sox17 Negative_regulation of Gene_expression of TGFB1 1 0.04 0 0
106 INT180861 TGFB1 Positive_regulation of MT1E 1 0.17 1.22 0
107 INT180852 TGFB1 Regulation of Transcription of TM4SF1 1 0.24 0.77 0
108 INT157810 TGFB1 Positive_regulation of Tagln 1 0.05 0.06 0
109 INT125799 Olr720 Negative_regulation of Positive_regulation of Tgfb1 1 0.00 0 0
110 INT180864 TGFB1 Regulation of Gene_expression of COL4A2 1 0.31 0.7 0
111 INT137935 Tgfb1 Regulation of TGFB3 1 0.00 0 0
112 INT180858 TGFB1 Regulation of Transcription of IGFBP3 1 0.24 0.77 0
113 INT268340 TGFBR2 Positive_regulation of Phosphorylation of TGFB1 1 0.25 0.68 0
114 INT134839 Binding of TGFB1 and YAP1 1 0.29 0.9 0
115 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0
116 INT299552 TGFB1 Positive_regulation of Phosphorylation of Alk 1 0.00 0.12 0
117 INT180848 TGFB1 Regulation of COL4A2 1 0.06 0.7 0
118 INT71540 TGFB1 Positive_regulation of Localization of Gnrh1 1 0.00 0 0
119 INT180844 TGFB1 Regulation of Gene_expression of VCAN 1 0.16 0.7 0
120 INT137929 IGF1 Regulation of TGFB3 1 0.00 0 0
121 INT180850 TGFB1 Regulation of Gene_expression of S100A10 1 0.24 0.7 0
122 INT157812 TGFB1 Positive_regulation of Pmfbp1 1 0.11 0.06 0
123 INT304093 Binding of IL10 and TGFB1 1 0.02 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ossification involved in bone remodeling. They are ordered first by their pain relevance and then by number of times they were reported in ossification involved in bone remodeling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
2 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
3 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
4 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
5 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
6 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
7 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
8 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
9 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
10 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
11 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
12 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
13 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
14 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
15 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
16 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96
17 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
18 INT12086 Regulation of Localization of TGFB1 4 0.43 1.65 2.09
19 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84
20 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
21 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51
22 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4
23 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3
24 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
25 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
26 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
27 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
28 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
29 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
30 INT14871 Binding of TGFB3 3 0.13 1.2 0.78
31 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76
32 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66
33 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
34 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6
35 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59
36 INT27659 Localization of TGFB3 3 0.29 0.52 0.4
37 INT14873 Positive_regulation of Gene_expression of TGFB3 2 0.25 1.14 0.29
38 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22
39 INT61823 Positive_regulation of TGFB3 2 0.01 1.64 0.2
40 INT122201 Binding of Tgfb1 1 0.16 0.17 0.17
41 INT133100 Negative_regulation of Localization of Tgfb1 2 0.28 1.48 0.15
42 INT81940 Regulation of TGFB3 3 0.14 0.45 0.1
43 INT14738 Negative_regulation of Regulation of TGFB1 2 0.41 0.81 0.09
44 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08
45 INT139093 Regulation of Negative_regulation of Tgfb1 1 0.27 0.44 0.06
46 INT136115 Positive_regulation of Regulation of TGFB1 1 0.11 0.16 0.05
47 INT185020 Positive_regulation of Negative_regulation of TGFB1 1 0.43 0.44 0.04
48 INT180881 Regulation of Positive_regulation of TGFB1 2 0.32 1.32 0.03
49 INT133097 Positive_regulation of Phosphorylation of Tgfb1 1 0.05 0.07 0
50 INT133099 Negative_regulation of Phosphorylation of Tgfb1 1 0.04 0.08 0
51 INT133098 Phosphorylation of Tgfb1 1 0.06 0.07 0
52 INT128712 Positive_regulation of Regulation of Tgfb1 1 0.15 0 0
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