GO:0043950

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Name positive regulation of cAMP-mediated signaling
Categary Process
Go Slim No
Go Link GO:0043950
Unique Molecular Interactions 497
Total Molecular Interactions 705
Total Single Events 5749
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cAMP-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of cAMP-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
4 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52
5 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
6 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
7 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
8 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
9 INT143946 Binding of Pebp1 and Mastl 1 0.00 2.04 3.82
10 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
11 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
12 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
13 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
14 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
15 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
16 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
17 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
18 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
19 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
20 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
21 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
22 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
23 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
24 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
25 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
26 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
27 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
28 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
29 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
30 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
31 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
32 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
33 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
34 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
35 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
36 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
37 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
38 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
39 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
40 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
41 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
42 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
43 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
44 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
45 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
46 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
47 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
48 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
49 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
50 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
51 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
52 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
53 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
54 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
55 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
56 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
57 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
58 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
59 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
60 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
61 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
62 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
63 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
64 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
65 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
66 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
67 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
68 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
69 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
70 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
71 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
72 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
73 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
74 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
75 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
76 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
77 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
78 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
79 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
80 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
81 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
82 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
83 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
84 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
85 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
86 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
87 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
88 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
89 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
90 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
91 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
92 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
93 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
94 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
95 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
96 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
97 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
98 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
99 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
100 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
101 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
102 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
103 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
104 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
105 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
106 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
107 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
108 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
109 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
110 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
111 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
112 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
113 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
114 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
115 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
116 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
117 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
118 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
119 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
120 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
121 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
122 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
123 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
124 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
125 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
126 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
127 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
128 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
129 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
130 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
131 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
132 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
133 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
134 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
135 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
136 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
137 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
138 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
139 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
140 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
141 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
142 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
143 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
144 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
145 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
146 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
147 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
148 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
149 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
150 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
151 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
152 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
153 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
154 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
155 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
156 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
157 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
158 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
159 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
160 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06
161 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06
162 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
163 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
164 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
165 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
166 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
167 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
168 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
169 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
170 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02
171 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
172 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
173 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 0.10 0 1
174 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
175 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 0.18 0.07 1
176 INT70105 SCD Positive_regulation of Oprm1 1 0.01 0 1
177 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
178 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
179 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
180 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
181 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
182 INT169500 Negative_regulation of Mirlet7a-1 Regulation of Oprm1 1 0.37 0 0.99
183 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
184 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
185 INT94989 Arrb2 Regulation of Regulation of Oprm1 1 0.24 0 0.98
186 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
187 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97
188 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
189 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
190 INT317543 Pag1 Positive_regulation of Oprm1 1 0.12 0.73 0.97
191 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
192 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96
193 INT83415 Binding of Oprm1 and Ntrk1 1 0.01 0 0.96
194 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
195 INT42482 Binding of Cpe and Pebp1 1 0.02 0 0.95
196 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
197 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
198 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
199 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
200 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of cAMP-mediated signaling. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of cAMP-mediated signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
3 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
4 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
5 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
6 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
7 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
8 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
9 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
10 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
11 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
12 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
13 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
14 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
15 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
16 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
17 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
18 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
19 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
20 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
21 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
22 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
23 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
24 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
25 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
26 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
27 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
28 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
29 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
30 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
31 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
32 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
33 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
34 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
35 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
36 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
37 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
38 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
39 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
40 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
41 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
42 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
43 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
44 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
45 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
46 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
47 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
48 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
49 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
50 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
51 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
52 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
53 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
54 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
55 INT2257 Localization of Gip 31 0.74 11.08 7.92
56 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
57 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
58 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
59 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
60 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
61 INT85764 Binding of PEBP1 9 0.44 4.52 7.2
62 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
63 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
64 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
65 INT33781 Binding of Pebp1 11 0.44 1.76 6.61
66 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
67 INT1280 Negative_regulation of Pebp1 7 0.28 2.12 6.45
68 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
69 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
70 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
71 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
72 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
73 INT4034 Negative_regulation of Gip 16 0.53 6.46 5.65
74 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
75 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
76 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
77 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
78 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
79 INT2258 Positive_regulation of Gip 16 0.60 5.51 3.67
80 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
81 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
82 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
83 INT21572 Gene_expression of Pebp1 9 0.71 2.52 3.3
84 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
85 INT4186 Negative_regulation of Localization of Gip 7 0.53 2.11 2.98
86 INT2256 Regulation of Gip 14 0.47 4.69 2.91
87 INT70377 Regulation of Transcription of Oprm1 3 0.47 0.93 2.78
88 INT122187 Positive_regulation of Crhr2 3 0.58 2.46 2.56
89 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
90 INT41136 Negative_regulation of Positive_regulation of Gip 4 0.37 1.66 2.45
91 INT101955 Gene_expression of Crhr2 6 0.64 3.62 2.31
92 INT71952 Regulation of Negative_regulation of Oprm1 3 0.43 0.09 2.18
93 INT227153 Negative_regulation of PEBP1 1 0.12 0.51 2.17
94 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
95 INT62522 Regulation of Phosphorylation of Oprm1 3 0.13 0 1.96
96 INT13707 Positive_regulation of Pebp1 3 0.41 0.24 1.88
97 INT142684 Protein_catabolism of OPRM1 2 0.66 0.48 1.81
98 INT142929 Regulation of Crhr2 1 0.44 1.28 1.73
99 INT1347 Localization of Pebp1 2 0.48 0.17 1.69
100 INT130552 Negative_regulation of Localization of Oprm1 2 0.31 0.37 1.53
101 INT105997 Positive_regulation of Protein_catabolism of Oprm1 2 0.66 0.41 1.45
102 INT21106 Regulation of Phosphorylation of Oprm1 3 0.61 0 1.43
103 INT101954 Binding of Crhr2 4 0.31 1.23 1.34
104 INT115804 Regulation of Localization of OPRM1 2 0.33 0.12 1.33
105 INT85667 Negative_regulation of Negative_regulation of Oprm1 3 0.37 0.54 1.31
106 INT85765 Localization of PEBP1 3 0.73 0.83 1.3
107 INT13705 Regulation of Pebp1 2 0.26 0.85 1.3
108 INT67450 Negative_regulation of Localization of OPRM1 2 0.06 0.24 1.26
109 INT36226 Gene_expression of GIP 13 0.67 3.05 1.25
110 INT28888 Positive_regulation of Crhr2 6 0.68 3.8 1.23
111 INT14138 Regulation of Localization of Oprm1 1 0.28 0 1.23
112 INT129374 Negative_regulation of Regulation of Oprm1 3 0.43 0.58 1.18
113 INT35786 Negative_regulation of Negative_regulation of OPRM1 2 0.33 0.91 1.1
114 INT29372 Localization of GIP 18 0.69 7.23 1.01
115 INT21108 Negative_regulation of Phosphorylation of Oprm1 2 0.43 0 0.98
116 INT4036 Positive_regulation of Localization of Gip 3 0.45 1.92 0.9
117 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81
118 INT123412 Negative_regulation of Transcription of Oprm1 2 0.56 0.06 0.79
119 INT101952 Negative_regulation of Crhr2 1 0.17 0.97 0.77
120 INT55921 Negative_regulation of Transcription of Oprm1 1 0.43 0 0.76
121 INT37289 Regulation of GIP 5 0.39 0.3 0.74
122 INT129375 Negative_regulation of Regulation of Oprm1 1 0.28 0.49 0.68
123 INT28889 Transcription of Crhr2 2 0.64 1.13 0.66
124 INT136833 Gene_expression of Gip 1 0.78 2.26 0.6
125 INT101949 Negative_regulation of Binding of Crhr2 1 0.24 0.6 0.55
126 INT15900 Gene_expression of PEBP1 5 0.61 2.57 0.44
127 INT148784 Negative_regulation of Crhr2 2 0.40 0.76 0.42
128 INT149198 Positive_regulation of Regulation of Oprm1 2 0.47 0.23 0.42
129 INT255071 Binding of GIP 2 0.28 1.39 0.42
130 INT161281 Negative_regulation of Positive_regulation of Pebp1 1 0.07 0 0.41
131 INT2254 Gene_expression of Gip 5 0.47 2.21 0.4
132 INT2255 Regulation of Localization of Gip 3 0.26 0.91 0.4
133 INT18646 Transcription of Pebp1 1 0.50 0.39 0.4
134 INT55423 Binding of Gip 2 0.45 0 0.39
135 INT144599 Gene_expression of Crhr2 3 0.49 2.16 0.36
136 INT46473 Negative_regulation of Negative_regulation of Gip 1 0.39 1.08 0.36
137 INT18041 Protein_catabolism of Oprm1 1 0.87 0 0.31
138 INT46472 Positive_regulation of Positive_regulation of Gip 1 0.37 0.53 0.23
139 INT255068 Positive_regulation of GIP 4 0.38 1.59 0.21
140 INT143393 Transcription of Crhr2 1 0.52 0.19 0.21
141 INT136870 Negative_regulation of Pebp1 1 0.33 0.1 0.19
142 INT136867 Localization of Pebp1 1 0.57 0.06 0.19
143 INT39916 Negative_regulation of Localization of GIP 1 0.30 0 0.17
144 INT112935 Binding of Crhr2 1 0.32 0.33 0.17
145 INT39917 Negative_regulation of GIP 3 0.46 1.08 0.15
146 INT96536 Protein_catabolism of Gip 1 0.64 0 0.15
147 INT85762 Positive_regulation of Transcription of PEBP1 1 0.46 0.1 0.15
148 INT85763 Transcription of PEBP1 1 0.63 0.1 0.15
149 INT39920 Regulation of Localization of GIP 1 0.42 0 0.15
150 INT136864 Gene_expression of Pebp1 3 0.59 0.43 0.14
151 INT280037 Localization of Gip 2 0.25 2.22 0.13
152 INT163408 Negative_regulation of Gene_expression of Crhr2 2 0.27 1.56 0.13
153 INT145052 Regulation of Pebp1 1 0.23 0.23 0.13
154 INT178420 Positive_regulation of PEBP1 3 0.42 1.77 0.12
155 INT173980 Positive_regulation of Gene_expression of Pebp1 1 0.17 0 0.12
156 INT68801 Regulation of Gene_expression of Pebp1 1 0.41 0 0.12
157 INT136832 Positive_regulation of Gene_expression of Gip 1 0.44 0.29 0.12
158 INT46553 Regulation of Gene_expression of Gip 1 0.09 0.08 0.08
159 INT165756 Positive_regulation of Gene_expression of Crhr2 1 0.31 0.62 0.07
160 INT205027 Positive_regulation of Positive_regulation of Crhr2 1 0.58 0.14 0.07
161 INT39918 Positive_regulation of Localization of GIP 1 0.37 0 0.07
162 INT165755 Regulation of Gene_expression of Crhr2 1 0.28 0.62 0.07
163 INT136874 Positive_regulation of Pebp1 2 0.38 0.19 0.05
164 INT267922 Positive_regulation of Gene_expression of Gip 1 0.04 0.97 0.05
165 INT332626 Protein_catabolism of Gip 1 0.27 0.49 0.04
166 INT321462 Negative_regulation of Negative_regulation of Gip 1 0.05 0.69 0.03
167 INT339939 Positive_regulation of Transcription of GIP 1 0.33 0.51 0.03
168 INT321463 Negative_regulation of Gip 1 0.05 0.68 0.03
169 INT187586 Regulation of Gene_expression of Pebp1 1 0.03 0.2 0
170 INT15901 Positive_regulation of Gene_expression of PEBP1 1 0.03 0 0
171 INT339937 Transcription of GIP 1 0.45 0.51 0
172 INT255067 Negative_regulation of Binding of GIP 1 0.32 0.31 0
173 INT205029 Regulation of Gene_expression of Crhr2 1 0.22 1.03 0
174 INT67344 Negative_regulation of Regulation of Gip 1 0.25 0.17 0
175 INT255031 Protein_catabolism of GIP 1 0.83 0.32 0
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