GO:0043967

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Name histone H4 acetylation
Categary Process
Go Slim No
Go Link GO:0043967
Unique Molecular Interactions 106
Total Molecular Interactions 139
Total Single Events 608
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone H4 acetylation. They are ordered first by their pain relevance and then by number of times they were reported for histone H4 acetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94367 Binding of ARRB1 and TP53INP2 1 0.25 0 1.3
2 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
3 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
4 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
5 INT85686 Binding of Arrb1 and Arrb2 1 0.14 0.09 0.79
6 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
7 INT94366 Binding of ARRB1 and OPRD1 1 0.11 0 0.67
8 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
9 INT77394 Binding of ARRB1 and GIPC1 1 0.01 0 0.56
10 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
11 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
12 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
13 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
14 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
15 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
16 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42
17 INT116678 Binding of ARRB1 and Oxtr 1 0.13 0.15 0.38
18 INT277985 Epo Positive_regulation of Epc1 1 0.03 1.36 0.36
19 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33
20 INT299956 Binding of PPARA and EPC1 1 0.09 0.34 0.29
21 INT120236 Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28
22 INT120237 Positive_regulation of Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28
23 INT198926 Binding of Apbb1 and Lrp1 5 0.12 2.18 0.24
24 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
25 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
26 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
27 INT334261 Binding of Irf4 and Irf5 1 0.22 0.42 0.18
28 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
29 INT223538 Binding of HAND1 and Tcf3 1 0.39 1.13 0.14
30 INT223530 Binding of Tcf3 and Szf1 1 0.33 0.92 0.13
31 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
32 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12
33 INT220639 Binding of Apbb1 and Ighd 1 0.12 0.31 0.12
34 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
35 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
36 INT277988 Csf3 Positive_regulation of Epc1 1 0.00 0.51 0.11
37 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
38 INT262146 Binding of Ncoa1 and Nr1i2 1 0.03 0.56 0.11
39 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
40 INT277987 Regulation of Csf3 Positive_regulation of Epc1 1 0.00 0.51 0.11
41 INT298267 Tcf3 Positive_regulation of Gene_expression of Runx1 1 0.21 0.6 0.1
42 INT156091 Afm Regulation of Epc1 1 0.01 0 0.09
43 INT110377 Binding of Ncoa1 and Pparg 1 0.02 0.26 0.08
44 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
45 INT223531 Binding of Hmga1 and Tcf3 1 0.26 0.57 0.07
46 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
47 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
48 INT308291 LY6E Regulation of EPC1 1 0.00 0 0.05
49 INT308292 CSF2 Positive_regulation of EPC1 1 0.10 0 0.05
50 INT287221 Tcf3 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
51 INT308290 LY6E Positive_regulation of EPC1 1 0.00 0 0.04
52 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
53 INT236149 Binding of Ncoa1 and Ppara 1 0.07 0 0.03
54 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
55 INT236597 Ncoa1 Positive_regulation of PELP1 1 0.41 0.17 0.03
56 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
57 INT243108 Pprc1 Negative_regulation of Ncoa1 1 0.00 0.53 0.03
58 INT236585 Ncoa2 Positive_regulation of Transcription of Ncoa1 1 0.27 0.23 0.03
59 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0
60 INT313597 Binding of BRCA2 and TOX3 1 0.11 0.7 0
61 INT356117 Binding of SORL1 and Apbb1 1 0.14 0.43 0
62 INT225583 Binding of Ncoa1 and Tpr 1 0.00 0.07 0
63 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0
64 INT233930 Binding of PPARA and Ncoa1 1 0.12 0.19 0
65 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
66 INT213746 Binding of Pecam1 and Epc1 1 0.09 0 0
67 INT314742 Binding of RAD51 and Brca2 1 0.06 1.05 0
68 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0
69 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
70 INT287072 Chrm2 Positive_regulation of Gene_expression of Irf4 1 0.18 0.06 0
71 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0
72 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 0.03 0.25 0
73 INT337405 MIR203 Regulation of LEF1 1 0.02 0.31 0
74 INT172604 Binding of EP300 and TP53 1 0.00 0 0
75 INT233928 PPARA Positive_regulation of Localization of Ncoa1 1 0.18 0.19 0
76 INT337411 Negative_regulation of MIR203 Positive_regulation of Gene_expression of LEF1 1 0.04 0.25 0
77 INT213747 Positive_regulation of Gtf3a Positive_regulation of Epc1 1 0.01 0 0
78 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
79 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
80 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
81 INT287060 Proc Regulation of Irf4 1 0.00 0.13 0
82 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0
83 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0
84 INT287076 Chrm2 Regulation of Irf4 1 0.10 0.09 0
85 INT287068 Irf4 Regulation of Igj 1 0.25 0.13 0
86 INT233927 PPARA Positive_regulation of Ncoa1 1 0.08 0.19 0
87 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
88 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
89 INT225571 Binding of Ncoa1 and Tfrc 1 0.01 0 0
90 INT337417 MIR203 Negative_regulation of LEF1 1 0.04 0.57 0
91 INT225579 Binding of Ncoa1 and D0Nrs1 1 0.00 0 0
92 INT220822 Binding of Myc and LEF1 1 0.26 0.08 0
93 INT220766 Binding of MAX and LEF1 1 0.40 0.08 0
94 INT172605 Positive_regulation of Binding of EP300 and TP53 1 0.00 0 0
95 INT261981 EP400 Negative_regulation of CYP1B1 1 0.01 0.22 0
96 INT243111 Binding of Crebbp and Ep300 1 0.16 0.17 0
97 INT225543 Binding of D0Nrs1 and Ep300 1 0.01 0 0
98 INT287066 Chrm2 Positive_regulation of Irf4 1 0.18 0.29 0
99 INT225563 Binding of Tpr and Ep300 1 0.00 0 0
100 INT260072 Binding of BRCA2 and FANCC 1 0.37 0.63 0
101 INT213745 Binding of Kdr and Epc1 1 0.17 0 0
102 INT319026 Binding of Npc1 and Ruvbl1 1 0.00 0.08 0
103 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0
104 INT213744 Binding of Cd34 and Epc1 1 0.12 0 0
105 INT198928 Binding of Apbb1 and Lrp8 1 0.07 0.17 0
106 INT225622 Binding of STL and Ep300 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone H4 acetylation. They are ordered first by their pain relevance and then by number of times they were reported in histone H4 acetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
2 INT77404 Gene_expression of ARRB1 19 0.62 1.53 7.22
3 INT77408 Binding of ARRB1 11 0.36 0.31 6.51
4 INT2213 Regulation of EP300 10 0.54 4.72 4.5
5 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
6 INT72618 Regulation of Tcf3 5 0.44 1.48 3.16
7 INT106833 Positive_regulation of ARRB1 4 0.39 1.21 2.71
8 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
9 INT77396 Regulation of ARRB1 6 0.35 2.04 2.22
10 INT72616 Negative_regulation of Tcf3 2 0.41 0.97 2.04
11 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
12 INT171514 Binding of EP300 13 0.32 4.32 2.01
13 INT77410 Positive_regulation of Gene_expression of ARRB1 3 0.55 0.21 1.98
14 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
15 INT30533 Negative_regulation of Epc1 13 0.38 5.69 1.72
16 INT172622 Localization of EP300 8 0.65 2.56 1.72
17 INT113539 Positive_regulation of Binding of ARRB1 1 0.02 0.11 1.72
18 INT161097 Gene_expression of Epc1 36 0.45 7.76 1.64
19 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
20 INT147692 Localization of Epc1 22 0.40 7.17 1.51
21 INT2214 Regulation of EP400 1 0.38 0.35 1.51
22 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
23 INT167357 Positive_regulation of EPC1 15 0.30 9.12 1.36
24 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
25 INT77398 Negative_regulation of ARRB1 1 0.47 0 1.31
26 INT106830 Positive_regulation of Positive_regulation of ARRB1 1 0.16 0.13 1.28
27 INT106832 Localization of ARRB1 2 0.22 0.3 1.21
28 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
29 INT72614 Negative_regulation of Regulation of Tcf3 1 0.41 0.17 1.2
30 INT159328 Localization of EPC1 11 0.59 7.08 1.14
31 INT77411 Regulation of Gene_expression of ARRB1 3 0.36 0.61 1.12
32 INT213740 Positive_regulation of Epc1 14 0.25 9.8 1.07
33 INT299966 Negative_regulation of EPC1 10 0.22 8.66 1.07
34 INT148941 Regulation of Epc1 6 0.16 4.05 1.05
35 INT106835 Positive_regulation of Localization of ARRB1 1 0.15 0.11 1.04
36 INT167650 Binding of Ep300 1 0.09 0.14 1
37 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
38 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79
39 INT85678 Binding of Arrb1 1 0.20 0.09 0.78
40 INT30050 Gene_expression of Tcf3 13 0.48 2.57 0.77
41 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
42 INT116081 Negative_regulation of Binding of ARRB1 1 0.41 0 0.72
43 INT77406 Negative_regulation of Negative_regulation of ARRB1 1 0.47 0 0.71
44 INT77401 Regulation of Regulation of ARRB1 1 0.25 0 0.69
45 INT236571 Transcription of Ncoa1 2 0.50 0.17 0.64
46 INT139186 Positive_regulation of APBB1 1 0.00 0.31 0.62
47 INT211906 Gene_expression of EPC1 15 0.19 3.75 0.61
48 INT105266 Localization of Tcf3 3 0.32 1.08 0.59
49 INT299965 Regulation of EPC1 7 0.23 4.44 0.53
50 INT92397 Binding of Epc1 6 0.30 1.93 0.53
51 INT120229 Binding of Ncoa1 6 0.35 1.04 0.44
52 INT200258 Binding of Irf4 2 0.21 0.43 0.43
53 INT156120 Localization of Arrb1 1 0.00 0 0.38
54 INT156119 Positive_regulation of Localization of Arrb1 1 0.00 0 0.38
55 INT276311 Gene_expression of Irf4 6 0.64 4.95 0.37
56 INT30052 Positive_regulation of Tcf3 3 0.41 0.27 0.37
57 INT287043 Positive_regulation of Irf4 7 0.57 2.81 0.36
58 INT299963 Positive_regulation of Localization of EPC1 1 0.26 1.54 0.36
59 INT187587 Binding of Ep300 11 0.35 2.37 0.34
60 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
61 INT124588 Gene_expression of Ncoa1 9 0.49 2.38 0.27
62 INT269813 Positive_regulation of Localization of Epc1 3 0.18 1.79 0.27
63 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25
64 INT142864 Positive_regulation of Phosphorylation of ARRB1 1 0.01 0 0.25
65 INT142865 Phosphorylation of ARRB1 1 0.01 0 0.25
66 INT220582 Binding of Apbb1 2 0.14 0.69 0.24
67 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
68 INT299971 Regulation of Localization of EPC1 1 0.10 1.13 0.24
69 INT236584 Regulation of Ncoa1 2 0.33 1.82 0.2
70 INT212787 Negative_regulation of Binding of EP300 1 0.13 0.53 0.2
71 INT256666 Regulation of Gene_expression of EP300 1 0.14 0.07 0.2
72 INT256661 Regulation of Positive_regulation of EP300 1 0.23 0.07 0.2
73 INT19359 Binding of BRCA2 5 0.47 2.63 0.19
74 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
75 INT213738 Positive_regulation of Gene_expression of Epc1 4 0.25 0.8 0.18
76 INT89690 Binding of Brca2 2 0.37 1.8 0.18
77 INT299984 Positive_regulation of Negative_regulation of EPC1 1 0.17 0.68 0.17
78 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15
79 INT90229 Transcription of Tcf3 2 0.12 0.39 0.13
80 INT299982 Binding of EPC1 1 0.18 3.24 0.13
81 INT89691 Regulation of Brca2 1 0.23 0.56 0.13
82 INT161096 Regulation of Localization of Epc1 3 0.17 1.05 0.12
83 INT133407 Binding of APBB1 2 0.35 1.63 0.09
84 INT321675 Gene_expression of Apbb1 1 0.32 1 0.09
85 INT107960 Positive_regulation of Ncoa1 3 0.37 1.59 0.08
86 INT234186 Localization of BRCA2 2 0.69 1.48 0.07
87 INT213742 Negative_regulation of Gene_expression of Epc1 1 0.22 0.51 0.07
88 INT233912 Localization of Ncoa1 4 0.73 0.53 0.05
89 INT236137 Positive_regulation of Localization of Ncoa1 3 0.10 0.34 0.05
90 INT321679 Positive_regulation of Gene_expression of Apbb1 1 0.28 0.56 0.05
91 INT292252 Phosphorylation of EP300 1 0.20 0.55 0.05
92 INT220802 Binding of LEF1 7 0.36 3.86 0.04
93 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
94 INT289110 Localization of LEF1 2 0.32 1.19 0.04
95 INT295091 Positive_regulation of Gene_expression of Tcf3 2 0.19 0.4 0.04
96 INT308297 Regulation of Gene_expression of EPC1 1 0.11 0 0.04
97 INT308299 Negative_regulation of Gene_expression of EPC1 1 0.11 0 0.04
98 INT319018 Binding of Ruvbl1 1 0.00 0.15 0.04
99 INT269812 Positive_regulation of Negative_regulation of Epc1 2 0.19 0.45 0.03
100 INT321677 Localization of Apbb1 1 0.31 0.29 0.03
101 INT299977 Negative_regulation of Localization of EPC1 1 0.16 1.34 0.03
102 INT235154 Transcription of Ep300 2 0.24 1.38 0
103 INT167536 Positive_regulation of BRCA2 2 0.49 0.29 0
104 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
105 INT234191 Positive_regulation of Localization of BRCA2 1 0.46 0.68 0
106 INT222914 Negative_regulation of Gene_expression of EP300 1 0.02 0.05 0
107 INT262009 Negative_regulation of Gene_expression of EP400 1 0.01 0 0
108 INT295084 Regulation of Gene_expression of Tcf3 1 0.20 0.36 0
109 INT198878 Regulation of Apbb1 1 0.11 0 0
110 INT314708 Gene_expression of Brca2 1 0.41 1.75 0
111 INT337456 Positive_regulation of Binding of LEF1 1 0.22 0 0
112 INT213736 Protein_catabolism of Epc1 1 0.38 0 0
113 INT314707 Regulation of Transcription of Brca2 1 0.27 0.56 0
114 INT234916 Gene_expression of Lef1 1 0.04 0.25 0
115 INT307187 Negative_regulation of Ncoa1 1 0.08 0.11 0
116 INT319020 Regulation of Ruvbl1 1 0.00 0 0
117 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0
118 INT225450 Negative_regulation of Gene_expression of Ncoa1 1 0.06 0.97 0
119 INT262008 Gene_expression of EP400 1 0.01 0 0
120 INT314705 Transcription of Brca2 1 0.42 0.56 0
121 INT299976 Negative_regulation of Binding of EPC1 1 0.16 0.55 0
122 INT262007 Negative_regulation of EP400 1 0.00 0 0
123 INT324467 Gene_expression of APBB1 1 0.75 1.66 0
124 INT299972 Positive_regulation of Positive_regulation of EPC1 1 0.19 0.84 0
125 INT337461 Positive_regulation of Transcription of LEF1 1 0.22 0.26 0
126 INT225336 Regulation of Binding of Ncoa1 1 0.06 0.07 0
127 INT173224 Regulation of BRCA2 1 0.21 1.3 0
128 INT213737 Positive_regulation of Positive_regulation of Epc1 1 0.25 0 0
129 INT319017 Positive_regulation of Ruvbl1 1 0.00 0 0
130 INT289108 Negative_regulation of Transcription of LEF1 1 0.11 0.32 0
131 INT236556 Positive_regulation of Gene_expression of Ncoa1 1 0.37 0.36 0
132 INT220775 Binding of Lef1 1 0.20 0.06 0
133 INT319019 Protein_catabolism of Ruvbl1 1 0.01 0 0
134 INT289124 Negative_regulation of Positive_regulation of LEF1 1 0.11 0.34 0
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