GO:0044027

From wiki-pain
Jump to: navigation, search
Name hypermethylation of CpG island
Categary Process
Go Slim No
Go Link GO:0044027
Unique Molecular Interactions 114
Total Molecular Interactions 132
Total Single Events 1509
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hypermethylation of CpG island. They are ordered first by their pain relevance and then by number of times they were reported for hypermethylation of CpG island. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
2 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
3 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
4 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
5 INT117007 Binding of Oprm1 and Sfpi1 1 0.50 0.07 0.63
6 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
7 INT117006 Sfpi1 Negative_regulation of Oprm1 1 0.39 0.29 0.49
8 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
9 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
10 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
11 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
12 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
13 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
14 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
15 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
16 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
17 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
18 INT121583 Negative_regulation of GSK3A Negative_regulation of Gene_expression of GDF15 1 0.11 0.49 0.2
19 INT307453 Bdnf Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.16 0.18
20 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
21 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
22 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
23 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
24 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
25 INT242881 SPI1 Negative_regulation of Regulation of TLR2 1 0.04 1.13 0.11
26 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
27 INT268634 Ptpn2 Positive_regulation of Positive_regulation of Gsk3b 1 0.02 1.08 0.11
28 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
29 INT268626 Mpz Positive_regulation of Positive_regulation of Gsk3b 1 0.29 1.08 0.11
30 INT32546 Gsk3b Negative_regulation of Localization of Gnrh1 1 0.05 0 0.1
31 INT32547 Gsk3b Negative_regulation of Localization of LH 1 0.04 0 0.1
32 INT268627 Ptpn2 Positive_regulation of Gsk3b 1 0.02 1.7 0.08
33 INT242880 Binding of SPI1 and TLR4 1 0.03 0.24 0.07
34 INT268630 Mpz Positive_regulation of Regulation of Gsk3b 1 0.18 0.57 0.07
35 INT354328 Gsk3b Regulation of Gs 1 0.16 0.84 0.07
36 INT354329 Gsk3b Regulation of Gene_expression of Gs 1 0.16 0.84 0.07
37 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
38 INT307454 Prkcg Regulation of Phosphorylation of Gsk3a 1 0.04 0.13 0.05
39 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
40 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
41 INT293494 Sfpi1 Regulation of Negative_regulation of Hsp90aa1 1 0.04 0.23 0.05
42 INT181814 Gsk3b Regulation of Gata4 1 0.06 0.37 0.05
43 INT193964 Mapk1 Negative_regulation of Gsk3b 1 0.00 0.74 0.05
44 INT307462 Gsk3a Regulation of Ntrk2 1 0.04 0.09 0.04
45 INT307455 Gsk3a Regulation of Bdnf 1 0.06 0.09 0.04
46 INT290810 Gsk3b Regulation of Arntl 1 0.15 0 0.04
47 INT303092 Gsk3b Positive_regulation of NEUROG2 1 0.01 0.16 0.03
48 INT254282 Sfpi1 Positive_regulation of Binding of Pam16 1 0.02 0.23 0.03
49 INT290808 Gsk3b Positive_regulation of Arntl 1 0.25 0.17 0.03
50 INT234981 Binding of Dsg3 and Negative_regulation of Gsk3b 1 0.07 0.3 0.03
51 INT303083 Rorb Regulation of Gsk3b 1 0.00 0.52 0.03
52 INT254285 Sfpi1 Positive_regulation of Gene_expression of THPO 1 0.02 0.17 0.03
53 INT234975 Binding of Dsg3 and Negative_regulation of Gsk3a 1 0.03 0.3 0.03
54 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03
55 INT303079 Gsk3b Positive_regulation of Cebpg 1 0.08 0.16 0.03
56 INT242884 INS Regulation of SPI1 1 0.03 0.3 0.03
57 INT265906 IGF1 Regulation of Gsk3b 1 0.25 1.31 0.03
58 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
59 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
60 INT307458 Ntrk2 Positive_regulation of Phosphorylation of Gsk3a 1 0.05 0 0
61 INT242876 Negative_regulation of Binding of SPI1 and TLR4 1 0.04 0.05 0
62 INT290811 Binding of Mgst1 and Gsk3b 1 0.05 0 0
63 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
64 INT284296 Mir155 Regulation of Spi1 1 0.25 0.36 0
65 INT307457 Negative_regulation of Pik3cb Positive_regulation of Gsk3a 1 0.06 0.08 0
66 INT268628 Mpz Positive_regulation of Phosphorylation of Gsk3b 1 0.25 0.43 0
67 INT293492 Hsp90aa1 Regulation of Gene_expression of Sfpi1 1 0.04 0.1 0
68 INT268635 Mpz Positive_regulation of Gsk3b 1 0.17 0.43 0
69 INT290809 Binding of Arntl and Gsk3b 1 0.20 0 0
70 INT350715 Sfpi1 Positive_regulation of Transcription of MIR424 1 0.09 0.25 0
71 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0
72 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
73 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
74 INT235077 Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.07 0.53 0
75 INT242879 Positive_regulation of Binding of SPI1 and TLR4 1 0.04 0.05 0
76 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
77 INT242885 Binding of POU2F1 and SPI1 1 0.01 0 0
78 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
79 INT307451 Fig4 Regulation of Phosphorylation of Gsk3a 1 0.01 0.06 0
80 INT281610 Positive_regulation of Akt1 Positive_regulation of Gsk3b 1 0.02 0.12 0
81 INT276212 Binding of Akt1 and Gsk3a 1 0.11 0 0
82 INT230713 Binding of Prkcd and Gsk3b 1 0.34 0 0
83 INT191135 Binding of DNMT3A and DNMT3B 1 0.09 0 0
84 INT268632 Mpz Regulation of Gsk3b 1 0.22 0 0
85 INT290806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
86 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0
87 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0
88 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
89 INT350705 Sfpi1 Positive_regulation of Mir223 1 0.04 0.13 0
90 INT307452 Negative_regulation of Pik3cb Positive_regulation of Phosphorylation of Gsk3a 1 0.06 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hypermethylation of CpG island. They are ordered first by their pain relevance and then by number of times they were reported in hypermethylation of CpG island. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
2 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
3 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
4 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22
5 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
6 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29
7 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
8 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61
9 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
10 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
11 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
12 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
13 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
14 INT92000 Gene_expression of Gsk3a 12 0.18 4.12 2.39
15 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
16 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
17 INT117003 Binding of Sfpi1 5 0.47 5.04 1.74
18 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57
19 INT163506 Binding of Gsk3a 4 0.32 1.41 1.31
20 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
21 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
22 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
23 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
24 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1
25 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
26 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92
27 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
28 INT253938 Positive_regulation of Gsk3a 3 0.06 3.4 0.9
29 INT91995 Positive_regulation of Gsk3a 8 0.14 2.84 0.86
30 INT307469 Regulation of Gsk3a 4 0.09 1.12 0.83
31 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
32 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
33 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
34 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
35 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
36 INT242889 Binding of SPI1 15 0.36 7.37 0.69
37 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
38 INT242903 Gene_expression of SPI1 5 0.13 9.68 0.63
39 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
40 INT230679 Positive_regulation of Binding of Gsk3b 3 0.42 1.42 0.58
41 INT151663 Regulation of Gsk3a 3 0.16 1.03 0.54
42 INT208537 Regulation of Gene_expression of Gsk3b 4 0.36 2.15 0.52
43 INT85759 Localization of Gsk3a 3 0.55 0.43 0.52
44 INT163507 Negative_regulation of Phosphorylation of Gsk3a 3 0.51 0.96 0.45
45 INT307472 Regulation of Negative_regulation of Gsk3a 2 0.05 0.83 0.45
46 INT288540 Negative_regulation of Binding of Gsk3b 4 0.53 2.12 0.43
47 INT208552 Negative_regulation of Negative_regulation of Gsk3b 3 0.31 1.8 0.43
48 INT307464 Regulation of Phosphorylation of Gsk3a 1 0.12 0.42 0.43
49 INT235064 Regulation of Positive_regulation of Gsk3b 3 0.41 1.5 0.42
50 INT204012 Regulation of Negative_regulation of Gsk3b 4 0.42 4.51 0.39
51 INT208538 Regulation of Phosphorylation of Gsk3b 3 0.49 4.49 0.38
52 INT181025 Localization of Sfpi1 3 0.80 4.96 0.38
53 INT151662 Negative_regulation of Gsk3a 3 0.15 0.55 0.37
54 INT66364 Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
55 INT80141 Negative_regulation of SPI1 6 0.08 5.44 0.34
56 INT84555 Negative_regulation of Spi1 6 0.42 0.71 0.34
57 INT181020 Positive_regulation of Gene_expression of Sfpi1 2 0.67 1.11 0.31
58 INT181051 Transcription of Sfpi1 1 0.62 1.1 0.29
59 INT268620 Regulation of Localization of Gsk3b 3 0.35 2.12 0.28
60 INT345254 Positive_regulation of Localization of Gsk3b 2 0.01 0.91 0.24
61 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24
62 INT204021 Transcription of Gsk3b 8 0.57 2.75 0.23
63 INT242900 Regulation of SPI1 3 0.26 1.12 0.23
64 INT101308 Positive_regulation of Spi1 2 0.67 0.38 0.23
65 INT268621 Positive_regulation of Localization of Gsk3b 4 0.40 1.54 0.22
66 INT116647 Positive_regulation of Phosphorylation of Gsk3b 1 0.37 0.18 0.22
67 INT181036 Positive_regulation of Sfpi1 3 0.49 0.96 0.21
68 INT121586 Positive_regulation of GSK3A 2 0.23 0.86 0.2
69 INT121585 Negative_regulation of Positive_regulation of GSK3A 1 0.11 0.49 0.2
70 INT101309 Gene_expression of Spi1 2 0.75 0.64 0.18
71 INT101307 Positive_regulation of Gene_expression of Spi1 1 0.67 0.28 0.18
72 INT106451 Regulation of Spi1 1 0.43 0 0.18
73 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
74 INT181033 Regulation of Sfpi1 2 0.40 1.58 0.13
75 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11
76 INT268617 Negative_regulation of Regulation of Gsk3b 3 0.28 1.84 0.11
77 INT289741 Phosphorylation of Gsk3a 1 0.24 0.45 0.11
78 INT91997 Regulation of Gene_expression of Gsk3a 1 0.03 0.56 0.1
79 INT309869 Regulation of Binding of Gsk3b 1 0.12 0.66 0.1
80 INT304667 Positive_regulation of SPI1 2 0.13 4.7 0.09
81 INT312871 Positive_regulation of Transcription of Gsk3b 2 0.29 0.15 0.09
82 INT351182 Positive_regulation of Binding of SPI1 1 0.08 1.25 0.09
83 INT234926 Protein_catabolism of Gsk3b 2 0.58 1.33 0.08
84 INT234906 Positive_regulation of Protein_catabolism of Gsk3b 2 0.33 1.33 0.08
85 INT307465 Positive_regulation of Positive_regulation of Gsk3a 1 0.10 0.24 0.07
86 INT307482 Regulation of Regulation of Gsk3a 1 0.05 0 0.07
87 INT242888 Negative_regulation of Binding of SPI1 1 0.10 0.41 0.06
88 INT242892 Regulation of Binding of SPI1 1 0.08 0.37 0.06
89 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
90 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
91 INT336062 Regulation of Localization of Gsk3b 1 0.03 0.48 0.04
92 INT310472 Negative_regulation of Gene_expression of Sfpi1 1 0.41 0.23 0.03
93 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0
94 INT268625 Regulation of Transcription of Gsk3b 2 0.15 0 0
95 INT322953 Localization of SPI1 2 0.13 2.17 0
96 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0
97 INT284294 Transcription of Spi1 1 0.67 0.36 0
98 INT191158 Transcription of DNMT3A 1 0.32 0.06 0
99 INT284295 Negative_regulation of Gene_expression of Spi1 1 0.41 0.36 0
100 INT191156 Binding of DNMT3A 1 0.16 0 0
101 INT191160 Localization of DNMT3A 1 0.35 0 0
102 INT106452 Negative_regulation of Positive_regulation of Spi1 1 0.30 0 0
103 INT268441 Regulation of Regulation of Gsk3b 1 0.07 0.72 0
104 INT191152 Negative_regulation of Transcription of DNMT3A 1 0.20 0.06 0
105 INT258227 Positive_regulation of Regulation of GSK3A 1 0.15 0 0
106 INT260480 Transcription of Gsk3b 1 0.02 3.08 0
107 INT152449 Regulation of Protein_catabolism of Gsk3b 1 0.12 0.49 0
108 INT351181 Positive_regulation of Gene_expression of SPI1 1 0.10 1.87 0
109 INT258225 Regulation of GSK3A 1 0.09 0 0
110 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
111 INT250466 Regulation of Gene_expression of Sfpi1 1 0.39 0.98 0
112 INT293482 Protein_catabolism of Sfpi1 1 0.09 0.52 0
113 INT307476 Negative_regulation of Gene_expression of Gsk3a 1 0.09 0.06 0
114 INT338263 Regulation of Gene_expression of DNMT3A 1 0.31 0.18 0
115 INT152451 Regulation of Gene_expression of Gsk3b 1 0.12 0.57 0
116 INT152448 Protein_catabolism of Gsk3b 1 0.28 0.49 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox