GO:0045059

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Name positive thymic T cell selection
Categary Process
Go Slim No
Go Link GO:0045059
Unique Molecular Interactions 96
Total Molecular Interactions 135
Total Single Events 1120
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive thymic T cell selection. They are ordered first by their pain relevance and then by number of times they were reported for positive thymic T cell selection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
2 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
3 INT195773 Binding of Cd74 and Mif 2 0.25 2.78 0.55
4 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
5 INT195774 Binding of MIF and Cd74 1 0.02 1.15 0.46
6 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43
7 INT174459 IL8 Positive_regulation of Gene_expression of Cd74 1 0.00 0.61 0.35
8 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
9 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
10 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
11 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19
12 INT182480 Binding of Cd1d1 and Cxcr6 1 0.27 0.25 0.15
13 INT43495 Cd74 Regulation of Gene_expression of Ifng 1 0.47 0 0.14
14 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
15 INT298052 Binding of Cd74 and Vip 1 0.00 1.05 0.13
16 INT87839 Binding of Cd74 and Dcn 1 0.36 0.21 0.13
17 INT180345 Binding of HLA-DMA and HLA-DRB4 1 0.00 1.51 0.12
18 INT277984 Negative_regulation of Epo Positive_regulation of Localization of Ptprc 1 0.02 0.77 0.12
19 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
20 INT253300 Itgam Positive_regulation of Gene_expression of Ptprc 1 0.19 0.11 0.09
21 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
22 INT337084 Negative_regulation of Binding of Cd74 and Mif 1 0.29 1.64 0.08
23 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
24 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
25 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
26 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
27 INT231507 Binding of Ptprc and Tlr4 2 0.21 1.22 0.06
28 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
29 INT236363 Regulation of Binding of Ptprc and Tlr4 1 0.25 1.23 0.06
30 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
31 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
32 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
33 INT348820 Cd74 Regulation of Gene_expression of TFDP3 1 0.07 0.16 0.04
34 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
35 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
36 INT288199 Binding of Ptprc and Trav6-3 1 0.00 0.05 0.03
37 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
38 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
39 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
40 INT236078 Binding of AGER and HLA-DMA 1 0.08 0.81 0
41 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
42 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
43 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
44 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
45 INT194716 Positive_regulation of Binding of VAV1 and ZAP70 1 0.04 0 0
46 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
47 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
48 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
49 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
50 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
51 INT194698 Binding of ZAP70 and LAT 1 0.04 0 0
52 INT296211 Binding of Ptprc and Tg(CAG-EGFP)D4Nagy 1 0.01 0.13 0
53 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
54 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
55 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
56 INT314374 Binding of Ptprc and Thy1 1 0.04 0.85 0
57 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0
58 INT228288 Binding of ENG and Ptprc 1 0.06 0.25 0
59 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
60 INT249850 Binding of Ptprc and Cd34 1 0.13 0.48 0
61 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
62 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
63 INT228285 Binding of Ptprc and Nt5e 1 0.06 0.25 0
64 INT298105 Ca2 Negative_regulation of Cd1d1 1 0.12 0.09 0
65 INT194687 Binding of VAV1 and ZAP70 1 0.03 0 0
66 INT245865 Binding of Cd34 and Ptprc 1 0.04 0 0
67 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
68 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
69 INT194734 ZAP70 Positive_regulation of Binding of VAV1 1 0.05 0 0
70 INT231510 Binding of Ptprc and Gopc 1 0.07 0.17 0
71 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
72 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
73 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
74 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
75 INT180350 Binding of HLA-DMA and ENAM 1 0.00 1.85 0
76 INT314372 Binding of Eng and Ptprc 1 0.04 0.84 0
77 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
78 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive thymic T cell selection. They are ordered first by their pain relevance and then by number of times they were reported in positive thymic T cell selection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT76120 Gene_expression of Ptprc 102 0.59 30.42 7.02
2 INT253970 Positive_regulation of Cd74 3 0.48 8.16 4.09
3 INT79477 Binding of HLA-DMA 19 0.26 13.78 3.47
4 INT187168 Binding of Cd74 13 0.27 11.2 3.44
5 INT174117 Gene_expression of Cd1d1 26 0.75 12.07 3.07
6 INT167039 Gene_expression of Cd74 24 0.40 17.12 2.84
7 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76
8 INT243350 Binding of CD74 2 0.11 4.86 2.72
9 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
10 INT187454 Binding of Ptprc 34 0.38 9.66 2.54
11 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
12 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
13 INT253975 Binding of Cd74 4 0.27 4.57 1.88
14 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
15 INT206528 Negative_regulation of Gene_expression of Ptprc 8 0.34 3.91 1.61
16 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59
17 INT128478 Positive_regulation of Ptprc 26 0.44 8.1 1.45
18 INT271443 Regulation of Cd74 1 0.33 2.73 1.4
19 INT90771 Positive_regulation of Ptprc 20 0.48 8.43 1.27
20 INT206515 Regulation of Gene_expression of Ptprc 6 0.39 3.4 1.22
21 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
22 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
23 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
24 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
25 INT147464 Binding of Ptprc 13 0.36 15.18 0.98
26 INT137807 Binding of Cd1d1 4 0.31 1.26 0.94
27 INT26531 Regulation of Srf 3 0.18 0.62 0.9
28 INT116058 Gene_expression of Cd74 2 0.56 0.55 0.89
29 INT161313 Phosphorylation of ZAP70 2 0.55 0.23 0.88
30 INT174420 Positive_regulation of Gene_expression of Cd74 3 0.20 1.92 0.81
31 INT45293 Transcription of Srf 2 0.47 0.79 0.76
32 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
33 INT116060 Negative_regulation of Gene_expression of Cd74 1 0.12 0 0.61
34 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
35 INT109505 Regulation of Ptprc 3 0.32 2.45 0.58
36 INT271439 Positive_regulation of Localization of Cd74 1 0.36 1.01 0.52
37 INT143131 Regulation of Ptprc 4 0.27 2.56 0.5
38 INT271435 Localization of Cd74 1 0.54 0.95 0.49
39 INT182468 Positive_regulation of Cd1d1 5 0.61 4.08 0.48
40 INT206484 Localization of Shh 2 0.75 1.14 0.46
41 INT174418 Regulation of Gene_expression of Cd74 1 0.04 0.9 0.46
42 INT345935 Regulation of ZAP70 1 0.01 0.41 0.45
43 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
44 INT318784 Gene_expression of ZAP70 2 0.13 1.33 0.44
45 INT254172 Negative_regulation of Gene_expression of Cd74 1 0.24 1.03 0.44
46 INT187463 Positive_regulation of Gene_expression of Ptprc 9 0.44 2.8 0.42
47 INT239036 Positive_regulation of HLA-DMA 4 0.67 1.44 0.4
48 INT174118 Regulation of Gene_expression of Cd1d1 1 0.44 1.42 0.4
49 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
50 INT62874 Gene_expression of CD74 1 0.00 0.64 0.37
51 INT231497 Negative_regulation of Binding of Ptprc 2 0.34 0.99 0.33
52 INT222639 Gene_expression of Cd1d1 2 0.65 0.65 0.32
53 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
54 INT147463 Positive_regulation of Binding of Ptprc 2 0.35 0.95 0.3
55 INT182465 Negative_regulation of Cd1d1 4 0.28 1.72 0.29
56 INT7610 Localization of Srf 3 0.67 0.98 0.27
57 INT3912 Localization of HLA-DMA 2 0.35 1.09 0.27
58 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
59 INT80059 Negative_regulation of Ptprc 8 0.41 1.85 0.25
60 INT187465 Localization of Ptprc 8 0.62 3.71 0.25
61 INT187460 Transcription of Ptprc 2 0.44 0.51 0.25
62 INT174116 Negative_regulation of Gene_expression of Cd1d1 1 0.31 0.51 0.24
63 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
64 INT182453 Positive_regulation of Gene_expression of Cd1d1 6 0.67 1.64 0.21
65 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
66 INT221116 Regulation of HLA-DMA 4 0.05 0.7 0.17
67 INT291908 Negative_regulation of HLA-DMA 1 0.08 0.14 0.17
68 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
69 INT280906 Negative_regulation of Ptprc 2 0.15 2.26 0.16
70 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
71 INT89766 Binding of SRF 1 0.17 0.89 0.15
72 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
73 INT187456 Regulation of Binding of Ptprc 1 0.29 0.51 0.15
74 INT253190 Localization of Shh 2 0.77 1.06 0.13
75 INT175046 Negative_regulation of Gene_expression of Ptprc 2 0.30 0.8 0.13
76 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
77 INT104537 Positive_regulation of ZAP70 2 0.67 0.42 0.12
78 INT131015 Negative_regulation of Cd74 1 0.17 0.25 0.12
79 INT231491 Regulation of Positive_regulation of Ptprc 1 0.35 0.18 0.1
80 INT175042 Localization of Ptprc 2 0.53 1.41 0.09
81 INT231493 Positive_regulation of Binding of Ptprc 1 0.39 0.19 0.09
82 INT270442 Transcription of Shh 1 0.53 0.25 0.09
83 INT298112 Negative_regulation of Cd1d1 1 0.42 0.09 0.09
84 INT213515 Binding of Shh 8 0.37 1.92 0.08
85 INT275437 Binding of ZAP70 1 0.09 0.06 0.08
86 INT270453 Regulation of Shh 1 0.27 0.83 0.08
87 INT291910 Positive_regulation of Gene_expression of HLA-DMA 1 0.10 0.06 0.08
88 INT205973 Binding of SHH 3 0.35 1.03 0.07
89 INT22789 Binding of Srf 1 0.37 0.07 0.07
90 INT256862 Regulation of Shh 1 0.25 0 0.07
91 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
92 INT218004 Regulation of Cd1d1 3 0.44 0.37 0.06
93 INT190544 Transcription of Srf 1 0.19 0.43 0.06
94 INT231501 Negative_regulation of Positive_regulation of Ptprc 1 0.34 0.38 0.06
95 INT190570 Localization of Srf 1 0.20 0.49 0.06
96 INT182470 Negative_regulation of Positive_regulation of Cd1d1 1 0.28 0.1 0.06
97 INT175044 Positive_regulation of Gene_expression of Ptprc 1 0.35 3.61 0.06
98 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
99 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
100 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
101 INT324127 Positive_regulation of Cd74 2 0.07 1.34 0.04
102 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
103 INT268102 Transcription of SRF 1 0.53 0.85 0.03
104 INT225413 Binding of Srf 1 0.10 0.27 0.03
105 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
106 INT253181 Transcription of Shh 1 0.68 0.54 0.03
107 INT157800 Gene_expression of Srf 2 0.45 0.88 0
108 INT231500 Phosphorylation of Ptprc 2 0.33 0.16 0
109 INT194148 Positive_regulation of CD74 2 0.27 0.68 0
110 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
111 INT324126 Negative_regulation of Binding of Cd74 1 0.08 0.31 0
112 INT175043 Regulation of Gene_expression of Ptprc 1 0.36 0.27 0
113 INT178216 Transcription of HLA-DMA 1 0.01 0.97 0
114 INT231492 Protein_catabolism of Ptprc 1 0.52 0.1 0
115 INT182467 Localization of Cd1d1 1 0.48 0.25 0
116 INT249711 Regulation of Regulation of HLA-DMA 1 0.02 0 0
117 INT221120 Regulation of Gene_expression of HLA-DMA 1 0.00 0.62 0
118 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
119 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
120 INT259807 Transcription of Ptprc 1 0.04 0.67 0
121 INT298114 Localization of Cd1d1 1 0.73 0 0
122 INT194783 Positive_regulation of Phosphorylation of ZAP70 1 0.27 0 0
123 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
124 INT324125 Positive_regulation of Binding of Cd74 1 0.09 0.62 0
125 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
126 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
127 INT290929 Binding of Shh 1 0.31 0.1 0
128 INT175045 Positive_regulation of Positive_regulation of Ptprc 1 0.35 1.35 0
129 INT291903 Negative_regulation of Binding of HLA-DMA 1 0.08 0 0
130 INT225408 Negative_regulation of Srf 1 0.05 0.39 0
131 INT157799 Negative_regulation of Gene_expression of Srf 1 0.18 0.07 0
132 INT218005 Phosphorylation of Cd1d1 1 0.05 0.17 0
133 INT218002 Positive_regulation of Cd1d1 1 0.03 0.27 0
134 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
135 INT157794 Phosphorylation of Srf 1 0.26 0.07 0
136 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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