GO:0045064

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Name T-helper 2 cell differentiation
Categary Process
Go Slim No
Go Link GO:0045064
Unique Molecular Interactions 144
Total Molecular Interactions 164
Total Single Events 1543
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for T-helper 2 cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for T-helper 2 cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190772 Il4 Negative_regulation of Gene_expression of Ptger2 1 0.03 1.28 1.49
2 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
3 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
4 INT190775 Gene_expression of Il4 Negative_regulation of Positive_regulation of FOSL1 1 0.39 2.42 1.4
5 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
6 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
7 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99
8 INT129214 RYBP Positive_regulation of Gene_expression of Il4 1 0.01 1.04 0.94
9 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78
10 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77
11 INT150995 Sfpq Positive_regulation of Gene_expression of Il4 1 0.06 0.71 0.74
12 INT209037 Il4 Positive_regulation of Csf2 1 0.03 0.38 0.73
13 INT209038 Il4 Positive_regulation of Ccr1 1 0.01 0.38 0.73
14 INT209058 Il4 Positive_regulation of Elf1 1 0.08 0.38 0.73
15 INT209034 Il4 Positive_regulation of Il17a 1 0.04 0.38 0.73
16 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 0.01 0.84 0.73
17 INT209064 Il4 Positive_regulation of Cxcl1 1 0.05 0.38 0.73
18 INT116020 Positive_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
19 INT116021 Binding of Il4 and Mavs 1 0.02 0.08 0.7
20 INT116019 Negative_regulation of Binding of Il4 and Mavs 1 0.02 0.08 0.7
21 INT325267 Il33 Positive_regulation of Gene_expression of Il4 1 0.16 1.59 0.69
22 INT184120 Il4 Positive_regulation of Stat6 3 0.09 2.39 0.67
23 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6
24 INT151460 Olr1745 Positive_regulation of Il4 1 0.04 0.83 0.59
25 INT228497 Il4 Regulation of Ncoa5 1 0.01 1.24 0.57
26 INT184243 Mthfd1 Negative_regulation of Gene_expression of Il4 1 0.02 0.88 0.56
27 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
28 INT351332 Positive_regulation of Il4 Positive_regulation of Gene_expression of Il10 1 0.09 1.78 0.53
29 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51
30 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
31 INT131364 Bcar3 Positive_regulation of Il4 1 0.00 0.37 0.51
32 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
33 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
34 INT70925 Binding of Ifng and Il4 2 0.14 0.9 0.5
35 INT184099 Il4 Positive_regulation of Stat4 1 0.13 0.28 0.49
36 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48
37 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48
38 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48
39 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48
40 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48
41 INT185067 Bpifa2 Positive_regulation of Il4 1 0.20 0.84 0.48
42 INT296114 Il4 Regulation of Gene_expression of Arg1 1 0.00 0.65 0.46
43 INT147977 Tnf Positive_regulation of Il4 1 0.01 1.12 0.41
44 INT228739 Il4 Positive_regulation of Gene_expression of Ccl17 1 0.14 0.66 0.39
45 INT237417 Il1rn Regulation of Il4 1 0.02 0.96 0.39
46 INT297423 Gene_expression of Il4 Regulation of Ppara 1 0.07 1.19 0.38
47 INT254278 Binding of Il13 and Il4 1 0.02 0.74 0.38
48 INT297425 Il4 Regulation of Ppara 1 0.07 1.17 0.38
49 INT70924 Binding of Il2 and Il4 1 0.07 0.34 0.36
50 INT181438 Il4 Regulation of Gene_expression of Ccl2 1 0.38 0.74 0.35
51 INT151677 Il4 Negative_regulation of Art2a-ps 1 0.00 0.61 0.35
52 INT151680 Il4 Negative_regulation of Oas1b 1 0.07 0.61 0.35
53 INT187818 Gene_expression of Il10 Positive_regulation of Gene_expression of Il4 1 0.09 0.69 0.35
54 INT54504 Pomc Positive_regulation of Gene_expression of Il4 1 0.13 0 0.34
55 INT140183 Il4 Positive_regulation of Gene_expression of Il10 1 0.12 0.73 0.34
56 INT140181 Gene_expression of Il4 Positive_regulation of Gene_expression of Il10 1 0.17 0.73 0.34
57 INT294762 Il4 Regulation of Il13 2 0.09 0.92 0.32
58 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
59 INT297422 Lvs Positive_regulation of Gene_expression of Il4 1 0.04 1.2 0.3
60 INT228734 Rae1 Negative_regulation of Il4 1 0.08 0.68 0.29
61 INT213802 Il4 Regulation of Gene_expression of Insrr 1 0.00 0.76 0.29
62 INT278214 Ciita Regulation of Gene_expression of Il4 1 0.45 1.53 0.28
63 INT185078 Bpifa2 Regulation of Il4 1 0.08 0.4 0.28
64 INT87369 Il4 Positive_regulation of Penk 1 0.37 0 0.28
65 INT251567 Il4 Negative_regulation of Gene_expression of Il10 1 0.01 0.96 0.27
66 INT251581 Il4 Negative_regulation of Gene_expression of TNF 1 0.05 0.95 0.26
67 INT194810 Il4 Regulation of Positive_regulation of Nfatc1 1 0.02 0.15 0.25
68 INT346912 Il6 Positive_regulation of Gene_expression of Il4 1 0.07 0.62 0.24
69 INT215396 Il4 Positive_regulation of Gene_expression of Ppara 1 0.03 0.23 0.23
70 INT186371 Il4 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23
71 INT67085 Penk Positive_regulation of Positive_regulation of Il4 1 0.06 0.08 0.23
72 INT254281 Il4 Negative_regulation of Gene_expression of Acp5 1 0.02 0.41 0.22
73 INT355877 Binding of Hand1 and Il4 1 0.14 0.25 0.22
74 INT284889 Gene_expression of Hand1 Positive_regulation of Gene_expression of Il4 1 0.21 0.4 0.18
75 INT329841 Il4 Regulation of Hand1 1 0.04 0.87 0.18
76 INT185077 Bpifa2 Positive_regulation of Gene_expression of Il4 1 0.15 0.22 0.18
77 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
78 INT266616 Il4 Positive_regulation of Il12a 1 0.01 0.4 0.17
79 INT315491 Hspg2 Negative_regulation of Gene_expression of Il4 1 0.04 0.22 0.17
80 INT261760 Il4 Positive_regulation of Phosphorylation of Stat6 1 0.50 0.48 0.16
81 INT302381 Il33 Regulation of Gene_expression of Il4 1 0.01 0.76 0.16
82 INT194829 Gata3 Positive_regulation of IL13 1 0.01 0.12 0.15
83 INT56596 Pomc Positive_regulation of Localization of Il4 1 0.20 0 0.15
84 INT194835 Gata3 Positive_regulation of IL5 1 0.01 0.12 0.15
85 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15
86 INT194833 Binding of IL5 and Gata3 1 0.01 0.12 0.15
87 INT305846 Polk Positive_regulation of Gene_expression of Il4 1 0.13 0.24 0.15
88 INT194827 Binding of IL13 and Gata3 1 0.01 0.12 0.15
89 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
90 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
91 INT334527 Sema3a Negative_regulation of Gene_expression of Il4 1 0.15 0.48 0.14
92 INT338422 Il4 Positive_regulation of Gtf3a 1 0.00 0.75 0.13
93 INT299262 Dep1 Positive_regulation of Gene_expression of Il4 1 0.03 0.82 0.13
94 INT330370 Positive_regulation of Binding of IL10 and Il4 1 0.01 0.47 0.13
95 INT194383 Il13 Positive_regulation of Gene_expression of Il4 1 0.00 1.75 0.13
96 INT194817 CD28 Positive_regulation of Il4 1 0.15 0.41 0.13
97 INT338428 Il4 Positive_regulation of Gata3 1 0.06 0.75 0.13
98 INT330369 Binding of IL10 and Il4 1 0.01 0.47 0.13
99 INT347017 Cd86 Positive_regulation of Gene_expression of Il4 1 0.03 0 0.13
100 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
101 INT194814 Cd3e Positive_regulation of Gene_expression of Il4 1 0.05 0 0.12
102 INT253078 Prok2 Negative_regulation of Il4 1 0.23 0.08 0.1
103 INT265211 Il4 Negative_regulation of Il23a 1 0.01 0.07 0.1
104 INT155945 Il4 Negative_regulation of Gene_expression of Tgif2 1 0.06 0.15 0.1
105 INT201348 Binding of Il4 and Ik 1 0.01 0.67 0.09
106 INT344427 Il4 Regulation of Gene_expression of Siglec5 1 0.14 0.35 0.09
107 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
108 INT311988 Il4 Positive_regulation of Mthfd1 1 0.08 0.28 0.08
109 INT278218 Hand1 Negative_regulation of Gene_expression of Il4 1 0.20 0.37 0.08
110 INT188361 Il4 Positive_regulation of Socs1 1 0.14 0.15 0.08
111 INT300655 Il4 Positive_regulation of Gene_expression of IFN1@ 1 0.22 0.82 0.08
112 INT194824 Il4 Positive_regulation of MAPK1 1 0.26 0 0.07
113 INT194834 Il4 Positive_regulation of Positive_regulation of MAPK1 1 0.18 0 0.06
114 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
115 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
116 INT194831 CD28 Positive_regulation of Gene_expression of Il4 1 0.15 0 0.06
117 INT228749 Il10 Regulation of Gene_expression of Il4 1 0.11 0.21 0.05
118 INT342042 Il4 Positive_regulation of Gene_expression of Il13 1 0.03 0 0.05
119 INT228763 Il4 Regulation of Gene_expression of Il13 1 0.15 0.21 0.05
120 INT228741 Il13 Regulation of Gene_expression of Il4 1 0.15 0.21 0.05
121 INT228756 Il5 Regulation of Gene_expression of Il4 1 0.13 0.21 0.05
122 INT228755 Il4 Regulation of Gene_expression of Il5 1 0.13 0.21 0.05
123 INT294765 Negative_regulation of Serpinb1-ps1 Positive_regulation of Il4 1 0.02 0.24 0.05
124 INT347016 Cd86 Regulation of Gene_expression of Il4 1 0.03 0.19 0.04
125 INT344430 Il4 Positive_regulation of Siglec5 1 0.23 0 0.04
126 INT344432 Il4 Positive_regulation of Gene_expression of Siglec5 1 0.32 0 0.04
127 INT186359 Stat6 Negative_regulation of Il4 1 0.06 0.78 0.04
128 INT186362 Il4 Negative_regulation of Transcription of Nos2 1 0.04 0.77 0.04
129 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
130 INT294759 Serpinb1-ps1 Positive_regulation of Il4 1 0.02 0.24 0.04
131 INT329973 Il4 Regulation of Gene_expression of Hspb8 1 0.00 0.68 0.03
132 INT186384 Il4 Negative_regulation of Gene_expression of IFNA1 1 0.01 0.48 0.03
133 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03
134 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
135 INT347013 Il4 Regulation of Gene_expression of Cd86 1 0.02 0.07 0
136 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
137 INT270204 TNF Positive_regulation of Il4 1 0.01 0.53 0
138 INT305852 Polk Positive_regulation of Positive_regulation of Il4 1 0.13 0.08 0
139 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.94 0
140 INT184093 Negative_regulation of Il4 Positive_regulation of Stat6 1 0.08 0.93 0
141 INT278207 Ciita Negative_regulation of Transcription of Il4 1 0.31 0.79 0
142 INT304174 Binding of IL1B and Il4 1 0.00 0.96 0
143 INT134561 Cpe Negative_regulation of Gene_expression of Il4 1 0.11 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for T-helper 2 cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in T-helper 2 cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12
2 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42
3 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4
4 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75
5 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34
6 INT20379 Localization of Il4 85 0.73 51.22 20.55
7 INT69303 Positive_regulation of Gene_expression of Il4 27 0.68 20.01 14.8
8 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15
9 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42
10 INT49884 Negative_regulation of Gene_expression of Il4 18 0.55 14.06 8.9
11 INT79693 Regulation of Il4 30 0.51 21.96 8.6
12 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54
13 INT50040 Localization of Il4 15 0.67 8.26 7.69
14 INT51741 Regulation of Gene_expression of Il4 23 0.36 12.7 7.39
15 INT58484 Regulation of Il4 12 0.45 8.67 6.09
16 INT67397 Transcription of Il4 15 0.54 11.36 6.06
17 INT67228 Regulation of Gene_expression of Il4 11 0.50 6.67 5.2
18 INT116011 Positive_regulation of Gata3 5 0.31 3.17 4.21
19 INT56594 Positive_regulation of Localization of Il4 17 0.48 10.17 4.15
20 INT202417 Gene_expression of Gata3 16 0.61 7.84 4.12
21 INT62497 Binding of Il4 7 0.26 4.19 3.88
22 INT92200 Negative_regulation of Localization of Il4 10 0.51 5.66 3.65
23 INT70919 Binding of Il4 19 0.36 6.58 3.59
24 INT97438 Transcription of Il4 17 0.67 9.17 3.4
25 INT202419 Positive_regulation of Gene_expression of Gata3 6 0.52 5.47 2.6
26 INT157049 Regulation of Localization of Il4 2 0.25 1.46 2.33
27 INT92119 Negative_regulation of Positive_regulation of Il4 3 0.14 1.88 2.2
28 INT76417 Positive_regulation of Positive_regulation of Il4 3 0.09 0.34 1.7
29 INT97434 Positive_regulation of Positive_regulation of Il4 8 0.40 3.51 1.66
30 INT184241 Regulation of Localization of Il4 4 0.15 3.89 1.58
31 INT118400 Positive_regulation of Transcription of Il4 2 0.35 1.78 1.53
32 INT116014 Transcription of Gata3 4 0.63 2.24 1.46
33 INT116015 Regulation of Gata3 3 0.22 1.41 1.42
34 INT116008 Binding of Gata3 2 0.34 1.37 1.41
35 INT116016 Positive_regulation of Positive_regulation of Gata3 2 0.21 0.5 1.28
36 INT147976 Regulation of Positive_regulation of Il4 2 0.32 2.25 1.23
37 INT59319 Negative_regulation of Positive_regulation of Il4 6 0.57 3.48 1.17
38 INT116012 Regulation of Positive_regulation of Gata3 1 0.20 0.07 0.71
39 INT116006 Positive_regulation of Transcription of Gata3 1 0.21 0.07 0.7
40 INT116010 Positive_regulation of Binding of Gata3 1 0.31 0.07 0.7
41 INT202416 Negative_regulation of Gata3 2 0.32 1.17 0.64
42 INT290660 Negative_regulation of Gene_expression of Gata3 1 0.25 1.52 0.6
43 INT186292 Positive_regulation of Negative_regulation of Il4 3 0.14 1.57 0.58
44 INT82425 Positive_regulation of Localization of Il4 1 0.45 0.69 0.58
45 INT237765 Phosphorylation of Il4 3 0.33 1.28 0.51
46 INT177622 Negative_regulation of Localization of Il4 2 0.03 1.42 0.42
47 INT97436 Positive_regulation of Transcription of Il4 3 0.51 1.8 0.38
48 INT335847 Positive_regulation of Phosphorylation of Il4 1 0.17 0.85 0.32
49 INT278194 Protein_catabolism of Il4 2 0.57 1.12 0.3
50 INT67400 Negative_regulation of Transcription of Il4 1 0.04 1.71 0.29
51 INT97435 Regulation of Transcription of Il4 2 0.45 0.32 0.18
52 INT194746 Phosphorylation of Gata3 1 0.10 0.08 0.12
53 INT307233 Localization of BCL3 1 0.19 0.84 0.11
54 INT278201 Negative_regulation of Transcription of Il4 1 0.27 0.28 0.08
55 INT338402 Regulation of Positive_regulation of Il4 1 0.19 0.53 0.07
56 INT307236 Negative_regulation of Localization of BCL3 1 0.10 0.33 0.05
57 INT298029 Positive_regulation of Regulation of Il4 1 0.15 0.39 0.04
58 INT307232 Negative_regulation of BCL3 1 0.09 0.24 0
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