GO:0045070

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Name positive regulation of viral genome replication
Categary Process
Go Slim No
Go Link GO:0045070
Unique Molecular Interactions 100
Total Molecular Interactions 166
Total Single Events 763
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of viral genome replication. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of viral genome replication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
2 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
3 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
4 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
5 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
6 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
7 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
8 INT142661 Binding of IFIT1 and NPY2R 1 0.00 2.49 1.08
9 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92
10 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
11 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
12 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
13 INT149493 PNOC Negative_regulation of CCL5 1 0.14 0.16 0.77
14 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
15 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
16 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
17 INT98951 Positive_regulation of Binding of NR5A2 and SP3 1 0.00 0 0.7
18 INT98957 Binding of NR5A2 and SP3 1 0.00 0 0.7
19 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
20 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59
21 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5
22 INT171278 TNFSF12 Positive_regulation of CCL5 1 0.02 0.93 0.48
23 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45
24 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
25 INT188572 CD14 Regulation of Gene_expression of CD28 1 0.11 0.6 0.4
26 INT316830 TNF Regulation of CCL5 1 0.02 1.02 0.39
27 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34
28 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32
29 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32
30 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
31 INT103279 PGR Negative_regulation of Gene_expression of CCL5 1 0.32 0.31 0.27
32 INT266802 Dlst Positive_regulation of CCL5 1 0.00 0.95 0.25
33 INT252815 Binding of CCL5 and TNF 1 0.02 0.75 0.25
34 INT80286 IFNG Positive_regulation of Gene_expression of CCL5 1 0.24 0.37 0.23
35 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23
36 INT80287 IL4 Positive_regulation of Gene_expression of CCL5 1 0.21 0.37 0.23
37 INT196635 CFTR Positive_regulation of Gene_expression of CCL5 1 0.07 0.44 0.21
38 INT295713 PTGER2 Positive_regulation of Regulation of CCL5 1 0.01 0.82 0.21
39 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19
40 INT188568 Negative_regulation of IRF6 Positive_regulation of CD28 1 0.05 0.19 0.19
41 INT217528 Binding of Tjp1 and Vapb 1 0.00 1.6 0.19
42 INT171127 Binding of CD28 and IFN1@ 1 0.39 0.36 0.19
43 INT170995 Binding of IFNA1 and Positive_regulation of Localization of CCL5 1 0.03 0.34 0.19
44 INT188571 IRF6 Positive_regulation of CD28 1 0.06 0.19 0.19
45 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
46 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18
47 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
48 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18
49 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
50 INT146552 Kcnab3 Positive_regulation of Nr5a2 1 0.07 0 0.17
51 INT329795 IL6 Positive_regulation of Transcription of CCL5 1 0.02 0.59 0.17
52 INT194700 CD28 Positive_regulation of MAPK1 1 0.10 0.55 0.16
53 INT194817 CD28 Positive_regulation of Il4 1 0.15 0.41 0.13
54 INT194717 CD28 Positive_regulation of IL13 1 0.03 0.41 0.13
55 INT171295 CXCL10 Positive_regulation of CCL5 1 0.04 0.06 0.12
56 INT190246 TARBP2 Positive_regulation of PKLR 1 0.01 0.41 0.1
57 INT62201 Binding of NR5A2 and Hsf1 1 0.00 0.67 0.09
58 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09
59 INT194674 CD28 Negative_regulation of Gene_expression of IL13 1 0.02 0.06 0.08
60 INT270201 Binding of CD28 and Cd86 1 0.10 0.58 0.08
61 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
62 INT270202 Binding of CD28 and Cd80 1 0.09 0.58 0.08
63 INT171297 TNF Positive_regulation of Localization of CCL5 1 0.17 0.66 0.07
64 INT194831 CD28 Positive_regulation of Gene_expression of Il4 1 0.15 0 0.06
65 INT190247 TARBP2 Negative_regulation of PKLR 1 0.01 0.2 0.05
66 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04
67 INT144220 Nr5a2 Regulation of LOC682801 1 0.00 0.07 0.04
68 INT144223 B4galt4 Regulation of Nr5a2 1 0.00 0.07 0.04
69 INT171279 IL6 Positive_regulation of CCL5 1 0.04 0.38 0.04
70 INT295854 Srpk2 Regulation of Localization of Srsf1 1 0.21 0 0.04
71 INT171301 TNF Positive_regulation of CCL5 1 0.16 0.38 0.04
72 INT288007 Binding of CD28 and CD40 1 0.05 0.51 0.03
73 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.03
74 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0
75 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0
76 INT225644 Binding of TARBP2 and Acp5 1 0.04 0.15 0
77 INT264683 Binding of VAPB and ALS2 1 0.29 1.1 0
78 INT127690 TNF Positive_regulation of Regulation of CCL5 1 0.33 0.17 0
79 INT225613 TARBP2 Positive_regulation of Prkdc 1 0.00 0 0
80 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0
81 INT171282 TNFSF12 Positive_regulation of Gene_expression of CCL5 1 0.01 0 0
82 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0
83 INT295870 Gene_expression of Srpk1 Negative_regulation of VEGFA 1 0.11 0 0
84 INT277811 Binding of CD28 and DCPS 1 0.04 0.05 0
85 INT225643 Binding of TARBP2 and Acsl1 1 0.00 0 0
86 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
87 INT276759 ABCB1 Regulation of TOP2A 1 0.04 0.61 0
88 INT109170 Abat Positive_regulation of Nr5a2 1 0.03 0 0
89 INT295871 Binding of RNPS1 and Srpk2 1 0.01 0.76 0
90 INT109171 Abat Positive_regulation of Phosphorylation of Nr5a2 1 0.03 0 0
91 INT225634 Binding of TARBP2 and MED23 1 0.04 0.15 0
92 INT305543 Binding of Top2a and Trp53 1 0.37 0.91 0
93 INT298864 VAPB Regulation of Negative_regulation of RAB7A 1 0.32 0.32 0
94 INT225618 TARBP2 Positive_regulation of gr 1 0.01 0 0
95 INT264682 Binding of VAPB and SETX 1 0.28 1.09 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of viral genome replication. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of viral genome replication. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
2 INT78901 Localization of CCL5 67 0.78 40.79 20.59
3 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
4 INT4240 Positive_regulation of CCL5 32 0.58 20.55 10.65
5 INT78895 Regulation of CCL5 30 0.46 20.45 10.18
6 INT73504 Binding of CD28 35 0.45 15.99 10.04
7 INT87495 Positive_regulation of Gene_expression of CCL5 26 0.69 13.85 9.46
8 INT92470 Negative_regulation of Gene_expression of CCL5 15 0.50 5.46 5.86
9 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27
10 INT4239 Negative_regulation of CCL5 15 0.40 10.92 4.26
11 INT103281 Transcription of CCL5 10 0.67 5.95 3.7
12 INT91929 Gene_expression of Nr5a2 5 0.31 2.15 3.52
13 INT124123 Positive_regulation of Localization of CCL5 12 0.67 7 3.37
14 INT78898 Regulation of Gene_expression of CCL5 9 0.42 5.7 3.11
15 INT194661 Binding of CCL5 9 0.46 6.07 2.73
16 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65
17 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28
18 INT174511 Positive_regulation of Gene_expression of CD28 7 0.41 4.31 1.83
19 INT194660 Positive_regulation of Binding of CCL5 1 0.42 2.74 1.72
20 INT78896 Negative_regulation of Localization of CCL5 8 0.57 2.43 1.59
21 INT171015 Positive_regulation of Positive_regulation of CCL5 3 0.42 3.63 1.51
22 INT171133 Localization of CD28 8 0.71 3.42 1.48
23 INT103285 Regulation of Localization of CCL5 3 0.44 1.11 0.89
24 INT279357 Regulation of Binding of CD28 1 0.18 0.3 0.72
25 INT126646 Negative_regulation of Gene_expression of Nr5a2 1 0.20 0.1 0.71
26 INT262118 Negative_regulation of Binding of Nr5a2 1 0.07 0.36 0.7
27 INT262041 Binding of Nr5a2 1 0.06 0.35 0.7
28 INT188586 Negative_regulation of Gene_expression of CD28 6 0.34 1.9 0.69
29 INT142662 Binding of IFIT1 2 0.02 2.26 0.66
30 INT83217 Positive_regulation of Nr5a2 3 0.16 0 0.49
31 INT109162 Negative_regulation of Nr5a2 2 0.15 0.12 0.47
32 INT194658 Positive_regulation of Transcription of CCL5 1 0.45 0.68 0.44
33 INT267606 Protein_catabolism of CCL5 2 0.48 1.39 0.43
34 INT270195 Positive_regulation of Positive_regulation of CD28 1 0.25 2.49 0.41
35 INT174476 Regulation of CD28 3 0.34 0.67 0.37
36 INT156401 Regulation of NR5A2 1 0.00 1.06 0.36
37 INT195733 Phosphorylation of CCL5 2 0.10 1.04 0.33
38 INT188577 Transcription of CD28 1 0.43 0.54 0.32
39 INT188583 Regulation of Transcription of CD28 1 0.22 0.54 0.32
40 INT103283 Negative_regulation of Transcription of CCL5 1 0.50 0.28 0.27
41 INT171131 Protein_catabolism of CD28 1 0.73 0.47 0.27
42 INT278163 Negative_regulation of Localization of CD28 1 0.08 0.87 0.26
43 INT303626 Positive_regulation of IFIT1 1 0.02 1.59 0.23
44 INT282377 Regulation of Positive_regulation of CCL5 1 0.05 1.12 0.22
45 INT118614 Regulation of IFIT1 1 0.00 0.38 0.21
46 INT346978 Negative_regulation of IFIT1 1 0.13 1.83 0.17
47 INT184997 Gene_expression of TOP2A 6 0.63 1.65 0.15
48 INT195730 Negative_regulation of Binding of CCL5 1 0.05 0.51 0.13
49 INT96222 Gene_expression of NR5A2 1 0.00 0.51 0.13
50 INT96220 Positive_regulation of Gene_expression of NR5A2 1 0.00 0.51 0.13
51 INT295848 Negative_regulation of Srpk1 1 0.35 0.63 0.1
52 INT96221 Positive_regulation of NR5A2 1 0.00 0.36 0.08
53 INT268846 Negative_regulation of Top2a 6 0.29 3.06 0.07
54 INT258473 Binding of TOP2A 3 0.05 1.65 0.05
55 INT295824 Positive_regulation of Gene_expression of Srpk1 1 0.41 0.39 0.05
56 INT295851 Gene_expression of Srpk1 1 0.46 1.72 0.05
57 INT243812 Binding of Nr5a2 1 0.05 0 0.05
58 INT276004 Localization of Vapb 1 0.04 0 0.03
59 INT276019 Binding of Vapb 1 0.03 0 0.03
60 INT295837 Phosphorylation of Srpk1 1 0.49 0.55 0.03
61 INT235686 Gene_expression of Top2a 5 0.60 4.34 0
62 INT118827 Regulation of TOP2A 4 0.04 1.75 0
63 INT36301 Negative_regulation of TOP2A 3 0.57 2.66 0
64 INT268847 Binding of Top2a 2 0.24 0.6 0
65 INT323996 Localization of IFIT1 1 0.56 0.37 0
66 INT295842 Phosphorylation of Srpk2 1 0.38 0.42 0
67 INT295833 Localization of Srpk1 1 0.42 0 0
68 INT295823 Regulation of Positive_regulation of Srpk1 1 0.27 0 0
69 INT295828 Positive_regulation of Gene_expression of Srpk2 1 0.32 1.93 0
70 INT303646 Gene_expression of IFIT1 1 0.03 0.97 0
71 INT308260 Positive_regulation of TOP2A 1 0.03 0.58 0
72 INT303642 Positive_regulation of Positive_regulation of IFIT1 1 0.02 0.55 0
73 INT295853 Negative_regulation of Gene_expression of Srpk2 1 0.20 0 0
74 INT256916 Regulation of Gene_expression of Top2a 1 0.47 1.2 0
75 INT295829 Positive_regulation of Localization of Srpk1 1 0.28 0 0
76 INT295830 Positive_regulation of Positive_regulation of Srpk1 1 0.41 0 0
77 INT239664 Positive_regulation of Gene_expression of TOP2A 1 0.01 0.1 0
78 INT295819 Negative_regulation of Gene_expression of Srpk1 1 0.25 0 0
79 INT109168 Positive_regulation of Phosphorylation of Nr5a2 1 0.20 0 0
80 INT256921 Regulation of Top2a 1 0.21 1.28 0
81 INT225465 Transcription of TARBP2 1 0.08 0.13 0
82 INT295839 Binding of Srpk1 1 0.22 1.2 0
83 INT264194 Positive_regulation of Binding of CD28 1 0.23 0.22 0
84 INT268845 Positive_regulation of Binding of Top2a 1 0.05 0.33 0
85 INT273508 Negative_regulation of Gene_expression of Top2a 1 0.21 0.17 0
86 INT355320 Gene_expression of Vapb 1 0.03 0.52 0
87 INT225458 Phosphorylation of TARBP2 1 0.09 0 0
88 INT295834 Positive_regulation of Srpk1 1 0.41 0 0
89 INT295827 Gene_expression of Srpk2 1 0.36 1.25 0
90 INT303645 Positive_regulation of Gene_expression of IFIT1 1 0.02 0.97 0
91 INT225459 Binding of TARBP2 1 0.05 0 0
92 INT225461 Negative_regulation of TARBP2 1 0.06 0 0
93 INT270194 Regulation of Gene_expression of CD28 1 0.22 1.1 0
94 INT109166 Phosphorylation of Nr5a2 1 0.32 0 0
95 INT295838 Positive_regulation of Phosphorylation of Srpk1 1 0.30 0.26 0
96 INT295821 Binding of Srpk2 1 0.22 0.75 0
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