GO:0045086

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Name positive regulation of interleukin-2 biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045086
Unique Molecular Interactions 964
Total Molecular Interactions 1514
Total Single Events 8599
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-2 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of interleukin-2 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
2 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
3 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
4 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
5 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
6 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
7 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
8 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
9 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
10 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
11 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
12 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
13 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
14 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
15 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
16 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
17 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
18 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
19 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
20 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
21 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
22 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
23 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
24 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
25 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
26 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
27 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
28 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
29 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
30 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
31 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
32 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
33 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
34 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
35 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
36 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
37 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
38 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
39 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
40 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
41 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
42 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
43 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
44 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
45 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
46 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
47 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
48 INT8409 IL1A Positive_regulation of Positive_regulation of Vip 1 0.01 0.63 1.27
49 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
50 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
51 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
52 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
53 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
54 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
55 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
56 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
57 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
58 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
59 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
60 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
61 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
62 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
63 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
64 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
65 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
66 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
67 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
68 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
69 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
70 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
71 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
72 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
73 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
74 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05
75 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
76 INT8410 IL1A Positive_regulation of Vip 1 0.02 0.68 1.05
77 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
78 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
79 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
80 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
81 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
82 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
83 INT103928 Binding of Cd28 and Trav6-3 3 0.03 0.55 0.98
84 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
85 INT69307 Prkcq Negative_regulation of TH1L 1 0.00 0.98 0.98
86 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
87 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
88 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
89 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
90 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
91 INT265210 Binding of Ctla4 and Cd28 2 0.16 1.45 0.93
92 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
93 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
94 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
95 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
96 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
97 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
98 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
99 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
100 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
101 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
102 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
103 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
104 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
105 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
106 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
107 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
108 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
109 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
110 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
111 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
112 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
113 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
114 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
115 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
116 INT237204 Binding of LGALS4 and Cd3e 1 0.15 2.61 0.8
117 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
118 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
119 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
120 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
121 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
122 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
123 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
124 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
125 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
126 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
127 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
128 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
129 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
130 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
131 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
132 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
133 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
134 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
135 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
136 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
137 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
138 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
139 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
140 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
141 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
142 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
143 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
144 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
145 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
146 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
147 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
148 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
149 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
150 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
151 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
152 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
153 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
154 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
155 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63
156 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63
157 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
158 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
159 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
160 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
161 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
162 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
163 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
164 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
165 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
166 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
167 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
168 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61
169 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
170 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
171 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
172 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
173 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
174 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
175 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
176 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
177 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
178 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59
179 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59
180 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
181 INT96240 Il13 Negative_regulation of Il1b 1 0.17 0.6 0.59
182 INT96242 Il13 Negative_regulation of Gene_expression of Il1b 1 0.15 0.67 0.59
183 INT73073 Binding of Cd3e and Oprk1 1 0.28 0.06 0.59
184 INT128603 Il1b Positive_regulation of Gene_expression of Fos 1 0.50 0.59 0.58
185 INT58342 Calca Negative_regulation of Localization of IL1B 1 0.00 0.6 0.58
186 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
187 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57
188 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57
189 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
190 INT60665 Il1b Regulation of Oprd1 1 0.05 0 0.57
191 INT58805 Il1b Negative_regulation of LH 1 0.24 0 0.56
192 INT182348 Binding of Cd3e and Crp 1 0.15 2.33 0.56
193 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
194 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
195 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
196 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
197 INT249624 Negative_regulation of Binding of CD86 and CTLA4 1 0.47 0.57 0.55
198 INT80752 Binding of Il1b and El4 1 0.49 0.08 0.54
199 INT134488 Il1b Regulation of Oxt 1 0.30 0.08 0.54
200 INT80751 Negative_regulation of Binding of Il1b and El4 1 0.60 0.08 0.54

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-2 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of interleukin-2 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
3 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
4 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
5 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
6 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
7 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
8 INT6849 Localization of IL1B 229 0.81 112.56 69.63
9 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
10 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
11 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
12 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
13 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
14 INT6484 Binding of IL1B 122 0.47 75.84 35.07
15 INT9347 Localization of Il1b 58 0.81 26.13 31.53
16 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
17 INT5966 Localization of Il1a 50 0.78 22.91 26.54
18 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
19 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
20 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
21 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
22 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
23 INT48081 Localization of Il1b 46 0.80 21.59 22.4
24 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
25 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
26 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19
27 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
28 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
29 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
30 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
31 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21
32 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
33 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
34 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
35 INT132178 Binding of CD80 41 0.47 15.55 12.98
36 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
37 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
38 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
39 INT36287 Binding of CD4 96 0.47 58.93 11.88
40 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
41 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36
42 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
43 INT16404 Regulation of CD4 54 0.61 33.05 10.29
44 INT73504 Binding of CD28 35 0.45 15.99 10.04
45 INT19620 Binding of CD86 30 0.47 12.01 9.89
46 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
47 INT15768 Gene_expression of Il1a 20 0.71 9.31 8.78
48 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
49 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75
50 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74
51 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
52 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
53 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57
54 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
55 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
56 INT17049 Localization of CD4 57 0.75 35.33 6.89
57 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
58 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
59 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
60 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
61 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
62 INT23034 Positive_regulation of Il1a 15 0.70 8.75 6.29
63 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
64 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
65 INT80750 Binding of Il1b 11 0.47 7.97 5.95
66 INT58468 Negative_regulation of Gene_expression of IL1A 10 0.58 9.39 5.57
67 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
68 INT10705 Binding of Il1b 9 0.36 2.8 5.53
69 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
70 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
71 INT69310 Negative_regulation of IL1A 10 0.43 7.83 5.05
72 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
73 INT50309 Binding of Il1a 22 0.40 5.4 4.49
74 INT59083 Positive_regulation of Gene_expression of IL1A 11 0.70 9.09 4.48
75 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
76 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27
77 INT23035 Regulation of Il1a 6 0.60 5.69 4.25
78 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
79 INT15462 Negative_regulation of Il1a 4 0.59 4.68 4.17
80 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
81 INT19189 Localization of IL1A 14 0.78 9.02 3.78
82 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
83 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41
84 INT188355 Binding of Cd28 25 0.34 8.29 3.38
85 INT36286 Binding of Cd3e 33 0.36 10.11 3.21
86 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
87 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
88 INT174117 Gene_expression of Cd1d1 26 0.75 12.07 3.07
89 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86
90 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
91 INT16447 Binding of IL1A 10 0.45 4.01 2.78
92 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
93 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
94 INT75685 Regulation of CD86 12 0.58 3.55 2.66
95 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65
96 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
97 INT19621 Positive_regulation of CD86 23 0.69 14 2.58
98 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
99 INT63846 Gene_expression of Prkcq 1 0.73 1.11 2.58
100 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
101 INT49984 Localization of Il1a 5 0.77 3.61 2.42
102 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42
103 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28
104 INT172078 Localization of Cd3e 22 0.37 9.88 2.27
105 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
106 INT150884 Transcription of Il1a 6 0.47 3.12 2.19
107 INT97134 Negative_regulation of CD80 8 0.57 5.09 2.11
108 INT49988 Positive_regulation of Gene_expression of Il1a 2 0.47 1.49 2.11
109 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
110 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
111 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
112 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
113 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
114 INT93912 Positive_regulation of CD80 11 0.56 7.01 1.88
115 INT174511 Positive_regulation of Gene_expression of CD28 7 0.41 4.31 1.83
116 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
117 INT19617 Negative_regulation of CD86 12 0.42 3.68 1.77
118 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
119 INT147636 Regulation of CD80 3 0.60 1.27 1.73
120 INT89926 Regulation of IL1A 10 0.60 7.12 1.72
121 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
122 INT209896 Positive_regulation of Gene_expression of CD80 19 0.49 11.9 1.59
123 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
124 INT209959 Negative_regulation of Binding of CD80 3 0.42 0.9 1.52
125 INT171133 Localization of CD28 8 0.71 3.42 1.48
126 INT49987 Transcription of Il1a 1 0.68 0.66 1.4
127 INT174486 Regulation of Gene_expression of CD4 12 0.36 6.09 1.39
128 INT94126 Positive_regulation of Cd28 9 0.50 4.23 1.33
129 INT70954 Negative_regulation of Cd3e 11 0.41 4.22 1.31
130 INT129253 Positive_regulation of Positive_regulation of Il1a 5 0.49 2.97 1.31
131 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
132 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
133 INT162757 Regulation of Localization of Il1a 3 0.37 1.22 1.25
134 INT63849 Regulation of Gene_expression of Prkcq 1 0.58 0.62 1.24
135 INT63847 Regulation of Prkcq 1 0.42 0.5 1.23
136 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
137 INT174557 Negative_regulation of Gene_expression of Cd28 7 0.43 4.42 1.2
138 INT59082 Regulation of Gene_expression of IL1A 3 0.45 2.07 1.2
139 INT63856 Positive_regulation of Gene_expression of Prkcq 1 0.47 0.53 1.16
140 INT174550 Negative_regulation of Cd28 7 0.33 4.7 1.06
141 INT9348 Regulation of Localization of Il1b 2 0.27 0.14 1.04
142 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02
143 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02
144 INT138543 Negative_regulation of Cd28 3 0.11 2.1 1.01
145 INT346201 Negative_regulation of Phosphorylation of IL1B 1 0.20 1.69 1.01
146 INT53571 Negative_regulation of Localization of Il1a 2 0.50 1.59 0.99
147 INT190077 Regulation of Transcription of Il1a 2 0.02 0.87 0.99
148 INT16446 Transcription of IL1A 4 0.69 1.76 0.96
149 INT264171 Positive_regulation of Positive_regulation of CD4 5 0.49 4.74 0.94
150 INT137807 Binding of Cd1d1 4 0.31 1.26 0.94
151 INT168280 Positive_regulation of Phosphorylation of Il1b 1 0.49 1.1 0.93
152 INT344365 Phosphorylation of Il1a 1 0.61 1.01 0.92
153 INT89669 Negative_regulation of Positive_regulation of Prkcq 1 0.08 0.23 0.87
154 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
155 INT89668 Positive_regulation of Prkcq 1 0.09 0.22 0.86
156 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
157 INT209958 Negative_regulation of Binding of CD86 1 0.40 0.28 0.85
158 INT147634 Regulation of Cd28 2 0.44 3.23 0.82
159 INT167942 Binding of Stat5b 1 0.26 0 0.82
160 INT83454 Positive_regulation of Negative_regulation of IL1A 1 0.50 0.62 0.81
161 INT189171 Positive_regulation of Localization of CD4 7 0.49 5.88 0.79
162 INT23033 Negative_regulation of Positive_regulation of Il1a 2 0.42 0.76 0.78
163 INT174492 Positive_regulation of Gene_expression of Cd3e 8 0.39 5.08 0.77
164 INT149698 Negative_regulation of Binding of Cd28 2 0.15 1.21 0.75
165 INT149697 Binding of Cd28 2 0.12 1.16 0.74
166 INT53576 Regulation of Gene_expression of Il1a 2 0.41 0.6 0.73
167 INT127822 Negative_regulation of Transcription of Il1b 2 0.42 1.2 0.72
168 INT279357 Regulation of Binding of CD28 1 0.18 0.3 0.72
169 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69
170 INT188586 Negative_regulation of Gene_expression of CD28 6 0.34 1.9 0.69
171 INT83453 Negative_regulation of Localization of IL1A 1 0.43 0.39 0.69
172 INT202428 Positive_regulation of Binding of CD4 4 0.37 2.11 0.68
173 INT265207 Positive_regulation of Gene_expression of Cd28 3 0.43 1.47 0.66
174 INT292526 Negative_regulation of Negative_regulation of Il1a 1 0.05 0.87 0.66
175 INT89812 Negative_regulation of Gene_expression of Il1a 1 0.24 0.58 0.66
176 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
177 INT329718 Transcription of Cd28 1 0.09 1.54 0.63
178 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
179 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
180 INT155485 Regulation of Gene_expression of CD86 7 0.61 3.73 0.6
181 INT93728 Gene_expression of Cd28 8 0.35 7.11 0.59
182 INT83618 Regulation of Positive_regulation of Il1b 2 0.44 1.04 0.58
183 INT81352 Negative_regulation of Regulation of IL1B 2 0.41 0.51 0.58
184 INT174556 Regulation of Gene_expression of Cd28 3 0.42 2.9 0.57
185 INT202427 Negative_regulation of Localization of CD4 2 0.32 3.1 0.56
186 INT89813 Positive_regulation of Localization of Il1a 1 0.28 0.47 0.55
187 INT147635 Regulation of Positive_regulation of CD80 1 0.44 0.38 0.53
188 INT147456 Negative_regulation of Positive_regulation of CD80 2 0.41 1.32 0.5
189 INT202426 Transcription of CD4 6 0.69 3.96 0.49
190 INT250838 Protein_catabolism of Il1a 1 0.13 1.16 0.49
191 INT182468 Positive_regulation of Cd1d1 5 0.61 4.08 0.48
192 INT172077 Positive_regulation of Localization of Cd3e 3 0.09 3.18 0.47
193 INT155265 Regulation of Cd3e 7 0.17 2.62 0.46
194 INT260119 Regulation of Localization of CD4 2 0.44 1.61 0.46
195 INT63850 Negative_regulation of Prkcq 1 0.40 0 0.46
196 INT200258 Binding of Irf4 2 0.21 0.43 0.43
197 INT250843 Negative_regulation of Protein_catabolism of Il1a 1 0.06 0.9 0.43
198 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
199 INT270195 Positive_regulation of Positive_regulation of CD28 1 0.25 2.49 0.41
200 INT260118 Regulation of Regulation of CD4 1 0.44 1.66 0.4
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