GO:0045087

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Name innate immune response
Categary Process
Go Slim No
Go Link GO:0045087
Unique Molecular Interactions 3516
Total Molecular Interactions 5020
Total Single Events 33713
Pain Genes Associated 267

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for innate immune response. They are ordered first by their pain relevance and then by number of times they were reported for innate immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
2 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
3 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
4 INT164362 Binding of NLRP1 and VTA1 1 0.15 2.37 4.67
5 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
6 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
7 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
8 INT56458 Binding of GPM6A and IGHG3 4 0.02 0 3.31
9 INT91649 Binding of Lbp and SPECC1 1 0.12 2.88 2.78
10 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
11 INT212505 Binding of pr and Lbp 1 0.01 4.26 2.62
12 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52
13 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
14 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
15 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
16 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
17 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
18 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
19 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
20 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
21 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
22 INT85041 Binding of IGHG3 and MAX 1 0.00 0 2.09
23 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
24 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
25 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
26 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
27 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
28 INT81914 Binding of HSF1 and NFKB1 1 0.05 1.54 1.85
29 INT203149 Binding of Mif and Osm 1 0.02 2.93 1.78
30 INT116092 TFF2 Positive_regulation of NFKB1 1 0.17 0.06 1.77
31 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 0.40 0.37 1.76
32 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
33 INT139190 Binding of Fadd and Fas 4 0.38 2.65 1.71
34 INT158302 Il23a Regulation of Gene_expression of Il17a 1 0.06 1.45 1.7
35 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
36 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 0.01 1.74 1.67
37 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64
38 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
39 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
40 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
41 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
42 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56
43 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
44 INT130839 Gfap Positive_regulation of S100B 1 0.51 1.9 1.56
45 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
46 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55
47 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
48 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
49 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
50 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
51 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
52 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
53 INT150392 Binding of MEFV and PSTPIP1 2 0.51 10.49 1.44
54 INT148451 Gene_expression of Inhbe Positive_regulation of Pik3cd 1 0.04 1.35 1.4
55 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
56 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
57 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
58 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
59 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
60 INT70181 PRCP Positive_regulation of FOS 1 0.58 0.36 1.26
61 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
62 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
63 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
64 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24
65 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
66 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
67 INT283426 Binding of Lcn2 and Nt5e 1 0.08 5.8 1.24
68 INT83422 Binding of FANCB and IGHG3 3 0.12 5.09 1.22
69 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
70 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
71 INT164365 Positive_regulation of Binding of NLRP1 and VTA1 1 0.14 0.6 1.21
72 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
73 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
74 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2
75 INT133046 TNF Positive_regulation of Positive_regulation of NFKB1 5 0.54 3.23 1.19
76 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
77 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
78 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
79 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
80 INT225067 Binding of ETF1 and IGHG3 1 0.03 4.52 1.17
81 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
82 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
83 INT150191 CEACAM3 Positive_regulation of Gene_expression of FOS 1 0.34 0.14 1.16
84 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
85 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
86 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16
87 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
88 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
89 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
90 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
91 INT76199 CASP1 Positive_regulation of CEL 1 0.06 0.32 1.14
92 INT227324 Binding of fd and Cd14 1 0.01 2.8 1.13
93 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
94 INT83427 Binding of IGHG3 and FRTS 3 0.03 1.92 1.12
95 INT62381 ADCY10 Positive_regulation of Localization of IGHG3 1 0.04 0.36 1.11
96 INT62380 ADCY10 Positive_regulation of IGHG3 1 0.03 0.36 1.11
97 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
98 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
99 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
100 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
101 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
102 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
103 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
104 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
105 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
106 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
107 INT329962 Binding of C5 and HEPACAM 1 0.03 2.25 1.06
108 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
109 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
110 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04
111 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
112 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
113 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
114 INT156245 NFKB1 Positive_regulation of Regulation of TNF 1 0.45 0.76 1.03
115 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
116 INT101065 MAP3K15 Positive_regulation of JUN 1 0.43 0.46 1.02
117 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
118 INT174910 Binding of LBP and IFIH1 1 0.04 1.01 1.01
119 INT113453 Ngf Positive_regulation of JUN 1 0.27 0.6 1.01
120 INT317584 Binding of Lbp and Pgp 1 0.24 1.08 0.99
121 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
122 INT94206 SP5 Regulation of Gene_expression of FOS 1 0.22 0.7 0.98
123 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
124 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
125 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
126 INT122144 Binding of Trpv1 and Prkd1 1 0.02 0.39 0.96
127 INT289173 PYCARD Regulation of MFGE8 1 0.05 0 0.96
128 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
129 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
130 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
131 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
132 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
133 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
134 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
135 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
136 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
137 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93
138 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
139 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
140 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
141 INT227325 Binding of IRF6 and Cd14 1 0.01 2.51 0.93
142 INT96260 Pik3cd Regulation of Plcg2 1 0.02 0 0.92
143 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
144 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
145 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
146 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
147 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
148 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
149 INT40636 Mif Negative_regulation of Pomc 1 0.25 0.07 0.9
150 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9
151 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
152 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89
153 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
154 INT116771 Binding of MAVS and MRGPRX1 1 0.00 0.51 0.89
155 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
156 INT210800 Bst2 Positive_regulation of Tnip1 1 0.36 0.54 0.89
157 INT210789 Bst2 Positive_regulation of B2m 1 0.32 0.54 0.89
158 INT210801 Bst2 Positive_regulation of Net1 1 0.35 0.54 0.89
159 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
160 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
161 INT252881 Crcp Positive_regulation of Gene_expression of Tacr1 1 0.00 0.28 0.88
162 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
163 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
164 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
165 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
166 INT203148 Mif Positive_regulation of Gene_expression of S100a8 1 0.00 1.56 0.87
167 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
168 INT164363 Regulation of Binding of NLRP1 and VTA1 1 0.14 0.45 0.86
169 INT161308 POMC Negative_regulation of Positive_regulation of JUN 1 0.12 0.27 0.86
170 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
171 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
172 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
173 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
174 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
175 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85
176 INT100283 TXN Negative_regulation of Gene_expression of POMC 1 0.54 0.5 0.85
177 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
178 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
179 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
180 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
181 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
182 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
183 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
184 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
185 INT328501 Sumo1 Negative_regulation of Gene_expression of Pglyrp1 1 0.00 1.54 0.83
186 INT106312 NFKB1 Regulation of S100A4 1 0.14 1.1 0.83
187 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
188 INT237379 Binding of Ebi3 and Il27 2 0.05 1.71 0.82
189 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
190 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
191 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
192 INT66206 Negative_regulation of TNF Positive_regulation of NFKB1 2 0.53 1.71 0.81
193 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
194 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
195 INT341367 CRX Positive_regulation of Positive_regulation of FOS 1 0.04 0.83 0.8
196 INT274785 S100B Positive_regulation of Ngf 1 0.05 0.61 0.8
197 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
198 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8
199 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
200 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79

Single Events

The table below shows the top 100 pain related interactions that have been reported for innate immune response. They are ordered first by their pain relevance and then by number of times they were reported in innate immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
2 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
3 INT1026 Binding of Lbp 207 0.48 150.96 119.16
4 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
5 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
6 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32
7 INT9664 Binding of LBP 127 0.48 94.9 63.42
8 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
9 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
10 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
11 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
12 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16
13 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
14 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05
15 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33
16 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
17 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
18 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25
19 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
20 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
21 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
22 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
23 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
24 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23
25 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13
26 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
27 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
28 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19
29 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
30 INT116737 Localization of Mif 63 0.81 52.97 28.11
31 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
32 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
33 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03
34 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73
35 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4
36 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15
37 INT48979 Regulation of Gene_expression of FOS 52 0.61 14.4 25.95
38 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89
39 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
40 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
41 INT1030 Localization of Lbp 52 0.74 38.92 24.91
42 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27
43 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
44 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
45 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
46 INT134651 Binding of TLR4 89 0.48 66.96 23.19
47 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04
48 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
49 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62
50 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
51 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
52 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
53 INT73625 Gene_expression of PPARG 108 0.78 104.85 21.42
54 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
55 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
56 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
57 INT40750 Gene_expression of Mif 61 0.78 34.59 20.28
58 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
59 INT756 Gene_expression of C3 138 0.75 100.6 19.2
60 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
61 INT52179 Regulation of Lbp 39 0.61 25.4 18.32
62 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
63 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87
64 INT116978 Gene_expression of CCR6 53 0.78 56 17.73
65 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67
66 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
67 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
68 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
69 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
70 INT164366 Localization of NLRP1 26 0.71 5.9 16.54
71 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53
72 INT25517 Regulation of NFKB1 41 0.61 22.28 16.09
73 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67
74 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
75 INT54572 Negative_regulation of Positive_regulation of NFKB1 46 0.58 21.45 15.47
76 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
77 INT116736 Positive_regulation of Mif 40 0.70 31.93 15.37
78 INT3002 Binding of SUGT1 62 0.24 55.9 14.91
79 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
80 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
81 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75
82 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61
83 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
84 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57
85 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
86 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
87 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
88 INT39733 Localization of NFKB1 59 0.79 22.76 13.99
89 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
90 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
91 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18
92 INT55168 Binding of NFKB1 55 0.48 22.94 13.15
93 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94
94 INT15246 Regulation of FOS 32 0.60 15.34 12.94
95 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
96 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78
97 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63
98 INT29745 Binding of APP 47 0.48 26.49 12.4
99 INT145425 Positive_regulation of NLRP1 19 0.47 6.93 12.09
100 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91
101 INT36287 Binding of CD4 96 0.47 58.93 11.88
102 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
103 INT65638 Negative_regulation of Gene_expression of Il1rl1 12 0.58 7.86 11.7
104 INT72949 Binding of Mif 31 0.46 23.12 11.65
105 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
106 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
107 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
108 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63
109 INT16449 Binding of IGHG3 67 0.48 39.55 10.59
110 INT27651 Gene_expression of S100A12 45 0.76 52.25 10.51
111 INT150540 Binding of TLR2 50 0.45 35.86 10.43
112 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
113 INT16404 Regulation of CD4 54 0.61 33.05 10.29
114 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29
115 INT60198 Binding of JUN 54 0.48 11.56 10.27
116 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08
117 INT123142 Gene_expression of DEFB4A 54 0.76 36.14 10.02
118 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01
119 INT57000 Localization of LBP 21 0.78 11.01 10.01
120 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
121 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47
122 INT179696 Negative_regulation of DAK 5 0.02 16.79 9.42
123 INT41569 Regulation of APP 32 0.62 17.15 9.4
124 INT71174 Gene_expression of CASP1 44 0.75 30.3 9.37
125 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
126 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18
127 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17
128 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
129 INT48978 Negative_regulation of FOS 41 0.57 11.94 9.14
130 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
131 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05
132 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
133 INT67612 Binding of PPARG 38 0.48 22.67 8.94
134 INT66213 Localization of RELA 63 0.78 14.71 8.77
135 INT34372 Gene_expression of Cfp 102 0.67 37.66 8.72
136 INT32624 Regulation of LBP 15 0.60 11.48 8.71
137 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
138 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
139 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68
140 INT117553 Regulation of MIF 10 0.56 12.76 8.67
141 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57
142 INT17333 Positive_regulation of Positive_regulation of FOS 17 0.67 6.06 8.4
143 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
144 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
145 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
146 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07
147 INT8694 Binding of Lgals3 38 0.48 14.82 8.05
148 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95
149 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
150 INT99163 Positive_regulation of Cd14 18 0.49 16.02 7.91
151 INT97516 Binding of PYCARD 46 0.36 7.06 7.85
152 INT32579 Binding of C4B 14 0.36 14.99 7.79
153 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79
154 INT573 Negative_regulation of C3 60 0.59 41.37 7.78
155 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75
156 INT178198 Gene_expression of C3 62 0.78 39.5 7.69
157 INT117543 Regulation of Gene_expression of CD14 21 0.59 6.66 7.67
158 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
159 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
160 INT47848 Negative_regulation of Positive_regulation of FOS 14 0.57 3.78 7.63
161 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
162 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
163 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
164 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
165 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37
166 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
167 INT184281 Binding of AGER 25 0.37 23.06 7.32
168 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
169 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
170 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17
171 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
172 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
173 INT75497 Regulation of JUN 28 0.61 11.04 7.09
174 INT66210 Regulation of Positive_regulation of NFKB1 16 0.60 9.46 7.08
175 INT116428 Gene_expression of Cybb 68 0.76 35.81 7.07
176 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
177 INT111377 Positive_regulation of Ifih1 16 0.60 11.22 6.99
178 INT60196 Binding of FOS 33 0.47 13.11 6.95
179 INT17049 Localization of CD4 57 0.75 35.33 6.89
180 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
181 INT1766 Negative_regulation of PYCARD 25 0.37 6.54 6.76
182 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
183 INT117544 Regulation of CD14 24 0.45 5.85 6.66
184 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
185 INT87432 Regulation of Gene_expression of Il1rl1 6 0.58 4.5 6.62
186 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
187 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56
188 INT517 Regulation of Mif 16 0.62 5.43 6.55
189 INT60692 Gene_expression of Pglyrp1 15 0.10 8.47 6.51
190 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47
191 INT5871 Binding of IFNA2 38 0.48 20.35 6.46
192 INT5847 Transcription of FOS 31 0.69 11.11 6.41
193 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
194 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36
195 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
196 INT150023 Positive_regulation of Il23a 25 0.38 18.33 6.32
197 INT57720 Localization of IGHG3 33 0.74 20.24 6.25
198 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
199 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17
200 INT183910 Negative_regulation of Gene_expression of Lbp 10 0.35 9.78 6.15
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