GO:0045088

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Name regulation of innate immune response
Categary Process
Go Slim No
Go Link GO:0045088
Unique Molecular Interactions 39
Total Molecular Interactions 48
Total Single Events 147
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of innate immune response. They are ordered first by their pain relevance and then by number of times they were reported for regulation of innate immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 0.01 1.74 1.67
2 INT348175 Binding of NIDDM1 and PTPN22 1 0.01 2.36 0.99
3 INT163946 Binding of ERAP1 and Il23r 1 0.23 0.56 0.72
4 INT160711 Binding of KIR3DL1 and ERAP1 1 0.15 0.71 0.71
5 INT314596 Isg15 Negative_regulation of Gene_expression of Samhd1 1 0.05 0.17 0.7
6 INT314597 Oasl1 Negative_regulation of Gene_expression of Samhd1 1 0.06 0.17 0.7
7 INT314595 Zbp1 Negative_regulation of Gene_expression of Samhd1 1 0.05 0.17 0.7
8 INT329961 Binding of IL2RA and PTPN22 1 0.35 1.87 0.63
9 INT348177 Binding of HLA-B and ERAP1 1 0.14 0.92 0.49
10 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
11 INT264504 Binding of CRYGD and PTPN22 1 0.04 0.42 0.31
12 INT259936 CTLA4 Regulation of PTPN22 1 0.45 1.64 0.28
13 INT259937 Binding of CSK and PTPN22 1 0.21 1.69 0.25
14 INT177661 Binding of Trib3 and Myo1f 1 0.00 0.54 0.24
15 INT101312 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.03 0.38 0.23
16 INT339516 Binding of Eif2ak2 and TIRAP 1 0.25 0.19 0.23
17 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
18 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
19 INT101310 Samhd1 Positive_regulation of Gene_expression of Aif1 1 0.04 0.19 0.12
20 INT42067 Rln1 Positive_regulation of Phosphorylation of Myo1f 1 0.11 0.1 0.1
21 INT215245 Binding of Myo1f and Chd7 1 0.00 0.64 0.1
22 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
23 INT54095 ERAP1 Regulation of Protein_catabolism of Fgg 1 0.00 0 0.09
24 INT259938 Binding of CTLA4 and PTPN22 1 0.36 0.85 0.08
25 INT343865 IRF6 Positive_regulation of TIRAP 1 0.03 0.28 0.08
26 INT42066 Rln1 Regulation of Phosphorylation of Myo1f 1 0.05 0.07 0.07
27 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
28 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
29 INT215240 Binding of Myo1f and Racgap1 1 0.01 0.77 0.04
30 INT259939 Negative_regulation of Binding of CSK and PTPN22 1 0.19 0.62 0.03
31 INT303406 Binding of NPAT and Myo1f 1 0.06 0 0
32 INT288981 Binding of DEFB1 and PTPN22 1 0.11 0 0
33 INT353436 Rock1 Positive_regulation of Myo1f 1 0.02 0.23 0
34 INT159710 Binding of Tap1 and ERAP1 1 0.04 0.11 0
35 INT152402 Binding of Il1a and ERAP1 1 0.00 0.06 0
36 INT200817 Akt1 Positive_regulation of Negative_regulation of Fgr 1 0.25 1.02 0
37 INT303396 Binding of Laptm5 and Myo1f 1 0.00 0 0
38 INT303390 Binding of Jag1 and Myo1f 1 0.07 0 0
39 INT303395 Positive_regulation of Binding of Jag1 and Myo1f 1 0.07 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of innate immune response. They are ordered first by their pain relevance and then by number of times they were reported in regulation of innate immune response. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT101299 Gene_expression of Samhd1 8 0.41 4.01 3.86
2 INT159709 Binding of ERAP1 12 0.47 3.42 2.91
3 INT231573 Binding of PTPN22 5 0.44 7.94 2.33
4 INT42140 Gene_expression of Myo1f 7 0.19 2.45 2.27
5 INT42065 Phosphorylation of Myo1f 13 0.38 2.05 1.71
6 INT42138 Binding of Myo1f 5 0.10 1.49 1.03
7 INT163757 Negative_regulation of Phosphorylation of Samhd1 1 0.11 0.16 0.89
8 INT163754 Phosphorylation of Samhd1 1 0.15 0.16 0.89
9 INT160408 Transcription of Samhd1 1 0.28 0.95 0.84
10 INT145747 Regulation of ERAP1 1 0.25 0.19 0.76
11 INT276176 Negative_regulation of Myo1f 4 0.12 1.85 0.71
12 INT154643 Negative_regulation of ERAP1 1 0.11 0.69 0.58
13 INT284454 Binding of Tirap 4 0.26 2.07 0.49
14 INT42139 Regulation of Myo1f 3 0.14 0.64 0.49
15 INT276175 Positive_regulation of Transcription of Myo1f 1 0.10 1.03 0.47
16 INT276194 Positive_regulation of Gene_expression of Myo1f 1 0.14 1.03 0.47
17 INT276190 Transcription of Myo1f 1 0.11 1.02 0.46
18 INT276191 Negative_regulation of Binding of Myo1f 1 0.09 0.05 0.46
19 INT230517 Localization of Myo1f 2 0.15 1.38 0.44
20 INT35501 Positive_regulation of Myo1f 5 0.69 1.73 0.39
21 INT66251 Negative_regulation of Phosphorylation of Myo1f 1 0.20 0 0.35
22 INT81801 Negative_regulation of Samhd1 1 0.00 0.09 0.31
23 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
24 INT276203 Negative_regulation of Gene_expression of Myo1f 1 0.09 0.38 0.23
25 INT101300 Positive_regulation of Gene_expression of Samhd1 1 0.09 0.38 0.23
26 INT195576 Binding of Myo1f 6 0.06 2.79 0.21
27 INT101303 Positive_regulation of Samhd1 1 0.09 0.3 0.19
28 INT276193 Regulation of Negative_regulation of Myo1f 1 0.09 0.38 0.14
29 INT343883 Gene_expression of TIRAP 2 0.65 0.28 0.09
30 INT343902 Positive_regulation of Gene_expression of TIRAP 1 0.22 0.28 0.09
31 INT4418 Positive_regulation of ERAP1 4 0.45 1.21 0.08
32 INT343889 Positive_regulation of TIRAP 1 0.20 0.11 0.06
33 INT265312 Gene_expression of Myo1f 3 0.10 1.44 0.04
34 INT202871 Regulation of Samhd1 1 0.08 0.06 0.04
35 INT195575 Localization of Myo1f 2 0.12 0.28 0.03
36 INT272938 Negative_regulation of Myo1f 1 0.03 1.06 0.03
37 INT202849 Binding of Samhd1 1 0.26 0.22 0.03
38 INT339489 Binding of TIRAP 1 0.36 0.05 0.03
39 INT159707 Gene_expression of ERAP1 4 0.66 0.69 0
40 INT345270 Negative_regulation of Tirap 1 0.02 0.15 0
41 INT163945 Positive_regulation of Gene_expression of ERAP1 1 0.26 0.09 0
42 INT303355 Positive_regulation of Localization of Myo1f 1 0.10 0.22 0
43 INT303375 Positive_regulation of Myo1f 1 0.08 0.22 0
44 INT292413 Negative_regulation of Binding of Myo1f 1 0.00 0.88 0
45 INT353415 Phosphorylation of Myo1f 1 0.08 0.61 0
46 INT254185 Positive_regulation of Tirap 1 0.32 0 0
47 INT254183 Regulation of Positive_regulation of Tirap 1 0.29 0 0
48 INT353421 Positive_regulation of Phosphorylation of Myo1f 1 0.05 0.5 0
49 INT200787 Negative_regulation of Fgr 1 0.52 1.01 0
50 INT303350 Regulation of Myo1f 1 0.09 0.26 0
51 INT200794 Gene_expression of Fgr 1 0.54 1.18 0
52 INT254176 Positive_regulation of Positive_regulation of Tirap 1 0.32 0 0
53 INT287856 Positive_regulation of Positive_regulation of Myo1f 1 0.03 0.11 0
54 INT303365 Protein_catabolism of Myo1f 1 0.10 0.29 0
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