GO:0045176

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Name apical protein localization
Categary Process
Go Slim No
Go Link GO:0045176
Unique Molecular Interactions 239
Total Molecular Interactions 314
Total Single Events 2727
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for apical protein localization. They are ordered first by their pain relevance and then by number of times they were reported for apical protein localization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
2 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
3 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
4 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
5 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
6 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15
7 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
8 INT306823 Binding of E2F4 and GOPC 1 0.06 0.23 0.91
9 INT269455 Binding of RAB5A and GOPC 1 0.08 0 0.82
10 INT293011 GPM6A Regulation of GOPC 1 0.00 0 0.81
11 INT144451 Napa Positive_regulation of Gene_expression of Nqo1 1 0.07 0.18 0.8
12 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77
13 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
14 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
15 INT264946 Binding of FPR1 and GOPC 1 0.08 0.21 0.64
16 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
17 INT264952 Binding of GOPC and BOC 1 0.05 0.22 0.64
18 INT284790 Trpa1 Positive_regulation of Regulation of Napa 1 0.19 0 0.59
19 INT284784 Trpv1 Positive_regulation of Regulation of Napa 1 0.20 0 0.59
20 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58
21 INT351581 Binding of ALB and GOPC 1 0.11 0 0.55
22 INT352891 Binding of ROS1 and GOPC 1 0.09 1.34 0.53
23 INT269449 Positive_regulation of Binding of RAB5A and GOPC 1 0.11 0 0.53
24 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
25 INT264945 GOPC Positive_regulation of Positive_regulation of FPR1 1 0.10 0.2 0.44
26 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4
27 INT338085 Binding of PYCARD and GOPC 1 0.05 0 0.39
28 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38
29 INT219683 Binding of CEL and GOPC 1 0.04 3.11 0.38
30 INT293201 GOPC Positive_regulation of Gene_expression of IFN1@ 1 0.14 0.18 0.36
31 INT250252 Binding of SLC1A2 and GOPC 1 0.05 0.44 0.35
32 INT250242 Binding of AQP4 and GOPC 1 0.06 0.39 0.35
33 INT250254 Binding of SLC1A3 and GOPC 1 0.02 0.44 0.35
34 INT249406 Binding of Napa and Dcaf12l2 1 0.01 0.1 0.35
35 INT284788 Napa Positive_regulation of Trpv1 1 0.31 0 0.35
36 INT306822 Binding of E2F2 and GOPC 1 0.05 0.53 0.35
37 INT224822 Binding of ENOX1 and GOPC 1 0.00 0.34 0.34
38 INT344923 Binding of CEBPZ and GOPC 1 0.06 0.24 0.33
39 INT264804 Binding of CNNM2 and GOPC 1 0.00 0.18 0.3
40 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29
41 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
42 INT266766 Binding of PGR and GOPC 1 0.00 1.08 0.29
43 INT187147 Positive_regulation of Binding of CXCL10 and GOPC 1 0.08 0.53 0.28
44 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
45 INT352894 Negative_regulation of Binding of ROS1 and GOPC 1 0.08 0.67 0.28
46 INT300548 Napa Positive_regulation of Gene_expression of Il23a 1 0.05 0.86 0.28
47 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
48 INT187143 Binding of CXCL10 and GOPC 1 0.06 0.53 0.28
49 INT352895 Positive_regulation of Binding of ROS1 and GOPC 1 0.08 0.68 0.26
50 INT270277 Binding of NPBWR1 and GOPC 1 0.07 0 0.25
51 INT284783 Napa Positive_regulation of Positive_regulation of Trpa1 1 0.20 0 0.25
52 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24
53 INT184403 Positive_regulation of GOPC Regulation of Gene_expression of KRT20 1 0.00 1.21 0.24
54 INT188195 GOPC Positive_regulation of MAPK1 2 0.21 0.32 0.22
55 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21
56 INT186781 Binding of NRIP1 and GOPC 1 0.05 0.49 0.2
57 INT313648 ISYNA1 Regulation of GOPC 1 0.02 0.08 0.2
58 INT284787 Napa Positive_regulation of Binding of Trpa1 1 0.22 0 0.2
59 INT284789 Napa Positive_regulation of Binding of Trpv1 1 0.22 0 0.2
60 INT284782 Napa Positive_regulation of Trpa1 1 0.30 0 0.2
61 INT236338 Negative_regulation of Binding of PCSK1 and GOPC 1 0.06 0.19 0.2
62 INT293056 Binding of ANXA5 and GOPC 1 0.06 0.51 0.19
63 INT299113 Binding of INPP5K and GOPC 1 0.18 2.69 0.19
64 INT229634 GOPC Positive_regulation of GAST 1 0.09 0.47 0.19
65 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
66 INT229042 GOPC Regulation of IL32 1 0.03 1.22 0.17
67 INT294110 Binding of CALCRL and GOPC 1 0.00 0 0.17
68 INT236339 Binding of PCSK1 and GOPC 1 0.05 0.14 0.17
69 INT229039 GOPC Regulation of Gene_expression of IL32 1 0.03 1.18 0.17
70 INT191337 Binding of IDO1 and GOPC 1 0.01 0.65 0.16
71 INT63914 Napa Negative_regulation of Npy 1 0.26 0 0.16
72 INT257986 Binding of PTGER2 and GOPC 1 0.04 0.42 0.16
73 INT191336 Binding of TSPO and GOPC 1 0.01 0.65 0.16
74 INT178704 GOPC Positive_regulation of Srr 1 0.02 0 0.16
75 INT178703 Regulation of GOPC Positive_regulation of Srr 1 0.02 0 0.16
76 INT254497 GOPC Regulation of Transcription of HNF4A 1 0.02 0.72 0.16
77 INT249833 Binding of CHI3L1 and GOPC 1 0.06 1.11 0.15
78 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15
79 INT238331 PDGFA Regulation of Gene_expression of GOPC 1 0.04 0 0.14
80 INT238330 Binding of PDGFA and Regulation of Gene_expression of GOPC 1 0.06 0 0.14
81 INT272024 Gene_expression of GOPC Positive_regulation of Localization of COL7A1 1 0.10 0.86 0.14
82 INT238338 Binding of EGF and Regulation of Gene_expression of GOPC 1 0.05 0 0.14
83 INT238341 GOPC Regulation of Transcription of ADAMTS1 1 0.04 0 0.14
84 INT238337 EGF Regulation of Gene_expression of GOPC 1 0.03 0 0.14
85 INT340109 GOPC Positive_regulation of Ltp 1 0.01 0.19 0.14
86 INT238334 GOPC Regulation of Transcription of ADAMTS5 1 0.04 0 0.14
87 INT249403 Binding of Snap25 and Napa 1 0.19 0 0.14
88 INT249412 Frg1 Positive_regulation of Binding of Napa 1 0.02 0.13 0.13
89 INT246364 GOPC Regulation of SETBP1 1 0.02 0.98 0.13
90 INT299553 GOPC Positive_regulation of Stat3 1 0.02 0 0.13
91 INT181929 GOPC Regulation of Gene_expression of TIMP1 1 0.00 0 0.12
92 INT249418 Stoml3 Regulation of Napa 1 0.00 0.3 0.12
93 INT223482 CRP Positive_regulation of GOPC 1 0.08 0.8 0.1
94 INT313486 GOPC Positive_regulation of P2RX1 1 0.13 0 0.1
95 INT249183 Binding of ITPR3 and GOPC 2 0.01 0.26 0.09
96 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09
97 INT113363 Napa Positive_regulation of Serpina3c 1 0.15 0.25 0.09
98 INT341054 Binding of PAEP and RAB14 1 0.00 0.28 0.09
99 INT274470 Binding of IL12A and GOPC 1 0.02 0.6 0.09
100 INT249413 Binding of Vamp2 and Napa 1 0.15 0.05 0.09
101 INT249411 Binding of Prkaca and Napa 1 0.12 0.1 0.09
102 INT201446 GOPC Positive_regulation of Slc6a3 1 0.03 0.07 0.08
103 INT254496 Binding of HNF4A and GOPC 1 0.10 0.34 0.08
104 INT210364 Binding of FUT1 and GOPC 1 0.01 0.53 0.08
105 INT254498 Binding of SREBF1 and GOPC 1 0.05 0.34 0.08
106 INT254495 Binding of PPARA and GOPC 1 0.04 0.34 0.08
107 INT249166 Phosphorylation of NCF1 Positive_regulation of Localization of GOPC 1 0.03 0.06 0.08
108 INT353666 Gene_expression of CD209 Negative_regulation of GOPC 1 0.06 0.67 0.08
109 INT249427 Binding of Gopc and Napa 1 0.10 0.12 0.07
110 INT352358 CD86 Positive_regulation of GOPC 1 0.30 0.13 0.07
111 INT266662 TIMP1 Regulation of Gene_expression of GOPC 1 0.06 0.11 0.06
112 INT249416 Binding of Scarb2 and Napa 1 0.02 0 0.05
113 INT328426 PRB4 Positive_regulation of GOPC 1 0.03 0.55 0.05
114 INT203638 Binding of MR1 and GOPC 1 0.04 1.43 0.05
115 INT204387 Binding of Napa and Sds 1 0.00 0 0.05
116 INT347072 GOPC Positive_regulation of Gene_expression of IL6 1 0.01 0.38 0.04
117 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04
118 INT170668 GOPC Regulation of CRP 1 0.07 0.32 0.04
119 INT282556 POU5F1 Positive_regulation of GOPC 1 0.06 0.06 0.04
120 INT266452 Binding of Acot1 and GOPC 1 0.02 1.23 0.04
121 INT341055 Binding of HRC and RAB14 1 0.00 0 0.04
122 INT170666 GOPC Regulation of ANGPTL5 1 0.06 0.32 0.04
123 INT296712 Binding of H2-K1 and GOPC 1 0.00 0.41 0.04
124 INT309727 Binding of C2 and GOPC 1 0.03 0 0.04
125 INT281652 GOPC Positive_regulation of C3 1 0.22 0.22 0.04
126 INT257992 PTGER2 Negative_regulation of GOPC 1 0.04 0 0.03
127 INT185651 GOPC Positive_regulation of AR 1 0.03 0.06 0.03
128 INT316218 GOPC Positive_regulation of BDKRB2 1 0.08 0.71 0.03
129 INT291786 GOPC Negative_regulation of Gene_expression of Gnat3 1 0.01 0 0.03
130 INT237155 LGALS4 Regulation of Gene_expression of GOPC 1 0.05 0 0.03
131 INT192914 Binding of ESR1 and GOPC 2 0.02 0.61 0
132 INT249417 Binding of Stx1a and Napa 1 0.13 0 0
133 INT309744 Binding of GOPC and TRPV4 1 0.09 0 0
134 INT308122 Binding of F13A1 and GOPC 1 0.01 0.25 0
135 INT200642 GOPC Regulation of AKT1 1 0.14 0.2 0
136 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0
137 INT210829 Binding of POMC and GOPC 1 0.06 0.15 0
138 INT238823 LTF Positive_regulation of GOPC 1 0.01 0.29 0
139 INT306114 GOPC Regulation of Gene_expression of FGF7 1 0.05 0.45 0
140 INT313293 Binding of KEAP1 and GOPC 1 0.04 0.24 0
141 INT273443 Positive_regulation of Binding of Snap25 and Napa 1 0.05 0 0
142 INT329568 GOPC Positive_regulation of Phosphorylation of MAPK1 1 0.04 0.79 0
143 INT269578 GOPC Positive_regulation of Phosphorylation of PTGIR 1 0.01 0 0
144 INT267261 GOPC Regulation of BMI1 1 0.06 0.75 0
145 INT312043 NAPA Regulation of TNF 1 0.26 0 0
146 INT249402 Binding of Mbp and Napa 1 0.17 0 0
147 INT278761 Binding of KBTBD10 and GOPC 1 0.14 0 0
148 INT177283 Binding of CXADR and GOPC 1 0.16 0 0
149 INT339800 P2RX1 Regulation of Negative_regulation of GOPC 1 0.04 0 0
150 INT278763 Binding of HOXA9 and GOPC 1 0.14 0 0
151 INT288002 Binding of COL2A1 and GOPC 1 0.12 0 0
152 INT224023 Binding of GOPC and P2RY12 1 0.02 0.69 0
153 INT278186 Binding of TP53 and GOPC 1 0.02 0.85 0
154 INT170587 GOPC Regulation of Gene_expression of ICAM1 1 0.13 0 0
155 INT298868 Binding of RAB7A and GOPC 1 0.07 1.64 0
156 INT313304 Binding of SQSTM1 and GOPC 1 0.04 0.24 0
157 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
158 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0
159 INT298301 Binding of BDNF and GOPC 1 0.03 0.47 0
160 INT269549 Regulation of GOPC Positive_regulation of RHOA 1 0.09 0 0
161 INT327970 GOPC Regulation of Gene_expression of BAD 1 0.08 0.6 0
162 INT198007 MTOR Regulation of Gene_expression of GOPC 1 0.08 1.33 0
163 INT349954 ARMC9 Regulation of GOPC 1 0.00 0 0
164 INT293814 Negative_regulation of ERBB2 Negative_regulation of Gene_expression of GOPC 1 0.02 0 0
165 INT309749 Binding of CA2 and GOPC 1 0.03 0 0
166 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
167 INT214890 GOPC Positive_regulation of CDKN1A 1 0.06 0.57 0
168 INT264978 Binding of BAG3 and GOPC 1 0.18 0.38 0
169 INT269571 Positive_regulation of GOPC Positive_regulation of RHOA 1 0.10 0 0
170 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
171 INT293412 GOPC Regulation of Localization of VEGFA 1 0.04 0.61 0
172 INT323590 Binding of Aldh2 and Napa 1 0.01 0.16 0
173 INT308124 GOPC Regulation of F13A1 1 0.01 0.25 0
174 INT265743 Binding of VEGFA and GOPC 1 0.15 0 0
175 INT269580 TMPO Positive_regulation of GOPC 1 0.05 0 0
176 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
177 INT324311 Binding of UMOD and SHROOM3 1 0.29 1.62 0
178 INT170459 Binding of CD1A and GOPC 1 0.07 0.1 0
179 INT184196 GOPC Negative_regulation of HYAL1 1 0.02 0 0
180 INT269555 GOPC Positive_regulation of RHOA 1 0.10 0 0
181 INT236017 GOPC Positive_regulation of MAPK8 1 0.09 0.17 0
182 INT265758 GOPC Positive_regulation of Gene_expression of FLT1 1 0.14 0 0
183 INT235018 Binding of DSP and GOPC 1 0.02 0.19 0
184 INT185652 Binding of AR and GOPC 1 0.03 0 0
185 INT269594 GOPC Positive_regulation of Phosphorylation of CFL1 1 0.04 0 0
186 INT331883 Binding of MAGEA4 and GOPC 1 0.03 0 0
187 INT265765 Binding of NRP1 and GOPC 1 0.13 0 0
188 INT221957 Binding of UTS2R and GOPC 1 0.02 0.08 0
189 INT191540 Binding of ABCA3 and GOPC 1 0.03 0.12 0
190 INT249175 Binding of CISH and GOPC 1 0.01 0.26 0
191 INT210286 Binding of ELAVL4 and GOPC 1 0.06 0.87 0
192 INT313946 Binding of PEE1 and GOPC 1 0.07 0.44 0
193 INT324310 Binding of STC1 and SHROOM3 1 0.24 1.61 0
194 INT273446 Binding of Vamp1 and Napa 1 0.02 0 0
195 INT286593 Binding of Pkd1 and GOPC 1 0.02 1.13 0
196 INT236010 GOPC Positive_regulation of AKT1 1 0.03 0.17 0
197 INT269562 GOPC Positive_regulation of Gene_expression of EPHA3 1 0.03 0 0
198 INT292510 Mlph Regulation of Gene_expression of GOPC 1 0.00 0.41 0
199 INT313303 Negative_regulation of SQSTM1 Positive_regulation of GOPC 1 0.05 0.39 0
200 INT292725 GOPC Positive_regulation of Protein_catabolism of Akt1 1 0.01 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for apical protein localization. They are ordered first by their pain relevance and then by number of times they were reported in apical protein localization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6
2 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75
3 INT15610 Localization of GOPC 223 0.65 68.26 28.7
4 INT105021 Binding of GOPC 187 0.40 60.39 20.38
5 INT171666 Regulation of GOPC 117 0.39 40.41 15.47
6 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41
7 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68
8 INT2513 Binding of Napa 80 0.42 4.29 6.51
9 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73
10 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51
11 INT170606 Regulation of Gene_expression of GOPC 31 0.37 6.08 3.31
12 INT115301 Negative_regulation of Binding of Napa 16 0.33 0.6 3.11
13 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98
14 INT115300 Negative_regulation of Napa 7 0.23 1 2.68
15 INT169987 Transcription of GOPC 45 0.60 21.88 2.61
16 INT109559 Localization of Napa 16 0.61 1.3 2.42
17 INT174979 Phosphorylation of GOPC 45 0.51 10.11 2.28
18 INT115299 Regulation of Napa 14 0.54 0.56 1.7
19 INT230716 Regulation of Binding of GOPC 2 0.10 0.26 1.59
20 INT181003 Negative_regulation of Localization of GOPC 11 0.30 1.93 1.22
21 INT188396 Positive_regulation of Positive_regulation of GOPC 13 0.42 1.78 1.21
22 INT120331 Gene_expression of Napa 6 0.51 1.15 1.17
23 INT180183 Regulation of Positive_regulation of GOPC 4 0.26 1.47 0.96
24 INT120332 Negative_regulation of Phosphorylation of Napa 1 0.08 0 0.95
25 INT120330 Phosphorylation of Napa 1 0.12 0 0.94
26 INT201251 Negative_regulation of NAPA 2 0.30 0 0.88
27 INT184418 Negative_regulation of Positive_regulation of GOPC 15 0.26 5.47 0.87
28 INT209108 Positive_regulation of Negative_regulation of GOPC 6 0.33 1.72 0.51
29 INT192587 Negative_regulation of Protein_catabolism of GOPC 4 0.22 1.15 0.41
30 INT284594 Regulation of Negative_regulation of Napa 1 0.24 0 0.41
31 INT188228 Positive_regulation of Phosphorylation of GOPC 7 0.29 0.72 0.4
32 INT204379 Positive_regulation of Napa 16 0.35 0.23 0.38
33 INT171922 Positive_regulation of Binding of GOPC 5 0.44 1.31 0.34
34 INT180182 Negative_regulation of Negative_regulation of GOPC 2 0.25 1.58 0.24
35 INT249381 Regulation of Binding of Napa 1 0.47 0.14 0.23
36 INT178840 Regulation of Localization of GOPC 5 0.25 0.78 0.14
37 INT204382 Positive_regulation of Binding of Napa 5 0.53 0 0.14
38 INT185720 Positive_regulation of Transcription of GOPC 1 0.06 0.23 0.12
39 INT246199 Negative_regulation of Phosphorylation of GOPC 10 0.18 2.18 0.11
40 INT341098 Positive_regulation of RAB14 1 0.00 0.28 0.09
41 INT341099 Binding of RAB14 1 0.00 0.28 0.09
42 INT312058 Localization of NAPA 1 0.54 0.29 0.08
43 INT301884 Gene_expression of SHROOM3 1 0.67 3.57 0.08
44 INT301897 Regulation of SHROOM3 1 0.24 1.52 0.07
45 INT237839 Negative_regulation of Transcription of GOPC 4 0.37 0.29 0.05
46 INT115302 Regulation of Localization of Napa 2 0.24 0 0.05
47 INT312052 Positive_regulation of Localization of NAPA 1 0.31 0.14 0.04
48 INT312053 Negative_regulation of Localization of NAPA 1 0.27 0.14 0.04
49 INT312060 Binding of NAPA 1 0.27 0.11 0.03
50 INT249382 Positive_regulation of Regulation of Napa 1 0.38 0 0.03
51 INT180973 Positive_regulation of Protein_catabolism of GOPC 1 0.17 0.67 0.03
52 INT175216 Negative_regulation of Binding of GOPC 5 0.10 2.05 0
53 INT277160 Positive_regulation of Regulation of GOPC 2 0.10 0.86 0
54 INT312054 Phosphorylation of NAPA 1 0.39 0 0
55 INT312066 Regulation of Gene_expression of NAPA 1 0.28 0 0
56 INT299728 Regulation of Transcription of GOPC 1 0.38 0 0
57 INT301899 Negative_regulation of SHROOM3 1 0.38 1.1 0
58 INT312067 Gene_expression of NAPA 1 0.48 0 0
59 INT341083 Gene_expression of RAB14 1 0.01 1.33 0
60 INT324331 Binding of SHROOM3 1 0.29 1.41 0
61 INT292476 Regulation of Phosphorylation of GOPC 1 0.04 0.63 0
62 INT204380 Positive_regulation of Positive_regulation of Napa 1 0.04 0.15 0
63 INT249386 Regulation of Regulation of Napa 1 0.54 0.06 0
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