GO:0045187

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Name regulation of circadian sleep/wake cycle, sleep
Categary Process
Go Slim No
Go Link GO:0045187
Unique Molecular Interactions 77
Total Molecular Interactions 97
Total Single Events 1109
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of circadian sleep/wake cycle, sleep. They are ordered first by their pain relevance and then by number of times they were reported for regulation of circadian sleep/wake cycle, sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
2 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
3 INT212662 KCNA1 Regulation of Localization of Cort 1 0.00 1.36 1.37
4 INT25111 Binding of PTGDS and PLEKHM1 1 0.01 0 0.97
5 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93
6 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
7 INT38905 Ptgfr Regulation of Ptgds 1 0.20 0 0.63
8 INT212659 KCNA1 Regulation of Cort 1 0.00 0.41 0.49
9 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
10 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44
11 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
12 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
13 INT290821 CRX Positive_regulation of Cort 1 0.14 0.51 0.41
14 INT264522 Binding of GPER and PTGDS 1 0.03 1.22 0.4
15 INT264525 Binding of PTGDS and PTGFR 1 0.02 1.22 0.39
16 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
17 INT264527 IL1B Positive_regulation of Gene_expression of PTGDS 1 0.07 0.75 0.38
18 INT81506 Drd3 Regulation of Positive_regulation of Fos 1 0.28 0 0.37
19 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
20 INT255555 Binding of Ptgds and Tfdp1 1 0.14 1.14 0.36
21 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
22 INT126767 Positive_regulation of Binding of PTGDS and PTGDR2 1 0.54 0.3 0.35
23 INT264521 PTGDS Negative_regulation of Positive_regulation of MMP1 1 0.06 1.42 0.34
24 INT51629 Binding of DRD3 and OPRK1 1 0.15 0 0.33
25 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
26 INT51631 Binding of DRD3 and PENK 1 0.08 0 0.33
27 INT147984 Ptgds Positive_regulation of Cpox 1 0.17 0.29 0.32
28 INT290854 Binding of hpc and Cort 1 0.01 0.79 0.32
29 INT147982 Cpox Positive_regulation of Gene_expression of Ptgds 1 0.17 0.3 0.32
30 INT290853 Cort Positive_regulation of hpc 1 0.01 0.79 0.32
31 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
32 INT46339 Ptgds Regulation of Localization of Lh 1 0.25 0 0.29
33 INT67529 PTGDS Positive_regulation of Positive_regulation of IL6 1 0.30 0.69 0.29
34 INT102923 Ptgds Regulation of Avp 1 0.02 0 0.27
35 INT105004 Binding of DRD3 and PDYN 1 0.23 0.49 0.26
36 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
37 INT352890 Binding of PTGDS and ROS1 1 0.13 0.67 0.25
38 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
39 INT264524 PTGDS Negative_regulation of Gene_expression of MMP1 1 0.09 0.5 0.22
40 INT46400 Negative_regulation of Drd3 Positive_regulation of Localization of Prl 1 0.15 0.09 0.22
41 INT69869 Binding of Ptgdr and Ptgds 1 0.06 0 0.22
42 INT264526 PTGDS Negative_regulation of Gene_expression of MMP13 1 0.12 0.5 0.22
43 INT46399 Negative_regulation of Drd3 Positive_regulation of Prl 1 0.15 0.09 0.22
44 INT264517 PTGDS Positive_regulation of TFDP1 1 0.17 0.5 0.22
45 INT264519 PTGDS Negative_regulation of Positive_regulation of TFDP1 1 0.15 0.5 0.22
46 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
47 INT153807 Scort1 Regulation of Cort 1 0.01 0.35 0.2
48 INT69868 Binding of Ptgds and Ptger1 1 0.01 0 0.18
49 INT352896 PTGDS Positive_regulation of Gene_expression of ROS1 1 0.12 0.91 0.18
50 INT207345 PTGDS Negative_regulation of Gene_expression of ABCA1 1 0.21 0 0.17
51 INT191609 Binding of Drd3 and Flna 1 0.06 0.42 0.17
52 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17
53 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
54 INT49058 Binding of IGHE and Positive_regulation of Localization of PTGDS 1 0.29 0.35 0.17
55 INT157097 Ddc Positive_regulation of Drd3 1 0.30 0.88 0.16
56 INT242318 Ptgds Positive_regulation of Trpa1 1 0.29 0.06 0.16
57 INT106506 Binding of Pparg and Ptgds 1 0.42 0.31 0.14
58 INT207360 PTGDS Negative_regulation of Negative_regulation of ABCA1 1 0.25 0 0.14
59 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14
60 INT207358 PTGDS Negative_regulation of CPOX 1 0.05 0 0.14
61 INT227556 Ptgds Positive_regulation of Ppara 1 0.18 0.62 0.13
62 INT354065 Pomc Regulation of Cort 1 0.07 1.69 0.12
63 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08
64 INT354072 Cort Regulation of Pomc 1 0.07 1.22 0.08
65 INT269545 PTGDS Regulation of PTGIR 1 0.01 0 0.04
66 INT354071 Pomc Positive_regulation of Localization of Cort 1 0.12 0.86 0.03
67 INT207361 PTGDS Regulation of Gene_expression of CYP27A1 1 0.01 0.05 0.03
68 INT354059 Negative_regulation of Pomc Regulation of Cort 1 0.12 0.74 0.03
69 INT269567 TMPO Positive_regulation of PTGDS 1 0.07 0 0
70 INT104529 Ada Negative_regulation of Positive_regulation of FSCN1 1 0.03 0 0
71 INT104530 Ada Negative_regulation of FSCN1 1 0.03 0 0
72 INT312950 Binding of ADA and HBN1 1 0.01 0.49 0
73 INT352065 Binding of PTGDS and PTGS2 1 0.28 0 0
74 INT269582 Negative_regulation of TMPO Positive_regulation of PTGDS 1 0.06 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of circadian sleep/wake cycle, sleep. They are ordered first by their pain relevance and then by number of times they were reported in regulation of circadian sleep/wake cycle, sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12319 Positive_regulation of Cort 52 0.61 22.55 29.35
2 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01
3 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
4 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67
5 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14
6 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
7 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
8 INT69866 Positive_regulation of Ptgds 26 0.70 16.25 8.33
9 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
10 INT4810 Localization of PTGDS 20 0.81 4.19 6.97
11 INT53729 Localization of Cort 14 0.69 6.31 6.97
12 INT64215 Gene_expression of Drd3 16 0.78 5.27 6.71
13 INT27868 Positive_regulation of Positive_regulation of Cort 9 0.59 1.13 6.64
14 INT115391 Gene_expression of Cort 18 0.59 9.43 6.53
15 INT12316 Negative_regulation of Cort 10 0.38 5.89 6.08
16 INT42799 Positive_regulation of Drd3 11 0.69 1.1 5.92
17 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
18 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
19 INT7996 Gene_expression of Ptgds 18 0.64 6.47 5.51
20 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
21 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08
22 INT36256 Regulation of Ada 9 0.62 4.99 5.07
23 INT24011 Binding of Drd3 13 0.47 3.03 4.64
24 INT114189 Positive_regulation of Cort 12 0.69 4.39 4.33
25 INT212655 Positive_regulation of Gene_expression of Cort 6 0.39 5.57 4.23
26 INT27758 Positive_regulation of PTGDS 20 0.67 10.74 4.22
27 INT76714 Binding of Drd3 9 0.37 2.33 4.09
28 INT134590 Localization of ADA 7 0.65 8.43 3.96
29 INT89329 Regulation of Gene_expression of Drd3 4 0.61 0.72 3.56
30 INT6994 Binding of Ptgds 15 0.36 7.06 3.54
31 INT50143 Negative_regulation of Gene_expression of Ptgds 10 0.48 5.82 3.54
32 INT72798 Binding of ADA 12 0.47 7.84 3.39
33 INT12981 Binding of Cort 6 0.48 2.76 3.37
34 INT34604 Binding of Ada 11 0.31 4.15 3.1
35 INT131494 Regulation of ADA 8 0.52 7.37 2.97
36 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88
37 INT99419 Regulation of Drd3 7 0.48 1.89 2.81
38 INT50149 Positive_regulation of Gene_expression of Ptgds 12 0.61 4.88 2.73
39 INT12318 Negative_regulation of Positive_regulation of Cort 7 0.43 3.89 2.65
40 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64
41 INT10085 Regulation of Cort 8 0.39 2.99 2.63
42 INT89326 Transcription of Drd3 4 0.37 0.67 2.58
43 INT25119 Binding of PTGDS 9 0.35 3.86 2.54
44 INT114188 Negative_regulation of Cort 7 0.41 3.69 2.53
45 INT50139 Regulation of Gene_expression of Ptgds 6 0.50 3.5 2.39
46 INT81312 Positive_regulation of Gene_expression of Ada 2 0.50 1.58 2.26
47 INT51047 Regulation of Drd3 4 0.53 2 2.2
48 INT14596 Localization of Ptgds 11 0.73 4.41 2.12
49 INT160326 Gene_expression of Cort 8 0.59 3.35 2.11
50 INT108982 Regulation of Gene_expression of Ptgds 6 0.51 1.64 2.07
51 INT105008 Binding of DRD3 5 0.36 3.15 2.05
52 INT61806 Regulation of Negative_regulation of Ada 1 0.30 0.63 1.89
53 INT89330 Positive_regulation of Binding of Drd3 1 0.31 0.16 1.81
54 INT267108 Negative_regulation of Gene_expression of DRD3 2 0.26 1.53 1.69
55 INT34605 Localization of Ada 7 0.80 0.13 1.61
56 INT27438 Negative_regulation of Ptgds 3 0.51 0.24 1.61
57 INT156213 Regulation of Cort 6 0.39 7.5 1.54
58 INT28425 Regulation of Ptgds 4 0.28 2.07 1.53
59 INT137927 Positive_regulation of Positive_regulation of Ada 1 0.03 1.31 1.47
60 INT30277 Protein_catabolism of Ada 3 0.52 0.9 1.42
61 INT181873 Regulation of Localization of ADA 1 0.07 1.98 1.41
62 INT160327 Localization of Cort 3 0.70 7.18 1.34
63 INT6991 Negative_regulation of Ptgds 5 0.55 3.83 1.32
64 INT12317 Regulation of Positive_regulation of Cort 2 0.23 1.18 1.32
65 INT112063 Regulation of Gene_expression of Drd3 2 0.09 1.84 1.31
66 INT44917 Negative_regulation of Gene_expression of PTGDS 6 0.50 2.98 1.27
67 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26
68 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26
69 INT82987 Transcription of DRD3 1 0.58 0.59 1.25
70 INT89328 Regulation of Transcription of Drd3 2 0.22 0.51 1.21
71 INT4570 Negative_regulation of Drd3 4 0.39 0.09 1.2
72 INT53728 Positive_regulation of Localization of Cort 2 0.41 0.9 1.19
73 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12
74 INT33803 Positive_regulation of Ptgds 4 0.50 1.09 1.1
75 INT89524 Transcription of Ptgds 3 0.46 1.34 1.09
76 INT60441 Positive_regulation of Positive_regulation of Drd3 1 0.21 0 1.07
77 INT88083 Negative_regulation of Drd3 3 0.58 0.88 1.01
78 INT127052 Transcription of Drd3 2 0.37 0.06 1
79 INT82989 Regulation of DRD3 1 0.23 0.45 0.99
80 INT111613 Regulation of PTGDS 6 0.52 3.29 0.93
81 INT163531 Regulation of Gene_expression of Cort 2 0.38 1.25 0.91
82 INT89331 Positive_regulation of Transcription of Drd3 1 0.21 0.09 0.85
83 INT119491 Positive_regulation of Positive_regulation of Drd3 1 0.46 0.17 0.83
84 INT160329 Positive_regulation of Localization of Cort 2 0.60 4.08 0.79
85 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76
86 INT220275 Protein_catabolism of Ptgds 1 0.81 2.18 0.74
87 INT89525 Positive_regulation of Transcription of Ptgds 1 0.41 0.32 0.73
88 INT40605 Negative_regulation of Negative_regulation of Ada 1 0.32 0 0.7
89 INT115952 Negative_regulation of Positive_regulation of Ptgds 1 0.02 0.43 0.65
90 INT168618 Regulation of Localization of Cort 2 0.53 0.55 0.64
91 INT127050 Positive_regulation of Transcription of Drd3 1 0.26 0.06 0.62
92 INT210028 Protein_catabolism of ADA 1 0.07 0.13 0.62
93 INT51284 Negative_regulation of Localization of PTGDS 1 0.51 0 0.6
94 INT46338 Negative_regulation of Regulation of Ptgds 1 0.37 0 0.58
95 INT28421 Negative_regulation of Regulation of Ptgds 1 0.26 0 0.56
96 INT151360 Positive_regulation of Binding of Ptgds 1 0.39 1.3 0.54
97 INT89285 Positive_regulation of Gene_expression of Drd3 2 0.60 0.09 0.52
98 INT104675 Positive_regulation of Gene_expression of Ptgds 1 0.13 0.34 0.48
99 INT160330 Positive_regulation of Gene_expression of Cort 2 0.44 1.16 0.46
100 INT206864 Transcription of PTGDS 3 0.45 1.04 0.45
101 INT147980 Regulation of Localization of Ptgds 1 0.26 0.34 0.45
102 INT58360 Negative_regulation of Positive_regulation of Ptgds 1 0.15 0.8 0.45
103 INT6992 Negative_regulation of Binding of Ptgds 2 0.39 0.93 0.44
104 INT143683 Negative_regulation of Gene_expression of ADA 1 0.09 0.28 0.44
105 INT119492 Positive_regulation of Negative_regulation of Drd3 1 0.69 0.07 0.43
106 INT56363 Regulation of Gene_expression of Ada 1 0.06 0.59 0.42
107 INT124636 Negative_regulation of Positive_regulation of Drd3 1 0.43 0.09 0.41
108 INT288539 Negative_regulation of Gene_expression of Cort 1 0.26 0.58 0.41
109 INT124635 Localization of Drd3 1 0.75 0.08 0.39
110 INT270028 Positive_regulation of Localization of Ptgds 2 0.45 0.61 0.36
111 INT317624 Regulation of Phosphorylation of Drd3 1 0.05 0.46 0.36
112 INT317616 Phosphorylation of Drd3 1 0.12 0.46 0.36
113 INT261442 Negative_regulation of Gene_expression of Drd3 1 0.04 0.7 0.35
114 INT44916 Negative_regulation of PTGDS 3 0.43 1.6 0.33
115 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33
116 INT220269 Positive_regulation of Phosphorylation of Ptgds 1 0.41 1.12 0.32
117 INT220278 Phosphorylation of Ptgds 1 0.66 1.06 0.32
118 INT160328 Positive_regulation of Positive_regulation of Cort 1 0.44 0.15 0.31
119 INT10084 Positive_regulation of Regulation of Cort 1 0.07 0.24 0.29
120 INT46337 Regulation of Ptgds 1 0.39 0 0.29
121 INT105005 Positive_regulation of Positive_regulation of DRD3 1 0.48 0.5 0.28
122 INT105006 Positive_regulation of DRD3 1 0.48 0.5 0.27
123 INT24010 Negative_regulation of Binding of Drd3 1 0.39 0 0.27
124 INT140796 Localization of Ptgds 1 0.69 0.56 0.24
125 INT159475 Positive_regulation of Binding of PTGDS 1 0.04 0.1 0.23
126 INT89286 Positive_regulation of Binding of Drd3 1 0.69 0 0.23
127 INT161817 Regulation of Localization of PTGDS 1 0.10 0.39 0.22
128 INT89284 Regulation of Binding of Drd3 1 0.45 0 0.2
129 INT344112 Regulation of Transcription of Drd3 1 0.04 0 0.2
130 INT100734 Binding of Ptgds 1 0.31 0.19 0.19
131 INT264543 Positive_regulation of Positive_regulation of PTGDS 1 0.42 0.35 0.14
132 INT264533 Regulation of Regulation of PTGDS 1 0.38 0.23 0.12
133 INT156212 Positive_regulation of Regulation of Cort 1 0.25 1.1 0.1
134 INT323226 Negative_regulation of Localization of ADA 1 0.35 3.05 0.1
135 INT110170 Positive_regulation of Positive_regulation of ADA 1 0.49 0.46 0.1
136 INT264540 Regulation of Gene_expression of PTGDS 1 0.52 0.23 0.06
137 INT354036 Negative_regulation of Localization of Cort 1 0.18 0.74 0.03
138 INT206878 Negative_regulation of Transcription of PTGDS 1 0.25 0.07 0
139 INT245086 Positive_regulation of Negative_regulation of PTGDS 1 0.26 0.75 0
140 INT200111 Phosphorylation of PTGDS 1 0.10 0.41 0
141 INT264547 Regulation of Positive_regulation of PTGDS 1 0.38 0 0
142 INT206867 Positive_regulation of Transcription of PTGDS 1 0.29 0.14 0
143 INT81680 Regulation of Binding of Ptgds 1 0.09 0 0
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