GO:0045190

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Name isotype switching
Categary Process
Go Slim No
Go Link GO:0045190
Unique Molecular Interactions 112
Total Molecular Interactions 221
Total Single Events 1673
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for isotype switching. They are ordered first by their pain relevance and then by number of times they were reported for isotype switching. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
2 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
3 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
4 INT83425 Binding of CD40LG and IGHG3 11 0.21 4.56 2.09
5 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
6 INT131853 CD40 Negative_regulation of Gene_expression of CD40LG 1 0.09 1.54 1.05
7 INT140936 Binding of Cd40lg and Ean5 1 0.07 1.03 0.98
8 INT160413 Tat Positive_regulation of Gene_expression of Cd40lg 1 0.50 0.98 0.86
9 INT125234 Positive_regulation of Binding of BCR and CD40LG 1 0.31 0.76 0.86
10 INT125233 Binding of BCR and CD40LG 1 0.23 0.75 0.85
11 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
12 INT117412 RYBP Negative_regulation of LIG4 1 0.00 0.42 0.76
13 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
14 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
15 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
16 INT258338 Binding of Aicda and Cr2 1 0.24 1.35 0.51
17 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
18 INT102599 Binding of EXOSC3 and TPPP3 3 0.39 2.61 0.48
19 INT179432 Binding of pcp and AICDA 1 0.03 3.51 0.43
20 INT258339 Binding of Aicda and Scara3 1 0.05 0.67 0.32
21 INT56250 Binding of NBN and NCOR2 1 0.00 0 0.3
22 INT191503 CD40LG Regulation of Gene_expression of F3 1 0.01 0.99 0.27
23 INT258343 Binding of Aicda and Kit 1 0.06 0.57 0.26
24 INT188699 Binding of Cd40lg and Eae1 1 0.05 1.51 0.24
25 INT182606 Binding of MSH2 and MSH3 1 0.12 1.4 0.21
26 INT350016 Binding of CD40LG and ARID1B 1 0.01 3.26 0.21
27 INT262640 Binding of HLA-DQA1 and AICDA 1 0.03 5.29 0.2
28 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
29 INT322733 CD40LG Positive_regulation of Gene_expression of CD40 1 0.08 0.62 0.18
30 INT322734 Binding of CD40LG and Positive_regulation of CD40 1 0.07 0.62 0.18
31 INT111802 Binding of CD40LG and TFPI 1 0.14 0.62 0.16
32 INT85445 NUBPL Negative_regulation of Gene_expression of CD40LG 1 0.01 0.31 0.16
33 INT29207 Msh2 Regulation of POMC 1 0.02 0.1 0.14
34 INT194576 Binding of ACLY and CD40LG 1 0.07 0.07 0.14
35 INT298476 CD40LG Positive_regulation of HLA-DRB1 1 0.01 0.33 0.12
36 INT258344 Scara3 Positive_regulation of Gene_expression of Aicda 1 0.07 0.5 0.12
37 INT298471 CD40LG Positive_regulation of CD80 1 0.04 0.33 0.12
38 INT182607 Binding of MLH1 and MSH3 1 0.04 0.81 0.11
39 INT262653 Binding of AICDA and Lmx1a 1 0.00 3.18 0.1
40 INT240770 Binding of CD40LG and F13A1 1 0.02 1.4 0.09
41 INT202505 Binding of Cd40lg and Positive_regulation of Positive_regulation of Nfasc 1 0.09 0.45 0.08
42 INT277807 CD40LG Regulation of CD40 1 0.21 0.17 0.08
43 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08
44 INT262639 Binding of HLA-DOA and AICDA 1 0.01 2.85 0.07
45 INT262638 Binding of HLA-DQB1 and AICDA 1 0.03 1.34 0.06
46 INT262636 Binding of HLA-DRB1 and AICDA 1 0.09 1.35 0.06
47 INT331561 Binding of Cd4 and Cd40lg 1 0.28 0.06 0.06
48 INT190044 Binding of Msh2 and Msh6 2 0.32 0.77 0.05
49 INT328667 Binding of CD40LG and CSF2 1 0.16 0.59 0.05
50 INT190050 Binding of Msh2 and Pms2 2 0.32 0.49 0.04
51 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04
52 INT321683 Binding of Aicda and Mapt 1 0.36 1.23 0.04
53 INT227774 Negative_regulation of Binding of Cd40 and Cd40lg 1 0.31 0.29 0.03
54 INT277243 Camk4 Regulation of Regulation of aicda 1 0.04 0.42 0.03
55 INT277223 Trib3 Regulation of Regulation of aicda 1 0.01 0.42 0.03
56 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03
57 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0
58 INT190061 Binding of MLH1 and Mlh1 1 0.01 0.92 0
59 INT219791 Cttn Regulation of AICDA 1 0.21 0.42 0
60 INT57107 Binding of Msh2 and Nts 1 0.22 0.22 0
61 INT286114 Binding of MSH6 and Mutyh 1 0.17 0 0
62 INT300616 Binding of MLH1 and PMS2 1 0.36 0.53 0
63 INT344266 Binding of APOH and CD40LG 1 0.04 0.31 0
64 INT252331 Binding of Cd40lg and Mthfd1 1 0.03 0.1 0
65 INT121318 Tgfb1 Negative_regulation of Ercc1 1 0.06 0.08 0
66 INT277809 Binding of CD4 and CD40LG 1 0.15 0 0
67 INT286653 Binding of CD40LG and OLR1 1 0.08 0.41 0
68 INT342252 Binding of Ercc1 and Tymp 1 0.29 1.24 0
69 INT285772 ERCC1 Positive_regulation of Binding of RAD51 1 0.05 0 0
70 INT101943 Binding of CD40LG and HSD11B1 1 0.08 0.23 0
71 INT121313 Tgfb1 Positive_regulation of Ercc1 1 0.07 0.08 0
72 INT308702 Binding of AQP4 and CD40LG 1 0.10 0 0
73 INT121315 Negative_regulation of Egfr Negative_regulation of Ercc1 1 0.42 0.08 0
74 INT336574 Binding of CD40LG and HCRTR1 1 0.05 0.1 0
75 INT83446 CD40LG Positive_regulation of Localization of CCL2 1 0.00 0.17 0
76 INT273518 Binding of ALB and NBN 1 0.06 0.47 0
77 INT285771 ERCC1 Regulation of Binding of RAD51 1 0.05 0 0
78 INT252334 Positive_regulation of Binding of Cd40 and Cd40lg 1 0.11 0.1 0
79 INT277136 Ebp Positive_regulation of Gene_expression of Mlh1 1 0.01 1.45 0
80 INT115239 Binding of Casp1 and EXOSC3 1 0.40 0.11 0
81 INT190049 Binding of Mlh1 and Msh3 1 0.24 0.22 0
82 INT190048 Binding of Mlh1 and Msh2 1 0.31 0.22 0
83 INT194926 Binding of CD40LG and Positive_regulation of BCR 1 0.04 0.39 0
84 INT262641 Binding of HLA-DRA and AICDA 1 0.04 0.53 0
85 INT212525 MSH6 Positive_regulation of Binding of C1qa 1 0.00 0.38 0
86 INT190062 Binding of MLH1 and Msh2 1 0.01 0.91 0
87 INT323185 Binding of LIG4 and OGG1 1 0.02 0.32 0
88 INT300617 Binding of MSH6 and MLH1 1 0.28 0.53 0
89 INT190047 Binding of Msh2 and Msh3 1 0.24 0.23 0
90 INT194927 Binding of CD40LG and Positive_regulation of CD79B 1 0.01 0.4 0
91 INT147062 LAMC2 Negative_regulation of CD40LG 1 0.47 0 0
92 INT212528 Binding of MSH6 and Apcs 1 0.00 0.68 0
93 INT233118 Binding of SIRT2 and AICDA 1 0.00 0.21 0
94 INT219792 Hcls1 Regulation of AICDA 1 0.29 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for isotype switching. They are ordered first by their pain relevance and then by number of times they were reported in isotype switching. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23
2 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46
3 INT258328 Gene_expression of Aicda 76 0.71 58.29 16.86
4 INT24816 Binding of CD40LG 68 0.47 45.48 11.56
5 INT85966 Gene_expression of Cd40lg 50 0.73 30.9 9.11
6 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7
7 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25
8 INT45753 Localization of CD40LG 45 0.79 32.31 5.28
9 INT85965 Binding of Cd40lg 26 0.45 16.76 4.52
10 INT5148 Regulation of CD40LG 25 0.44 21.58 4.05
11 INT140933 Binding of Cd40lg 1 0.38 4.2 3.6
12 INT140931 Gene_expression of Cd40lg 5 0.61 5.2 3.33
13 INT85971 Positive_regulation of Gene_expression of Cd40lg 14 0.66 7.61 3.29
14 INT125237 Negative_regulation of Gene_expression of CD40LG 16 0.54 9.9 3.27
15 INT85970 Positive_regulation of Cd40lg 21 0.53 8.51 3.16
16 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17
17 INT258311 Positive_regulation of Gene_expression of Aicda 9 0.60 8.51 1.74
18 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7
19 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6
20 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58
21 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46
22 INT121307 Gene_expression of Ercc1 4 0.73 12.69 1.37
23 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12
24 INT258316 Binding of Aicda 1 0.30 2.24 1.08
25 INT188667 Localization of Cd40lg 5 0.57 3.29 1.07
26 INT188664 Negative_regulation of Cd40lg 7 0.33 3.99 1.04
27 INT140928 Negative_regulation of Gene_expression of Cd40lg 1 0.46 1.09 1.01
28 INT92139 Binding of MLH1 12 0.42 15.62 1
29 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93
30 INT258313 Positive_regulation of Aicda 6 0.46 2.14 0.85
31 INT160406 Transcription of Cd40lg 2 0.52 1.52 0.83
32 INT258315 Negative_regulation of Gene_expression of Aicda 1 0.54 1.79 0.8
33 INT193203 Gene_expression of AICDA 30 0.58 3.54 0.78
34 INT92142 Binding of MSH2 5 0.46 5.64 0.75
35 INT258321 Regulation of Gene_expression of Aicda 1 0.42 1.47 0.75
36 INT250281 Positive_regulation of Positive_regulation of CD40LG 3 0.23 3.19 0.73
37 INT85969 Regulation of Gene_expression of Cd40lg 2 0.43 1.96 0.69
38 INT25176 Regulation of Msh2 3 0.37 0.48 0.68
39 INT9835 Binding of AICDA 29 0.47 6.76 0.66
40 INT285262 Regulation of Cd40lg 3 0.34 1.48 0.66
41 INT178201 Negative_regulation of Binding of Cd40lg 2 0.33 2.92 0.64
42 INT56251 Binding of NBN 4 0.38 3.16 0.62
43 INT130373 Regulation of Gene_expression of CD40LG 3 0.60 1.87 0.59
44 INT333877 Protein_catabolism of LIG4 2 0.03 2.03 0.57
45 INT277232 Gene_expression of aicda 11 0.49 6.76 0.55
46 INT83435 Negative_regulation of Binding of CD40LG 2 0.39 0.96 0.55
47 INT236370 Positive_regulation of Phosphorylation of CD40LG 1 0.37 0.59 0.55
48 INT25175 Gene_expression of Msh2 2 0.55 0.4 0.52
49 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51
50 INT83436 Positive_regulation of Binding of CD40LG 3 0.33 0.85 0.49
51 INT68907 Regulation of AICDA 4 0.44 0.77 0.47
52 INT121310 Positive_regulation of Ercc1 2 0.45 1.78 0.42
53 INT219001 Gene_expression of ERCC1 12 0.54 3.77 0.38
54 INT41179 Negative_regulation of EXOSC3 1 0.42 0.08 0.35
55 INT151274 Negative_regulation of Gene_expression of Cd40lg 3 0.32 2.16 0.3
56 INT219780 Positive_regulation of AICDA 23 0.49 2.27 0.29
57 INT233127 Positive_regulation of Gene_expression of AICDA 4 0.11 0.91 0.29
58 INT258320 Negative_regulation of Aicda 2 0.50 2.29 0.29
59 INT258329 Negative_regulation of Binding of Aicda 1 0.34 0.58 0.29
60 INT153836 Phosphorylation of CD40LG 2 0.79 0.47 0.28
61 INT107983 Gene_expression of MSH6 6 0.51 5.57 0.27
62 INT121311 Positive_regulation of Gene_expression of Ercc1 3 0.62 1.23 0.21
63 INT258312 Localization of Aicda 4 0.64 0.88 0.2
64 INT285263 Positive_regulation of Negative_regulation of Cd40lg 1 0.26 0.34 0.19
65 INT76125 Transcription of CD40LG 5 0.55 2.66 0.18
66 INT182627 Regulation of MSH2 1 0.26 2.27 0.18
67 INT169875 Negative_regulation of Ercc1 3 0.43 3.07 0.17
68 INT219192 Positive_regulation of Regulation of CD40LG 2 0.43 2.9 0.17
69 INT179431 Localization of AICDA 9 0.78 2.34 0.16
70 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16
71 INT332303 Localization of Cd40lg 1 0.00 0.26 0.14
72 INT285264 Regulation of Localization of Cd40lg 1 0.25 0.42 0.13
73 INT219164 Regulation of Positive_regulation of CD40LG 1 0.04 1.51 0.13
74 INT182621 Localization of MLH1 9 0.64 9.31 0.12
75 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12
76 INT147244 Regulation of MLH1 3 0.08 2.64 0.12
77 INT182623 Localization of MSH2 3 0.77 5.49 0.12
78 INT233119 Regulation of Gene_expression of AICDA 2 0.03 0.12 0.12
79 INT277234 Regulation of aicda 1 0.39 2.88 0.12
80 INT257930 Regulation of Binding of Cd40lg 1 0.13 1.14 0.12
81 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11
82 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11
83 INT258319 Transcription of Aicda 1 0.55 0.28 0.11
84 INT240780 Negative_regulation of Localization of CD40LG 2 0.24 0.72 0.1
85 INT258310 Positive_regulation of Localization of Aicda 1 0.40 0.19 0.1
86 INT252306 Positive_regulation of Binding of Cd40lg 1 0.22 0.55 0.1
87 INT15504 Positive_regulation of Msh2 1 0.33 0.15 0.09
88 INT285813 Negative_regulation of ERCC1 13 0.30 2.03 0.08
89 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07
90 INT298117 Binding of aicda 1 0.02 0.46 0.06
91 INT285261 Regulation of Positive_regulation of Cd40lg 1 0.15 0.11 0.05
92 INT273525 Regulation of NBN 1 0.49 1.28 0.05
93 INT190022 Positive_regulation of Mlh1 2 0.38 3.16 0.03
94 INT190039 Gene_expression of Mlh1 3 0.68 6.14 0
95 INT107991 Positive_regulation of Gene_expression of MSH6 3 0.38 1.35 0
96 INT190020 Gene_expression of Msh2 2 0.69 0.69 0
97 INT190038 Binding of Mlh1 2 0.28 3.11 0
98 INT212518 Localization of MSH6 2 0.10 2.66 0
99 INT190035 Binding of Msh6 2 0.28 2.72 0
100 INT233128 Regulation of Binding of AICDA 1 0.03 0 0
101 INT211582 Transcription of Mlh1 1 0.41 0.34 0
102 INT206928 Transcription of MSH2 1 0.52 0.4 0
103 INT342249 Binding of Ercc1 1 0.33 2.69 0
104 INT268375 Positive_regulation of Positive_regulation of MLH1 1 0.12 0.76 0
105 INT285815 Binding of ERCC1 1 0.26 0 0
106 INT190012 Regulation of Mlh1 1 0.34 0.34 0
107 INT182625 Positive_regulation of Localization of MSH2 1 0.45 2.47 0
108 INT260848 Transcription of NBN 1 0.57 0.54 0
109 INT320730 Positive_regulation of Gene_expression of NBN 1 0.60 1.84 0
110 INT277235 Positive_regulation of Regulation of aicda 1 0.30 0.36 0
111 INT190058 Positive_regulation of Localization of MLH1 1 0.02 0.84 0
112 INT185286 Transcription of MLH1 1 0.06 1.12 0
113 INT277230 Negative_regulation of aicda 1 0.28 1.33 0
114 INT260850 Regulation of Gene_expression of NBN 1 0.38 0.57 0
115 INT285814 Positive_regulation of ERCC1 1 0.35 0.14 0
116 INT320479 Regulation of Localization of AICDA 1 0.19 0.08 0
117 INT121309 Localization of Ercc1 1 0.29 0 0
118 INT350584 Negative_regulation of Gene_expression of Mlh1 1 0.51 2.21 0
119 INT190015 Binding of Msh2 1 0.27 1.41 0
120 INT305347 Negative_regulation of Gene_expression of Msh6 1 0.25 2.22 0
121 INT277238 Localization of aicda 1 0.51 0.65 0
122 INT211715 Negative_regulation of Gene_expression of MSH6 1 0.06 1.09 0
123 INT169276 Localization of NBN 1 0.08 0.08 0
124 INT268369 Positive_regulation of Negative_regulation of MLH1 1 0.11 0.76 0
125 INT107990 Positive_regulation of Gene_expression of MLH1 1 0.15 0 0
126 INT233123 Negative_regulation of AICDA 1 0.02 0 0
127 INT107984 Positive_regulation of Gene_expression of MSH2 1 0.11 0 0
128 INT182624 Positive_regulation of Positive_regulation of MSH2 1 0.45 1.24 0
129 INT342250 Negative_regulation of Gene_expression of Ercc1 1 0.40 0.99 0
130 INT298109 Positive_regulation of Gene_expression of aicda 1 0.03 0 0
131 INT285819 Negative_regulation of Negative_regulation of ERCC1 1 0.30 0.18 0
132 INT233122 Positive_regulation of Positive_regulation of AICDA 1 0.03 0 0
133 INT273522 Negative_regulation of Gene_expression of NBN 1 0.34 0.91 0
134 INT211583 Regulation of Transcription of Mlh1 1 0.27 0.34 0
135 INT268359 Positive_regulation of MLH1 1 0.12 0.76 0
136 INT323201 Binding of LIG4 1 0.03 0.32 0
137 INT298108 Negative_regulation of Binding of aicda 1 0.02 0 0
138 INT175425 Negative_regulation of Negative_regulation of MLH1 1 0.19 0.73 0
139 INT304071 Binding of MSH6 1 0.28 1.11 0
140 INT350588 Negative_regulation of Mlh1 1 0.38 3.05 0
141 INT305349 Gene_expression of Msh6 1 0.46 2.21 0
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