GO:0045214

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Name sarcomere organization
Categary Process
Go Slim No
Go Link GO:0045214
Unique Molecular Interactions 55
Total Molecular Interactions 66
Total Single Events 726
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sarcomere organization. They are ordered first by their pain relevance and then by number of times they were reported for sarcomere organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11
2 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
3 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
4 INT89875 Pdyn Positive_regulation of Localization of Myh6 1 0.09 0 0.66
5 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
6 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
7 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
8 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
9 INT130740 Regulation of Binding of Tnnt2 and Mb 1 0.00 0.47 0.19
10 INT130741 Binding of Tnnt2 and Mb 1 0.01 0.47 0.19
11 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
12 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14
13 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
14 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
15 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
16 INT168856 Binding of Tnnt2 and Fabp3 1 0.05 0.57 0.09
17 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08
18 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
19 INT216130 SRF Positive_regulation of Gene_expression of EGR1 1 0.49 0.32 0.07
20 INT279767 Binding of IGHG3 and KRT19 1 0.01 0.84 0.07
21 INT216129 SRF Positive_regulation of Gene_expression of FOS 1 0.28 0.32 0.07
22 INT317416 Binding of FN1 and ITGB1 1 0.47 0.69 0.05
23 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05
24 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
25 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04
26 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04
27 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
28 INT279762 Binding of KRT18 and KRT19 1 0.01 0.43 0.04
29 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03
30 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
31 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
32 INT190632 Binding of Srf and Yy1 1 0.20 0.14 0
33 INT322244 Binding of Hcm and Mybpc3 1 0.11 0.85 0
34 INT303342 Binding of NPAT and TCAP 1 0.40 0 0
35 INT303404 Binding of TCAP and Jag1 1 0.39 0 0
36 INT217144 MIR21 Negative_regulation of TPM1 1 0.06 1.03 0
37 INT322259 Binding of Hcm and Tpm1 1 0.10 0.85 0
38 INT225590 Ncoa6 Regulation of Srf 1 0.08 0.21 0
39 INT322249 Binding of Hcm and Tnnt2 1 0.11 0.86 0
40 INT232898 Binding of KRT1 and Krt8 1 0.27 1.22 0
41 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
42 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0
43 INT232892 Krt18 Positive_regulation of Gene_expression of Krt8 1 0.30 0.09 0
44 INT232889 Binding of Krt18 and Krt8 1 0.22 1.09 0
45 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
46 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0
47 INT272197 Binding of CAPN3 and DYSF 1 0.42 0.38 0
48 INT277310 Binding of Tnnt2 and Mbnl1 1 0.18 1.1 0
49 INT322257 Binding of Mybpc3 and Myh7 1 0.34 0.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sarcomere organization. They are ordered first by their pain relevance and then by number of times they were reported in sarcomere organization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63957 Positive_regulation of Tnnt2 33 0.69 18.56 5.41
2 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
3 INT137702 Binding of TTN 7 0.35 4.48 3.62
4 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
5 INT168097 Transcription of Tnnt2 1 0.07 2.12 2.47
6 INT81247 Gene_expression of Tnnt2 9 0.31 2.06 2.37
7 INT118896 Regulation of Tnnt2 4 0.44 2.94 2.09
8 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
9 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82
10 INT168602 Negative_regulation of Itgb1 3 0.21 1.29 1.73
11 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
12 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
13 INT72458 Positive_regulation of Tnnt2 5 0.69 5.59 1.38
14 INT47434 Gene_expression of Tnnt2 14 0.60 10.4 1.37
15 INT104636 Regulation of TTN 2 0.33 0 1.29
16 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
17 INT96117 Negative_regulation of Tnnt2 3 0.13 1.61 1.1
18 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06
19 INT10448 Positive_regulation of Srf 3 0.47 0.89 1.03
20 INT135032 Negative_regulation of SRF 1 0.49 0 1.03
21 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
22 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
23 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
24 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97
25 INT26531 Regulation of Srf 3 0.18 0.62 0.9
26 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
27 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83
28 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
29 INT45293 Transcription of Srf 2 0.47 0.79 0.76
30 INT45489 Gene_expression of SRF 5 0.77 3.29 0.71
31 INT63958 Regulation of Tnnt2 7 0.45 5.36 0.7
32 INT272206 Gene_expression of CAPN3 4 0.77 3.83 0.7
33 INT89870 Localization of Myh6 1 0.26 0 0.65
34 INT64536 Binding of Tnnt2 4 0.32 2.47 0.64
35 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
36 INT39728 Regulation of TCAP 1 0.00 0 0.61
37 INT45292 Negative_regulation of Transcription of Srf 1 0.06 0.65 0.59
38 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
39 INT145225 Transcription of ITGB1 1 0.10 0.1 0.52
40 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51
41 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
42 INT232840 Positive_regulation of Gene_expression of Krt8 1 0.44 4.51 0.42
43 INT232825 Positive_regulation of Krt8 1 0.44 6.83 0.42
44 INT111822 Binding of Krt8 6 0.34 4.61 0.39
45 INT64537 Localization of Tnnt2 5 0.76 1.57 0.37
46 INT73898 Positive_regulation of Regulation of Tnnt2 1 0.44 0.83 0.37
47 INT342958 Positive_regulation of Gene_expression of CAPN3 1 0.69 0.66 0.35
48 INT119073 Negative_regulation of ITGB1 1 0.01 0.1 0.33
49 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31
50 INT18821 Positive_regulation of Gene_expression of Srf 2 0.35 0.63 0.31
51 INT345368 Negative_regulation of Krt8 1 0.00 7.25 0.31
52 INT7610 Localization of Srf 3 0.67 0.98 0.27
53 INT256425 Negative_regulation of Negative_regulation of KRT19 1 0.06 1.59 0.26
54 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
55 INT232970 Localization of KRT19 4 0.41 3.41 0.23
56 INT206746 Gene_expression of TPM1 7 0.75 2.15 0.21
57 INT305392 Binding of NKX2-5 1 0.22 0.93 0.21
58 INT232824 Regulation of Krt8 1 0.29 1.64 0.21
59 INT272202 Negative_regulation of CAPN3 4 0.59 0.99 0.2
60 INT225973 Binding of Itgb1 2 0.08 1.1 0.2
61 INT245860 Gene_expression of Itgb1 8 0.42 5.37 0.19
62 INT342960 Regulation of CAPN3 1 0.45 0.39 0.18
63 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
64 INT342959 Protein_catabolism of CAPN3 1 0.87 0.41 0.16
65 INT89766 Binding of SRF 1 0.17 0.89 0.15
66 INT89767 Positive_regulation of Binding of SRF 1 0.23 0.89 0.15
67 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
68 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13
69 INT195420 Positive_regulation of TPM1 3 0.67 0.07 0.12
70 INT222042 Localization of ITGB1 3 0.29 0.72 0.12
71 INT287862 Phosphorylation of Tnnt2 1 0.42 0.07 0.12
72 INT311275 Regulation of Gene_expression of Tnnt2 2 0.34 1.33 0.1
73 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
74 INT121284 Positive_regulation of Gene_expression of Tnnt2 2 0.46 0.89 0.1
75 INT323415 Regulation of NKX2-5 1 0.39 0.71 0.1
76 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
77 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1
78 INT193893 Gene_expression of Tpm1 5 0.65 1.65 0.09
79 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
80 INT121285 Regulation of Positive_regulation of Tnnt2 2 0.45 0.84 0.09
81 INT355176 Regulation of Binding of TTN 1 0.29 0.78 0.09
82 INT232822 Negative_regulation of Gene_expression of Krt8 5 0.36 2.3 0.08
83 INT168853 Binding of Tnnt2 2 0.19 0.4 0.08
84 INT197520 Positive_regulation of Gene_expression of TTN 1 0.09 0 0.08
85 INT217224 Regulation of TPM1 2 0.34 2.9 0.07
86 INT22789 Binding of Srf 1 0.37 0.07 0.07
87 INT305387 Positive_regulation of Gene_expression of NKX2-5 1 0.31 0.72 0.07
88 INT22790 Positive_regulation of Binding of Srf 1 0.50 0.07 0.07
89 INT190544 Transcription of Srf 1 0.19 0.43 0.06
90 INT342956 Positive_regulation of Negative_regulation of CAPN3 1 0.46 0.16 0.06
91 INT190570 Localization of Srf 1 0.20 0.49 0.06
92 INT232850 Phosphorylation of Krt8 7 0.52 3.8 0.05
93 INT232957 Binding of KRT19 3 0.23 0.97 0.05
94 INT226169 Positive_regulation of Gene_expression of Tpm1 2 0.49 1.17 0.05
95 INT322228 Gene_expression of Mybpc3 1 0.62 0.44 0.05
96 INT104302 Localization of Tnnt2 2 0.70 0.52 0.04
97 INT183436 Positive_regulation of Localization of Tnnt2 1 0.30 0.45 0.04
98 INT265497 Positive_regulation of TTN 2 0.04 0 0.03
99 INT225411 Positive_regulation of Srf 1 0.05 0.27 0.03
100 INT268102 Transcription of SRF 1 0.53 0.85 0.03
101 INT225413 Binding of Srf 1 0.10 0.27 0.03
102 INT157800 Gene_expression of Srf 2 0.45 0.88 0
103 INT268299 Positive_regulation of Gene_expression of Itgb1 2 0.38 1.37 0
104 INT239989 Gene_expression of Myh6 2 0.55 0 0
105 INT255134 Positive_regulation of Localization of Tnnt2 1 0.44 0.15 0
106 INT105753 Positive_regulation of Gene_expression of SRF 1 0.01 0.13 0
107 INT225977 Regulation of Binding of Itgb1 1 0.07 0.41 0
108 INT272203 Binding of CAPN3 1 0.37 0.23 0
109 INT232832 Localization of Krt8 1 0.48 0.84 0
110 INT232847 Negative_regulation of Protein_catabolism of Krt8 1 0.33 0.13 0
111 INT342957 Positive_regulation of CAPN3 1 0.43 0.18 0
112 INT248591 Positive_regulation of Gene_expression of TPM1 1 0.67 0.07 0
113 INT239982 Positive_regulation of Positive_regulation of Myh6 1 0.46 0 0
114 INT287846 Positive_regulation of Phosphorylation of Tnnt2 1 0.25 0 0
115 INT232820 Protein_catabolism of Krt8 1 0.55 0.13 0
116 INT193842 Negative_regulation of Tpm1 1 0.09 0 0
117 INT197519 Positive_regulation of Regulation of TTN 1 0.09 0 0
118 INT245366 Regulation of Itgb1 1 0.03 0 0
119 INT232849 Negative_regulation of Phosphorylation of Krt8 1 0.27 0.24 0
120 INT296937 Localization of TPM1 1 0.73 0.63 0
121 INT239981 Positive_regulation of Myh6 1 0.46 0 0
122 INT355317 Negative_regulation of Gene_expression of Itgb1 1 0.20 0.14 0
123 INT239986 Regulation of Myh6 1 0.25 0 0
124 INT342954 Positive_regulation of Positive_regulation of CAPN3 1 0.43 0.1 0
125 INT195418 Negative_regulation of Binding of TPM1 1 0.41 0.1 0
126 INT232836 Regulation of Gene_expression of Krt8 1 0.29 1.57 0
127 INT342961 Negative_regulation of Gene_expression of CAPN3 1 0.43 0.1 0
128 INT255106 Positive_regulation of Binding of Tnnt2 1 0.44 0.17 0
129 INT291604 Binding of ITGB1 1 0.05 0.16 0
130 INT303380 Protein_catabolism of TCAP 1 0.64 0 0
131 INT332457 Transcription of KRT19 1 0.28 0.19 0
132 INT105752 Positive_regulation of SRF 1 0.01 0.13 0
133 INT195419 Binding of TPM1 1 0.36 0.09 0
134 INT268104 Negative_regulation of Gene_expression of SRF 1 0.38 0.16 0
135 INT232846 Regulation of Positive_regulation of Krt8 1 0.29 0.71 0
136 INT248559 Positive_regulation of Tpm1 1 0.13 0.07 0
137 INT213446 Regulation of Gene_expression of SRF 1 0.22 0.71 0
138 INT197522 Localization of TTN 1 0.14 0 0
139 INT232851 Positive_regulation of Phosphorylation of Krt8 1 0.32 0.47 0
140 INT280923 Localization of Itgb1 1 0.40 0.72 0
141 INT225408 Negative_regulation of Srf 1 0.05 0.39 0
142 INT157799 Negative_regulation of Gene_expression of Srf 1 0.18 0.07 0
143 INT157794 Phosphorylation of Srf 1 0.26 0.07 0
144 INT175647 Regulation of Gene_expression of ITGB1 1 0.01 0.4 0
145 INT296939 Positive_regulation of Localization of TPM1 1 0.49 0.63 0
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