GO:0045236

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Name CXCR chemokine receptor binding
Categary Function
Go Slim No
Go Link GO:0045236
Unique Molecular Interactions 62
Total Molecular Interactions 108
Total Single Events 468
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for CXCR chemokine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for CXCR chemokine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
2 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
3 INT149844 Negative_regulation of Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.26
4 INT149845 Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.24
5 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22
6 INT105109 Cxcl12 Positive_regulation of JUN 1 0.01 1.07 1.05
7 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95
8 INT182198 Binding of CXCR5 and CXCL12 1 0.33 1.25 0.94
9 INT182209 Binding of CXCL12 and CXCL13 1 0.30 1.24 0.93
10 INT166135 Regulation of Binding of Cxcl12 and Cxcr4 1 0.30 0.9 0.91
11 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88
12 INT254004 Cxcl12 Positive_regulation of Cxcr4 1 0.47 1.29 0.86
13 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85
14 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66
15 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6
16 INT253998 Cyp3a23/3a1 Positive_regulation of Binding of Cxcl12 1 0.10 0.65 0.55
17 INT253990 Cyp3a23/3a1 Positive_regulation of Cxcl12 1 0.09 0.65 0.55
18 INT105110 Cxcl12 Positive_regulation of NFKB1 1 0.06 0.54 0.53
19 INT105108 Negative_regulation of Cxcl12 Positive_regulation of NFKB1 1 0.05 0.54 0.53
20 INT181441 Csf2 Positive_regulation of Cxcl12 1 0.02 1.69 0.39
21 INT190290 Binding of CXCL12 and VIPR1 1 0.06 0 0.33
22 INT322964 Binding of IL8 and Cxcl12 1 0.30 0.2 0.32
23 INT333246 Binding of Cxcr4 and Cxcl12 3 0.34 0.99 0.27
24 INT291352 Positive_regulation of CXCL12 Positive_regulation of ERBB2 1 0.17 0.88 0.22
25 INT253991 Negative_regulation of Binding of Cxcl12 and Cxcr4 1 0.43 0.41 0.21
26 INT333250 Binding of Cxcr7 and Cxcl12 1 0.19 1.39 0.18
27 INT353361 Positive_regulation of Binding of Cxcr4 and Cxcl12 1 0.46 0 0.17
28 INT291354 CXCL12 Positive_regulation of EPHB2 1 0.42 2.02 0.16
29 INT333255 Cxcl12 Regulation of Mcl1 1 0.12 1.12 0.15
30 INT333241 Cxcl12 Regulation of Bcl2l11 1 0.18 1.11 0.15
31 INT353359 Binding of Cxcl12 and Regulation of Nes 1 0.25 0.3 0.15
32 INT353360 Binding of Cxcl12 and Positive_regulation of Gene_expression of Hist1h3f 1 0.03 0.3 0.15
33 INT333242 Bcl2l11 Positive_regulation of Gene_expression of Cxcl12 1 0.18 1.48 0.1
34 INT291358 Binding of CXCL12 and CXCR7 1 0.20 0.11 0.09
35 INT333251 Binding of Bcl2l11 and Cxcl12 1 0.14 1.74 0.08
36 INT249968 Cxcr4 Positive_regulation of Cxcl12 1 0.17 0.55 0.08
37 INT333256 Gene_expression of Cxcl12 Negative_regulation of Ptk2b 1 0.10 0.99 0.07
38 INT333260 Gene_expression of Cxcl12 Negative_regulation of Gene_expression of Ptk2 1 0.21 1 0.07
39 INT333247 Gene_expression of Cxcl12 Negative_regulation of Pxn 1 0.09 1 0.07
40 INT333243 Gene_expression of Cxcl12 Negative_regulation of Bcar1 1 0.15 1 0.07
41 INT333257 Gene_expression of Cxcl12 Negative_regulation of Ptk2 1 0.21 1 0.07
42 INT291355 CXCL12 Positive_regulation of Gene_expression of HGF 1 0.06 1.53 0.06
43 INT345307 CXCL12 Positive_regulation of Gene_expression of MMP15 1 0.00 2.5 0.05
44 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05
45 INT333254 Binding of Mcl1 and Cxcl12 1 0.10 0.88 0.04
46 INT333244 Positive_regulation of Binding of Mcl1 and Cxcl12 1 0.13 0.88 0.04
47 INT291356 CXCL12 Positive_regulation of AKT1 1 0.04 1.28 0.03
48 INT333249 Cxcl12 Positive_regulation of Positive_regulation of Bak1 1 0.30 0.32 0.03
49 INT121650 Negative_regulation of Binding of CXCL12 and CXCR4 2 0.47 1.61 0
50 INT245071 Binding of CXCL12 and KDELR1 1 0.04 1.49 0
51 INT121652 Binding of CCR5 and CXCL12 1 0.33 0.2 0
52 INT333258 Gene_expression of Cxcl12 Positive_regulation of Positive_regulation of Bak1 1 0.15 0.55 0
53 INT121649 Binding of CD4 and CXCL12 1 0.29 0.2 0
54 INT245077 Binding of ESR1 and CXCL12 1 0.06 1.42 0
55 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
56 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
57 INT299130 Cxcl12 Positive_regulation of Gene_expression of Fgf2 1 0.15 0.38 0
58 INT299140 Cxcl12 Positive_regulation of Transcription of VEGFA 1 0.03 0.38 0
59 INT333248 Bcl2l11 Regulation of Gene_expression of Cxcl12 1 0.11 0.52 0
60 INT333033 Binding of Itch and Laptm5 1 0.01 0 0
61 INT299129 Cxcl12 Positive_regulation of Transcription of Fgf2 1 0.16 0.38 0
62 INT333031 Binding of Itch and Mul1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for CXCR chemokine receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in CXCR chemokine receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79
2 INT222233 Gene_expression of Cxcl12 42 0.69 32.64 10.13
3 INT126478 Gene_expression of Cxcl12 78 0.77 58.69 8.01
4 INT136309 Positive_regulation of Cxcl12 24 0.62 12.45 5.58
5 INT121661 Binding of CXCL12 25 0.37 11.27 3.82
6 INT253983 Binding of Cxcl12 8 0.43 5.33 3.71
7 INT130646 Regulation of CXCL12 14 0.47 7.67 3.48
8 INT181386 Positive_regulation of Cxcl12 12 0.69 15.35 2.84
9 INT253982 Positive_regulation of Binding of Cxcl12 1 0.45 3.85 2.6
10 INT130638 Regulation of Cxcl12 6 0.34 2.91 2.44
11 INT121659 Positive_regulation of CXCL12 8 0.53 9.17 2.36
12 INT108482 Positive_regulation of Gene_expression of CXCL12 7 0.53 9.72 2.36
13 INT222230 Positive_regulation of Gene_expression of Cxcl12 11 0.59 5.26 2.13
14 INT297679 Positive_regulation of Gene_expression of Cxcl12 6 0.69 8.02 2.02
15 INT253972 Positive_regulation of Positive_regulation of Cxcl12 1 0.45 3.22 1.71
16 INT113110 Negative_regulation of CXCL12 8 0.43 6.01 1.63
17 INT222227 Localization of Cxcl12 5 0.64 1.61 1.59
18 INT254252 Localization of Cxcl12 9 0.76 7.17 1.49
19 INT130647 Regulation of Gene_expression of CXCL12 6 0.39 5.01 1.38
20 INT245089 Localization of CXCL12 8 0.65 10.17 1.28
21 INT211294 Binding of Cxcl12 4 0.45 2.89 1.05
22 INT222231 Transcription of Cxcl12 4 0.55 2.25 0.91
23 INT300848 Negative_regulation of Cxcl12 3 0.40 2.29 0.69
24 INT291371 Positive_regulation of Localization of CXCL12 2 0.35 2.8 0.65
25 INT333232 Negative_regulation of Gene_expression of Cxcl12 4 0.42 3.35 0.57
26 INT222238 Regulation of Localization of Cxcl12 1 0.22 0.6 0.55
27 INT136310 Negative_regulation of Cxcl12 3 0.37 3.29 0.51
28 INT280914 Positive_regulation of Localization of Cxcl12 3 0.44 3.99 0.47
29 INT291367 Negative_regulation of Gene_expression of CXCL12 3 0.32 4.15 0.47
30 INT281148 Negative_regulation of Transcription of Cxcl12 1 0.26 1.12 0.47
31 INT281140 Regulation of Binding of Cxcl12 1 0.28 0.93 0.47
32 INT281149 Positive_regulation of Localization of Cxcl12 1 0.31 0.42 0.45
33 INT274228 Positive_regulation of Positive_regulation of Cxcl12 4 0.44 2.82 0.23
34 INT299139 Positive_regulation of Transcription of Cxcl12 1 0.37 0.28 0.21
35 INT245087 Transcription of CXCL12 2 0.46 2.04 0.2
36 INT333239 Regulation of Gene_expression of Cxcl12 1 0.43 3.48 0.19
37 INT312713 Protein_catabolism of CXCL12 1 0.37 0.45 0.17
38 INT253969 Regulation of Gene_expression of Cxcl12 3 0.40 1.56 0.15
39 INT253981 Negative_regulation of Gene_expression of Cxcl12 3 0.39 1.7 0.13
40 INT233555 Regulation of Cxcl12 2 0.43 4.12 0.13
41 INT299136 Protein_catabolism of Cxcl12 1 0.56 1.15 0.09
42 INT353357 Regulation of Positive_regulation of Cxcl12 1 0.27 0.62 0.08
43 INT333206 Negative_regulation of Localization of Cxcl12 1 0.41 1.11 0.08
44 INT333233 Negative_regulation of Positive_regulation of Cxcl12 1 0.41 1.11 0.08
45 INT291363 Positive_regulation of Binding of CXCL12 1 0.38 0.36 0.03
46 INT333019 Binding of Itch 1 0.13 0 0
47 INT245083 Regulation of Positive_regulation of CXCL12 1 0.39 1.6 0
48 INT333021 Negative_regulation of Positive_regulation of Itch 1 0.14 0 0
49 INT333024 Positive_regulation of Itch 1 0.17 0 0
50 INT333210 Regulation of Localization of Cxcl12 1 0.58 0.56 0
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