GO:0045254

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Name pyruvate dehydrogenase complex
Categary Component
Go Slim No
Go Link GO:0045254
Unique Molecular Interactions 93
Total Molecular Interactions 119
Total Single Events 504
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pyruvate dehydrogenase complex. They are ordered first by their pain relevance and then by number of times they were reported for pyruvate dehydrogenase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT237286 Dlat Regulation of Prep 1 0.01 0 1.57
2 INT309140 Dlat Positive_regulation of Creb1 1 0.06 1.1 0.9
3 INT291552 Binding of Dlat and Sec22b 1 0.01 0.95 0.67
4 INT237285 Dlat Negative_regulation of Prep 1 0.01 0 0.62
5 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
6 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
7 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
8 INT309136 Dlat Positive_regulation of Gene_expression of Car1 1 0.03 0.99 0.45
9 INT309129 Dlat Positive_regulation of Gene_expression of Btg1 1 0.00 1.05 0.42
10 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
11 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
12 INT17059 Binding of DLD and Oxt 1 0.03 0.22 0.41
13 INT309138 Tecr Negative_regulation of Dlat 1 0.00 0.77 0.4
14 INT291545 Binding of Dlat and St8sia2 1 0.14 0.44 0.37
15 INT309148 Dlat Positive_regulation of Cks2 1 0.00 0.54 0.36
16 INT263359 Dlat Negative_regulation of Gars 1 0.15 0.31 0.35
17 INT291555 Binding of ESR1 and Dlat 1 0.01 0.6 0.35
18 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
19 INT309151 Dlat Positive_regulation of Positive_regulation of Ephb1 1 0.02 0.57 0.33
20 INT291543 Binding of Dlat and Gper 1 0.15 0.37 0.33
21 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
22 INT309133 Dlat Positive_regulation of Ephb1 1 0.02 0.54 0.27
23 INT309141 Dlat Positive_regulation of Car1 1 0.03 0.19 0.24
24 INT263366 Dlat Regulation of Glyr1 1 0.03 0 0.22
25 INT309124 Dlat Negative_regulation of Positive_regulation of Mapk8 1 0.02 0.27 0.22
26 INT309117 Dlat Positive_regulation of Gsdmc 1 0.00 0.24 0.2
27 INT263363 Binding of Dlat and Gars 1 0.11 0.18 0.18
28 INT263365 Glyr1 Regulation of Dlat 1 0.03 0.18 0.17
29 INT309149 Dlat Regulation of Gsdmc 1 0.00 0.38 0.15
30 INT76965 Mpo Negative_regulation of DLD 1 0.26 0.91 0.07
31 INT352943 Pik3cb Positive_regulation of Pdk1 1 0.09 0.21 0.06
32 INT201439 Dlat Regulation of Localization of Slc6a3 1 0.04 0 0.06
33 INT310321 DLD Negative_regulation of COQ10A 1 0.01 0.06 0.05
34 INT263364 Dlat Positive_regulation of Gars 1 0.14 0 0.04
35 INT263360 Dlat Positive_regulation of Regulation of Gars 1 0.14 0 0.04
36 INT309146 Dlat Positive_regulation of Phosphorylation of Rorb 1 0.00 0 0.04
37 INT309111 Dlat Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.04
38 INT263362 Dlat Regulation of Gars 1 0.14 0 0.04
39 INT201442 Dlat Regulation of Slc6a3 1 0.04 0.18 0.04
40 INT321297 Positive_regulation of Binding of Akt1 and Pdk1 1 0.15 0.13 0.03
41 INT197593 Dlat Positive_regulation of Rb1 1 0.04 0 0.03
42 INT321291 Binding of Akt1 and Pdk1 1 0.11 0.13 0.03
43 INT165165 Dlat Positive_regulation of Positive_regulation of Mapk3 1 0.00 0 0
44 INT173769 Dlat Regulation of Ghr 1 0.04 0 0
45 INT339402 Binding of Dlat and Tymp 1 0.19 0 0
46 INT339405 Negative_regulation of Binding of Dlat and Tymp 1 0.22 0 0
47 INT176919 Binding of DLD and Bpifa2 1 0.00 0.08 0
48 INT197588 Dlat Regulation of Pgr 1 0.04 0.26 0
49 INT272391 Dlat Regulation of PRS 1 0.00 0 0
50 INT176920 DLD Positive_regulation of Binding of Bpifa2 1 0.00 0.08 0
51 INT165164 Dlat Positive_regulation of Mapk3 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pyruvate dehydrogenase complex. They are ordered first by their pain relevance and then by number of times they were reported in pyruvate dehydrogenase complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94
2 INT17056 Gene_expression of DLD 37 0.57 13.15 5.47
3 INT187346 Regulation of Dlat 12 0.29 1.82 4.28
4 INT42317 Negative_regulation of Dlat 21 0.43 3.13 4.11
5 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06
6 INT39945 Binding of Dlat 27 0.32 14.95 3.88
7 INT12796 Binding of DLD 20 0.36 6.71 3.02
8 INT7142 Positive_regulation of DLD 22 0.60 7.69 2.76
9 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48
10 INT276172 Negative_regulation of Gene_expression of Pdk1 1 0.30 0.62 2.04
11 INT276200 Gene_expression of Pdk1 1 0.48 0.62 1.99
12 INT276182 Phosphorylation of Pdk1 1 0.59 1.04 1.5
13 INT263356 Localization of Dlat 4 0.48 1.51 1.28
14 INT263349 Negative_regulation of Gene_expression of Dlat 4 0.27 2.59 0.96
15 INT61613 Regulation of DLD 6 0.34 2.96 0.92
16 INT161019 Positive_regulation of Gene_expression of Dlat 6 0.32 1.19 0.79
17 INT48909 Localization of DLD 9 0.63 3.37 0.75
18 INT321314 Positive_regulation of Pdk1 3 0.22 0.74 0.55
19 INT55594 Negative_regulation of Positive_regulation of DLD 1 0.02 0.62 0.53
20 INT197603 Positive_regulation of Binding of Dlat 3 0.23 0.67 0.35
21 INT291537 Regulation of Regulation of Dlat 1 0.24 0.44 0.29
22 INT185730 Negative_regulation of Negative_regulation of Dlat 2 0.14 0.35 0.21
23 INT201437 Regulation of Gene_expression of Dlat 2 0.29 0.09 0.18
24 INT263355 Regulation of Negative_regulation of Dlat 1 0.25 0 0.18
25 INT128120 Transcription of DLD 1 0.67 0 0.18
26 INT43708 Negative_regulation of Binding of DLD 1 0.35 0.17 0.17
27 INT309108 Positive_regulation of Localization of Dlat 1 0.08 0.1 0.15
28 INT83129 Protein_catabolism of DLD 1 0.02 0 0.12
29 INT137756 Regulation of Negative_regulation of DLD 1 0.02 0.09 0.09
30 INT309105 Negative_regulation of Binding of Dlat 1 0.07 0.12 0.06
31 INT244341 Regulation of Binding of DLD 1 0.30 0.19 0.06
32 INT152819 Negative_regulation of Pdk1 1 0.02 0.25 0.06
33 INT276206 Negative_regulation of Phosphorylation of Pdk1 1 0.31 0.31 0.06
34 INT352937 Regulation of Pdk1 1 0.10 0.07 0.04
35 INT263354 Negative_regulation of Localization of Dlat 1 0.27 0 0
36 INT312328 Transcription of Dlat 1 0.08 0.12 0
37 INT217416 Positive_regulation of Positive_regulation of DLD 1 0.42 0.19 0
38 INT221520 Negative_regulation of Gene_expression of DLD 1 0.04 0.27 0
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