GO:0045321

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Name leukocyte activation
Categary Process
Go Slim No
Go Link GO:0045321
Unique Molecular Interactions 81
Total Molecular Interactions 126
Total Single Events 830
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for leukocyte activation. They are ordered first by their pain relevance and then by number of times they were reported for leukocyte activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
2 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
3 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
4 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
5 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
6 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
7 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
8 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
9 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
10 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
11 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
12 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
13 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
14 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
15 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
16 INT264135 Socs1 Positive_regulation of Protein_catabolism of TOLLIP 1 0.00 0.33 0.41
17 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
18 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
19 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
20 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
21 INT191505 NLRP3 Positive_regulation of Protein_catabolism of EDN1 1 0.00 1.1 0.28
22 INT256227 Binding of EDN1 and VEGFA 1 0.18 2.92 0.25
23 INT178095 EDN1 Positive_regulation of MMP3 1 0.04 0.88 0.24
24 INT178076 EDN1 Positive_regulation of MMP2 1 0.04 0.88 0.24
25 INT178085 EDN1 Positive_regulation of MMP7 1 0.06 0.89 0.24
26 INT178141 EDN1 Positive_regulation of Timp1 1 0.30 0.89 0.24
27 INT178075 EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
28 INT178104 EDN1 Positive_regulation of Localization of TIMP1 1 0.05 0.83 0.24
29 INT178094 Positive_regulation of EDN1 Positive_regulation of PLAU 1 0.06 0.95 0.24
30 INT178142 EDN1 Positive_regulation of Localization of Timp1 1 0.28 0.89 0.24
31 INT178077 EDN1 Positive_regulation of MMP9 1 0.06 0.88 0.24
32 INT182272 EDN1 Regulation of Gene_expression of MMP13 1 0.26 0.87 0.22
33 INT182265 EDN1 Positive_regulation of NOS2 1 0.24 0.56 0.22
34 INT182263 EDN1 Positive_regulation of MMP1 1 0.15 0.43 0.21
35 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
36 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
37 INT182258 EDN1 Positive_regulation of Positive_regulation of MMP1 1 0.15 0.47 0.19
38 INT182271 EDN1 Positive_regulation of Localization of MMP13 1 0.27 0.47 0.19
39 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
40 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16
41 INT94022 Positive_regulation of Binding of EDN1 and INSRR 1 0.06 0 0.16
42 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
43 INT94021 Binding of EDN1 and EDN2 1 0.26 0 0.16
44 INT94014 Positive_regulation of Binding of EDN1 and EDN3 1 0.36 0 0.16
45 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
46 INT182261 EDN1 Regulation of Gene_expression of MMP1 1 0.17 0.7 0.15
47 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
48 INT161798 Positive_regulation of Binding of EDN1 and ING1 1 0.06 0.66 0.13
49 INT161800 Binding of EDN1 and ING1 1 0.05 0.65 0.13
50 INT178083 EDN1 Positive_regulation of Gene_expression of VEGFA 1 0.09 1.8 0.13
51 INT206065 EDN1 Positive_regulation of IL6 1 0.03 0.47 0.12
52 INT178101 EDN1 Negative_regulation of Phosphorylation of BCL2 1 0.03 1 0.12
53 INT77863 EDN1 Positive_regulation of POMC 1 0.50 0.34 0.12
54 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
55 INT182270 EDN1 Positive_regulation of Gene_expression of MMP1 1 0.18 0.55 0.1
56 INT242257 Binding of EDN1 and ELF3 1 0.17 0.21 0.08
57 INT178100 Gene_expression of EDNRB Positive_regulation of EDN1 1 0.17 1.11 0.08
58 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
59 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
60 INT182269 EDN1 Positive_regulation of Localization of MMP1 1 0.17 0.31 0.07
61 INT242258 ELF3 Negative_regulation of EDN1 1 0.15 0.09 0.07
62 INT172382 AGT Positive_regulation of Localization of EDN1 1 0.03 0.34 0.07
63 INT182268 Negative_regulation of MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
64 INT182274 MAPK14 Negative_regulation of Gene_expression of EDN1 1 0.22 0.31 0.07
65 INT172381 AVP Positive_regulation of Localization of EDN1 1 0.01 0.34 0.07
66 INT178096 EDN1 Positive_regulation of Gene_expression of EDNRB 1 0.17 1.01 0.07
67 INT178090 EDN1 Positive_regulation of Phosphorylation of GJA1 1 0.09 0.88 0.06
68 INT182259 EDN1 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.27 0.05
69 INT182264 EDN1 Positive_regulation of Positive_regulation of MAPK14 1 0.26 0.1 0.05
70 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04
71 INT178091 EDN1 Positive_regulation of Gene_expression of PTGER2 1 0.01 0.74 0.04
72 INT178098 EDN1 Positive_regulation of Transcription of VEGFA 1 0.08 0.76 0.04
73 INT306514 EDN1 Positive_regulation of EDNRB 1 0.11 0.98 0.04
74 INT178082 EDN1 Positive_regulation of VEGFA 1 0.08 0.77 0.04
75 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03
76 INT256228 EDNRB Positive_regulation of EDN1 1 0.26 0.62 0.03
77 INT292081 Binding of EDN1 and NCOR2 1 0.00 0.98 0.03
78 INT284143 EDN1 Positive_regulation of CA2 1 0.03 0.37 0
79 INT182267 EDN1 Regulation of Gene_expression of NOS2 1 0.36 0 0
80 INT182257 EDN1 Positive_regulation of Phosphorylation of AKT1 1 0.21 0.05 0
81 INT230723 ERVW-1 Positive_regulation of Gene_expression of EDN1 1 0.00 1.95 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for leukocyte activation. They are ordered first by their pain relevance and then by number of times they were reported in leukocyte activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
2 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
3 INT9191 Localization of EDN1 94 0.81 57.01 14.78
4 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
5 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
6 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
7 INT10237 Binding of EDN1 40 0.48 16 8.48
8 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
9 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
10 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
11 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
12 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
13 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
14 INT49255 Protein_catabolism of EDN1 5 0.99 2.66 0.95
15 INT69422 Positive_regulation of Negative_regulation of EDN1 2 0.43 0.96 0.95
16 INT49254 Transcription of EDN1 5 0.69 2.42 0.94
17 INT72393 Phosphorylation of TOLLIP 1 0.01 0.14 0.92
18 INT61591 Negative_regulation of Localization of EDN1 11 0.59 2.09 0.85
19 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82
20 INT49252 Positive_regulation of Localization of EDN1 17 0.69 6.55 0.66
21 INT49256 Regulation of Positive_regulation of EDN1 2 0.45 2.5 0.65
22 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44
23 INT264131 Protein_catabolism of TOLLIP 1 0.01 0.32 0.4
24 INT72392 Positive_regulation of Phosphorylation of TOLLIP 1 0.01 0.06 0.39
25 INT156920 Phosphorylation of EDN1 4 0.61 0.66 0.19
26 INT284152 Regulation of Transcription of EDN1 1 0.32 0.44 0.13
27 INT49257 Positive_regulation of Transcription of EDN1 2 0.46 1.1 0.08
28 INT203855 Regulation of TOLLIP 1 0.00 0.16 0.03
29 INT49261 Negative_regulation of Protein_catabolism of EDN1 1 0.58 0 0
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