GO:0045322

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Name unmethylated CpG binding
Categary Function
Go Slim No
Go Link GO:0045322
Unique Molecular Interactions 62
Total Molecular Interactions 73
Total Single Events 530
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for unmethylated CpG binding. They are ordered first by their pain relevance and then by number of times they were reported for unmethylated CpG binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
4 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
5 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
6 INT144547 Binding of Mecp2 and Sin3a 1 0.40 0.87 0.76
7 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
8 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
9 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
10 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
11 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64
12 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64
13 INT168256 Binding of MLL and TNFRSF1B 1 0.00 1.2 0.53
14 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
15 INT247265 Mecp2 Regulation of Fos 1 0.25 0.38 0.52
16 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51
17 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49
18 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
19 INT280479 Binding of Mecp2 and Sin3a 1 0.00 1.54 0.35
20 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
21 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
22 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27
23 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
24 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
25 INT280475 Binding of Bdnf and Mecp2 1 0.11 0.92 0.22
26 INT280478 Mecp2 Negative_regulation of Gene_expression of Bdnf 1 0.13 0.94 0.22
27 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21
28 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2
29 INT329068 Tlr9 Positive_regulation of Localization of IFNA1 1 0.03 1.54 0.19
30 INT280487 Negative_regulation of Binding of Mecp2 and Sin3a 1 0.00 0.77 0.18
31 INT318969 Mecp2 Regulation of Gene_expression of Bdnf 1 0.17 0.28 0.17
32 INT333271 Tlr9 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
33 INT247266 Binding of Mecp2 and Fos 1 0.30 0.18 0.13
34 INT247267 Binding of Egr1 and Mecp2 1 0.12 0.18 0.13
35 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11
36 INT232653 Binding of CD2 and MLL 1 0.02 0.27 0.1
37 INT215461 Binding of MLL and TNFSF13B 1 0.01 1.62 0.1
38 INT247264 Mecp2 Positive_regulation of Gtf2i 1 0.02 0 0.08
39 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08
40 INT248209 Camk2a Positive_regulation of Phosphorylation of Mecp2 1 0.52 0 0.08
41 INT156144 MLL Positive_regulation of Epcam 1 0.00 0.47 0.06
42 INT156143 MLL Positive_regulation of PECAM1 1 0.00 0.47 0.06
43 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05
44 INT228610 Binding of DNMT3B and ASPRV1 1 0.02 0 0.05
45 INT290165 Tlr9 Positive_regulation of Gene_expression of IFNA1 1 0.10 1.2 0.04
46 INT290161 Tlr9 Positive_regulation of Gene_expression of Pdc 1 0.21 1.2 0.04
47 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0
48 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
49 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
50 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
51 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0
52 INT241257 DNMT3B Positive_regulation of OPCML 1 0.35 0.68 0
53 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
54 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
55 INT253331 Binding of DNMT3B and SP140 1 0.04 0.17 0
56 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
57 INT191135 Binding of DNMT3A and DNMT3B 1 0.09 0 0
58 INT324814 Binding of Ighm and Tlr9 1 0.06 0.17 0
59 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for unmethylated CpG binding. They are ordered first by their pain relevance and then by number of times they were reported in unmethylated CpG binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
2 INT29988 Gene_expression of Mecp2 27 0.78 5.45 9.47
3 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
4 INT144539 Phosphorylation of Mecp2 3 0.82 6.18 6.2
5 INT135359 Positive_regulation of Mecp2 4 0.70 4.35 6.05
6 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31
7 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
8 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
9 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7
10 INT318967 Gene_expression of Mecp2 9 0.77 11.52 3.55
11 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18
12 INT121531 Negative_regulation of DNMT3B 13 0.36 3.46 3.05
13 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
14 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83
15 INT144541 Negative_regulation of Gene_expression of Mecp2 3 0.42 1.43 1.9
16 INT247261 Negative_regulation of Mecp2 1 0.42 1.71 1.78
17 INT144538 Regulation of Phosphorylation of Mecp2 2 0.45 1.87 1.77
18 INT135355 Binding of Mecp2 4 0.37 0.83 1.72
19 INT144542 Positive_regulation of Phosphorylation of Mecp2 2 0.68 1.43 1.5
20 INT318963 Positive_regulation of Mecp2 5 0.50 1.78 1.49
21 INT157500 Localization of DNMT3B 12 0.73 2.21 1.38
22 INT247263 Regulation of Mecp2 4 0.60 1.31 1.32
23 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
24 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25
25 INT280467 Negative_regulation of Mecp2 5 0.59 3.33 1.21
26 INT322088 Regulation of Regulation of DNMT3B 1 0.03 2.74 1.12
27 INT285716 Negative_regulation of Gene_expression of DNMT3B 1 0.21 0.96 0.96
28 INT247262 Negative_regulation of Positive_regulation of Mecp2 1 0.42 0.85 0.8
29 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
30 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
31 INT318962 Negative_regulation of Gene_expression of Mecp2 2 0.43 0.5 0.7
32 INT183395 Localization of Mecp2 4 0.75 1.76 0.69
33 INT280463 Binding of Mecp2 3 0.37 4 0.63
34 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
35 INT241287 Positive_regulation of Gene_expression of DNMT3B 3 0.40 1.21 0.57
36 INT139312 Negative_regulation of Gene_expression of MLL 2 0.00 1.22 0.56
37 INT168257 Binding of MLL 4 0.02 4.25 0.53
38 INT247256 Negative_regulation of Phosphorylation of Mecp2 1 0.57 0.63 0.52
39 INT288490 Binding of Tlr9 1 0.25 1.88 0.51
40 INT188677 Positive_regulation of Positive_regulation of Tlr9 2 0.29 1.22 0.49
41 INT78201 Regulation of MLL 2 0.02 0.79 0.48
42 INT247259 Positive_regulation of Gene_expression of Mecp2 1 0.68 0.13 0.46
43 INT280468 Positive_regulation of Localization of Mecp2 3 0.50 1.76 0.45
44 INT318964 Negative_regulation of Localization of Mecp2 1 0.43 0.53 0.43
45 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
46 INT284455 Regulation of Gene_expression of Tlr9 1 0.30 1.19 0.37
47 INT280462 Positive_regulation of Phosphorylation of Mecp2 1 0.12 1.69 0.37
48 INT135356 Positive_regulation of Binding of Mecp2 1 0.50 0.1 0.36
49 INT232656 Localization of MLL 2 0.05 2.33 0.29
50 INT329061 Positive_regulation of Tlr9 1 0.47 2.05 0.29
51 INT338882 Regulation of Regulation of Mecp2 1 0.24 0.56 0.29
52 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28
53 INT236357 Negative_regulation of Positive_regulation of Tlr9 2 0.33 3.1 0.27
54 INT248208 Phosphorylation of Mecp2 3 0.82 1.17 0.26
55 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24
56 INT247260 Regulation of Gene_expression of Mecp2 1 0.60 0.06 0.21
57 INT227872 Positive_regulation of MLL 7 0.01 2.44 0.19
58 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
59 INT191163 Transcription of DNMT3B 4 0.50 0.46 0.13
60 INT151569 Transcription of Tlr9 3 0.69 0.75 0.11
61 INT151566 Positive_regulation of Transcription of Tlr9 2 0.47 0.67 0.11
62 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07
63 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
64 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
65 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0
66 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0
67 INT191158 Transcription of DNMT3A 1 0.32 0.06 0
68 INT320943 Negative_regulation of Phosphorylation of Mecp2 1 0.43 0.33 0
69 INT191157 Negative_regulation of Transcription of DNMT3B 1 0.19 0.06 0
70 INT191156 Binding of DNMT3A 1 0.16 0 0
71 INT191160 Localization of DNMT3A 1 0.35 0 0
72 INT161253 Regulation of Gene_expression of Tlr9 1 0.09 0.18 0
73 INT185991 Regulation of Gene_expression of DNMT3B 1 0.37 0 0
74 INT191152 Negative_regulation of Transcription of DNMT3A 1 0.20 0.06 0
75 INT320939 Transcription of Mecp2 1 0.69 0.2 0
76 INT328132 Regulation of Mecp2 1 0.40 1 0
77 INT324755 Positive_regulation of Binding of Tlr9 1 0.26 0.17 0
78 INT320952 Regulation of Gene_expression of Mecp2 1 0.45 0.87 0
79 INT161254 Regulation of Tlr9 1 0.09 0.18 0
80 INT320949 Negative_regulation of Binding of Mecp2 1 0.43 0.21 0
81 INT341085 Positive_regulation of Positive_regulation of MLL 1 0.01 0.15 0
82 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
83 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
84 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
85 INT338263 Regulation of Gene_expression of DNMT3A 1 0.31 0.18 0
86 INT329056 Positive_regulation of Gene_expression of Tlr9 1 0.43 0.09 0
87 INT151568 Negative_regulation of Transcription of Tlr9 1 0.41 0.08 0
88 INT341498 Negative_regulation of Gene_expression of Tlr9 1 0.11 0.38 0
89 INT320950 Positive_regulation of Gene_expression of Mecp2 1 0.50 1.24 0
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