GO:0045347

From wiki-pain
Jump to: navigation, search
Name negative regulation of MHC class II biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045347
Unique Molecular Interactions 130
Total Molecular Interactions 183
Total Single Events 1317
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of MHC class II biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of MHC class II biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
2 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
3 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
4 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
5 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
6 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26
7 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
8 INT70036 LTA Regulation of Negative_regulation of IL10 1 0.03 1.42 1.21
9 INT70046 IL12A Regulation of IL10 1 0.07 1.42 1.21
10 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
11 INT70040 TNF Regulation of Negative_regulation of IL10 1 0.09 1.42 1.21
12 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
13 INT70041 LTA Regulation of IL10 1 0.03 1.42 1.21
14 INT70034 IL12A Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
15 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
16 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
17 INT203103 ACAN Negative_regulation of Gene_expression of IL10 1 0.02 1.31 1.12
18 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
19 INT267597 IL10 Negative_regulation of Gene_expression of TNF 1 0.03 2.24 1.1
20 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
21 INT226337 Binding of IL10 and IL10RA 2 0.24 2.51 0.85
22 INT221034 IL10 Positive_regulation of Localization of CCL18 1 0.19 1.3 0.84
23 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
24 INT221415 IRF6 Positive_regulation of Gene_expression of IL10 2 0.05 1.73 0.75
25 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 0.05 1.1 0.75
26 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72
27 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
28 INT104835 IRF6 Positive_regulation of IL10 4 0.32 0.91 0.69
29 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69
30 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69
31 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
32 INT117007 Binding of Oprm1 and Sfpi1 1 0.50 0.07 0.63
33 INT172145 IL10 Negative_regulation of Gene_expression of CSF2 1 0.04 0.69 0.59
34 INT130287 POMC Regulation of Localization of IL10 1 0.12 0.1 0.59
35 INT203105 MMP3 Negative_regulation of Gene_expression of IL10 1 0.06 0.69 0.56
36 INT96089 Binding of F2 and Pf4 1 0.00 1.31 0.56
37 INT286349 IRF6 Positive_regulation of Localization of IL10 1 0.03 1.22 0.55
38 INT271874 IL10 Negative_regulation of TNF 1 0.07 0.78 0.5
39 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
40 INT117006 Sfpi1 Negative_regulation of Oprm1 1 0.39 0.29 0.49
41 INT90262 Binding of TAT and Pf4 1 0.03 5.64 0.48
42 INT271873 IL10 Regulation of Gene_expression of IK 1 0.00 0.81 0.47
43 INT271872 IL10 Regulation of IK 1 0.00 0.81 0.47
44 INT72088 IL10 Positive_regulation of POMC 1 0.15 0 0.46
45 INT323903 CNDP1 Positive_regulation of IL10 1 0.00 0.9 0.46
46 INT323906 ACCS Positive_regulation of IL10 1 0.05 0.9 0.45
47 INT96095 Binding of Selp and Pf4 1 0.01 1.2 0.45
48 INT96097 Binding of SELP and Pf4 1 0.13 1.2 0.45
49 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43
50 INT316121 IL10 Regulation of Gene_expression of HLA-DRA 1 0.09 0.46 0.42
51 INT294780 IL6 Positive_regulation of IL10 2 0.10 1.26 0.39
52 INT227906 IL10 Regulation of Gene_expression of IL1B 1 0.07 0.57 0.38
53 INT227909 IL10 Regulation of Gene_expression of TNF 1 0.21 0.57 0.38
54 INT179201 NLRP1 Regulation of Gene_expression of IL10 1 0.06 0.77 0.36
55 INT104836 IGKV2OR2-1 Negative_regulation of Gene_expression of IL10 1 0.01 0 0.36
56 INT194641 Binding of IL10 and TNF 2 0.14 1.09 0.35
57 INT144049 IL10 Negative_regulation of Gene_expression of PTGES 1 0.35 0.47 0.35
58 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
59 INT307019 MT1JP Positive_regulation of Gene_expression of IL10 1 0.03 0.58 0.32
60 INT90263 Binding of PPBP and Pf4 1 0.03 3.71 0.31
61 INT227910 TNF Positive_regulation of Gene_expression of IL10 1 0.22 0.68 0.29
62 INT194682 Negative_regulation of MAPK1 Positive_regulation of Gene_expression of IL10 1 0.05 0.17 0.27
63 INT120856 PRL Positive_regulation of Localization of IL10 1 0.29 0.5 0.26
64 INT328064 IL10 Positive_regulation of FAAH 1 0.05 1.48 0.26
65 INT226361 Binding of IL10 and IL22RA1 1 0.00 0.17 0.26
66 INT203165 Binding of IL10 and PTGER2 1 0.01 0.5 0.25
67 INT113419 IL10 Negative_regulation of Gene_expression of IL18 1 0.31 0.86 0.24
68 INT234755 IL10 Positive_regulation of IFN1@ 1 0.08 0.68 0.23
69 INT194702 MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.16 0.23
70 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23
71 INT227905 IL10 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.48 0.22
72 INT170993 IL10 Positive_regulation of Gene_expression of CCR1 1 0.12 0.34 0.22
73 INT221022 IL10 Positive_regulation of CCL18 1 0.19 0.38 0.22
74 INT330382 IFNA1 Positive_regulation of Gene_expression of IL10 1 0.06 0.83 0.21
75 INT209857 IL10 Negative_regulation of Gene_expression of CD36 1 0.31 0.16 0.2
76 INT226338 IL19 Positive_regulation of Gene_expression of IL10 1 0.01 0.56 0.2
77 INT226351 IL19 Positive_regulation of IL10 1 0.01 0.55 0.2
78 INT286348 IL8 Positive_regulation of IL10 1 0.08 0.18 0.19
79 INT221023 IL13 Positive_regulation of Gene_expression of IL10 1 0.01 0.13 0.19
80 INT262905 Binding of IL10 and MDD1 1 0.40 1.03 0.19
81 INT221021 IL4 Positive_regulation of Gene_expression of IL10 1 0.01 0.13 0.19
82 INT264189 HR Positive_regulation of Gene_expression of IL10 1 0.00 1.48 0.19
83 INT221032 IL10 Positive_regulation of Gene_expression of CCL18 1 0.14 0.13 0.19
84 INT323134 Binding of IL10 and IL12A 1 0.06 0.55 0.18
85 INT316129 Binding of HLA-DRA and IL10 1 0.12 3.1 0.17
86 INT316132 IL10 Regulation of MARCH1 1 0.11 2.12 0.17
87 INT316122 IL10 Regulation of Gene_expression of MARCH1 1 0.19 2.12 0.17
88 INT353036 IL4 Positive_regulation of Localization of IL10 1 0.03 0.99 0.16
89 INT104829 Negative_regulation of IRF6 Positive_regulation of IL10 1 0.30 0 0.16
90 INT198307 IL10 Positive_regulation of Gene_expression of IGHG3 2 0.01 1.21 0.15
91 INT104830 IGKV2OR2-1 Regulation of Gene_expression of IL10 1 0.00 0 0.15
92 INT104832 Binding of IL10 and NFKB1 1 0.15 0 0.15
93 INT221031 IL10 Positive_regulation of Binding of TNF 1 0.05 0.28 0.14
94 INT220305 Binding of IL6 and IL10 1 0.00 0.51 0.14
95 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
96 INT330370 Positive_regulation of Binding of IL10 and Il4 1 0.01 0.47 0.13
97 INT330369 Binding of IL10 and Il4 1 0.01 0.47 0.13
98 INT316126 IL10 Regulation of CD14 1 0.12 0.22 0.13
99 INT300731 IL10 Negative_regulation of Gene_expression of IGHE 1 0.03 0.23 0.13
100 INT202543 Binding of IGHE and IL10 1 0.03 0.79 0.12
101 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
102 INT274471 IL12A Negative_regulation of Gene_expression of IL10 1 0.02 0.99 0.1
103 INT316131 IL10 Regulation of Regulation of HLA-DRA 1 0.09 1.31 0.09
104 INT79446 IL10 Negative_regulation of Transcription of PDE4B 1 0.44 0 0.08
105 INT316125 IL10 Regulation of KRT20 1 0.00 1.06 0.08
106 INT316127 IL10 Regulation of UBR1 1 0.00 1.06 0.08
107 INT79445 IL10 Negative_regulation of Gene_expression of PDE4B 1 0.43 0 0.08
108 INT264188 DCPS Positive_regulation of Gene_expression of IL10 1 0.02 0.59 0.08
109 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
110 INT248344 Binding of IL10 and SNRNP70 1 0.04 0.6 0.05
111 INT293494 Sfpi1 Regulation of Negative_regulation of Hsp90aa1 1 0.04 0.23 0.05
112 INT219149 FBXO8 Positive_regulation of Localization of IL10 1 0.01 0.14 0.05
113 INT185376 IFNG Regulation of IL10 1 0.01 0.69 0.04
114 INT185383 IL10 Regulation of TLR2 1 0.06 0.68 0.04
115 INT231759 IL10 Positive_regulation of Gene_expression of HMOX1 1 0.06 0.7 0.04
116 INT194642 IL10 Positive_regulation of TNF 1 0.18 0.22 0.04
117 INT185386 IL10 Regulation of CSF2 1 0.02 0.68 0.04
118 INT254282 Sfpi1 Positive_regulation of Binding of Pam16 1 0.02 0.23 0.03
119 INT254285 Sfpi1 Positive_regulation of Gene_expression of THPO 1 0.02 0.17 0.03
120 INT284296 Mir155 Regulation of Spi1 1 0.25 0.36 0
121 INT293492 Hsp90aa1 Regulation of Gene_expression of Sfpi1 1 0.04 0.1 0
122 INT350715 Sfpi1 Positive_regulation of Transcription of MIR424 1 0.09 0.25 0
123 INT187571 Binding of FANCB and Pf4 1 0.00 0.46 0
124 INT262904 Binding of IL10 and RS1 1 0.01 0.05 0
125 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0
126 INT195200 IL10 Positive_regulation of Gene_expression of IGHE 1 0.07 1.78 0
127 INT350705 Sfpi1 Positive_regulation of Mir223 1 0.04 0.13 0
128 INT346971 Binding of IL4 and IL10 1 0.12 0.16 0
129 INT304093 Binding of IL10 and TGFB1 1 0.02 1.21 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of MHC class II biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of MHC class II biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84
2 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5
3 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66
4 INT74423 Localization of IL10 91 0.80 61.6 22.95
5 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96
6 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39
7 INT14962 Gene_expression of Pf4 27 0.76 22.48 10.88
8 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87
9 INT73497 Regulation of IL10 33 0.45 22.6 9.19
10 INT60527 Transcription of IL10 16 0.56 13.57 6.42
11 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97
12 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29
13 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22
14 INT142162 Binding of IL10 30 0.37 21.9 4.84
15 INT130290 Positive_regulation of Localization of IL10 16 0.47 9.38 4.75
16 INT41358 Localization of Pf4 11 0.79 6.06 2.89
17 INT32394 Regulation of Pf4 12 0.23 6.07 2.85
18 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07
19 INT117003 Binding of Sfpi1 5 0.47 5.04 1.74
20 INT20347 Positive_regulation of PF4 5 0.67 2.91 1.72
21 INT14961 Positive_regulation of Gene_expression of Pf4 4 0.30 3.42 1.7
22 INT17693 Localization of PF4 2 0.68 1.26 1.56
23 INT262908 Negative_regulation of Localization of IL10 5 0.43 4 1.5
24 INT58032 Positive_regulation of Localization of Pf4 3 0.67 1.72 1.46
25 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
26 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1
27 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
28 INT23359 Negative_regulation of PF4 6 0.58 3.54 0.97
29 INT74424 Regulation of Localization of IL10 3 0.31 0.91 0.93
30 INT171008 Positive_regulation of Transcription of IL10 1 0.15 1.33 0.89
31 INT3086 Binding of Pf4 14 0.47 7.1 0.86
32 INT182059 Positive_regulation of Positive_regulation of IL10 3 0.17 1.86 0.77
33 INT307819 Negative_regulation of Positive_regulation of Pf4 1 0.06 0.44 0.76
34 INT32314 Positive_regulation of Positive_regulation of Pf4 2 0.49 2.65 0.71
35 INT327768 Regulation of Transcription of IL10 1 0.17 0.13 0.61
36 INT27383 Transcription of Pf4 2 0.66 1.19 0.58
37 INT27382 Positive_regulation of Transcription of Pf4 1 0.48 0.55 0.51
38 INT17650 Positive_regulation of Gene_expression of PF4 1 0.45 0.31 0.51
39 INT323141 Positive_regulation of Negative_regulation of IL10 1 0.37 1.06 0.44
40 INT352983 Protein_catabolism of IL10 1 0.13 1.04 0.41
41 INT279364 Regulation of Negative_regulation of IL10 1 0.04 0.49 0.39
42 INT279367 Negative_regulation of Regulation of IL10 1 0.06 0.49 0.39
43 INT181025 Localization of Sfpi1 3 0.80 4.96 0.38
44 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
45 INT84555 Negative_regulation of Spi1 6 0.42 0.71 0.34
46 INT181020 Positive_regulation of Gene_expression of Sfpi1 2 0.67 1.11 0.31
47 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
48 INT298496 Protein_catabolism of PF4 1 0.40 0.47 0.3
49 INT181051 Transcription of Sfpi1 1 0.62 1.1 0.29
50 INT299798 Negative_regulation of Transcription of IL10 1 0.07 0.73 0.27
51 INT101308 Positive_regulation of Spi1 2 0.67 0.38 0.23
52 INT181036 Positive_regulation of Sfpi1 3 0.49 0.96 0.21
53 INT101309 Gene_expression of Spi1 2 0.75 0.64 0.18
54 INT34635 Positive_regulation of Regulation of Pf4 1 0.05 0.39 0.18
55 INT101307 Positive_regulation of Gene_expression of Spi1 1 0.67 0.28 0.18
56 INT106451 Regulation of Spi1 1 0.43 0 0.18
57 INT182061 Regulation of Positive_regulation of IL10 1 0.12 1.07 0.18
58 INT39120 Regulation of Gene_expression of Pf4 2 0.02 0.21 0.16
59 INT231956 Phosphorylation of IL10 1 0.26 0.07 0.16
60 INT104841 Negative_regulation of Positive_regulation of IL10 1 0.27 0 0.14
61 INT181033 Regulation of Sfpi1 2 0.40 1.58 0.13
62 INT219179 Positive_regulation of Regulation of IL10 1 0.08 0.45 0.13
63 INT17694 Regulation of PF4 2 0.44 1.18 0.12
64 INT284514 Regulation of Regulation of PF4 1 0.20 1.19 0.12
65 INT47448 Binding of PF4 2 0.22 0.16 0.08
66 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
67 INT50166 Protein_catabolism of Pf4 1 0.01 0.5 0.08
68 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
69 INT36269 Negative_regulation of Gene_expression of PF4 1 0.25 0.59 0.07
70 INT310472 Negative_regulation of Gene_expression of Sfpi1 1 0.41 0.23 0.03
71 INT284294 Transcription of Spi1 1 0.67 0.36 0
72 INT284295 Negative_regulation of Gene_expression of Spi1 1 0.41 0.36 0
73 INT337478 Binding of HDAC2 1 0.14 0.07 0
74 INT106452 Negative_regulation of Positive_regulation of Spi1 1 0.30 0 0
75 INT248345 Regulation of Binding of IL10 1 0.45 0.78 0
76 INT250466 Regulation of Gene_expression of Sfpi1 1 0.39 0.98 0
77 INT293482 Protein_catabolism of Sfpi1 1 0.09 0.52 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox