GO:0045351

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Name type I interferon biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045351
Unique Molecular Interactions 70
Total Molecular Interactions 93
Total Single Events 294
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for type I interferon biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for type I interferon biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
2 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
3 INT171896 Binding of Ifnar1 and Il1rn 1 0.00 0.81 0.54
4 INT171899 Binding of Ifnar1 and Il1 1 0.01 0.75 0.52
5 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
6 INT348031 Binding of Irf3 and Tbk1 1 0.17 2.82 0.4
7 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
8 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
9 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
10 INT288205 Binding of Cd14 and Myd88 1 0.10 0.57 0.28
11 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
12 INT256063 Myd88 Positive_regulation of Gene_expression of Mcpt1 1 0.13 0.56 0.27
13 INT295269 S100a8 Regulation of Irf7 1 0.01 0.28 0.24
14 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
15 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
16 INT348789 Positive_regulation of Binding of MYD88 and Tlr4 1 0.46 0.93 0.2
17 INT348027 Gramd3 Negative_regulation of Irf3 1 0.00 1.39 0.2
18 INT348041 Binding of IFNA1 and Irf3 1 0.02 1.41 0.2
19 INT348013 Negative_regulation of Binding of Irf3 and Tbk1 1 0.21 1.41 0.2
20 INT343837 TICAM1 Positive_regulation of IRF3 1 0.03 0.19 0.19
21 INT343854 TIRAP Positive_regulation of IRF3 1 0.06 0.19 0.19
22 INT179504 Tlr4 Regulation of Myd88 1 0.07 0.29 0.17
23 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
24 INT343863 Binding of IRF1 and IRF3 1 0.03 0.12 0.17
25 INT251349 Ifnar1 Positive_regulation of Rock1 1 0.01 1.27 0.16
26 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
27 INT278394 Myd88 Regulation of Phosphorylation of Hps5 1 0.11 0.35 0.15
28 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
29 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13
30 INT346501 MYD88 Positive_regulation of Nfkb1 1 0.01 0.5 0.13
31 INT316817 Ifnar1 Positive_regulation of Phosphorylation of Insrr 1 0.00 0.43 0.13
32 INT254201 Myd88 Positive_regulation of Ik 1 0.00 0.14 0.12
33 INT251348 Ifnar1 Positive_regulation of Limk2 1 0.01 1.12 0.11
34 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1
35 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
36 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
37 INT314590 Binding of Ifnar1 and Positive_regulation of Mapk14 1 0.16 0 0.1
38 INT314599 Binding of Ifnar1 and Positive_regulation of Mapk1 1 0.14 0 0.1
39 INT314588 Binding of Ifnar1 and Positive_regulation of Raf1 1 0.13 0 0.1
40 INT314594 Binding of Ifnar1 and Positive_regulation of Akt1 1 0.43 0 0.1
41 INT334266 Binding of Irak1 and Myd88 2 0.35 0.16 0.09
42 INT228333 Binding of IFNA1 and IRF9 2 0.04 0.53 0.09
43 INT350073 Binding of co and Myd88 1 0.00 0.17 0.08
44 INT254223 Tlr3 Positive_regulation of Myd88 1 0.16 0.23 0.08
45 INT350477 Tlr4 Positive_regulation of Positive_regulation of Irf3 1 0.22 0.12 0.06
46 INT350481 Tlr4 Positive_regulation of Gene_expression of Myd88 1 0.26 0.06 0.06
47 INT334260 Negative_regulation of Binding of Myd88 and Il1 1 0.01 0.4 0.06
48 INT334258 Binding of Myd88 and Irak4 2 0.26 0.24 0.05
49 INT346457 IRF3 Positive_regulation of IFNA1 1 0.03 0.56 0.05
50 INT350802 Binding of MYD88 and TLR3 1 0.01 0 0.04
51 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04
52 INT238008 Myd88 Regulation of Hand1 1 0.03 0.82 0.04
53 INT333559 TBK1 Regulation of Phosphorylation of IRF3 1 0.17 0.35 0.04
54 INT333633 Thse Positive_regulation of Transcription of IRF3 1 0.00 1.13 0.03
55 INT290313 Binding of MYD88 and TLR7 1 0.03 0.1 0.03
56 INT299006 Binding of Il18 and Myd88 1 0.21 0.19 0.03
57 INT350077 Negative_regulation of Binding of Myd88 and Tlr4 1 0.12 0.16 0
58 INT348039 Binding of Myd88 and Irak2 1 0.22 0 0
59 INT290155 Atp6v1e1 Positive_regulation of Gene_expression of Irf7 1 0.14 0.21 0
60 INT333639 Tlr4 Positive_regulation of IRF3 1 0.31 0 0
61 INT286772 Binding of Irf7 and Tusc2 1 0.20 0.17 0
62 INT333565 TRAM1 Regulation of Phosphorylation of IRF3 1 0.17 0.59 0
63 INT324696 Binding of Myd88 and Mapk10 1 0.05 0.68 0
64 INT333563 PRKCA Positive_regulation of Gene_expression of IRF3 1 0.05 0.06 0
65 INT333630 Tlr4 Regulation of Phosphorylation of IRF3 1 0.39 0.59 0
66 INT333637 Smpd1 Positive_regulation of IRF3 1 0.09 0.62 0
67 INT228627 Nss1 Negative_regulation of Ifnar1 1 0.02 0 0
68 INT333638 Positive_regulation of Tlr4 Positive_regulation of Localization of IRF3 1 0.29 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for type I interferon biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in type I interferon biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
2 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
3 INT142754 Binding of Myd88 20 0.36 9.61 3.8
4 INT181523 Gene_expression of Ifnar1 16 0.67 7.79 1.72
5 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65
6 INT188675 Positive_regulation of Irf3 8 0.52 0.98 1.36
7 INT246928 Negative_regulation of Myd88 12 0.38 6.16 1.3
8 INT233970 Regulation of Myd88 7 0.45 5.2 1.28
9 INT149625 Negative_regulation of Ifnar1 2 0.36 4.36 1.23
10 INT157929 Positive_regulation of Ifnar1 7 0.41 3.52 1.06
11 INT237858 Positive_regulation of MYD88 5 0.49 2.93 0.9
12 INT250171 Localization of Myd88 4 0.72 1.95 0.88
13 INT166126 Gene_expression of MYD88 5 0.54 2.67 0.84
14 INT256920 Binding of Irf3 2 0.36 1.38 0.84
15 INT264973 Binding of MYD88 4 0.35 1.2 0.74
16 INT254178 Regulation of Positive_regulation of Irf3 2 0.29 0.07 0.73
17 INT56193 Binding of Ifnar1 4 0.31 1.94 0.71
18 INT314582 Positive_regulation of Binding of Irf3 1 0.33 0.07 0.68
19 INT334226 Positive_regulation of Localization of Myd88 1 0.36 0.54 0.67
20 INT233973 Negative_regulation of Gene_expression of Myd88 4 0.38 1.32 0.61
21 INT161152 Binding of IRF9 1 0.04 0.28 0.59
22 INT264963 Positive_regulation of Binding of MYD88 1 0.17 0.18 0.52
23 INT188685 Positive_regulation of Positive_regulation of Irf3 4 0.37 0.61 0.49
24 INT246422 Transcription of MYD88 2 0.52 0.77 0.38
25 INT256056 Positive_regulation of Binding of Myd88 2 0.48 0.36 0.36
26 INT282787 Positive_regulation of Positive_regulation of Ifnar1 2 0.06 0.86 0.32
27 INT203076 Positive_regulation of Positive_regulation of Myd88 1 0.19 0.65 0.32
28 INT203072 Positive_regulation of Myd88 1 0.19 0.65 0.32
29 INT237066 Positive_regulation of Irf7 6 0.54 3.56 0.29
30 INT197492 Regulation of Gene_expression of Myd88 2 0.39 1.95 0.27
31 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22
32 INT347992 Negative_regulation of Transcription of Irf3 1 0.28 1.41 0.2
33 INT347984 Negative_regulation of Irf3 1 0.28 1.38 0.2
34 INT347990 Transcription of Irf3 1 0.35 1.4 0.2
35 INT333601 Phosphorylation of IRF3 6 0.73 2.09 0.19
36 INT242901 Regulation of Gene_expression of MYD88 2 0.18 0.19 0.19
37 INT242897 Positive_regulation of Gene_expression of MYD88 2 0.20 0.27 0.19
38 INT233971 Transcription of Myd88 2 0.60 1.01 0.17
39 INT334237 Negative_regulation of Binding of Myd88 1 0.30 1.16 0.12
40 INT333604 Localization of IRF3 1 0.71 2.75 0.12
41 INT306310 Positive_regulation of Positive_regulation of Myd88 1 0.38 0.41 0.12
42 INT242898 Regulation of MYD88 2 0.33 0.88 0.11
43 INT329055 Gene_expression of Myd88 1 0.72 1.18 0.11
44 INT333625 Positive_regulation of IRF3 7 0.61 3.49 0.09
45 INT181528 Positive_regulation of Gene_expression of Ifnar1 4 0.43 1.06 0.08
46 INT334227 Positive_regulation of Regulation of Myd88 1 0.36 0.63 0.08
47 INT329054 Negative_regulation of Gene_expression of Myd88 1 0.54 0.13 0.06
48 INT254170 Positive_regulation of Positive_regulation of Irf7 1 0.10 0.17 0.06
49 INT333620 Transcription of IRF3 1 0.63 1.12 0.06
50 INT333598 Gene_expression of IRF3 1 0.60 0.58 0.05
51 INT329067 Positive_regulation of Gene_expression of Myd88 1 0.64 0.12 0.05
52 INT333591 Negative_regulation of Gene_expression of IRF3 1 0.38 0.53 0.05
53 INT333607 Positive_regulation of Localization of IRF3 1 0.61 0.4 0.04
54 INT333618 Positive_regulation of Phosphorylation of IRF3 1 0.41 0.24 0.04
55 INT333605 Regulation of Transcription of IRF3 1 0.40 0 0.03
56 INT333608 Negative_regulation of IRF3 1 0.38 1.92 0.03
57 INT333597 Regulation of Positive_regulation of IRF3 1 0.54 0.35 0.03
58 INT286751 Binding of Irf7 2 0.16 0.3 0
59 INT333615 Regulation of Gene_expression of IRF3 1 0.40 0 0
60 INT333624 Regulation of Phosphorylation of IRF3 1 0.40 0.59 0
61 INT237070 Regulation of Irf7 1 0.21 1.44 0
62 INT333616 Regulation of IRF3 1 0.24 1.14 0
63 INT333623 Binding of IRF3 1 0.32 0 0
64 INT50949 Gene_expression of IRF9 1 0.27 0 0
65 INT290138 Gene_expression of Irf7 1 0.40 0.2 0
66 INT333603 Negative_regulation of Localization of IRF3 1 0.52 0 0
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