GO:0045356

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Name positive regulation of interferon-alpha biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045356
Unique Molecular Interactions 86
Total Molecular Interactions 106
Total Single Events 812
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interferon-alpha biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of interferon-alpha biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
2 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
3 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
4 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
5 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
6 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
7 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
8 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
9 INT183695 Binding of Tlr3 and Ducm1 1 0.04 2.75 0.56
10 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
11 INT158599 Tlr3 Positive_regulation of Binding of Fas 1 0.55 0.86 0.48
12 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
13 INT178218 IFNA1 Regulation of Tlr7 1 0.04 0.87 0.37
14 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
15 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
16 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
17 INT137160 TLR7 Positive_regulation of Gene_expression of CXCR3 1 0.35 0.34 0.32
18 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32
19 INT330383 Binding of TLR2 and TLR3 1 0.07 2.77 0.31
20 INT330378 Positive_regulation of Binding of TLR2 and TLR3 1 0.10 2.78 0.31
21 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31
22 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29
23 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29
24 INT137169 Binding of TLR5 and TLR7 1 0.25 0.33 0.29
25 INT306018 Binding of Tlr4 and Tlr9 1 0.15 0.92 0.27
26 INT288497 Binding of Tlr7 and Tlr9 1 0.21 0.97 0.27
27 INT137167 Binding of IFNG and TLR3 1 0.24 0.32 0.27
28 INT334256 Binding of Tlr9 and Iars 1 0.02 0.68 0.24
29 INT324873 Binding of Jun and Tlr3 1 0.01 1.54 0.22
30 INT260437 Positive_regulation of Tlr7 Positive_regulation of Positive_regulation of Il12a 1 0.03 0.27 0.21
31 INT350006 Tlr4 Regulation of Positive_regulation of Tlr3 1 0.41 0.17 0.21
32 INT260440 Negative_regulation of Tlr9 Negative_regulation of Positive_regulation of IFNA1 1 0.03 0.96 0.21
33 INT260441 Negative_regulation of Tlr7 Negative_regulation of Positive_regulation of IFNA1 1 0.05 0.96 0.21
34 INT350005 Tlr3 Positive_regulation of Il17rb 1 0.09 0.32 0.21
35 INT260436 Positive_regulation of Tlr9 Negative_regulation of Positive_regulation of Tlr7 1 0.14 0.65 0.2
36 INT330371 Binding of TLR3 and Ifx 1 0.17 1.12 0.2
37 INT329068 Tlr9 Positive_regulation of Localization of IFNA1 1 0.03 1.54 0.19
38 INT339505 Tlr3 Positive_regulation of Eif2ak2 1 0.14 0.09 0.19
39 INT246414 TLR4 Regulation of Gene_expression of TLR3 1 0.35 1.16 0.17
40 INT333271 Tlr9 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
41 INT346500 TLR3 Positive_regulation of Nfkb1 1 0.01 0.49 0.13
42 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
43 INT183702 Binding of Tlr3 and Pilra 1 0.02 0.64 0.11
44 INT183694 Ducm1 Positive_regulation of Gene_expression of Tlr3 1 0.03 0.23 0.11
45 INT278397 Hps5 Positive_regulation of Tlr9 1 0.15 0.21 0.11
46 INT324870 Binding of Ticam1 and Tlr3 1 0.03 0.76 0.11
47 INT294777 PAM Positive_regulation of TLR9 1 0.00 0.17 0.1
48 INT294773 IRF6 Positive_regulation of TLR9 1 0.06 0.17 0.1
49 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08
50 INT254223 Tlr3 Positive_regulation of Myd88 1 0.16 0.23 0.08
51 INT346452 TLR3 Positive_regulation of TBK1 1 0.03 0.45 0.06
52 INT346456 TLR3 Positive_regulation of IKBKE 1 0.02 0.45 0.06
53 INT329045 Binding of Unc93b1 and Tlr3 1 0.03 0.7 0.05
54 INT260435 Binding of Tlr9 and Tlr7 1 0.09 0.71 0.05
55 INT246413 TLR4 Regulation of TLR3 1 0.28 0.81 0.05
56 INT290165 Tlr9 Positive_regulation of Gene_expression of IFNA1 1 0.10 1.2 0.04
57 INT350802 Binding of MYD88 and TLR3 1 0.01 0 0.04
58 INT290161 Tlr9 Positive_regulation of Gene_expression of Pdc 1 0.21 1.2 0.04
59 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04
60 INT350800 Binding of TLR3 and TICAM1 1 0.01 0 0.04
61 INT290313 Binding of MYD88 and TLR7 1 0.03 0.1 0.03
62 INT337167 Binding of TLR3 and Positive_regulation of CD83 1 0.13 0.31 0.03
63 INT337174 Binding of TLR3 and Positive_regulation of CCR7 1 0.15 0.31 0.03
64 INT337183 Binding of TLR3 and Positive_regulation of CD274 1 0.16 0.31 0.03
65 INT337179 Binding of TLR3 and Positive_regulation of CD86 1 0.10 0.31 0.03
66 INT284563 Tlr3 Positive_regulation of Mat1a 1 0.22 2.43 0
67 INT348015 Binding of Tlr4 and Tlr3 1 0.19 0 0
68 INT285422 Regulation of Binding of TLR1 and TLR3 1 0.30 0 0
69 INT246412 Binding of TLR3 and TLR4 1 0.38 0 0
70 INT285426 Binding of TLR1 and TLR3 1 0.25 0 0
71 INT246411 Positive_regulation of Binding of TLR3 and TLR4 1 0.51 0 0
72 INT284566 Tlr3 Positive_regulation of Mthfd1 1 0.17 2.43 0
73 INT324814 Binding of Ighm and Tlr9 1 0.06 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interferon-alpha biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of interferon-alpha biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
2 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
3 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
4 INT183681 Positive_regulation of Tlr3 20 0.62 16.25 4.54
5 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
6 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33
7 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
8 INT158595 Gene_expression of Tlr3 25 0.69 12.09 4.07
9 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
10 INT158596 Binding of Tlr3 24 0.47 11.66 3.69
11 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
12 INT204524 Binding of TLR9 17 0.43 11.69 2.76
13 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21
14 INT188678 Binding of Tlr7 14 0.32 6.6 1.89
15 INT178188 Positive_regulation of Tlr7 12 0.40 6.33 1.77
16 INT174689 Gene_expression of Tlr7 11 0.67 8.24 1.56
17 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
18 INT186810 Positive_regulation of TLR3 13 0.65 6.37 1.37
19 INT150730 Regulation of Tlr3 2 0.45 6.51 1.37
20 INT219159 Positive_regulation of TLR7 8 0.55 2.37 1.32
21 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
22 INT150729 Negative_regulation of Tlr3 3 0.43 3.26 1.14
23 INT186807 Positive_regulation of Gene_expression of TLR3 8 0.53 7.19 1.08
24 INT288489 Transcription of Tlr3 1 0.51 3.85 1.05
25 INT288483 Gene_expression of Tlr3 8 0.72 4.51 0.97
26 INT120599 Binding of Tlr7 2 0.27 2.16 0.96
27 INT186804 Binding of TLR3 14 0.45 8.41 0.79
28 INT280014 Binding of TLR7 4 0.14 3.52 0.76
29 INT288495 Gene_expression of Tlr7 3 0.50 2.83 0.76
30 INT294787 Localization of TLR9 2 0.67 2.35 0.75
31 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
32 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
33 INT255974 Transcription of Tlr3 10 0.49 6.11 0.7
34 INT186798 Regulation of TLR3 5 0.42 3.13 0.69
35 INT322032 Binding of TLR8 3 0.32 2.57 0.69
36 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
37 INT204525 Negative_regulation of Gene_expression of TLR3 2 0.54 1.8 0.61
38 INT288485 Regulation of Transcription of Tlr3 1 0.20 0.85 0.61
39 INT246423 Negative_regulation of TLR3 1 0.40 2.2 0.6
40 INT178202 Regulation of Tlr7 2 0.34 1.69 0.59
41 INT254177 Positive_regulation of Positive_regulation of Tlr3 3 0.41 2.06 0.58
42 INT183685 Positive_regulation of Gene_expression of Tlr3 4 0.61 1.5 0.53
43 INT260425 Positive_regulation of Gene_expression of Tlr7 3 0.39 2.88 0.53
44 INT288490 Binding of Tlr9 1 0.25 1.88 0.51
45 INT285448 Positive_regulation of Gene_expression of TLR7 4 0.61 2.58 0.5
46 INT245223 Negative_regulation of Gene_expression of TLR7 3 0.37 2.81 0.5
47 INT188677 Positive_regulation of Positive_regulation of Tlr9 2 0.29 1.22 0.49
48 INT260427 Negative_regulation of Tlr7 2 0.33 1.42 0.42
49 INT237905 Positive_regulation of Binding of Tlr3 1 0.30 0.79 0.42
50 INT178171 Localization of Tlr7 1 0.51 0.53 0.41
51 INT204533 Regulation of Gene_expression of TLR9 8 0.55 2.81 0.4
52 INT183680 Localization of Tlr3 6 0.71 1.69 0.39
53 INT219171 Negative_regulation of Positive_regulation of TLR9 1 0.18 1.3 0.39
54 INT219182 Negative_regulation of Positive_regulation of TLR7 1 0.24 1.3 0.39
55 INT182134 Transcription of TLR9 2 0.72 1.21 0.37
56 INT284455 Regulation of Gene_expression of Tlr9 1 0.30 1.19 0.37
57 INT246419 Positive_regulation of Negative_regulation of TLR3 1 0.43 0.67 0.34
58 INT207897 Positive_regulation of TLR8 3 0.17 2.52 0.33
59 INT329061 Positive_regulation of Tlr9 1 0.47 2.05 0.29
60 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28
61 INT204528 Negative_regulation of Gene_expression of TLR9 5 0.52 4.47 0.27
62 INT236357 Negative_regulation of Positive_regulation of Tlr9 2 0.33 3.1 0.27
63 INT207896 Gene_expression of TLR8 3 0.36 2.82 0.26
64 INT219175 Localization of TLR7 2 0.49 1.32 0.25
65 INT204531 Negative_regulation of TLR9 1 0.43 1.29 0.25
66 INT186803 Transcription of TLR3 6 0.67 1.54 0.2
67 INT245222 Regulation of TLR7 2 0.39 1.52 0.19
68 INT254194 Regulation of Positive_regulation of Tlr3 2 0.52 0.79 0.19
69 INT288491 Positive_regulation of Transcription of Tlr3 1 0.37 1.85 0.19
70 INT336418 Negative_regulation of Binding of Tlr3 1 0.36 0.59 0.16
71 INT350779 Positive_regulation of Positive_regulation of TLR9 1 0.08 0.8 0.15
72 INT204527 Regulation of TLR9 7 0.40 2.88 0.12
73 INT186797 Localization of TLR3 2 0.70 2.69 0.12
74 INT120600 Positive_regulation of Binding of Tlr7 1 0.04 0.17 0.12
75 INT260428 Regulation of Gene_expression of Tlr7 1 0.25 1.01 0.12
76 INT151569 Transcription of Tlr9 3 0.69 0.75 0.11
77 INT186809 Positive_regulation of Transcription of TLR3 2 0.65 0.5 0.11
78 INT151566 Positive_regulation of Transcription of Tlr9 2 0.47 0.67 0.11
79 INT246420 Regulation of Gene_expression of TLR3 1 0.57 0.79 0.11
80 INT188681 Positive_regulation of Binding of Tlr7 1 0.17 0 0.11
81 INT255970 Regulation of Transcription of Tlr3 1 0.24 0.89 0.09
82 INT280012 Positive_regulation of Binding of TLR7 1 0.18 1.11 0.09
83 INT280015 Positive_regulation of Binding of TLR9 1 0.12 1.11 0.09
84 INT329066 Positive_regulation of Gene_expression of Tlr3 1 0.43 1.12 0.08
85 INT322026 Positive_regulation of Positive_regulation of TLR7 1 0.40 0.06 0.08
86 INT228376 Binding of Tlr3 2 0.45 2.2 0.07
87 INT285436 Negative_regulation of Transcription of TLR3 1 0.24 0.32 0.07
88 INT334959 Regulation of Gene_expression of TLR8 1 0.21 0.91 0.05
89 INT288492 Negative_regulation of Gene_expression of Tlr7 1 0.32 0.63 0.04
90 INT329051 Positive_regulation of Tlr3 1 0.65 0.33 0.04
91 INT320335 Positive_regulation of Transcription of Tlr3 1 0.43 0.13 0.03
92 INT204526 Positive_regulation of Transcription of TLR9 1 0.50 0.06 0.03
93 INT186806 Positive_regulation of Binding of TLR3 1 0.39 0.07 0.03
94 INT334960 Positive_regulation of Gene_expression of TLR8 1 0.23 0.82 0.03
95 INT324758 Negative_regulation of Positive_regulation of Tlr7 1 0.21 0.22 0.03
96 INT265417 Positive_regulation of Positive_regulation of TLR3 2 0.16 1.1 0
97 INT294790 Regulation of Localization of TLR9 1 0.40 0 0
98 INT260426 Regulation of Gene_expression of Tlr3 1 0.23 0.77 0
99 INT285438 Regulation of Regulation of TLR9 1 0.40 0 0
100 INT110559 Positive_regulation of Tlr7 1 0.04 0.19 0
101 INT161253 Regulation of Gene_expression of Tlr9 1 0.09 0.18 0
102 INT322621 Regulation of Positive_regulation of TLR3 1 0.04 0.41 0
103 INT324755 Positive_regulation of Binding of Tlr9 1 0.26 0.17 0
104 INT161254 Regulation of Tlr9 1 0.09 0.18 0
105 INT329056 Positive_regulation of Gene_expression of Tlr9 1 0.43 0.09 0
106 INT242886 Transcription of TLR8 1 0.21 0.08 0
107 INT151568 Negative_regulation of Transcription of Tlr9 1 0.41 0.08 0
108 INT242890 Regulation of Transcription of TLR8 1 0.13 0.09 0
109 INT341498 Negative_regulation of Gene_expression of Tlr9 1 0.11 0.38 0
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