GO:0045409

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Name negative regulation of interleukin-6 biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045409
Unique Molecular Interactions 257
Total Molecular Interactions 412
Total Single Events 1843
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-6 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of interleukin-6 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
2 INT353717 Binding of Ghrl and Vta1 1 0.15 0 1.68
3 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44
4 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
5 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
6 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
7 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
8 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
9 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
10 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
11 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
12 INT137563 Ghrl Positive_regulation of Gene_expression of Npy 1 0.59 0 0.87
13 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
14 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
15 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
16 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
17 INT226122 Ghrl Regulation of Cnr1 1 0.25 0.09 0.76
18 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
19 INT353718 Binding of Rbm39 and Ghsr 1 0.01 0 0.76
20 INT353716 Ghrl Positive_regulation of Vta1 1 0.33 0 0.74
21 INT353722 Rbm39 Positive_regulation of Localization of Ghrl 1 0.01 0 0.65
22 INT167139 Binding of Ghrl and Mln 1 0.04 0.56 0.65
23 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
24 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
25 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52
26 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
27 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
28 INT226125 Ghrl Positive_regulation of Cnr1 1 0.44 0.06 0.46
29 INT328385 Binding of GHS and Ghrl 1 0.15 1.89 0.45
30 INT295548 Ghrl Regulation of Regulation of Ghrh 1 0.30 0 0.45
31 INT226126 Negative_regulation of Ghrl Regulation of Prkag1 1 0.06 0.17 0.45
32 INT118208 Ghrl Negative_regulation of Localization of Prl 1 0.39 0 0.44
33 INT325391 Binding of Ghrl and Ghsr 2 0.17 0.14 0.43
34 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43
35 INT328377 Binding of GAST and Ghrl 1 0.03 0.62 0.43
36 INT226127 Regulation of Ghrl Regulation of Prkag1 1 0.05 0.07 0.42
37 INT295533 Ghrl Regulation of Npy 1 0.23 0.09 0.42
38 INT226116 Ghrl Regulation of Positive_regulation of Npy 1 0.17 0 0.41
39 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4
40 INT226129 Ghrl Regulation of Localization of Prkag1 1 0.05 0.07 0.4
41 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36
42 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35
43 INT118210 Ghrl Negative_regulation of Prl 1 0.53 0 0.33
44 INT226124 Ghrl Positive_regulation of Prkag1 1 0.06 0.24 0.33
45 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33
46 INT137561 Ghrl Regulation of Gene_expression of Npy 1 0.53 0 0.32
47 INT137386 Ghrl Regulation of Gene_expression of Pigm 1 0.00 0.36 0.3
48 INT188288 Ghrl Regulation of Gene_expression of Pou1f1 1 0.07 0 0.3
49 INT137385 Ghrl Negative_regulation of Gene_expression of Pigm 1 0.01 0.36 0.3
50 INT83750 Gh1 Regulation of Gene_expression of Ghsr 1 0.36 0 0.29
51 INT295549 Ghrl Positive_regulation of Gene_expression of Ghsr 1 0.29 0 0.29
52 INT295526 Ghrl Positive_regulation of Gene_expression of Fos 1 0.41 0.08 0.29
53 INT157082 Ghrl Positive_regulation of Localization of Gh1 2 0.22 0.18 0.28
54 INT137562 Ghrl Positive_regulation of Gene_expression of Agrp 1 0.30 0 0.28
55 INT295531 Ghrl Negative_regulation of Gene_expression of Ghrh 1 0.25 0 0.27
56 INT157080 Ghrl Positive_regulation of Localization of Gnrhr 2 0.23 0.7 0.26
57 INT295541 Ghrl Positive_regulation of Ghrh 1 0.31 0 0.26
58 INT16895 Regulation of GHSR Regulation of GH1 1 0.23 0 0.26
59 INT54263 Ghsr Regulation of Localization of Gh1 1 0.23 0 0.26
60 INT328378 GH1 Regulation of Gene_expression of Ghrl 1 0.02 0.39 0.25
61 INT118211 Ghrl Positive_regulation of Localization of Prl 1 0.63 0 0.24
62 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23
63 INT164251 Ghrl Negative_regulation of Localization of Gnrh1 1 0.34 0 0.22
64 INT35211 Ghsr Positive_regulation of Localization of Gh1 5 0.31 0 0.21
65 INT352961 Ghrl Positive_regulation of Localization of GHSR 1 0.18 1.19 0.21
66 INT157083 Ghrl Regulation of Gene_expression of Ppt1 1 0.40 0 0.2
67 INT316203 Ghsr Positive_regulation of Transcription of Agrp 1 0.02 1.5 0.19
68 INT295542 Ghrl Positive_regulation of Gene_expression of Ghrh 1 0.33 0 0.19
69 INT325390 Binding of Ghrl and Gpr39 1 0.19 0 0.18
70 INT323494 Ghrl Regulation of Ins1 1 0.16 2.12 0.17
71 INT328386 GHS Positive_regulation of Localization of Ghrl 1 0.10 0.88 0.17
72 INT328379 Ghrl Positive_regulation of CRH 1 0.16 1.17 0.16
73 INT16892 GHSR Positive_regulation of Localization of GH1 1 0.36 0 0.15
74 INT83748 Ghsr Positive_regulation of Gene_expression of Fos 1 0.27 0 0.15
75 INT118209 Ghrl Regulation of Localization of Prl 1 0.56 0 0.15
76 INT17523 Ghsr Positive_regulation of Localization of Gh 2 0.02 0.24 0.13
77 INT328374 GHRH Positive_regulation of Ghrl 1 0.13 0.26 0.13
78 INT328384 Ghrl Positive_regulation of ALPL 1 0.01 0.93 0.13
79 INT295540 Binding of Gh and Ghrl 2 0.10 0.13 0.12
80 INT226132 Ghrl Positive_regulation of Gene_expression of Prkag1 1 0.06 0 0.12
81 INT226117 Ghrl Positive_regulation of Gene_expression of Mastl 1 0.02 0 0.12
82 INT295545 Ghrl Positive_regulation of Gh 1 0.15 0 0.11
83 INT295528 Ghsr Positive_regulation of Gene_expression of Fos 1 0.61 0 0.11
84 INT295551 Ghrl Positive_regulation of Localization of Gh 1 0.15 0 0.1
85 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1
86 INT328364 Binding of GHRH and Ghrl 1 0.09 0.2 0.1
87 INT328372 Ghrl Positive_regulation of Transcription of GH1 1 0.04 0.27 0.1
88 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
89 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
90 INT295544 Gene_expression of Ghsr Positive_regulation of Gene_expression of Fos 1 0.44 0 0.09
91 INT157079 Ghrl Positive_regulation of Gnrhr 1 0.23 0 0.09
92 INT157081 Ghrl Positive_regulation of Gh1 1 0.22 0 0.09
93 INT295527 Gene_expression of Ghrl Positive_regulation of Gene_expression of Fos 1 0.29 0 0.09
94 INT328373 Negative_regulation of Ghrl Positive_regulation of Localization of GH1 1 0.05 0.31 0.08
95 INT188291 Ghrl Regulation of Localization of LH 1 0.03 0 0.08
96 INT325418 Ghrl Positive_regulation of Ghsr 1 0.16 0 0.08
97 INT162762 Ghrl Regulation of Son 1 0.36 0 0.07
98 INT328366 GPR39 Regulation of Localization of Ghrl 1 0.11 0.2 0.07
99 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07
100 INT323490 Ghsr Regulation of Ins1 1 0.26 0.54 0.07
101 INT84505 Ghsr Positive_regulation of Localization of Gnrhr 1 0.20 0 0.07
102 INT328380 AR Negative_regulation of Gene_expression of Ghrl 1 0.01 0.55 0.07
103 INT295550 Binding of Ghrh and Ghrl 1 0.21 0.06 0.07
104 INT295529 Ghrl Regulation of Localization of Gh 1 0.20 0 0.06
105 INT17524 Negative_regulation of Ghsr Regulation of Gh 1 0.01 0 0.06
106 INT17526 Ghsr Regulation of Gh 1 0.01 0 0.06
107 INT295537 Ghsr Positive_regulation of Localization of Gh 1 0.24 0 0.06
108 INT328387 INS Negative_regulation of Gene_expression of Ghrl 1 0.01 0.6 0.05
109 INT323498 Ghsr Positive_regulation of Ins1 1 0.24 0.23 0.05
110 INT328371 Ghrl Negative_regulation of INS 1 0.03 0.13 0.05
111 INT328376 Ghrl Negative_regulation of SST 1 0.03 0.13 0.05
112 INT328383 Ghrl Negative_regulation of MBOAT4 1 0.26 0 0.05
113 INT323482 Ghrl Negative_regulation of Ins1 1 0.13 0.24 0.05
114 INT229820 Fos Positive_regulation of Gene_expression of Ghrl 1 0.02 0.05 0.05
115 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05
116 INT328365 Binding of JAG2 and Ghrl 1 0.03 0.07 0.05
117 INT323485 Ghrl Negative_regulation of Localization of Ins1 1 0.15 1.99 0.05
118 INT222498 Ghrh Positive_regulation of Gene_expression of Ghrl 1 0.10 0.19 0.04
119 INT328363 Ghrl Negative_regulation of PLOD1 1 0.02 0.11 0.04
120 INT222497 Negative_regulation of Gh1 Negative_regulation of Ghrl 1 0.01 0.2 0.04
121 INT328332 Ghrl Negative_regulation of Abo 1 0.01 0 0.04
122 INT295532 Ghsr Positive_regulation of Localization of Ghrh 1 0.40 0 0.03
123 INT328362 LYPLA1 Regulation of Ghrl 1 0.04 0.07 0.03
124 INT323497 Negative_regulation of Ghsr Positive_regulation of Ins1 1 0.24 0 0.03
125 INT175560 Binding of GPER and GHRL 1 0.01 1.14 0.03
126 INT322876 Binding of PDCD10 and Inpp5d 1 0.03 0.46 0.03
127 INT97896 Ghrl Positive_regulation of Localization of Gh 1 0.48 0.37 0.03
128 INT328381 Ghrl Positive_regulation of NPY 1 0.06 0.15 0.03
129 INT28372 CPM Regulation of GHRL 2 0.05 0 0
130 INT222536 Ghrl Positive_regulation of Transcription of Pou1f1 1 0.03 0.13 0
131 INT188289 Ghrl Negative_regulation of Gnrh1 1 0.08 0.17 0
132 INT188295 Binding of KITLG and Ghrl 1 0.02 0.09 0
133 INT328369 Ghrl Negative_regulation of CRH 1 0.16 0.15 0
134 INT28371 CPN2 Regulation of GHRL 1 0.00 0 0
135 INT76601 Ghsr Positive_regulation of Localization of Prl 1 0.69 0 0
136 INT269944 Gata6 Regulation of Gene_expression of Foxj1 1 0.19 0 0
137 INT323489 Ghrl Regulation of Regulation of Ins1 1 0.09 0.07 0
138 INT76602 Ghsr Regulation of Prl 1 0.27 0 0
139 INT323493 Binding of Ins1 and Ghrl 1 0.12 1.25 0
140 INT117795 ABCA1 Regulation of GHRL 1 0.00 0 0
141 INT269933 Foxa2 Regulation of Gene_expression of Foxj1 1 0.27 0 0
142 INT323499 Ghrl Positive_regulation of Ins1 1 0.21 0.25 0
143 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0
144 INT17540 Ghsr Regulation of GHRH 1 0.22 0 0
145 INT163696 Ghrl Regulation of Efs 1 0.05 0 0
146 INT188292 Ghrl Regulation of Gnrhr 1 0.01 0.19 0
147 INT323500 Ghrl Positive_regulation of Grb2 1 0.13 0.5 0
148 INT323495 Ghrl Positive_regulation of Irs1 1 0.20 0.5 0
149 INT188287 Ghrl Regulation of Gh1 1 0.01 0.19 0
150 INT188293 Ghrl Negative_regulation of LH 1 0.03 0.17 0
151 INT188290 Ghrl Regulation of Gene_expression of Kitlg 1 0.02 0.15 0
152 INT323487 Ghrl Positive_regulation of Phosphorylation of Akt1 1 0.09 0.77 0
153 INT76603 Ghsr Positive_regulation of Gh1 1 0.19 0 0
154 INT328368 Ghrl Positive_regulation of INS 1 0.04 0.22 0
155 INT163697 Ghrl Regulation of Gene_expression of Efs 1 0.09 0 0
156 INT17525 Ghsr Regulation of Lhb 1 0.01 0 0
157 INT323496 Binding of Rip and Ghsr 1 0.08 0.34 0
158 INT269939 Foxa1 Regulation of Gene_expression of Foxj1 1 0.26 0 0
159 INT331405 Binding of Gh and Ghsr 1 0.08 0.13 0
160 INT76600 Ghsr Positive_regulation of Prl 1 0.22 0 0
161 INT325420 Ghrl Regulation of Mag 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-6 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of interleukin-6 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14
2 INT14513 Localization of Ghrl 52 0.78 29.26 11.63
3 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7
4 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68
5 INT224964 Localization of Ghrl 30 0.59 7.71 8.77
6 INT226106 Negative_regulation of Ghrl 12 0.40 3.98 5.39
7 INT18661 Localization of Ghsr 32 0.78 3.19 5.2
8 INT117855 Negative_regulation of Ghrl 29 0.57 17.52 5
9 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6
10 INT141285 Positive_regulation of Localization of Ghrl 11 0.63 9.38 3.86
11 INT132317 Positive_regulation of Gene_expression of Ghrl 20 0.49 21 3.57
12 INT226114 Binding of Ghrl 18 0.36 4.34 3.54
13 INT118207 Binding of Ghrl 11 0.47 7.39 3.52
14 INT19009 Positive_regulation of Ghsr 17 0.64 5.71 2.78
15 INT35251 Regulation of Ghrl 21 0.60 8.26 2.6
16 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59
17 INT323469 Negative_regulation of Localization of Ghrl 4 0.29 0.4 2.49
18 INT226105 Regulation of Ghrl 10 0.50 2.36 2.26
19 INT35210 Gene_expression of Ghsr 39 0.75 6 2.24
20 INT30202 Positive_regulation of GHRL 5 0.44 3.04 2.22
21 INT323480 Negative_regulation of Ghsr 4 0.36 0.9 2.06
22 INT188282 Regulation of Gene_expression of Ghrl 16 0.31 10.08 1.95
23 INT164017 Negative_regulation of Localization of Ghrl 2 0.53 3.12 1.88
24 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76
25 INT97892 Positive_regulation of Gene_expression of Ghrl 31 0.49 13.43 1.7
26 INT19007 Binding of Ghsr 5 0.46 0.46 1.6
27 INT224947 Positive_regulation of Localization of Ghrl 3 0.34 0.48 1.4
28 INT161750 Transcription of Ghrl 14 0.67 7.05 1.23
29 INT57852 Regulation of Ghsr 15 0.59 1.02 1.1
30 INT149090 Positive_regulation of Ghsr 10 0.70 2.33 1.06
31 INT323462 Regulation of Gene_expression of Ghrl 2 0.27 0.15 1
32 INT16898 Localization of GHSR 8 0.74 1.76 0.91
33 INT75050 Binding of GHSR 3 0.47 0.64 0.89
34 INT353715 Negative_regulation of Gene_expression of Ghsr 1 0.35 0 0.89
35 INT161751 Positive_regulation of Transcription of Ghrl 3 0.49 3.89 0.81
36 INT323980 Regulation of Localization of Ghrl 5 0.60 3.04 0.8
37 INT323979 Negative_regulation of Negative_regulation of Ghrl 2 0.42 0.98 0.76
38 INT295519 Localization of Ghsr 7 0.72 0.75 0.68
39 INT166886 Negative_regulation of Gene_expression of Ghrl 3 0.41 4.11 0.66
40 INT163329 Negative_regulation of GHRL 5 0.58 7.34 0.65
41 INT4783 Localization of GHRL 5 0.11 1.28 0.61
42 INT19005 Positive_regulation of Positive_regulation of Ghsr 1 0.49 0 0.53
43 INT224959 Positive_regulation of Gene_expression of Ghsr 5 0.45 1.09 0.5
44 INT202229 Regulation of GHRL 3 0.07 1.8 0.47
45 INT4780 Positive_regulation of Gene_expression of GHRL 2 0.06 1.03 0.45
46 INT16897 Gene_expression of GHSR 6 0.77 0.46 0.41
47 INT58364 Positive_regulation of GHSR 2 0.56 0.35 0.39
48 INT325380 Positive_regulation of Positive_regulation of Ghrl 2 0.45 1.35 0.35
49 INT330616 Positive_regulation of Gene_expression of Inpp5d 2 0.49 0.89 0.34
50 INT137559 Negative_regulation of Regulation of Ghrl 1 0.32 0 0.34
51 INT188281 Transcription of Ghsr 1 0.66 0.8 0.34
52 INT41640 Binding of GHRL 2 0.15 1.78 0.32
53 INT287775 Transcription of Ghrl 3 0.41 1.27 0.31
54 INT330615 Gene_expression of Inpp5d 2 0.66 0.78 0.31
55 INT295517 Negative_regulation of Gene_expression of Ghrl 2 0.32 0.91 0.28
56 INT295520 Regulation of Positive_regulation of Ghrl 1 0.24 0.16 0.26
57 INT98692 Negative_regulation of Regulation of Ghsr 2 0.21 0.15 0.24
58 INT16900 Negative_regulation of GHSR 1 0.42 0 0.22
59 INT330612 Positive_regulation of Localization of Inpp5d 1 0.02 0.35 0.22
60 INT330610 Localization of Inpp5d 1 0.02 0.3 0.22
61 INT83747 Regulation of Gene_expression of Ghsr 2 0.26 0.27 0.21
62 INT347641 Regulation of Positive_regulation of Inpp5d 1 0.27 0.33 0.19
63 INT57851 Regulation of Regulation of Ghsr 1 0.04 0 0.19
64 INT347643 Positive_regulation of Inpp5d 1 0.46 0.33 0.18
65 INT325379 Regulation of Positive_regulation of Ghrl 1 0.26 0.23 0.17
66 INT65898 Negative_regulation of Ghsr 3 0.26 2.01 0.16
67 INT323470 Binding of Ghsr 4 0.40 1.94 0.13
68 INT293628 Regulation of Transcription of Ghrl 1 0.31 0.96 0.13
69 INT293629 Negative_regulation of Gene_expression of GHRL 1 0.02 0.79 0.13
70 INT323468 Negative_regulation of Negative_regulation of Ghrl 1 0.21 0.14 0.12
71 INT325417 Regulation of Positive_regulation of Ghsr 1 0.41 0.1 0.09
72 INT328361 Positive_regulation of Negative_regulation of Ghrl 1 0.24 0.12 0.07
73 INT323466 Negative_regulation of Binding of Ghrl 1 0.21 0.36 0.07
74 INT287774 Negative_regulation of Transcription of Ghrl 1 0.02 1.28 0.05
75 INT302734 Negative_regulation of Positive_regulation of Ghrl 2 0.41 1.58 0.04
76 INT226110 Positive_regulation of Binding of Ghrl 1 0.30 0 0.04
77 INT323461 Negative_regulation of Localization of Ghsr 1 0.35 0.76 0.04
78 INT323471 Regulation of Localization of Ghrl 1 0.22 0 0.04
79 INT76597 Positive_regulation of Gene_expression of Ghsr 7 0.63 2.51 0.03
80 INT188284 Negative_regulation of Gene_expression of Ghsr 2 0.41 0.17 0.03
81 INT293630 Regulation of Gene_expression of GHRL 1 0.01 0.54 0.03
82 INT293631 Negative_regulation of Positive_regulation of GHRL 1 0.02 0.89 0.03
83 INT323464 Phosphorylation of Ghrl 1 0.40 0.19 0.03
84 INT323460 Transcription of Ghsr 1 0.59 0.84 0.03
85 INT328291 Protein_catabolism of Ghrl 1 0.13 0.17 0
86 INT269905 Positive_regulation of Foxj1 1 0.32 0.08 0
87 INT350662 Regulation of Inpp5d 1 0.06 0.16 0
88 INT331401 Regulation of Ghsr 1 0.38 0 0
89 INT328352 Protein_catabolism of Ghrl 1 0.86 0.15 0
90 INT323481 Transcription of GHSR 1 0.67 0 0
91 INT269900 Gene_expression of Foxj1 1 0.49 0.25 0
92 INT76598 Positive_regulation of Localization of Ghsr 1 0.45 0 0
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