GO:0045410

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Name positive regulation of interleukin-6 biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045410
Unique Molecular Interactions 1228
Total Molecular Interactions 1780
Total Single Events 9468
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-6 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of interleukin-6 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
4 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
6 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
7 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
8 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
9 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
10 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
11 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
12 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
13 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
14 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
15 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
16 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
17 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
18 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
19 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
20 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
21 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
22 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
23 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
24 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
25 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
26 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
27 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
28 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
29 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
30 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
31 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
32 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
33 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
34 INT92057 Ifng Positive_regulation of Gene_expression of Ik 1 0.03 0.45 1.49
35 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
36 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
37 INT83626 Ifng Positive_regulation of Gene_expression of Cd59 1 0.33 2.19 1.41
38 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
39 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
40 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
41 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
42 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
43 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
44 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
45 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
46 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
47 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
48 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
49 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
50 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
51 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
52 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
53 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
54 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
55 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
56 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
57 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
58 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
59 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
60 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
61 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
62 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
63 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
64 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
65 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
66 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
67 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
68 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
69 INT122889 Ifng Positive_regulation of Gene_expression of HLA-E 1 0.02 0.97 1.1
70 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
71 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
72 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
73 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
74 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
75 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
76 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
77 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
78 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
79 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
80 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
81 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
82 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
83 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
84 INT113235 Tacr1 Regulation of Gene_expression of Ifng 1 0.26 1 1.04
85 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
86 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
87 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
88 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
89 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
90 INT88879 Ifng Positive_regulation of Nfkb1 1 0.01 0.26 1.01
91 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
92 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
93 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
94 INT94493 Avp Positive_regulation of Gene_expression of Ifng 1 0.05 1.73 0.97
95 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
96 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
97 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
98 INT77142 Binding of IFNG and IL4 2 0.03 1.16 0.95
99 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
100 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
101 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
102 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
103 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
104 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92
105 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
106 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
107 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
108 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
109 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
110 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
111 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
112 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
113 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
114 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
115 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
116 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85
117 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
118 INT120999 Binding of Oprm1 and Ifng 1 0.22 0.57 0.84
119 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
120 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
121 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
122 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
123 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
124 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
125 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
126 INT94331 IFNG Positive_regulation of CXCL10 4 0.11 1.31 0.82
127 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
128 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
129 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
130 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
131 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
132 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
133 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
134 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
135 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
136 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
137 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
138 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
139 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
140 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
141 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
142 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
143 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
144 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
145 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
146 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
147 INT146460 IFNG Positive_regulation of Gene_expression of TNFRSF10D 1 0.03 1.46 0.72
148 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
149 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
150 INT151679 Ifng Negative_regulation of Oas1b 1 0.12 1.24 0.71
151 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
152 INT146461 IFNG Positive_regulation of NFKB1 1 0.01 1.44 0.71
153 INT151676 Ifng Negative_regulation of Art2a-ps 1 0.00 1.25 0.71
154 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
155 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
156 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
157 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
158 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
159 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
160 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
161 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
162 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
163 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
164 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
165 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
166 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
167 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
168 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
169 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
170 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
171 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
172 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
173 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
174 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
175 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
176 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
177 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
178 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
179 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
180 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
181 INT142076 IL4 Negative_regulation of Gene_expression of IFNG 1 0.01 1.58 0.64
182 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
183 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
184 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
185 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
186 INT56235 Ifng Positive_regulation of Gene_expression of RT1-EC2 1 0.23 0.33 0.62
187 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
188 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
189 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
190 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
191 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
192 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
193 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
194 INT154530 Positive_regulation of Ifng Negative_regulation of Il10 1 0.33 0.63 0.61
195 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
196 INT154533 Ifng Negative_regulation of Il4 1 0.11 0.62 0.6
197 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
198 INT154531 Ifng Negative_regulation of Il10 1 0.30 0.61 0.6
199 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
200 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of interleukin-6 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of interleukin-6 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
3 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
4 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
5 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
6 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
7 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
8 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
9 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14
10 INT6849 Localization of IL1B 229 0.81 112.56 69.63
11 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6
12 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
13 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
14 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
15 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
16 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
17 INT6484 Binding of IL1B 122 0.47 75.84 35.07
18 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
19 INT9347 Localization of Il1b 58 0.81 26.13 31.53
20 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
21 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
22 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
23 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
24 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08
25 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77
26 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
27 INT8518 Localization of Ifng 53 0.81 36.68 24.13
28 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
29 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05
30 INT48081 Localization of Il1b 46 0.80 21.59 22.4
31 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
32 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
33 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
34 INT25222 Positive_regulation of Gene_expression of Ifng 32 0.50 24.18 19.58
35 INT19509 Localization of Ifng 55 0.78 28.25 18.67
36 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35
37 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
38 INT24209 Negative_regulation of Ifng 37 0.57 16.52 17.15
39 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89
40 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
41 INT10360 Positive_regulation of Ifng 33 0.68 21.73 15.19
42 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
43 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
44 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
45 INT4931 Localization of IFNG 53 0.78 33.25 13.65
46 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
47 INT7532 Negative_regulation of Gene_expression of Ifng 33 0.59 18.56 13.14
48 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
49 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
50 INT5057 Negative_regulation of Gene_expression of IFNG 23 0.58 8.33 12.3
51 INT9160 Negative_regulation of Ifng 31 0.58 16.37 11.84
52 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91
53 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
54 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
55 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
56 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
57 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
58 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
59 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
60 INT5326 Regulation of Ifng 12 0.55 4.56 7.19
61 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
62 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
63 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
64 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
65 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
66 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
67 INT74154 Transcription of Ifng 14 0.67 10.33 6.21
68 INT15803 Regulation of IFNG 21 0.44 12.57 5.98
69 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
70 INT80750 Binding of Il1b 11 0.47 7.97 5.95
71 INT5186 Regulation of Ifng 11 0.45 8.78 5.9
72 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
73 INT10705 Binding of Il1b 9 0.36 2.8 5.53
74 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
75 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
76 INT62132 Regulation of Gene_expression of Ifng 12 0.62 1.28 4.77
77 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
78 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
79 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
80 INT34054 Regulation of Gene_expression of IFNG 8 0.42 3.69 3.76
81 INT87027 Positive_regulation of Localization of IFNG 12 0.67 5.78 3.35
82 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
83 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
84 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
85 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
86 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
87 INT67078 Binding of Ifng 7 0.48 4.84 2.73
88 INT15197 Regulation of Gene_expression of Ifng 8 0.34 2.66 2.69
89 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
90 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
91 INT111145 Negative_regulation of Positive_regulation of Ifng 7 0.41 2.21 2.61
92 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
93 INT91669 Negative_regulation of Localization of IFNG 5 0.57 4.1 2.58
94 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
95 INT16964 Binding of IFNG 27 0.48 14.31 2.45
96 INT73980 Transcription of Ifng 12 0.72 5.42 2.4
97 INT70918 Positive_regulation of Localization of Ifng 5 0.45 2.79 2.33
98 INT67437 Negative_regulation of Localization of Ifng 7 0.47 2.23 2.28
99 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
100 INT112784 Positive_regulation of Positive_regulation of IFNG 11 0.49 7.84 2.18
101 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
102 INT140818 Positive_regulation of Positive_regulation of Ifng 2 0.47 4.2 2.06
103 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
104 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
105 INT111530 Positive_regulation of Regulation of Ifng 1 0.41 0.32 2.01
106 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
107 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
108 INT222903 Gene_expression of TLR1 20 0.60 8.77 1.9
109 INT11136 Positive_regulation of Localization of Ifng 4 0.49 3.13 1.89
110 INT61627 Transcription of IFNG 6 0.69 4.28 1.83
111 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
112 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
113 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
114 INT113716 Positive_regulation of Transcription of Ifng 1 0.53 2.56 1.61
115 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
116 INT56228 Positive_regulation of Positive_regulation of Ifng 2 0.43 2.83 1.4
117 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
118 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
119 INT11137 Negative_regulation of Localization of Ifng 3 0.38 2.45 1.26
120 INT19923 Regulation of Localization of Ifng 3 0.22 1.1 1.25
121 INT109243 Regulation of Positive_regulation of IFNG 1 0.45 1.27 1.23
122 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
123 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
124 INT111536 Positive_regulation of Negative_regulation of Ifng 1 0.41 0.35 1.18
125 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
126 INT9348 Regulation of Localization of Il1b 2 0.27 0.14 1.04
127 INT122884 Positive_regulation of Transcription of Ifng 1 0.39 1.08 1.03
128 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02
129 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02
130 INT346201 Negative_regulation of Phosphorylation of IL1B 1 0.20 1.69 1.01
131 INT168280 Positive_regulation of Phosphorylation of Il1b 1 0.49 1.1 0.93
132 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
133 INT103303 Negative_regulation of Transcription of Ifng 6 0.43 2.7 0.83
134 INT43488 Regulation of Positive_regulation of Ifng 1 0.42 0.71 0.83
135 INT64635 Binding of Ifng 2 0.36 0.57 0.81
136 INT89340 Positive_regulation of EREG 5 0.69 4.98 0.77
137 INT11138 Regulation of Localization of Ifng 2 0.56 0.8 0.77
138 INT73240 Negative_regulation of Transcription of IFNG 1 0.41 0.92 0.76
139 INT140708 Gene_expression of Tlr1 10 0.50 5.24 0.72
140 INT127822 Negative_regulation of Transcription of Il1b 2 0.42 1.2 0.72
141 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
142 INT116009 Regulation of Negative_regulation of Ifng 1 0.44 0.09 0.67
143 INT61622 Positive_regulation of Transcription of IFNG 1 0.26 0.29 0.63
144 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
145 INT56231 Regulation of Positive_regulation of Ifng 1 0.39 0.33 0.62
146 INT83618 Regulation of Positive_regulation of Il1b 2 0.44 1.04 0.58
147 INT81352 Negative_regulation of Regulation of IL1B 2 0.41 0.51 0.58
148 INT116045 Negative_regulation of Positive_regulation of Ifng 2 0.03 2.5 0.57
149 INT204864 Negative_regulation of Negative_regulation of Tlr4 3 0.30 2.05 0.56
150 INT61109 Negative_regulation of Positive_regulation of IFNG 1 0.53 0.57 0.5
151 INT284454 Binding of Tirap 4 0.26 2.07 0.49
152 INT246926 Negative_regulation of Transcription of Tlr4 3 0.41 1.78 0.49
153 INT242887 Positive_regulation of Gene_expression of TLR1 2 0.28 1.87 0.49
154 INT147606 Positive_regulation of TLR1 5 0.67 4.35 0.47
155 INT152229 Positive_regulation of Regulation of Tlr4 2 0.40 0.29 0.46
156 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
157 INT123721 Negative_regulation of Negative_regulation of Ifng 1 0.34 0.26 0.45
158 INT288184 Binding of Tlr1 8 0.29 4.73 0.4
159 INT161299 Gene_expression of TLR6 2 0.57 0.82 0.4
160 INT185313 Regulation of Transcription of Tlr4 3 0.20 0.49 0.39
161 INT230469 Binding of TLR1 6 0.40 1.81 0.38
162 INT178182 Negative_regulation of Binding of Tlr4 3 0.33 2.13 0.38
163 INT89341 Gene_expression of EREG 3 0.78 2.38 0.38
164 INT91975 Regulation of Binding of IL1B 2 0.14 0.66 0.38
165 INT174684 Gene_expression of Tlr6 2 0.44 2.62 0.36
166 INT153878 Negative_regulation of Negative_regulation of Il1b 1 0.42 0.78 0.36
167 INT217464 Binding of Traf6 5 0.29 1.28 0.35
168 INT89342 Transcription of EREG 1 0.69 1.22 0.35
169 INT242895 Negative_regulation of Gene_expression of TLR1 3 0.38 0.95 0.34
170 INT209937 Negative_regulation of Protein_catabolism of IL1B 2 0.24 1.15 0.32
171 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
172 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
173 INT230494 Regulation of Binding of Tlr4 3 0.45 2.97 0.31
174 INT89339 Regulation of EREG 2 0.27 1.86 0.31
175 INT9156 Negative_regulation of Regulation of Ifng 1 0.19 0.94 0.3
176 INT242891 Transcription of TLR1 5 0.56 0.86 0.26
177 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
178 INT275828 Positive_regulation of Gene_expression of Tlr1 2 0.24 1.75 0.26
179 INT204866 Regulation of Localization of Tlr4 3 0.37 0.66 0.25
180 INT215080 Positive_regulation of Negative_regulation of Tlr4 1 0.31 0.05 0.23
181 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
182 INT155532 Regulation of Regulation of IL1B 2 0.26 0.32 0.22
183 INT255967 Transcription of Tlr1 2 0.35 2.56 0.21
184 INT312860 Positive_regulation of Binding of IFNG 1 0.42 0.09 0.21
185 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
186 INT94336 Phosphorylation of IFNG 1 0.19 0.25 0.21
187 INT245220 Regulation of TLR1 1 0.36 1.6 0.21
188 INT100769 Negative_regulation of Transcription of Ifng 3 0.42 0.7 0.2
189 INT281991 Regulation of Negative_regulation of Il1b 1 0.03 0.77 0.2
190 INT285447 Binding of TLR6 4 0.36 0.48 0.18
191 INT334246 Positive_regulation of Protein_catabolism of Tlr4 1 0.07 0.18 0.18
192 INT117736 Regulation of Localization of Il1b 1 0.02 1.33 0.18
193 INT324855 Binding of Tlr6 1 0.14 2.39 0.17
194 INT306008 Positive_regulation of Transcription of Tlr4 2 0.50 1.41 0.16
195 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
196 INT290324 Positive_regulation of Binding of TLR1 1 0.22 0.48 0.14
197 INT290321 Negative_regulation of Positive_regulation of TLR1 1 0.19 0.48 0.14
198 INT285444 Localization of TLR1 2 0.63 0.47 0.13
199 INT355270 Positive_regulation of Transcription of Tlr1 1 0.01 1.76 0.12
200 INT58590 Protein_catabolism of IFNG 2 0.84 0.75 0.1
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