GO:0045415

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Name negative regulation of interleukin-8 biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045415
Unique Molecular Interactions 120
Total Molecular Interactions 166
Total Single Events 866
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-8 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of interleukin-8 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
2 INT62019 CSF2 Regulation of ELANE 1 0.03 0.47 1.21
3 INT312097 ELANE Regulation of ALOX5 1 0.08 1.75 1.05
4 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
5 INT62017 ELANE Positive_regulation of Localization of ACOT1 1 0.05 0.35 0.98
6 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
7 INT32441 POMC Positive_regulation of ELANE 1 0.13 0.09 0.83
8 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
9 INT312101 ELANE Regulation of ALOX5AP 1 0.21 1.11 0.73
10 INT293010 ELANE Regulation of Localization of LTF 1 0.00 0.54 0.67
11 INT312105 ELANE Positive_regulation of Localization of PTGER2 4 0.03 1.3 0.64
12 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
13 INT32782 Binding of Vip and Elane 1 0.17 0 0.61
14 INT57248 ELANE Regulation of Gene_expression of CGA 1 0.05 0 0.52
15 INT312118 ELANE Regulation of PTGES 1 0.22 0.92 0.49
16 INT65006 DAK Negative_regulation of ELANE 1 0.05 0.35 0.47
17 INT312112 ELANE Regulation of Transcription of ALOX5 1 0.09 0.82 0.47
18 INT221026 ELANE Positive_regulation of Gene_expression of CCL18 1 0.01 0.57 0.45
19 INT56631 Negative_regulation of FPR1 Positive_regulation of ELANE 1 0.38 0.54 0.44
20 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
21 INT293007 IRF6 Positive_regulation of ELANE 1 0.00 0 0.42
22 INT221027 ELANE Positive_regulation of IL8 2 0.14 1.3 0.4
23 INT312123 ELANE Positive_regulation of ALOX5 1 0.09 0.74 0.4
24 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
25 INT312086 ELANE Positive_regulation of MMP13 1 0.13 0.64 0.39
26 INT312750 Elane Positive_regulation of Positive_regulation of Ltp 1 0.01 0.38 0.34
27 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33
28 INT312099 ELANE Positive_regulation of Gene_expression of PTGER2 1 0.02 0.64 0.32
29 INT346286 ELANE Positive_regulation of MAPK1 1 0.06 0.65 0.32
30 INT346281 Binding of ELANE and MAPK1 1 0.04 0.65 0.32
31 INT312085 ELANE Regulation of Regulation of ALOX5 1 0.09 0.64 0.32
32 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29
33 INT116358 Binding of C3 and ELANE 1 0.12 0 0.29
34 INT116356 Positive_regulation of Binding of C3 and ELANE 1 0.16 0 0.29
35 INT312115 ELANE Positive_regulation of Transcription of PTGES 1 0.25 0.53 0.25
36 INT312569 IL6 Positive_regulation of Localization of ELANE 1 0.11 1.05 0.24
37 INT15829 Ambp Regulation of Positive_regulation of ELANE 1 0.00 0 0.24
38 INT202422 IL8 Positive_regulation of Localization of ELANE 1 0.02 0.91 0.24
39 INT222178 SERPINB1 Regulation of ELANE 1 0.00 1.04 0.23
40 INT259623 Binding of Eln and Elane 1 0.02 1.38 0.23
41 INT133166 ELANE Regulation of Tnf 1 0.01 0.98 0.22
42 INT57250 ELANE Positive_regulation of Localization of CGA 1 0.08 0 0.21
43 INT310939 Binding of ELANE and COPD 1 0.08 1.51 0.2
44 INT252814 ELANE Positive_regulation of Positive_regulation of CCL2 1 0.05 0.8 0.2
45 INT310938 Binding of ELANE and HRCT1 1 0.02 1.5 0.2
46 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18
47 INT259634 Elane Positive_regulation of Gene_expression of COPD 1 0.01 0.92 0.17
48 INT221025 TNF Positive_regulation of ELANE 1 0.01 0.13 0.17
49 INT346305 Binding of ELANE and Col2a1 1 0.00 0.98 0.17
50 INT312109 ELANE Positive_regulation of EGR1 1 0.15 0.23 0.16
51 INT312100 ELANE Positive_regulation of Binding of EGR1 1 0.16 0.23 0.16
52 INT312111 ELANE Regulation of Transcription of PTGES 1 0.22 0.23 0.16
53 INT116359 Positive_regulation of Binding of C4A and ELANE 1 0.14 0 0.15
54 INT221030 ELANE Positive_regulation of CXCL10 1 0.01 0.24 0.15
55 INT312126 ELANE Positive_regulation of ALOX5AP 1 0.20 0.25 0.15
56 INT22820 ADRA1D Regulation of ELANE 1 0.21 0 0.15
57 INT312092 ELANE Positive_regulation of Gene_expression of EGR1 1 0.19 0.21 0.15
58 INT221035 ELANE Positive_regulation of CCL18 1 0.01 0.24 0.15
59 INT21453 Ambp Regulation of ELANE 1 0.00 0 0.15
60 INT221019 ELANE Positive_regulation of CCL3 1 0.00 0.24 0.15
61 INT116357 Binding of C4A and ELANE 1 0.11 0 0.14
62 INT312096 ELANE Positive_regulation of Transcription of ALOX5 1 0.06 0.27 0.13
63 INT252785 ELANE Regulation of Gene_expression of FBRS 1 0.00 0.5 0.13
64 INT179234 Binding of SERPINA6 and ELANE 1 0.01 0.22 0.12
65 INT312570 AMBP Regulation of Negative_regulation of ELANE 1 0.06 0.95 0.12
66 INT191759 NFASC Negative_regulation of ELANE 1 0.00 0.98 0.11
67 INT312094 ELANE Positive_regulation of PTGES 1 0.29 0.34 0.11
68 INT324828 ELANE Positive_regulation of Localization of Ecm1 1 0.00 0.61 0.09
69 INT312103 ELANE Regulation of Gene_expression of ALOX5 1 0.06 0.15 0.08
70 INT24660 Positive_regulation of Binding of ELANE and SERPINA1 1 0.17 0.73 0.08
71 INT259622 Elane Positive_regulation of Protein_catabolism of Ecm1 1 0.00 0.38 0.08
72 INT312093 ELANE Regulation of Gene_expression of ALOX5AP 1 0.13 0.15 0.08
73 INT21452 Ambp Regulation of Gene_expression of ELANE 1 0.00 0 0.08
74 INT56377 AMBP Negative_regulation of Elane 1 0.00 1.43 0.08
75 INT24659 Binding of ELANE and SERPINA1 1 0.13 0.73 0.08
76 INT312113 ELANE Positive_regulation of Gene_expression of ALOX5AP 1 0.23 0.14 0.07
77 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
78 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
79 INT346302 ELANE Regulation of Col2a1 1 0.00 0.3 0.05
80 INT339020 SERPINA1 Negative_regulation of ELANE 1 0.07 0.59 0.05
81 INT312110 ELANE Positive_regulation of Gene_expression of ALOX5 1 0.09 0.07 0.04
82 INT346283 Binding of COL11A1 and ELANE 1 0.01 0.08 0.04
83 INT312117 Negative_regulation of ELANE Positive_regulation of ALOX5AP 1 0.17 0.08 0.04
84 INT179903 Binding of ELANE and SRI 1 0.17 1.07 0.03
85 INT312125 Binding of ELANE and PTGES 1 0.13 0.07 0.03
86 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
87 INT252820 ELANE Positive_regulation of Gene_expression of COL1A1 1 0.01 0.58 0
88 INT179904 Positive_regulation of ELANE Positive_regulation of NYS3 1 0.10 0.92 0
89 INT238402 ELANE Positive_regulation of Gene_expression of CDKN1A 1 0.03 0.48 0
90 INT238396 ELANE Regulation of PPARA 1 0.04 0.65 0
91 INT252796 ELANE Regulation of COL1A1 1 0.01 0.57 0
92 INT252798 ELANE Regulation of Gene_expression of ROS1 1 0.04 0.16 0
93 INT280845 Binding of ELANE and Avp 1 0.06 0 0
94 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
95 INT337408 Binding of TCF4 and KLF4 1 0.09 0 0
96 INT312107 ELANE Positive_regulation of Gene_expression of COX18 1 0.04 0 0
97 INT238406 Binding of ELANE and PPARA 1 0.07 0.43 0
98 INT252775 ELANE Regulation of Gene_expression of MMRN1 1 0.01 0.16 0
99 INT346284 Binding of ELANE and MR1 1 0.00 0.31 0
100 INT179905 Positive_regulation of ELANE Positive_regulation of SRI 1 0.19 0.92 0
101 INT252771 ELANE Regulation of FBN1 1 0.00 0.57 0
102 INT311063 ELANE Positive_regulation of HSF1 1 0.18 0.54 0
103 INT238405 ELANE Positive_regulation of PPARA 1 0.08 0.46 0
104 INT252813 ELANE Positive_regulation of COL1A1 1 0.01 0.57 0
105 INT252811 ELANE Regulation of FUT1 1 0.01 0.57 0
106 INT312120 ELANE Regulation of Localization of PTGER2 1 0.03 0 0
107 INT209391 Binding of ELANE and Cpox 1 0.01 0.25 0
108 INT238398 ELANE Positive_regulation of Gene_expression of BAX 1 0.05 0.47 0
109 INT311062 ELANE Positive_regulation of Localization of HSF1 1 0.22 0.91 0
110 INT312098 ELANE Regulation of Gene_expression of COX18 1 0.05 0 0
111 INT238399 ELANE Positive_regulation of SRA1 1 0.01 0.07 0
112 INT280847 Avp Regulation of Binding of ELANE 1 0.07 0 0
113 INT238390 ELANE Positive_regulation of Gene_expression of TP53 1 0.04 0.42 0
114 INT252776 ELANE Regulation of Gene_expression of COL1A1 1 0.01 0.58 0
115 INT252819 ELANE Positive_regulation of Localization of ROS1 1 0.04 0.05 0
116 INT238391 ELANE Positive_regulation of PCNA 1 0.01 0.07 0
117 INT311060 ELANE Regulation of Localization of HSF1 1 0.20 0.74 0
118 INT238403 PPARA Regulation of ELANE 1 0.04 0.65 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of interleukin-8 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of interleukin-8 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94
2 INT2609 Localization of ELANE 111 0.81 50.22 26.63
3 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09
4 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79
5 INT2605 Regulation of ELANE 39 0.61 18.22 7.11
6 INT116420 Localization of Elane 16 0.14 7.8 6
7 INT10100 Binding of ELANE 22 0.47 15.32 5.19
8 INT17582 Negative_regulation of Localization of ELANE 17 0.53 6.11 4.89
9 INT179656 Gene_expression of Elane 12 0.32 9.44 3.53
10 INT22891 Positive_regulation of Localization of ELANE 16 0.69 11.52 3.42
11 INT42581 Regulation of Gene_expression of ELANE 11 0.38 9.25 3.38
12 INT22823 Positive_regulation of Positive_regulation of ELANE 12 0.45 6.89 3.35
13 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12
14 INT28731 Negative_regulation of Elane 14 0.14 8.97 3.01
15 INT124583 Negative_regulation of Elane 8 0.29 5.26 2.14
16 INT42583 Protein_catabolism of ELANE 8 0.89 4.33 2.11
17 INT51502 Positive_regulation of Elane 5 0.22 2.3 1.94
18 INT36245 Negative_regulation of Gene_expression of ELANE 11 0.40 5.32 1.88
19 INT83358 Positive_regulation of Elane 8 0.21 8.14 1.83
20 INT5652 Negative_regulation of Positive_regulation of ELANE 7 0.37 2.46 1.21
21 INT17805 Regulation of Localization of ELANE 7 0.59 1.88 1.08
22 INT32443 Negative_regulation of Binding of ELANE 2 0.11 0.54 0.89
23 INT203132 Negative_regulation of Gene_expression of Elane 1 0.20 1.5 0.86
24 INT116419 Negative_regulation of Localization of Elane 2 0.01 0.58 0.82
25 INT142422 Regulation of Positive_regulation of ELANE 1 0.02 0.65 0.78
26 INT46295 Regulation of Negative_regulation of ELANE 4 0.39 2.34 0.76
27 INT153008 Gene_expression of Elane 3 0.66 1.66 0.67
28 INT51501 Positive_regulation of Positive_regulation of Elane 1 0.09 0.5 0.59
29 INT179665 Protein_catabolism of Elane 3 0.15 3.19 0.52
30 INT179666 Positive_regulation of Gene_expression of Elane 3 0.21 1.84 0.5
31 INT153430 Binding of Elane 2 0.47 1.92 0.48
32 INT235200 Positive_regulation of Negative_regulation of ELANE 3 0.38 1.68 0.46
33 INT252736 Transcription of ELANE 2 0.25 0.94 0.39
34 INT52071 Negative_regulation of Negative_regulation of ELANE 2 0.13 0.78 0.36
35 INT21451 Regulation of Regulation of ELANE 2 0.07 0.06 0.35
36 INT273175 Negative_regulation of Gene_expression of Elane 1 0.04 0.71 0.29
37 INT185122 Regulation of Localization of Elane 1 0.01 0.12 0.27
38 INT273176 Positive_regulation of Gene_expression of Elane 1 0.04 0.63 0.26
39 INT272891 Positive_regulation of Positive_regulation of Elane 1 0.08 1.01 0.25
40 INT272872 Positive_regulation of Protein_catabolism of Elane 1 0.08 1 0.24
41 INT259604 Positive_regulation of Binding of Elane 1 0.09 0.81 0.23
42 INT259617 Negative_regulation of Binding of Elane 1 0.08 0.67 0.16
43 INT111240 Localization of Elane 1 0.78 0.59 0.15
44 INT111241 Negative_regulation of Localization of Elane 1 0.57 0.59 0.15
45 INT272869 Negative_regulation of Negative_regulation of Elane 1 0.06 1.02 0.14
46 INT312139 Regulation of Transcription of ELANE 1 0.16 0.18 0.13
47 INT307233 Localization of BCL3 1 0.19 0.84 0.11
48 INT282593 Gene_expression of KLF4 8 0.61 1.09 0.09
49 INT83359 Regulation of Elane 2 0.11 3.61 0.05
50 INT307236 Negative_regulation of Localization of BCL3 1 0.10 0.33 0.05
51 INT179651 Negative_regulation of Protein_catabolism of Elane 1 0.04 0.75 0.05
52 INT282606 Positive_regulation of Gene_expression of KLF4 2 0.54 0.8 0.04
53 INT287710 Regulation of Regulation of Elane 1 0.11 1.38 0.03
54 INT282592 Regulation of KLF4 1 0.26 0.14 0.03
55 INT70328 Phosphorylation of ELANE 2 0.29 0.15 0
56 INT294852 Negative_regulation of KLF4 2 0.20 0.49 0
57 INT294855 Negative_regulation of Gene_expression of KLF4 1 0.13 0.49 0
58 INT337469 Binding of KLF4 1 0.17 0 0
59 INT294846 Positive_regulation of Negative_regulation of KLF4 1 0.15 0.49 0
60 INT339596 Localization of KLF4 1 0.26 0 0
61 INT307232 Negative_regulation of BCL3 1 0.09 0.24 0
62 INT294861 Positive_regulation of KLF4 1 0.15 0.49 0
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