GO:0045429

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Name positive regulation of nitric oxide biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045429
Unique Molecular Interactions 5763
Total Molecular Interactions 8247
Total Single Events 75288
Pain Genes Associated 73

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of nitric oxide biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of nitric oxide biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
4 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
5 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
6 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
7 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
8 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
9 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
10 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
11 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
12 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
13 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
14 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
15 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
16 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
17 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
18 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
19 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
20 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
21 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
22 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
23 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
24 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
25 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
26 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
27 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
28 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
29 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
30 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
31 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
32 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
33 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
34 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
35 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
36 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
37 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
38 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
39 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
40 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
41 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
42 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
43 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
44 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
45 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
46 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
47 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
48 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
49 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
50 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
51 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
52 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
53 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
54 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
55 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
56 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
57 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
58 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
59 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
60 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
61 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
62 INT69057 H2-M3 Regulation of Klkb1 1 0.00 0.42 2.71
63 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
64 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
65 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
66 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
67 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
68 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
69 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
70 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
71 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
72 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
73 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
74 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
75 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
76 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
77 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
78 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
79 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
80 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
81 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
82 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
83 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
84 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
85 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
86 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
87 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
88 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
89 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
90 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
91 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
92 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
93 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
94 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
95 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
96 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
97 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
98 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
99 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
100 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
101 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
102 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
103 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
104 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
105 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
106 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
107 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
108 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
109 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
110 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
111 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
112 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
113 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
114 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
115 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
116 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
117 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
118 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
119 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
120 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
121 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
122 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
123 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
124 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
125 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
126 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
127 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
128 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
129 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
130 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
131 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
132 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
133 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
134 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
135 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
136 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
137 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
138 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
139 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92
140 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
141 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
142 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
143 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9
144 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
145 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
146 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9
147 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
148 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
149 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
150 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88
151 INT338691 Binding of Trpv1 and Aff3 1 0.24 1.21 1.88
152 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
153 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
154 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
155 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
156 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
157 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
158 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
159 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
160 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
161 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83
162 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
163 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
164 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
165 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
166 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
167 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
168 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
169 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
170 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
171 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
172 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
173 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
174 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75
175 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
176 INT182565 Ptger2 Regulation of Trpv1 1 0.25 1.34 1.73
177 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
178 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
179 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
180 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
181 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
182 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
183 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
184 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
185 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
186 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
187 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
188 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
189 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
190 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
191 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
192 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
193 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
194 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
195 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
196 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
197 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
198 INT147654 DYT10 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.93 1.62
199 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
200 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of nitric oxide biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of nitric oxide biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
2 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
3 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
4 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
5 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
6 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42
7 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
8 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
9 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
10 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
11 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
12 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
13 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
14 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
15 INT6852 Localization of TNF 883 0.81 705.95 270.84
16 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
18 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59
19 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
20 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
21 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
22 INT6481 Binding of TNF 624 0.48 510.2 214.82
23 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
24 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
25 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
26 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
27 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
28 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
29 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
30 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
31 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
32 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
33 INT812 Localization of INS 1026 0.81 515.6 145.31
34 INT9660 Regulation of TNF 363 0.62 312.94 139.99
35 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
36 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
37 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
38 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
39 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
40 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
41 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
42 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
43 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
44 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
45 INT12082 Localization of IL6 365 0.81 241.78 105.78
46 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
47 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
48 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
49 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
50 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
51 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
52 INT10166 Localization of Tnf 237 0.81 153.95 88.64
53 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
54 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
55 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
56 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71
57 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
58 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
59 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
60 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
61 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
62 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23
63 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
64 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
65 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
66 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
67 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14
68 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
69 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
70 INT6849 Localization of IL1B 229 0.81 112.56 69.63
71 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15
72 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6
73 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
74 INT19511 Localization of Il6 212 0.81 118.17 67.67
75 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
76 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
77 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
78 INT11937 Localization of Il6 228 0.81 139.83 64.39
79 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
80 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
81 INT96622 Localization of Trpv1 110 0.81 59.82 63.25
82 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
83 INT10706 Regulation of Il6 150 0.62 93.23 62.34
84 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
85 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
86 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
87 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
88 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
89 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
90 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
91 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
92 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
93 INT251 Regulation of INS 398 0.62 232.47 55.04
94 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
95 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
96 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
97 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
98 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
99 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
100 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71
101 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
102 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
103 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
104 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
105 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
106 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
107 INT9210 Regulation of IL6 166 0.62 125.61 49.95
108 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
109 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
110 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
111 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
112 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
113 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
114 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
115 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
116 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
117 INT98498 Binding of Trpv1 75 0.48 33.67 44.4
118 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
119 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
120 INT13354 Transcription of TNF 108 0.72 85.81 42.32
121 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
122 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
123 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
124 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
125 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
126 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
127 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
128 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
129 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
130 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
131 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
132 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
133 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
134 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
135 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
136 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55
137 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
138 INT6484 Binding of IL1B 122 0.47 75.84 35.07
139 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
140 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77
141 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28
142 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
143 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
144 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68
145 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
146 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
147 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
148 INT9655 Regulation of Il6 98 0.62 70.92 31.95
149 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
150 INT35406 Localization of Tnf 94 0.81 64.63 31.65
151 INT9347 Localization of Il1b 58 0.81 26.13 31.53
152 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
153 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
154 INT8691 Localization of Insr 85 0.80 9.27 30.32
155 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
156 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
157 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
158 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
159 INT86437 Binding of IL6 154 0.48 121.22 29.3
160 INT5300 Regulation of Insr 54 0.60 11.33 29.26
161 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
162 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
163 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
164 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
165 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
166 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
167 INT20462 Binding of ESR1 210 0.44 102.7 26.34
168 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28
169 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
170 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
171 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
172 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6
173 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
174 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
175 INT103320 Positive_regulation of Positive_regulation of Trpv1 44 0.70 27.73 25.28
176 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08
177 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01
178 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77
179 INT9377 Positive_regulation of Positive_regulation of TRPV1 43 0.70 15.81 24.47
180 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
181 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
182 INT8518 Localization of Ifng 53 0.81 36.68 24.13
183 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
184 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
185 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2
186 INT134651 Binding of TLR4 89 0.48 66.96 23.19
187 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05
188 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
189 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
190 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52
191 INT48081 Localization of Il1b 46 0.80 21.59 22.4
192 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
193 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
194 INT89056 Phosphorylation of Trpv1 46 0.82 13.52 22.16
195 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13
196 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03
197 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
198 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54
199 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
200 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
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