GO:0045446

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Name endothelial cell differentiation
Categary Process
Go Slim No
Go Link GO:0045446
Unique Molecular Interactions 82
Total Molecular Interactions 181
Total Single Events 847
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endothelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for endothelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
2 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
3 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
4 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
5 INT148381 UFM1 Positive_regulation of JAG1 1 0.00 1.13 0.63
6 INT292814 Binding of VEGFA and Kdr 8 0.18 3.63 0.48
7 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44
8 INT237453 Binding of STAR and MESP1 1 0.00 0.47 0.42
9 INT226381 S1PR1 Positive_regulation of Gene_expression of IK 1 0.00 0.64 0.38
10 INT337156 Kdr Positive_regulation of Gtf3a 1 0.01 0.77 0.35
11 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34
12 INT135891 S1pr1 Regulation of Prps1 1 0.01 0.15 0.33
13 INT302842 Binding of S1PR1 and S1pr1 1 0.24 0.92 0.32
14 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3
15 INT337162 Binding of Kdr and Iqgap1 1 0.32 0.98 0.28
16 INT323436 VEGFA Regulation of Kdr 1 0.03 0.77 0.23
17 INT302846 Negative_regulation of Binding of S1PR1 and S1pr1 1 0.28 0.41 0.18
18 INT302844 Positive_regulation of Binding of S1PR1 and S1pr1 1 0.32 0.52 0.15
19 INT230761 VEGFA Positive_regulation of Kdr 2 0.02 2.16 0.12
20 INT337155 Binding of Kdr and Ros1 1 0.06 0.46 0.12
21 INT337159 Binding of ecs and Kdr 1 0.04 0.46 0.12
22 INT299955 Binding of KDR and FTSJ3 1 0.04 1.07 0.09
23 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08
24 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08
25 INT265750 Binding of FLT1 and KDR 1 0.37 0.54 0.07
26 INT292811 Zfp787 Negative_regulation of Phosphorylation of Kdr 1 0.01 0.45 0.06
27 INT298699 Kdr Regulation of Tek 1 0.11 0.28 0.06
28 INT105268 VEGFA Positive_regulation of KDR 2 0.18 0.22 0.05
29 INT105267 Negative_regulation of VEGFA Positive_regulation of KDR 1 0.16 0.22 0.05
30 INT251778 Negative_regulation of TXK Positive_regulation of KDR 1 0.03 0.99 0.05
31 INT345371 Binding of Flt4 and Kdr 1 0.10 1.12 0.05
32 INT251779 TXK Positive_regulation of KDR 1 0.03 0.99 0.05
33 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04
34 INT315913 VEGFA Regulation of KDR 1 0.03 0.32 0.04
35 INT292083 Binding of KDR and TXK 1 0.04 1.52 0.04
36 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
37 INT332483 Binding of JAG1 and SGPP2 1 0.21 0.23 0.04
38 INT292095 Negative_regulation of Binding of KDR and TXK 1 0.04 1.53 0.04
39 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04
40 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03
41 INT224304 KDR Positive_regulation of Binding of VEGFA 1 0.24 0.36 0.03
42 INT343476 Epo Positive_regulation of Kdr 1 0.11 0.31 0.03
43 INT224306 KDR Positive_regulation of VEGFA 1 0.24 0.36 0.03
44 INT343474 Epo Positive_regulation of Gene_expression of Kdr 1 0.11 0.32 0.03
45 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
46 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0
47 INT258203 S1PR1 Positive_regulation of GTPBP4 1 0.00 0.29 0
48 INT198016 Localization of KDR Negative_regulation of VEGFA 1 0.08 0.95 0
49 INT298684 ecs Positive_regulation of Gene_expression of KDR 1 0.01 1.2 0
50 INT290592 Binding of KDR and Cdh5 1 0.07 0.08 0
51 INT312330 Binding of Kdr and Flt1 1 0.12 0.37 0
52 INT265562 Gla Positive_regulation of Gene_expression of Kdr 1 0.05 0.51 0
53 INT300447 Kdr Regulation of VEGFA 1 0.07 0.25 0
54 INT292082 MIR1200 Negative_regulation of KDR 1 0.00 1.24 0
55 INT258207 S1PR1 Positive_regulation of Phosphorylation of IFI44 1 0.13 0 0
56 INT345375 VEGFA Positive_regulation of Gene_expression of Kdr 1 0.02 1.2 0
57 INT227218 Binding of JAG1 and CD8A 1 0.05 0.5 0
58 INT322844 Binding of KDR and PIK3CD 1 0.04 0 0
59 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
60 INT324662 Negative_regulation of Kdr Positive_regulation of Vash1 1 0.51 0.55 0
61 INT265563 Gla Positive_regulation of Transcription of Kdr 1 0.04 0.51 0
62 INT322850 Binding of KDR and PDCD10 1 0.14 0 0
63 INT300437 Kdr Regulation of Gene_expression of Flt1 1 0.42 0.26 0
64 INT258206 S1PR1 Positive_regulation of Phosphorylation of MAPK1 1 0.12 0 0
65 INT300443 VEGFA Positive_regulation of Phosphorylation of Kdr 1 0.08 0.64 0
66 INT314744 Binding of KDR and Akt1 1 0.13 0.66 0
67 INT298702 Tek Regulation of Kdr 1 0.03 0.33 0
68 INT300438 Efna1 Negative_regulation of Phosphorylation of Kdr 1 0.42 0.66 0
69 INT300436 Flt1 Negative_regulation of Kdr 1 0.35 0.4 0
70 INT353125 Negative_regulation of Binding of VEGFA and Kdr 1 0.04 5.92 0
71 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0
72 INT205614 Gm6668 Negative_regulation of Kdr 1 0.01 1.5 0
73 INT198012 KDR Negative_regulation of VEGFA 1 0.08 0.93 0
74 INT345372 Col18a1 Positive_regulation of Kdr 1 0.20 1.42 0
75 INT351603 Binding of ERBB2 and KDR 1 0.13 0.55 0
76 INT198000 Gene_expression of KDR Negative_regulation of VEGFA 1 0.08 0.94 0
77 INT265770 Binding of KDR and GOPC 1 0.10 0 0
78 INT198010 KDR Negative_regulation of MTOR 1 0.11 0.95 0
79 INT198002 KDR Negative_regulation of PDGFA 1 0.09 0.94 0
80 INT213745 Binding of Kdr and Epc1 1 0.17 0 0
81 INT298700 Kdr Regulation of Manea 1 0.01 0.33 0
82 INT331701 Fgf4 Positive_regulation of Gene_expression of Kdr 1 0.11 0.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for endothelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in endothelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
2 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
3 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
4 INT62678 Negative_regulation of JAG1 8 0.41 6.95 3.5
5 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29
6 INT144580 Regulation of S1pr1 1 0.44 0.32 2.1
7 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86
8 INT162725 Binding of Kdr 13 0.42 8.86 1.79
9 INT144581 Gene_expression of S1pr1 4 0.77 1.64 1.77
10 INT117033 Gene_expression of JAG1 13 0.65 11.46 1.52
11 INT199567 Binding of Kdr 18 0.47 13.81 1.34
12 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2
13 INT226466 Gene_expression of S1PR1 2 0.56 4.51 1.14
14 INT237456 Gene_expression of MESP1 1 0.03 1.33 1.12
15 INT200556 Regulation of Kdr 8 0.28 6.04 1.01
16 INT260471 Positive_regulation of Gene_expression of Kdr 9 0.61 8.37 0.99
17 INT173100 Binding of KDR 39 0.39 22.48 0.81
18 INT297469 Regulation of Binding of Kdr 1 0.54 2.01 0.8
19 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77
20 INT258247 Positive_regulation of S1PR1 1 0.50 0.65 0.73
21 INT127684 Negative_regulation of Kdr 6 0.37 3.19 0.7
22 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66
23 INT74781 Regulation of JAG1 6 0.39 2.75 0.63
24 INT148382 Positive_regulation of JAG1 5 0.23 3.88 0.63
25 INT151401 Localization of JAG1 4 0.65 1.88 0.58
26 INT213000 Binding of S1PR1 9 0.47 2.33 0.54
27 INT135887 Localization of S1pr1 1 0.80 0.52 0.52
28 INT292795 Regulation of Kdr 5 0.40 3.86 0.42
29 INT237457 Positive_regulation of Gene_expression of MESP1 1 0.02 0.45 0.4
30 INT151400 Binding of JAG1 14 0.37 7.96 0.39
31 INT131773 Regulation of KDR 12 0.49 12.01 0.39
32 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36
33 INT288109 Localization of Kdr 4 0.46 2.84 0.33
34 INT173097 Localization of KDR 20 0.73 12.73 0.31
35 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31
36 INT173091 Transcription of KDR 3 0.55 1.39 0.27
37 INT148798 Regulation of Phosphorylation of KDR 1 0.44 0 0.27
38 INT291184 Regulation of Gene_expression of Kdr 3 0.54 4.81 0.25
39 INT125027 Positive_regulation of Kdr 15 0.50 7.73 0.24
40 INT258243 Regulation of Gene_expression of S1PR1 1 0.32 0 0.21
41 INT258232 Positive_regulation of Gene_expression of S1PR1 1 0.50 0.61 0.21
42 INT200555 Negative_regulation of Gene_expression of Kdr 8 0.38 3.78 0.19
43 INT318204 Positive_regulation of Positive_regulation of KDR 2 0.14 0.68 0.19
44 INT105269 Negative_regulation of Positive_regulation of KDR 2 0.41 1.35 0.15
45 INT302812 Positive_regulation of Binding of S1PR1 1 0.45 0.52 0.15
46 INT297468 Transcription of Kdr 6 0.63 1.85 0.14
47 INT258223 Negative_regulation of Binding of S1PR1 1 0.31 0 0.13
48 INT323422 Regulation of Regulation of Kdr 1 0.17 0.5 0.13
49 INT292809 Phosphorylation of Kdr 3 0.72 1.99 0.12
50 INT292807 Negative_regulation of Phosphorylation of Kdr 3 0.37 1.56 0.12
51 INT200557 Regulation of Gene_expression of Kdr 6 0.44 2.72 0.11
52 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09
53 INT258561 Negative_regulation of Negative_regulation of KDR 1 0.11 0.91 0.09
54 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08
55 INT200853 Negative_regulation of Binding of Kdr 2 0.11 0.93 0.06
56 INT179116 Localization of Kdr 1 0.58 4.65 0.06
57 INT189580 Positive_regulation of Gene_expression of KDR 9 0.49 5.9 0.05
58 INT198034 Positive_regulation of Localization of KDR 3 0.29 2.17 0.05
59 INT219231 Positive_regulation of Gene_expression of JAG1 1 0.40 1.18 0.05
60 INT255669 Regulation of Positive_regulation of Kdr 1 0.08 1.1 0.03
61 INT199552 Phosphorylation of Kdr 4 0.38 1.27 0
62 INT265544 Transcription of Kdr 4 0.50 3.14 0
63 INT291191 Negative_regulation of Gene_expression of Kdr 4 0.24 4.46 0
64 INT265799 Regulation of Binding of KDR 2 0.38 0.64 0
65 INT258231 Phosphorylation of S1PR1 2 0.45 0.95 0
66 INT300429 Negative_regulation of Transcription of Kdr 2 0.38 0.49 0
67 INT265783 Regulation of Localization of KDR 2 0.37 0.64 0
68 INT324642 Positive_regulation of Protein_catabolism of Kdr 1 0.61 0.64 0
69 INT302619 Regulation of Transcription of Kdr 1 0.32 0.47 0
70 INT353123 Negative_regulation of Negative_regulation of Kdr 1 0.05 0.78 0
71 INT265779 Positive_regulation of Protein_catabolism of KDR 1 0.41 0.08 0
72 INT324652 Protein_catabolism of Kdr 1 0.87 0.64 0
73 INT258241 Transcription of S1PR1 1 0.38 0.13 0
74 INT270350 Positive_regulation of S1pr1 1 0.32 0.98 0
75 INT300433 Positive_regulation of Phosphorylation of Kdr 1 0.61 1.1 0
76 INT179106 Positive_regulation of Localization of Kdr 1 0.33 0.44 0
77 INT257560 Regulation of Negative_regulation of JAG1 1 0.13 0.48 0
78 INT322861 Positive_regulation of Binding of KDR 1 0.13 0 0
79 INT199564 Negative_regulation of Phosphorylation of Kdr 1 0.27 1.12 0
80 INT258245 Regulation of S1PR1 1 0.44 0.55 0
81 INT265808 Protein_catabolism of KDR 1 0.81 0.08 0
82 INT179113 Negative_regulation of Localization of Kdr 1 0.31 0.41 0
83 INT324653 Positive_regulation of Transcription of Kdr 1 0.41 0.64 0
84 INT258240 Localization of S1PR1 1 0.21 0 0
85 INT258229 Negative_regulation of S1PR1 1 0.31 0 0
86 INT258233 Positive_regulation of Transcription of S1PR1 1 0.33 0.07 0
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