GO:0045541

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Name negative regulation of cholesterol biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045541
Unique Molecular Interactions 131
Total Molecular Interactions 182
Total Single Events 1887
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cholesterol biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cholesterol biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
2 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
3 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
4 INT297332 Apoe Negative_regulation of Gene_expression of Mpz 1 0.02 1.09 0.87
5 INT208354 Binding of Apoe and Hdl1 12 0.13 8.37 0.77
6 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
7 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
8 INT297344 Apoe Regulation of Binding of Alms1 1 0.08 1.1 0.61
9 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
10 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
11 INT254761 Igh-Dex Positive_regulation of Apoe 1 0.00 0.08 0.52
12 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
13 INT116862 Apoe Positive_regulation of Il10 1 0.30 0.69 0.5
14 INT116863 Apoe Negative_regulation of Hand1 1 0.37 0.69 0.5
15 INT254768 DNMT1 Positive_regulation of Gene_expression of Apoe 1 0.02 0.05 0.49
16 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46
17 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
18 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
19 INT254760 Igh-Dex Positive_regulation of Gene_expression of Apoe 1 0.00 0 0.42
20 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
21 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
22 INT254759 Igh-Dex Positive_regulation of Localization of Apoe 1 0.00 0.32 0.28
23 INT254769 Binding of LDLR and Apoe 1 0.03 0 0.28
24 INT297338 Apoe Regulation of Gnb5 1 0.06 1.12 0.27
25 INT254772 DNMT1 Positive_regulation of Apoe 1 0.02 0 0.25
26 INT78293 Binding of Apoe and Ldlr 1 0.20 0.25 0.24
27 INT78295 Binding of Ptpra and Apoe 1 0.42 0.25 0.24
28 INT297334 Gnb5 Regulation of Apoe 1 0.09 0.83 0.24
29 INT78294 Negative_regulation of Binding of Ptpra and Apoe 1 0.48 0.25 0.24
30 INT254773 PPARA Positive_regulation of Gene_expression of Apoe 1 0.01 0.07 0.24
31 INT78292 Negative_regulation of Binding of Apoe and Ldlr 1 0.23 0.25 0.24
32 INT254774 DNMT1 Positive_regulation of Localization of Apoe 1 0.01 0.31 0.23
33 INT134494 Binding of APOE and Alb 1 0.11 0.45 0.2
34 INT305508 Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
35 INT305511 Negative_regulation of Binding of Sod1 and Slc17a6 1 0.03 1.1 0.2
36 INT28562 SOD1 Negative_regulation of Pacs1 1 0.03 2.63 0.19
37 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
38 INT250949 Binding of KIR3DL2 and SOD1 1 0.24 0.55 0.18
39 INT208360 Binding of Abca1 and Apoe 1 0.15 0.74 0.17
40 INT197499 Binding of Apoe and Tfrc 1 0.14 1.54 0.17
41 INT122528 Apoe Regulation of Eno2 1 0.05 0.29 0.16
42 INT122529 Apoe Regulation of S100B 1 0.18 0.29 0.16
43 INT297345 Apoe Negative_regulation of Csf2 1 0.17 0.66 0.16
44 INT252575 Rpe Negative_regulation of SOD1 1 0.03 2.39 0.14
45 INT240909 Hmgcr Regulation of Gene_expression of Sod1 1 0.03 0.53 0.14
46 INT297333 Apoe Negative_regulation of Positive_regulation of Tlr4 1 0.10 1.02 0.14
47 INT297343 Binding of Apoe and Tlr4 1 0.09 0.94 0.14
48 INT297339 Tlr4 Negative_regulation of Gene_expression of Apoe 1 0.10 0.73 0.13
49 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11
50 INT208361 Positive_regulation of Binding of Apoe and Hdl1 1 0.12 1.22 0.1
51 INT297346 Apoe Negative_regulation of Localization of TNF 1 0.48 0.26 0.1
52 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08
53 INT303337 Binding of SOD1 and Igfals 1 0.06 1.27 0.08
54 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
55 INT346695 Negative_regulation of SOD1 Positive_regulation of Negative_regulation of Hist3h2a 1 0.00 0.41 0.08
56 INT31986 NTS Positive_regulation of Binding of SOD1 1 0.16 0 0.08
57 INT300641 Binding of APOE and CRP 1 0.41 0.81 0.07
58 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
59 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07
60 INT308663 Apoe Regulation of Car2 1 0.02 0.44 0.07
61 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
62 INT326067 APOA1 Positive_regulation of Localization of APOE 1 0.61 4.22 0.07
63 INT220724 Binding of IGFALS and SOD1 1 0.06 2.1 0.06
64 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05
65 INT251468 Binding of APOE and DBT 1 0.03 1.18 0.05
66 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05
67 INT240888 Sod1 Regulation of Gene_expression of Ins1 1 0.08 0.18 0.04
68 INT208356 Hdl1 Positive_regulation of Apoe 1 0.12 1.25 0.04
69 INT235551 Gene_expression of Hras1 Negative_regulation of Positive_regulation of Apoe 1 0.03 0.57 0.04
70 INT266897 Nfe2l2 Positive_regulation of Sod1 1 0.11 0.19 0.04
71 INT208357 Hdl1 Positive_regulation of Localization of Apoe 1 0.12 1.26 0.04
72 INT347416 Tlr4 Negative_regulation of SOD1 1 0.00 0.36 0.04
73 INT208350 Positive_regulation of Hdl1 Positive_regulation of Apoe 1 0.12 1.27 0.04
74 INT290181 Binding of APOE and PLTP 1 0.17 1.61 0.04
75 INT240905 Gene_expression of Sod1 Negative_regulation of Phosphorylation of Creb1 1 0.32 0.1 0.03
76 INT240881 Gene_expression of Sod1 Positive_regulation of Phosphorylation of Foxo1 1 0.38 0.07 0.03
77 INT292416 SOD1 Regulation of Cat 1 0.01 0.45 0.03
78 INT194483 Binding of Apoe and Chol1 1 0.24 0.51 0.03
79 INT240875 Gene_expression of Sod1 Negative_regulation of Gene_expression of Pck1 1 0.33 0.27 0.03
80 INT208352 Apoe Regulation of Localization of Em 1 0.04 1.15 0.03
81 INT194481 Binding of Apoe and Apob 1 0.07 0.51 0.03
82 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03
83 INT240876 Gene_expression of Sod1 Negative_regulation of Pck1 1 0.33 0.27 0.03
84 INT239181 Gene_expression of Gh Negative_regulation of Sod1 1 0.24 0.33 0
85 INT341487 Binding of APOE and TLR2 1 0.00 0.3 0
86 INT329340 UCN2 Positive_regulation of SOD1 1 0.02 1.12 0
87 INT333853 Binding of SOD1 and Gtf3a 1 0.00 0 0
88 INT326065 APOE Positive_regulation of LCAT 1 0.53 0.84 0
89 INT209987 Binding of APOE and LDLR 1 0.24 0 0
90 INT208349 Regulation of Binding of Apoc3 and Apoe 1 0.01 0.38 0
91 INT240887 Binding of Sod1 and Gopc 1 0.10 0.08 0
92 INT204320 SOD1 Positive_regulation of Protein_catabolism of ROS1 1 0.06 0.05 0
93 INT90283 Binding of APOE and Il1a 1 0.01 0 0
94 INT201080 Binding of APOE and HLA-C 1 0.41 0.31 0
95 INT353802 Binding of APOE and Apob 1 0.05 0.83 0
96 INT333854 Binding of SOD1 and Creb1 1 0.02 0 0
97 INT208355 Binding of Apoc3 and Apoe 1 0.01 0.76 0
98 INT291716 Binding of SOD1 and Rxra 1 0.21 0 0
99 INT198933 Binding of Apoe and App 1 0.33 0.19 0
100 INT353801 Binding of APOE and Cd320 1 0.22 0.83 0
101 INT232575 SNRNP70 Regulation of SOD1 1 0.12 0.65 0
102 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
103 INT326059 APOA1 Positive_regulation of Gene_expression of APOE 1 0.61 0.38 0
104 INT229418 Mpo Positive_regulation of Sod1 1 0.20 0.71 0
105 INT353804 Binding of APOE and Ldlr 1 0.16 0.84 0
106 INT326057 APOA1 Regulation of Localization of APOE 1 0.54 1.36 0
107 INT240882 Sod1 Positive_regulation of Phosphorylation of Creb1 1 0.31 0.1 0
108 INT229826 Fos Positive_regulation of Sod1 1 0.42 0.38 0
109 INT201082 Binding of APOE and HLA-B 1 0.54 1.54 0
110 INT302672 Gene_expression of Zmat3 Positive_regulation of Sod1 1 0.05 0.05 0
111 INT234164 Binding of Sod1 and Dynll1 1 0.06 1.27 0
112 INT240896 Gene_expression of Sod1 Negative_regulation of Ros1 1 0.12 0.69 0
113 INT347418 Tlr4 Positive_regulation of SOD1 1 0.01 0 0
114 INT284093 VWF Negative_regulation of APOE 1 0.40 2.32 0
115 INT186247 CGA Regulation of Gene_expression of SOD1 1 0.01 0.35 0
116 INT240874 Sod1 Negative_regulation of Ros1 1 0.11 0.09 0
117 INT347417 Positive_regulation of Tlr4 Positive_regulation of SOD1 1 0.01 0 0
118 INT312769 Binding of Apoe and Pon1 1 0.04 0.86 0
119 INT353803 Binding of APOE and Hdl1 1 0.01 0.83 0
120 INT302671 Zmat3 Positive_regulation of Gene_expression of Sod1 1 0.04 0.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cholesterol biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cholesterol biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
2 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
3 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
4 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
5 INT197493 Localization of Apoe 61 0.79 27.48 7.06
6 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94
7 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
8 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72
9 INT63042 Binding of Apoe 59 0.48 31.23 5.88
10 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
11 INT55758 Positive_regulation of Apoe 15 0.70 11.71 4.69
12 INT15033 Gene_expression of Apoe 18 0.78 14.97 3.75
13 INT104624 Negative_regulation of Apoe 26 0.59 19.25 3.71
14 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52
15 INT72141 Binding of Apoe 11 0.37 10.91 3.27
16 INT97710 Localization of Apoe 1 0.79 7.18 3.2
17 INT50080 Binding of APOE 38 0.45 29.61 2.67
18 INT91899 Binding of Sod1 17 0.47 11.56 2.63
19 INT31989 Binding of SOD1 43 0.47 19.38 2.55
20 INT97713 Negative_regulation of Apoe 4 0.59 4.57 2.52
21 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
22 INT208344 Positive_regulation of Localization of Apoe 22 0.48 9.6 2.27
23 INT142265 Regulation of Apoe 20 0.60 9.52 2.23
24 INT84060 Regulation of Apoe 4 0.62 3.33 2.05
25 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
26 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
27 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
28 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
29 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61
30 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
31 INT91900 Localization of Sod1 12 0.77 6.62 1.51
32 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
33 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
34 INT217388 Negative_regulation of Gene_expression of Apoe 11 0.59 6.07 1.4
35 INT97716 Transcription of Apoe 3 0.53 2.61 1.36
36 INT97715 Regulation of Gene_expression of Apoe 3 0.62 1.98 1.23
37 INT113336 Positive_regulation of Gene_expression of Apoe 3 0.70 1.79 1.23
38 INT117100 Positive_regulation of Gene_expression of Sod1 5 0.60 1.18 1.2
39 INT159543 Localization of SOD1 29 0.75 8.62 1.06
40 INT217390 Negative_regulation of Positive_regulation of Apoe 3 0.37 1.95 1.05
41 INT129398 Negative_regulation of Gene_expression of SOD1 22 0.43 7.11 1.02
42 INT97714 Negative_regulation of Localization of Apoe 1 0.58 1.83 0.97
43 INT135836 Negative_regulation of Sod1 5 0.25 1.62 0.82
44 INT142597 Regulation of Binding of Apoe 1 0.34 2.21 0.8
45 INT129630 Regulation of Sod1 6 0.44 4.94 0.73
46 INT197495 Negative_regulation of Localization of Apoe 6 0.43 2.19 0.73
47 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72
48 INT28561 Regulation of Gene_expression of SOD1 9 0.61 2.83 0.71
49 INT270428 Negative_regulation of Binding of APOE 2 0.41 1.16 0.7
50 INT113335 Regulation of Transcription of Apoe 1 0.27 0.51 0.7
51 INT175580 Localization of APOE 10 0.76 18.84 0.65
52 INT97708 Regulation of Localization of Apoe 1 0.61 2.06 0.62
53 INT113334 Positive_regulation of Positive_regulation of Apoe 1 0.50 0.6 0.56
54 INT162429 Negative_regulation of Gene_expression of Sod1 6 0.48 2.46 0.53
55 INT197322 Protein_catabolism of Apoe 6 0.71 3.52 0.51
56 INT217370 Phosphorylation of Apoe 2 0.63 1.8 0.49
57 INT96816 Regulation of APOE 8 0.45 6.62 0.44
58 INT97712 Negative_regulation of Transcription of Apoe 1 0.43 1.05 0.4
59 INT187472 Regulation of Gene_expression of Sod1 5 0.53 2.68 0.37
60 INT131542 Negative_regulation of Gene_expression of APOE 6 0.40 3.92 0.33
61 INT311128 Positive_regulation of Regulation of Apoe 1 0.30 0.3 0.3
62 INT175687 Transcription of Apoe 4 0.72 2.12 0.29
63 INT96815 Regulation of Gene_expression of APOE 2 0.62 1.1 0.29
64 INT129632 Negative_regulation of Transcription of Sod1 1 0.43 0.69 0.28
65 INT129631 Transcription of Sod1 1 0.52 0.69 0.28
66 INT97711 Positive_regulation of Transcription of Apoe 1 0.46 1.06 0.27
67 INT254756 Regulation of Positive_regulation of Apoe 1 0.20 0.22 0.26
68 INT129399 Transcription of SOD1 6 0.66 3.08 0.25
69 INT323964 Negative_regulation of Binding of Apoe 1 0.39 0.35 0.22
70 INT198892 Regulation of Binding of Apoe 6 0.45 2.94 0.21
71 INT220727 Regulation of Binding of SOD1 1 0.42 1.46 0.21
72 INT238309 Negative_regulation of Gene_expression of Sod1 3 0.38 1.09 0.2
73 INT116432 Positive_regulation of Positive_regulation of SOD1 3 0.40 3.88 0.2
74 INT193810 Phosphorylation of APOE 2 0.27 1.13 0.2
75 INT174127 Positive_regulation of Positive_regulation of Sod1 2 0.45 4.9 0.19
76 INT240279 Negative_regulation of Positive_regulation of SOD1 5 0.43 2.45 0.18
77 INT319180 Regulation of Transcription of SOD1 1 0.21 0.3 0.17
78 INT254754 Regulation of Localization of Apoe 1 0.20 0.39 0.17
79 INT238306 Regulation of Gene_expression of Sod1 1 0.39 0.46 0.16
80 INT254755 Positive_regulation of Transcription of Apoe 1 0.16 0.41 0.16
81 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14
82 INT198894 Regulation of Gene_expression of Apoe 2 0.44 0.56 0.14
83 INT204370 Negative_regulation of Binding of SOD1 4 0.41 0.82 0.13
84 INT314356 Positive_regulation of Localization of SOD1 1 0.04 0.82 0.13
85 INT104623 Regulation of Negative_regulation of Apoe 2 0.45 0.73 0.12
86 INT229429 Localization of Sod1 2 0.65 0.8 0.12
87 INT326081 Negative_regulation of Localization of APOE 1 0.56 2.23 0.11
88 INT204330 Protein_catabolism of SOD1 8 0.84 4.75 0.1
89 INT268725 Positive_regulation of Negative_regulation of SOD1 3 0.35 2.41 0.1
90 INT177582 Regulation of Sod1 2 0.24 0.39 0.1
91 INT203330 Negative_regulation of Binding of Sod1 1 0.28 1.03 0.1
92 INT300643 Positive_regulation of Binding of APOE 1 0.44 0.8 0.09
93 INT252574 Negative_regulation of Regulation of SOD1 1 0.06 1.11 0.09
94 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09
95 INT342172 Regulation of Regulation of SOD1 1 0.02 0.75 0.08
96 INT205147 Regulation of Phosphorylation of APOE 1 0.06 0.34 0.07
97 INT97709 Positive_regulation of Localization of Apoe 1 0.68 1.02 0.07
98 INT208336 Positive_regulation of Binding of Apoe 1 0.48 0.7 0.05
99 INT208333 Positive_regulation of Positive_regulation of Apoe 1 0.48 0.65 0.05
100 INT272876 Negative_regulation of Localization of Sod1 1 0.18 0.57 0.03
101 INT240277 Negative_regulation of Protein_catabolism of SOD1 1 0.42 1.23 0.03
102 INT326070 Regulation of Localization of APOE 1 0.58 1.21 0.03
103 INT191285 Positive_regulation of Localization of APOE 3 0.66 3.06 0
104 INT326073 Transcription of APOE 2 0.51 1.94 0
105 INT50081 Positive_regulation of Positive_regulation of APOE 2 0.49 0.18 0
106 INT250969 Regulation of Positive_regulation of SOD1 2 0.44 0.38 0
107 INT174131 Regulation of Negative_regulation of Sod1 1 0.43 0.52 0
108 INT253184 Binding of Sod1 1 0.33 0.06 0
109 INT268728 Negative_regulation of Negative_regulation of SOD1 1 0.24 0 0
110 INT174130 Positive_regulation of Binding of Sod1 1 0.48 0.72 0
111 INT118577 Positive_regulation of Binding of SOD1 1 0.28 0.16 0
112 INT326524 Negative_regulation of Transcription of APOE 1 0.30 1.71 0
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