GO:0045579

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Name positive regulation of B cell differentiation
Categary Process
Go Slim No
Go Link GO:0045579
Unique Molecular Interactions 114
Total Molecular Interactions 145
Total Single Events 844
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of B cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of B cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
2 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
3 INT231751 Binding of Il2rg and Jak3 1 0.03 1.56 0.67
4 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
5 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
6 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
7 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
8 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
9 INT5856 Bad Positive_regulation of Gene_expression of Penk 1 0.02 0.37 0.5
10 INT300547 Il6 Positive_regulation of Il21 1 0.02 0.78 0.39
11 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
12 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
13 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
14 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
15 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
16 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
17 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
18 INT29984 Bad Positive_regulation of Localization of Prl 1 0.15 0 0.3
19 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
20 INT172901 Binding of Bad and Bcl2l1 3 0.13 6.51 0.27
21 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
22 INT120376 Bad Positive_regulation of Gene_expression of Oxtr 1 0.08 0 0.22
23 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
24 INT302930 Binding of Pnp and Chrm2 1 0.00 0.64 0.15
25 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
26 INT289248 Il6 Positive_regulation of Gene_expression of Il21 1 0.06 0.69 0.15
27 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
28 INT184129 Socs2 Negative_regulation of Stat5a 1 0.22 0.05 0.13
29 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
30 INT150390 Binding of CD27 and MEFV 1 0.27 0.85 0.12
31 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
32 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
33 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
34 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
35 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1
36 INT347647 Inpp5d Negative_regulation of Pik3r1 1 0.31 0.37 0.1
37 INT275184 Bad Positive_regulation of Positive_regulation of Bcl2l1 1 0.12 0.62 0.09
38 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
39 INT276304 PRDM1 Regulation of TSC1 1 0.01 1.29 0.09
40 INT276391 Prdm1 Regulation of TSC1 1 0.00 1.29 0.09
41 INT276375 Binding of Prdm1 and MIR9-1 1 0.12 1.12 0.08
42 INT276383 Binding of PRDM1 and Mirlet7a-1 1 0.39 1.12 0.08
43 INT276334 Binding of Prdm1 and Mirlet7a-1 1 0.12 1.13 0.08
44 INT265893 BAD Regulation of FOXO1 1 0.03 1.08 0.06
45 INT331153 Akt1 Positive_regulation of Bad 1 0.03 0.92 0.04
46 INT331155 Akt1 Positive_regulation of Binding of Bad 1 0.04 0.93 0.04
47 INT331156 Akt1 Positive_regulation of Phosphorylation of Bad 1 0.02 0.91 0.04
48 INT266661 AKT1 Regulation of BAD 2 0.10 1.86 0.03
49 INT322876 Binding of PDCD10 and Inpp5d 1 0.03 0.46 0.03
50 INT214547 Binding of CD27 and SLEB1 1 0.05 1.38 0.03
51 INT303056 Rorb Regulation of Bad 1 0.00 0.52 0.03
52 INT185856 Binding of BAD and BCL2L1 4 0.39 2.73 0
53 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0
54 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
55 INT229815 Fos Regulation of Bad 1 0.09 0.31 0
56 INT353192 Stat5a Positive_regulation of Plxna3 1 0.01 0 0
57 INT320351 Pnp Regulation of Ighg2b 1 0.02 0.31 0
58 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
59 INT292447 Negative_regulation of Binding of BAD and BCL2L1 1 0.02 0.81 0
60 INT185854 BID Positive_regulation of BAD 1 0.39 0.74 0
61 INT285909 AKT1 Regulation of Phosphorylation of Bad 1 0.01 0.4 0
62 INT302145 Positive_regulation of AKT1 Positive_regulation of Phosphorylation of BAD 1 0.07 0.9 0
63 INT86001 Binding of Pnp and Alms1 1 0.03 0 0
64 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
65 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
66 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
67 INT302137 Binding of BAD and BAK1 1 0.07 0.93 0
68 INT287069 Proc Regulation of Prdm1 1 0.00 0.13 0
69 INT320352 Pnp Positive_regulation of Ighg2b 1 0.03 0.08 0
70 INT292462 LAMB2 Positive_regulation of BAD 1 0.00 0.7 0
71 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
72 INT335953 Binding of BCL2 and Bad 1 0.14 0.37 0
73 INT327970 GOPC Regulation of Gene_expression of BAD 1 0.08 0.6 0
74 INT302926 Binding of Pnp and Pbrm1 1 0.01 0.96 0
75 INT270656 Binding of Il21 and Idd3 1 0.30 0.92 0
76 INT292458 Negative_regulation of Binding of BAD and BCL2 1 0.01 0.81 0
77 INT287065 Prdm1 Regulation of Igj 1 0.12 0.13 0
78 INT287073 Gopc Positive_regulation of Gene_expression of Prdm1 1 0.10 0.15 0
79 INT292459 Phosphorylation of BAD Negative_regulation of Binding of BCL2L1 1 0.02 0.82 0
80 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
81 INT295048 Bad Regulation of RYBP 1 0.00 1.64 0
82 INT292502 Mlph Regulation of Gene_expression of BAD 1 0.01 0.4 0
83 INT278372 Binding of Syk and Pycard 1 0.06 0 0
84 INT172908 Binding of Bad and Bax 1 0.01 1.34 0
85 INT278399 Syk Positive_regulation of Localization of Ctsb 1 0.09 0.28 0
86 INT189110 Binding of Pnp and Asprv1 1 0.00 0 0
87 INT329745 AKT1 Negative_regulation of BAD 1 0.03 1.43 0
88 INT292508 Mlph Regulation of Phosphorylation of BAD 1 0.01 1.52 0
89 INT201760 Binding of BCL2L1 and Positive_regulation of Bad 1 0.01 0.3 0
90 INT287075 Positive_regulation of Vav1 Positive_regulation of Gene_expression of Prdm1 1 0.14 0.15 0
91 INT302929 Binding of Pnp and Spna1 1 0.00 0.35 0
92 INT353190 Stat5a Positive_regulation of Cyp2c11 1 0.31 0 0
93 INT292501 Mlph Positive_regulation of Phosphorylation of BAD 1 0.01 0.39 0
94 INT278405 Tlr4 Positive_regulation of Syk 1 0.06 0 0
95 INT335951 Binding of Bad and Tgif2lx1 1 0.00 0.37 0
96 INT302172 Binding of BAD and BAX 1 0.06 0.93 0
97 INT292457 PTK2 Regulation of BAD 1 0.03 0.76 0
98 INT209444 Stam Positive_regulation of Syk 1 0.01 0.26 0
99 INT278392 Syk Regulation of Positive_regulation of Ctsb 1 0.06 0 0
100 INT201743 Bad Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
101 INT302132 Negative_regulation of Binding of BAD and BAK1 1 0.06 0.93 0
102 INT278396 Msu Positive_regulation of Phosphorylation of Syk 1 0.25 0.27 0
103 INT154173 Binding of SIPA1 and SYK 1 0.16 0.46 0
104 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of B cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of B cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT224648 Gene_expression of Il21 15 0.39 18.71 7.47
2 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52
3 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
4 INT33229 Gene_expression of Bad 9 0.70 6.95 4.15
5 INT51654 Regulation of Bad 21 0.40 12.18 4.06
6 INT3437 Negative_regulation of Bad 5 0.48 1.66 2.99
7 INT29983 Localization of Bad 5 0.28 4.44 2.52
8 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
9 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
10 INT44979 Positive_regulation of Pnp 11 0.59 5.61 2.41
11 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
12 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07
13 INT224636 Positive_regulation of Il21 6 0.45 6.16 1.97
14 INT95904 Gene_expression of CD27 45 0.76 26.17 1.93
15 INT43143 Binding of Bad 8 0.21 5.12 1.81
16 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
17 INT40322 Binding of Pnp 12 0.38 11.13 1.78
18 INT224626 Negative_regulation of Il21 3 0.10 3.51 1.67
19 INT93427 Negative_regulation of Bad 4 0.02 2.5 1.63
20 INT5855 Positive_regulation of Bad 12 0.61 12.26 1.56
21 INT119835 Positive_regulation of Gene_expression of BAD 6 0.44 7.66 1.51
22 INT18495 Regulation of Bad 6 0.19 4.79 1.45
23 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41
24 INT154081 Negative_regulation of Localization of Bad 2 0.16 2.06 1.31
25 INT126605 Negative_regulation of Binding of Stat5a 1 0.58 0.15 1.27
26 INT108340 Negative_regulation of Phosphorylation of BAD 11 0.49 8.29 1.02
27 INT353937 Localization of Il21 1 0.52 2.44 1.01
28 INT132177 Binding of CD27 3 0.19 1.84 1
29 INT224624 Binding of Il21 2 0.09 1.61 0.99
30 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
31 INT159668 Positive_regulation of Bad 8 0.45 6.32 0.89
32 INT184015 Positive_regulation of Stat5a 9 0.46 3.32 0.86
33 INT108341 Positive_regulation of BAD 8 0.42 8.75 0.85
34 INT167938 Positive_regulation of Phosphorylation of Stat5b 1 0.33 0 0.85
35 INT133767 Transcription of Bad 2 0.57 1.72 0.84
36 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
37 INT167942 Binding of Stat5b 1 0.26 0 0.82
38 INT275180 Positive_regulation of Phosphorylation of Bad 4 0.40 3.79 0.77
39 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
40 INT201628 Positive_regulation of Gene_expression of Bad 12 0.68 13.86 0.72
41 INT50440 Negative_regulation of Pnp 5 0.36 2.14 0.66
42 INT153802 Positive_regulation of Localization of BAD 1 0.30 0.64 0.66
43 INT153799 Localization of BAD 1 0.45 0.63 0.66
44 INT126606 Negative_regulation of Stat5a 1 0.43 0.08 0.64
45 INT331152 Positive_regulation of Localization of Bad 1 0.19 1.35 0.64
46 INT331150 Negative_regulation of Gene_expression of Bad 1 0.10 1.33 0.63
47 INT159942 Positive_regulation of Stat5a 3 0.41 0.95 0.61
48 INT126612 Negative_regulation of Phosphorylation of Stat5a 1 0.42 0.1 0.61
49 INT132324 Localization of SYK 2 0.78 1.9 0.59
50 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
51 INT108339 Positive_regulation of Phosphorylation of BAD 6 0.58 3.95 0.55
52 INT150000 Positive_regulation of Positive_regulation of BAD 2 0.14 3.1 0.55
53 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
54 INT231743 Positive_regulation of Binding of Il21 1 0.12 1.13 0.51
55 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
56 INT142871 Negative_regulation of Gene_expression of Bad 7 0.51 6.52 0.49
57 INT159667 Negative_regulation of Positive_regulation of Bad 4 0.20 3.13 0.48
58 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
59 INT105886 Phosphorylation of Bad 3 0.23 2.15 0.47
60 INT149999 Negative_regulation of Gene_expression of BAD 4 0.13 5.46 0.45
61 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
62 INT167941 Phosphorylation of Stat5b 1 0.58 0 0.42
63 INT187159 Negative_regulation of Binding of CD27 1 0.22 0.63 0.41
64 INT300543 Regulation of Il21 1 0.04 0.98 0.4
65 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
66 INT294539 Binding of BAD 3 0.36 2.35 0.37
67 INT17050 Regulation of CD27 1 0.01 1.38 0.35
68 INT154175 Regulation of SYK 2 0.62 1.48 0.34
69 INT330616 Positive_regulation of Gene_expression of Inpp5d 2 0.49 0.89 0.34
70 INT192983 Regulation of Regulation of Bad 1 0.01 0.3 0.33
71 INT330615 Gene_expression of Inpp5d 2 0.66 0.78 0.31
72 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
73 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
74 INT353932 Positive_regulation of Gene_expression of Il21 1 0.30 0.16 0.27
75 INT302274 Negative_regulation of Positive_regulation of BAD 1 0.13 1.31 0.27
76 INT135807 Positive_regulation of Negative_regulation of Bad 1 0.35 0.24 0.27
77 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
78 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
79 INT278154 Regulation of Syk 1 0.05 0.98 0.22
80 INT330612 Positive_regulation of Localization of Inpp5d 1 0.02 0.35 0.22
81 INT330610 Localization of Inpp5d 1 0.02 0.3 0.22
82 INT278147 Localization of Syk 1 0.30 0.98 0.22
83 INT169061 Gene_expression of Pnp 19 0.66 9.39 0.21
84 INT169062 Positive_regulation of Gene_expression of Pnp 6 0.49 3.6 0.21
85 INT206970 Negative_regulation of BAD 3 0.22 3.3 0.19
86 INT214569 Positive_regulation of Localization of CD27 3 0.49 2.16 0.19
87 INT347641 Regulation of Positive_regulation of Inpp5d 1 0.27 0.33 0.19
88 INT167940 Regulation of Stat5b 1 0.43 0 0.19
89 INT163189 Localization of CD27 7 0.74 5.31 0.18
90 INT347643 Positive_regulation of Inpp5d 1 0.46 0.33 0.18
91 INT201637 Regulation of Gene_expression of Bad 4 0.23 2.99 0.17
92 INT184024 Binding of Stat5a 1 0.25 0.11 0.17
93 INT214566 Positive_regulation of CD27 1 0.68 13.39 0.17
94 INT184055 Positive_regulation of Binding of Stat5a 1 0.33 0.12 0.17
95 INT273054 Positive_regulation of Binding of Bad 2 0.14 2.66 0.16
96 INT350667 Positive_regulation of Transcription of Stat5a 1 0.29 0.47 0.16
97 INT350637 Transcription of Stat5a 1 0.40 0.46 0.16
98 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
99 INT276356 Positive_regulation of PRDM1 4 0.49 2.07 0.14
100 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
101 INT161613 Regulation of Phosphorylation of BAD 3 0.11 2.36 0.13
102 INT276368 Gene_expression of PRDM1 2 0.75 1.4 0.13
103 INT276309 Negative_regulation of Prdm1 1 0.18 1.97 0.13
104 INT153486 Positive_regulation of Gene_expression of Bad 1 0.62 0.74 0.13
105 INT276340 Negative_regulation of PRDM1 1 0.57 1.98 0.13
106 INT172857 Binding of Bad 2 0.36 2.86 0.12
107 INT220368 Negative_regulation of Positive_regulation of Stat5a 1 0.34 0.46 0.11
108 INT162014 Protein_catabolism of Bad 1 0.76 0.29 0.1
109 INT275411 Binding of Syk 1 0.09 0.12 0.1
110 INT275179 Localization of Bad 2 0.69 0.66 0.09
111 INT169060 Negative_regulation of Gene_expression of Pnp 3 0.42 0.95 0.08
112 INT297111 Regulation of Transcription of PRDM1 1 0.44 0.41 0.08
113 INT211097 Negative_regulation of Binding of Pnp 1 0.08 1.27 0.08
114 INT350646 Negative_regulation of Positive_regulation of Stat5a 1 0.25 0.23 0.08
115 INT313905 Localization of Stat5a 1 0.21 0.33 0.08
116 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
117 INT297112 Transcription of PRDM1 1 0.69 0.41 0.07
118 INT214554 Positive_regulation of Positive_regulation of CD27 1 0.49 3.37 0.07
119 INT297114 Positive_regulation of Transcription of PRDM1 1 0.45 0.41 0.07
120 INT276312 Positive_regulation of Prdm1 2 0.19 1.44 0.06
121 INT276322 Gene_expression of Prdm1 2 0.30 1.3 0.06
122 INT206969 Regulation of BAD 8 0.15 5.32 0.05
123 INT218757 Regulation of Pnp 4 0.15 5.51 0.04
124 INT184061 Negative_regulation of Stat5a 2 0.29 1.85 0.04
125 INT278363 Binding of Syk 1 0.32 0.3 0.04
126 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04
127 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03
128 INT214567 Negative_regulation of CD27 5 0.42 3.05 0
129 INT173796 Gene_expression of Stat5a 5 0.56 1.41 0
130 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0
131 INT214576 Regulation of Gene_expression of CD27 2 0.44 1.66 0
132 INT292467 Regulation of Gene_expression of BAD 2 0.11 1.38 0
133 INT280520 Regulation of Gene_expression of Pnp 1 0.15 0.55 0
134 INT154178 Binding of SYK 1 0.37 0.46 0
135 INT200800 Positive_regulation of Phosphorylation of Stat5a 1 0.36 0.24 0
136 INT278354 Positive_regulation of Phosphorylation of Syk 1 0.31 0.23 0
137 INT275951 Negative_regulation of Phosphorylation of Syk 1 0.34 0.2 0
138 INT214556 Regulation of Negative_regulation of CD27 1 0.44 1.73 0
139 INT350662 Regulation of Inpp5d 1 0.06 0.16 0
140 INT214571 Positive_regulation of Gene_expression of CD27 1 0.49 7.77 0
141 INT285838 Positive_regulation of Binding of CD27 1 0.25 0.56 0
142 INT278348 Positive_regulation of Gene_expression of Syk 1 0.33 0 0
143 INT214565 Negative_regulation of Positive_regulation of CD27 1 0.42 1.8 0
144 INT278326 Regulation of Positive_regulation of Syk 1 0.18 0 0
145 INT175515 Regulation of Phosphorylation of Bad 1 0.08 1.69 0
146 INT320332 Transcription of Pnp 1 0.05 0.05 0
147 INT330030 Positive_regulation of Regulation of Bad 1 0.21 0.71 0
148 INT194939 Regulation of Phosphorylation of SYK 1 0.18 0.31 0
149 INT214560 Negative_regulation of Gene_expression of CD27 1 0.42 3.45 0
150 INT302919 Negative_regulation of Regulation of Pnp 1 0.04 1.71 0
151 INT200799 Positive_regulation of Gene_expression of Stat5a 1 0.36 0.37 0
152 INT183523 Transcription of Il21 1 0.52 0.53 0
153 INT353174 Gene_expression of Stat5b 1 0.48 0 0
154 INT335937 Negative_regulation of Phosphorylation of Bad 1 0.15 0.41 0
155 INT287056 Positive_regulation of Gene_expression of Prdm1 1 0.27 0.16 0
156 INT200790 Positive_regulation of Positive_regulation of Stat5a 1 0.36 0.24 0
157 INT278346 Positive_regulation of Negative_regulation of Syk 1 0.33 0 0
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