GO:0045603

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Name positive regulation of endothelial cell differentiation
Categary Process
Go Slim No
Go Link GO:0045603
Unique Molecular Interactions 94
Total Molecular Interactions 117
Total Single Events 817
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of endothelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of endothelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
2 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
3 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
4 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
5 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
6 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
7 INT309129 Dlat Positive_regulation of Gene_expression of Btg1 1 0.00 1.05 0.42
8 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
9 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
10 INT147356 Egr1 Positive_regulation of Gene_expression of Btg1 1 0.14 1.56 0.28
11 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
12 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
13 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
14 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
15 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
16 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
17 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
18 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
19 INT123180 Bmp6 Positive_regulation of Lamtor1 1 0.01 0.61 0.14
20 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
21 INT123194 Bmp6 Positive_regulation of TAF9 1 0.18 0.61 0.14
22 INT123193 Bmp6 Positive_regulation of Negative_regulation of TAF9 1 0.18 0.61 0.14
23 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
24 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
25 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
26 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
27 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
28 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
29 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
30 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
31 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
32 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
33 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
34 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
35 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
36 INT313508 Binding of ALOX12 and CRP 1 0.06 0.44 0.03
37 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
38 INT313552 Binding of ALOX12 and Cor 1 0.01 0.99 0.03
39 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
40 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
41 INT313501 Binding of ALOX12 and ICAM1 1 0.10 0.54 0.03
42 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
43 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
44 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
45 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0
46 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
47 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
48 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
49 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
50 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
51 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
52 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
53 INT310186 Binding of Gdf2 and Bmpr2 1 0.02 0 0
54 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
55 INT327873 Postn Regulation of Notch1 1 0.41 0 0
56 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
57 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
58 INT356083 Binding of App and Notch1 1 0.02 0.2 0
59 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
60 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
61 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
62 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
63 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
64 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
65 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
66 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
67 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
68 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
69 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
70 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
71 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
72 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
73 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
74 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
75 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
76 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
77 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0
78 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
79 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
80 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
81 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
82 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
83 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
84 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of endothelial cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of endothelial cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
2 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
3 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
4 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
5 INT39990 Negative_regulation of BMP6 1 0.59 0 3.05
6 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
7 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
8 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
9 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
10 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
11 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
12 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
13 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
14 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
15 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
16 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
17 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
18 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
19 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
20 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
21 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27
22 INT39991 Negative_regulation of Negative_regulation of BMP6 1 0.43 0 1.24
23 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
24 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
25 INT110780 Localization of Notch1 2 0.06 0.47 1.19
26 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
27 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
28 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
29 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
30 INT6833 Binding of Notch1 4 0.36 0.05 0.94
31 INT52213 Regulation of Localization of Bmp6 1 0.44 0.39 0.93
32 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
33 INT52215 Localization of Bmp6 1 0.73 0.37 0.88
34 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
35 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
36 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
37 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
38 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
39 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
40 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
41 INT309100 Gene_expression of Btg1 2 0.05 2.38 0.64
42 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
43 INT39994 Positive_regulation of BMP6 1 0.50 0 0.63
44 INT39992 Positive_regulation of Negative_regulation of BMP6 1 0.47 0 0.62
45 INT39993 Regulation of BMP6 2 0.39 0.29 0.6
46 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
47 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
48 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
49 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
50 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
51 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
52 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
53 INT27543 Positive_regulation of ALOX12 1 0.09 2.09 0.48
54 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
55 INT52214 Regulation of Gene_expression of Bmp6 1 0.37 0.19 0.46
56 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
57 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
58 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
59 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
60 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
61 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
62 INT147351 Gene_expression of Btg1 3 0.43 2.05 0.38
63 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38
64 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
65 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
66 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
67 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
68 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
69 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
70 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
71 INT147352 Positive_regulation of Btg1 1 0.19 1.54 0.27
72 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
73 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
74 INT336931 Negative_regulation of Btg1 1 0.03 1.32 0.22
75 INT336929 Negative_regulation of Gene_expression of Btg1 1 0.04 1.35 0.22
76 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
77 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
78 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
79 INT193945 Binding of Notch1 7 0.15 1.28 0.19
80 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
81 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
82 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
83 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
84 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
85 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
86 INT297455 Positive_regulation of Gdf2 1 0.01 0.75 0.15
87 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
88 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
89 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
90 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
91 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
92 INT149266 Gene_expression of BMP6 2 0.77 0.56 0.1
93 INT198335 Regulation of ALOX12 1 0.00 0.11 0.1
94 INT150032 Gene_expression of ALOX12 7 0.65 0.61 0.09
95 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
96 INT57599 Positive_regulation of Btg1 2 0.03 2 0.09
97 INT188645 Binding of ALOX12 2 0.30 3.07 0.09
98 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
99 INT149264 Positive_regulation of Gene_expression of BMP6 1 0.69 0.34 0.08
100 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
101 INT150031 Negative_regulation of Gene_expression of ALOX12 2 0.41 0.05 0.07
102 INT149265 Localization of BMP6 1 0.74 0.31 0.07
103 INT150033 Negative_regulation of ALOX12 1 0.57 0.05 0.07
104 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
105 INT193845 Localization of Notch1 2 0.78 0.32 0.05
106 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
107 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
108 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
109 INT298336 Phosphorylation of Notch1 1 0.02 0.13 0.04
110 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
111 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03
112 INT254991 Negative_regulation of Gene_expression of BMP6 1 0.13 0.22 0.03
113 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
114 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
115 INT265340 Binding of Acvrl1 3 0.30 0.46 0
116 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0
117 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
118 INT196027 Binding of Bmp4 2 0.13 0.97 0
119 INT142119 Regulation of Bmp4 2 0.58 0.29 0
120 INT297242 Transcription of Notch1 1 0.19 0.25 0
121 INT310166 Regulation of Acvrl1 1 0.07 0 0
122 INT264724 Negative_regulation of Positive_regulation of Notch1 1 0.03 0.77 0
123 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
124 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
125 INT313548 Phosphorylation of ALOX12 1 0.57 0.12 0
126 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
127 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
128 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
129 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
130 INT339667 Localization of Bmp4 1 0.38 0.27 0
131 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
132 INT300174 Negative_regulation of Gene_expression of NOTCH1 1 0.04 0.53 0
133 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
134 INT313541 Negative_regulation of Phosphorylation of ALOX12 1 0.30 0.18 0
135 INT234247 Negative_regulation of Protein_catabolism of NOTCH1 1 0.05 0 0
136 INT130094 Regulation of Positive_regulation of NOTCH1 1 0.45 0.52 0
137 INT310181 Binding of Gdf2 1 0.04 0 0
138 INT310182 Gene_expression of Gdf2 1 0.06 0.48 0
139 INT313550 Positive_regulation of Gene_expression of ALOX12 1 0.35 0.43 0
140 INT264723 Negative_regulation of Gene_expression of Notch1 1 0.03 0.83 0
141 INT327858 Positive_regulation of Protein_catabolism of Notch1 1 0.45 0.13 0
142 INT327861 Positive_regulation of Localization of Notch1 1 0.67 0 0
143 INT273836 Positive_regulation of Regulation of Notch1 1 0.15 0.05 0
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